Evolution of low molecular weight immunoglobulins--IV. IgY-like immunoglobulins of birds, reptiles and amphibians, precursors of mammalian IgA.

abstract：:Bifunctional antigens composed of one L-tyrosine-p-azobenzenearsonate (Tyr-ABA) carrier epitope and one dinitrophenyl (DNP) haptenic epitope separated by 6-aminocaproyl or polyprolyl spacers induced weak IgM anti-DNP plaque-forming cell (PFC) responses in the spleens of mice immunized intraperitoneally, without detect...

journal_title：Molecular immunology

authors： Kaymakcalan Z,Nitecki DE,Lewis GK,Goodman JW

更新日期：1984-06-01 00:00:00

abstract：:Infection of ruminants and humans with Fasciola gigantica is attracting increasing attention due to its economic impact and public health significance. However, little is known of innate immune responses during F. gigantica infection. Here, we investigated the expression profiles of genes involved in Toll-like recepto...

journal_title：Molecular immunology

authors： Zhang FK,Hou JL,Guo AJ,Tian AL,Sheng ZA,Zheng WB,Huang WY,Elsheikha HM,Zhu XQ

更新日期：2018-02-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a chronic disease characterized by autoimmune-mediated destruction of pancreatic insulin-producing beta cells. Interleukin (IL)-18 is a pro-inflammatory cytokine implicated in the pathogenesis of a number of inflammatory diseases. Here, we analyzed IL-18 levels in the plasma of juveniles with ...

journal_title：Molecular immunology

authors： Harms RZ,Yarde DN,Guinn Z,Lorenzo-Arteaga KM,Corley KP,Cabrera MS,Sarvetnick NE

更新日期：2015-04-01 00:00:00

abstract：:Most cells are believed to be capable of producing type I interferons (IFN I) as part of an innate immune response against, for instance, viral infections. In macrophages, IFN I is potently induced upon cytoplasmic exposure to foreign nucleic acids. Infection of these cells with herpesviruses leads to triggering of th...

journal_title：Molecular immunology

authors： Gram AM,Sun C,Landman SL,Oosenbrug T,Koppejan HJ,Kwakkenbos MJ,Hoeben RC,Paludan SR,Ressing ME

更新日期：2017-11-01 00:00:00

abstract：:We describe several proteins that are components of the rabbit B cell receptor complex. Two proteins (37 kDa and 42 kDa) were found in non-covalent association with IgM expressed on B cells from peripheral blood. These proteins were also immunoprecipitated by anti-B29 (Ig-beta) and anti-mb1 (Ig-alpha) monoclonal antib...

journal_title：Molecular immunology

authors： Fitts MG,Metzger DW,Hendershot LM,Mage RG

更新日期：1995-07-01 00:00:00

abstract：:Four different proteases were screened for their capability of selectively digesting murine monoclonal IgGl to obtain active F(ab)2. For the screening, a series of five different mouse monoclonal antibodies (IgGl, k) was used, recognizing different tumor-associated antigens and currently used for radioimmunoimaging st...

journal_title：Molecular immunology

authors： Mariani M,Camagna M,Tarditi L,Seccamani E

更新日期：1991-01-01 00:00:00

abstract：:Many biological properties of immune complexes (IC) depend upon their size. Quasi-elastic light scattering (QLS) was used to measure a mean equivalent hydrodynamic radius (Rh) and variance of the distribution of model IC composed of bovine serum albumin (BSA) as antigen (Ag) and combinations of two or three well-chara...

journal_title：Molecular immunology

authors： Yarmush DM,Murphy RM,Colton CK,Fisch M,Yarmush ML

更新日期：1988-01-01 00:00:00

abstract：:The capacity of α-galactosylceramide (α-GalCer) to act as an anti-cancer agent in mice through the specific stimulation of type I NKT (iNKT) cells has prompted extensive investigation to translate this finding to the clinic. However, low frequencies of iNKT cells in cancer patients and their hypo-responsiveness to rep...

journal_title：Molecular immunology

authors： Painter GF,Burn OK,Hermans IF

更新日期：2021-02-01 00:00:00

abstract：:UL16 binding proteins (ULBPs) are ligands for the NK cell activating receptor NKG2D. A cDNA encoding a porcine ULBP-like protein (PULBP) was cloned and the predicted amino acid sequence exhibited 35-52% identity to human ULBPs. Southern blot analysis suggested that there is only one ULBP-like gene in the pig genome. T...

journal_title：Molecular immunology

authors： García-Borges CN,Phanavanh B,Saraswati S,Dennis RA,Crew MD

更新日期：2005-04-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are important components of the host's innate immune response against microbial invasion. The cysteine-rich AMPs such as defensin and hepcidin have been extensively studied, but the recently identified cysteine-rich liver-expressed antimicrobial peptide 2 (LEAP-2) has been characterized f...

journal_title：Molecular immunology

authors： Bao B,Peatman E,Xu P,Li P,Zeng H,He C,Liu Z

更新日期：2006-02-01 00:00:00

abstract：:Dynamic interactions between major histocompatibility complex (MHC) class I heavy chains and beta2-microglobulin (beta2m) play a critical role in their stability on the cell surface, and their ability to present peptide antigens to CD8+ T-cells. A cursory review of protein sequence homologies and three-dimensional cry...

journal_title：Molecular immunology

authors： Shields MJ,Hodgson W,Ribaudo RK

更新日期：1999-06-01 00:00:00

abstract：:The cancer immunosurveillance hypothesis has found strong experimental support in recent years. It is believed that cytotoxic lymphocytes are important effectors in this process. PKCtheta plays an essential role in proliferation, activation and survival of these cells, but also proliferation and survival of leukemic T...

