Searching for autoimmunity in "antibiotic-refractory" Lyme arthritis.

abstract：:Attempts to develop peptide vaccines, based on a limited number of peptides face two problems: HLA polymorphism and the high mutation rate of viral epitopes. We have developed a new genomic method that ensures maximal coverage and thus maximal applicability of the peptide vaccine. The same method also promises a large...

journal_title：Molecular immunology

authors： Vider-Shalit T,Raffaeli S,Louzoun Y

更新日期：2007-02-01 00:00:00

abstract：:The immunological role of exosomes in autoimmune encephalitis (AE) remains uncharacterized and not examined. In this study we ought to determine whether exosomes are generated in AE and to define the presence of cell surface neuronal autoantigens (autoAgs) in the cargo. Exosomes were isolated from cerebrospinal fluid ...

journal_title：Molecular immunology

authors： Gu J,Jin T,Li Z,Chen H,Xia H,Xu X,Gui Y

更新日期：2021-01-11 00:00:00

abstract：:Activation of p38 MAP kinase in T cells leads to increased interferon-gamma production in CD4+ and CD8+ T cells, and the selective cell death of CD8+ T cells. To address the role of p38 MAP kinase activation in T cells during an in vivo immune response, we examined the response against the influenza virus in transgeni...

journal_title：Molecular immunology

authors： Conze D,Lumsden J,Enslen H,Davis RJ,Le Gros G,Rincón M

更新日期：2000-06-01 00:00:00

abstract：:Leucine-rich repeat-containing G-protein-coupled receptors (LGRs) form a subfamily of the large superfamily of G-protein-coupled receptors. LGRs can be divided into three groups. LGR2 from Drosophila melanogaster is involved in cuticle tanning (melanization and sclerotization). In this study, one LGR2 (MnLGR2) was ide...

journal_title：Molecular immunology

authors： Cao X,Zhang C,Zhang R,Wang K,Dai X,Huang X,Ren Q

更新日期：2020-10-01 00:00:00

abstract：:Immature dendritic cells (iDCs) are bone marrow-derived professional antigen-presenting cells, exhibit very low levels of the co-stimulatory molecules CD80 (B7-1), CD86 (B7-2), and CD40 and major histocompatibility complex (MHC) class II and play a critical role in triggering antigen-specific immunotolerance. The enzy...

journal_title：Molecular immunology

authors： Na N,Luo Y,Zhao D,Yang S,Hong L,Li H,Miao B,Qiu J

更新日期：2016-11-01 00:00:00

abstract：:Most studies of the immune responses in allergic rhinitis have focused on IgE antibodies to mixtures of allergenic proteins. Based on our previous studies of the major mountain cedar allergen Jun a 1, we sought to describe a broader assessment of the humoral immune responses to a single, dominant allergen, in three gr...

journal_title：Molecular immunology

authors： Goldblum RM,Madagoda-Desilva RS,Zhang Y,van Bavel J,Midoro-Horiuti T

更新日期：2018-09-01 00:00:00

abstract：:Mutations within the 5'-non-coding region of the bcl-6 gene can occur in lymphomas that originate from germinal centers (GCs), as well as in normal memory and GC B cells. Mutations in the p53 gene occur in 50% of human cancers. Since both bcl-6 and p53 can be mutated in certain circumstances, we investigated the accum...

journal_title：Molecular immunology

authors： Yavuz AS,Monson NL,Yavuz S,Grammer AC,Longo N,Girschick HJ,Lipsky PE

更新日期：2002-11-01 00:00:00

abstract：:A highly purified preparation of a monoclonal antibody to vasoactive intestinal peptide (VIP) was analysed by gel filtration. Three peaks of VIP hydrolysing activity were observed, corresponding to the 150 kDa tetramer IgG, 80 kDa dimer of the heavy and light chains (H-L dimer) and 25 kDa L chain monomer. The hydrolyt...

journal_title：Molecular immunology

authors： Li L,Sun M,Gao QS,Paul S

更新日期：1996-05-01 00:00:00

abstract：:The peptide editor HLA-DM (DM) catalyzes the exchange of peptides bound to MHC class II molecules within antigen presenting cells by generating a "peptide-receptive" MHC class II conformation (MHC(receptive)) to which peptides readily bind and rapidly unbind. While recent work has uncovered the determinants of DM reco...

journal_title：Molecular immunology

authors： Narayan K,Su KW,Chou CL,Khoruzhenko S,Sadegh-Nasseri S

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:A T cell subtype with the CD4+CD25-FoxP3+ phenotype was recently described. We aimed to investigate the frequency of these cells and their ability to produce cytokines in tumor-draining lymph nodes from patients with breast cancer (BC). MATERIALS AND METHODS:Mononuclear cells from lymph nodes of 20 patients...

