Evolution of low molecular weight immunoglobulins--IV. IgY-like immunoglobulins of birds, reptiles and amphibians, precursors of mammalian IgA.

Abstract:

:Radioimmunochemical studies on the comparison of the immunological cross-reactivity between the 7-S Igs of birds, reptiles and amphibians (IgY-like Igs) and the IgA of mammals (man and pig) using 125I-chicken IgY and anti-chicken IgY(Fc) or anti-chicken IgY(H) antibodies from rabbits and carp for the detection led to the conclusion that there are close antigenic relationships between them. Therefore, the IgY-like Igs seem to be the precursors for the IgA class of mammals. From that, we give a phylogenetic tree of Igs in accordance with the evolutionary development of vertebrates.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Hädge D,Ambrosius H

doi

10.1016/0161-5890(84)90022-1

subject

Has Abstract

pub_date

1984-08-01 00:00:00

pages

699-707

issue

8

eissn

0161-5890

issn

1872-9142

journal_volume

21

pub_type

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