journal_title：Molecular immunology

authors： Niakan A,Faghih Z,Talei AR,Ghaderi A

更新日期：2019-12-01 00:00:00

abstract：:To investigate the interaction of DNA and anti-DNA antibodies in the immune complex disease of systemic lupus erythematosus, the fine specificity of binding of a monoclonal anti-DNA antibody was determined. This antibody, termed Cll, was derived from the fusion of spleen cells from an autoimmune MRL-lpr/lpr mouse with...

journal_title：Molecular immunology

authors： Pisetsky DS,Caster SA

更新日期：1982-05-01 00:00:00

abstract：:Idiotypic-like interactions between mAbs directed against cytidine (Cyd) or guanosine (Guo) nucleosides were characterized. These mAbs, Cyd-1 (IgG2b, kappa), Guo-1 (IgG1, kappa) and Guo-2 (IgG1, kappa) were derived from splenocytes of A/J mice immunized with Cyd-KLH or Guo-KLH and recognized the nucleoside base moieti...

journal_title：Molecular immunology

authors： Cottet MH,Denoyelle C,Bordenave G

更新日期：1994-01-01 00:00:00

abstract：:This paper describes additional structural analyses of the p24 cell surface molecule recognized by monoclonal antibody BA-2. Since BA-2 is broadly reactive with a variety of normal and malignant lymphohematopoietic and nonlymphohematopoietic cells, we examined the structure of p24 expressed on different cell types. Tr...

journal_title：Molecular immunology

authors： LeBien TW,Pirruccello SJ,McCormack RT,Bradley JG

更新日期：1985-10-01 00:00:00

abstract：:White spot syndrome virus (WSSV) has caused great economic damage to shrimp aquaculture. Previous studies have shown that WSSV successfully usurps the immunity system of the host for its own gene regulation. To investigate the role of shrimp high mobility group box (HMGB) proteins in WSSV gene regulation, two Litopena...

journal_title：Molecular immunology

authors： Chen YH,Jia XT,Huang XD,Zhang S,Li M,Xie JF,Weng SP,He JG

更新日期：2011-02-01 00:00:00

abstract：:Cimetidine, a histamine type-2 receptor antagonist, is known to inhibit the growth of several tumors in human and animals, however the mechanism of action underlying this effect remains largely unknown. Here, in the mice model of 3LL lung tumor, cimetidine showed significant inhibition of tumor growth. However, an in ...

journal_title：Molecular immunology

authors： Zheng Y,Xu M,Li X,Jia J,Fan K,Lai G

更新日期：2013-05-01 00:00:00

abstract：:Bothropasin is a hemorrhagic snake venom metalloproteinase (SVMP) from Bothrops jararaca venom, the snake responsible for most bites in Southeastern Brazil. SVMPs, such as bothropasin, are involved in the main bothropic envenoming symptoms, which include hemorrhage, inflammation, necrosis and blood coagulation deficie...

journal_title：Molecular immunology

authors： Molina Molina DA,Guerra-Duarte C,Naves de Souza DL,Costal-Oliveira F,Ávila GR,Soccol VT,Machado-de-Ávila RA,Chávez-Olórtegui C

更新日期：2018-12-01 00:00:00

abstract：:T regulatory (Treg)/T-helper (Th) 17 imbalance has been shown to integrate with epigenetics to result in the development of autoimmune diseases. We aim to investigate the influence of disease staging on Treg/Th17 cells and whether the aberrant DNA methylation is implicated in the development of rheumatoid arthritis (R...

journal_title：Molecular immunology

authors： Huang Y,Wang H,Ba X,Chen Z,Wang Y,Qin K,Huang Y,Shen P,Tu S

更新日期：2020-11-01 00:00:00

abstract：:The goal of this study was to identify potential transcriptomic markers in developing asthma by an integrative analysis of multiple public microarray data sets. Using the R software and bioconductor packages, we performed a statistical analysis to identify differentially expressed (DE) genes in asthma, and further per...

journal_title：Molecular immunology

authors： Fang F,Pan J,Li Y,Li Y,Feng X,Wang J

更新日期：2017-12-01 00:00:00

abstract：:Immunization of different mice strains with a recombinant fusion protein composed of the vector-encoded N-terminal leader peptide CroLac (containing lambda Cro and LacI fragments) and a part of the transmembrane protein of HIV-1 (gp41) led to a high anti-CroLac humoral immune response. A detailed analysis of this resp...

journal_title：Molecular immunology

authors： Scheerlinck JP,DeLeys R,Saman E,Brys L,Geldhof A,De Baetselier P

更新日期：1993-06-01 00:00:00

abstract：:Human IgE antibodies from nine allergic subjects were found to react with poly-L-lysine (PLL) and other polyamines. Radioimmunoassay inhibition studies indicated that the two amino groups, but not the carboxyl, in lysine contributed to the antibody binding and 4-aminomethyl-1,8-octanediamine, a compound containing thr...

journal_title：Molecular immunology

authors： Zhao Z,Baldo BA,O'Brien RM,Plomley RF

更新日期：2000-04-01 00:00:00

abstract：:The A/J murine hybridoma cell line 40-150 secretes antidigoxin antibodies with high affinity for digoxin. A first-order spontaneous mutant (40-150 A2.4) produces antibodies containing a mutation at heavy chain position 94 resulting in reduced affinity for digoxin. A second-order mutant (40-150 A2.4 P.10) derived from ...

journal_title：Molecular immunology

authors： Shaw SY,Margolies MN

更新日期：1992-04-01 00:00:00

abstract：:Previous studies showed that P2 receptors are involved in neutrophil migration via stimulation of chemokine release and by facilitating chemoattractant gradient sensing. Here, we have investigated whether these receptors are involved in LPS-induced neutrophil transendothelial migration (TEM) using a Boyden chamber whe...

journal_title：Molecular immunology

authors： Kukulski F,Ben Yebdri F,Bahrami F,Fausther M,Tremblay A,Sévigny J

更新日期：2010-02-01 00:00:00

abstract：:Of the antioxidant/prooxidant mechanisms mediating the regulation of inflammatory mediators, particularly cytokines, oxidative stress-related pathways remain a cornerstone. It is conspicuous that there is a strong association between free radical accumulation (ROS/RNS; oxidative stress) and the evolution of inflammati...

journal_title：Molecular immunology

authors： Haddad JJ,Harb HL

更新日期：2005-05-01 00:00:00

abstract：:Many biological properties of immune complexes (IC) depend upon their size. Quasi-elastic light scattering (QLS) was used to measure a mean equivalent hydrodynamic radius (Rh) and variance of the distribution of model IC composed of bovine serum albumin (BSA) as antigen (Ag) and combinations of two or three well-chara...

journal_title：Molecular immunology

authors： Yarmush DM,Murphy RM,Colton CK,Fisch M,Yarmush ML

更新日期：1988-01-01 00:00:00

abstract：:Programmed cell death protein 1 (PD1) is a cell-surface receptor that plays a vital regulatory role in suppressing inflammatory T cell activity; therefore, it is an ideal target for T cell-redirecting therapies. Here, we describe a cynomolgus macaque model for studying the transfer of PD1-modified T cells. We develope...

journal_title：Molecular immunology

authors： Gao CE,Song Q,Zhang M,Li J,Miao Y,Li Z,Dong J

更新日期：2020-08-01 00:00:00

abstract：:Recently, basophils have been suggested to produce inflammatory mediators in response to IgE in the absence of allergens. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the initiation of inflammatory responses by recruiting various immune cells to the site of allergic inflammation. In the presen...

journal_title：Molecular immunology

authors： Ahn KB,Jeon JH,Kang SS,Chung DK,Yun CH,Han SH

更新日期：2014-11-01 00:00:00

abstract：:Coinfection with leishmaniasis and schistosomiasis has been associated with increased time to healing of cutaneous lesions of leishmaniasis. The objective of this study was to evaluate the effect of Leishmania braziliensis infection on co-cultures of monocyte-derived dendritic cells (MoDCs) with autologous lymphocytes...

journal_title：Molecular immunology

authors： Lopes DM,de Almeida TVVS,de Souza RDP,Ribeiro LEV,Page B,Fernandes JS,Carvalho EM,Cardoso LS

更新日期：2018-01-01 00:00:00

abstract：:The complement system plays a central role in a number of human inflammatory diseases, and there is a significant need for development of complement-directed therapies. The discovery of an arsenal of anti-complement proteins secreted by the pathogen Staphylococcus aureus brought with it the potential for harnessing th...

journal_title：Molecular immunology

authors： Summers BJ,Garcia BL,Woehl JL,Ramyar KX,Yao X,Geisbrecht BV

更新日期：2015-10-01 00:00:00

abstract：:This study aimed to co-culture Jurkat T lymphocytes with inactivated Mycobacterium tuberculosis (Mtb H37Ra), explore whether T lymphocytes could phagocytose H37Ra cells, and determine the underlying mechanism. Jurkat T lymphocytes were co-cultured with H37Ra cells, and confocal laser scanning microscopy, electron micr...

journal_title：Molecular immunology

authors： Zhang M,Zhu Q,Shi M,Liu Y,Ma L,Yang Y,Feng D,Dai W,Zhang L,Kang T,Chen P,He Y,Liu T,Zhao Q,Wang W,Zhi J,Feng G,Zhao G

更新日期：2015-08-01 00:00:00

abstract：:The collection of epitopes present within the variable regions of the tumor-specific clonal immunoglobulin expressed by B cell lymphomas (idiotype, Id) can serve as a target for active immunotherapy. Traditionally, tumor-derived Id protein is chemically conjugated to the immunogenic foreign carrier protein keyhole lim...

journal_title：Molecular immunology

authors： Kafi K,Betting DJ,Yamada RE,Bacica M,Steward KK,Timmerman JM

更新日期：2009-01-01 00:00:00