journal_title：Molecular immunology

authors： Garaude J,Kaminski S,Charni S,Aguilò JI,Jacquet C,Plays M,Hernandez J,Rodriguez F,Hipskind RA,Anel A,Villalba M

更新日期：2008-07-01 00:00:00

abstract：:Endogenous mouse mammary tumor proviruses (MMTV; Mtv loci) deletes Vbeta6 expressing T cells in the thymus of Mtv-7(+) DBA/2 (H2(d)) mice through negative selection. We found that in Mtv-7(-) BALB/c (H2(d)) mice, Vbeta6 is a dominant V gene used in T cell responses to an 18 amino acid long peptide antigen: EYKEYAEYAEY...

journal_title：Molecular immunology

authors： Kilgannon P,Novak Z,Fotedar A,Singh B

更新日期：2010-02-01 00:00:00

abstract：:Abs reactive to DNA and DNA/histone complexes are a distinguished characteristic of primary immunoglobulin repertoires in autoimmune B6.MRL-Faslpr and MRL/MpJ-Faslpr mice. These mice are defective in Fas receptor, which is critical for the apoptosis of autoreactive B cells by an extrinsic pathway. In the present study...

journal_title：Molecular immunology

authors： Li S,Liu W,Li Y,Zhao S,Liu C,Hu M,Yue W,Liu Y,Wang Y,Yang R,Xiang R,Liu F

更新日期：2016-10-01 00:00:00

abstract：:The primary structure of a human mu heavy chain (DAG) protein is described. The native protein is a circular decamer with a molecular weight (Mr) of 500 kDa, each decamer being constituted of the constant domains C mu 2, C mu 3 and C mu4 and interlinked by 15 disulfide bridges. At its NH2-terminal each monomeric chain...

journal_title：Molecular immunology

authors： Mihaesco C,Ferrara P,Guillemot JC,Congy N,Gendron MC,Roy JP,Sizaret PY,Mihaesco E

更新日期：1990-08-01 00:00:00

abstract：:Mastocytosis is an incurable and sometimes fatal haematological disorder grossly described as the accumulation of abnormal mast cells in the bone marrow and other organs causing tissue and organ damage. The clinical manifestations of this disease are extremely variable; disease phenotypes range from indolent to aggres...

journal_title：Molecular immunology

authors： Soucie E,Brenet F,Dubreuil P

更新日期：2015-01-01 00:00:00

abstract：:B cells play a critical role in immune responses both in physiological and pathological conditions, and microRNAs have been shown to play important roles in regulating B cell proliferation and function. MiR-146a has been shown to modulate T cell immunity, but its function in regulating B cell response remains partiall...

journal_title：Molecular immunology

authors： Li F,Huang Y,Huang YY,Kuang YS,Wei YJ,Xiang L,Zhang XJ,Jia ZC,Jiang S,Li JY,Wan Y

更新日期：2017-12-01 00:00:00

abstract：:Glucocorticoids down regulate the inducible nitric oxide synthase (iNOS) gene both transcriptionally and post-transcriptionally. The post-transcriptional events are suggested to involve destabilization of the iNOS transcript although the molecular mechanisms for this effect are not known. Recently, our laboratory demo...

journal_title：Molecular immunology

authors： Söderberg M,Raffalli-Mathieu F,Lang MA

更新日期：2007-05-01 00:00:00

abstract：:Leucine-rich repeat-containing G-protein-coupled receptors (LGRs) form a subfamily of the large superfamily of G-protein-coupled receptors. LGRs can be divided into three groups. LGR2 from Drosophila melanogaster is involved in cuticle tanning (melanization and sclerotization). In this study, one LGR2 (MnLGR2) was ide...

journal_title：Molecular immunology

authors： Cao X,Zhang C,Zhang R,Wang K,Dai X,Huang X,Ren Q

更新日期：2020-10-01 00:00:00

abstract：:In this review we introduce the basic principles of epigenetic gene regulation and discuss them in the context of dendritic cell (DC) development and differentiation. Epigenetic mechanisms control the accessibility of chromatin for DNA binding proteins and thus they control gene expression. These mechanisms comprise c...

journal_title：Molecular immunology

authors： Chauvistré H,Seré K

更新日期：2020-12-01 00:00:00

abstract：:The recognition structure responsible for binding to conventional antigen on target cells has not previously been described for nonspecific cytotoxic cells (NCC) or for mammalian natural killer (NK) cells. Although several biochemical pathways may be available for initiation of the lytic cycle in NCC, evidence present...

journal_title：Molecular immunology

authors： Jaso-Friedmann L,Leary JH 3rd,Evans DL

更新日期：1997-08-01 00:00:00

abstract：:Peripheral blood B lymphocytes have been isolated from healthy individuals who were immunized with lymphocytes from HLA-incompatible donors and transformed with Epstein-Barr virus to produce human monoclonal cell lines specific for human HLA molecules. The cell lines have been previously characterized and are known to...

journal_title：Molecular immunology

authors： Andris JS,Abraham SR,Pascual V,Pistillo MP,Mantero S,Ferrara GB,Capra JD

更新日期：1995-10-01 00:00:00

abstract：:Dendritic cells (DCs) play an important role in antigen presentation, which is an essential step for the induction of antigen-specific adaptive immunity. Inactivated bacterial whole cell vaccines have been widely used to prevent many bacterial infections because they elicit good immunogenicity due to the presence of v...

journal_title：Molecular immunology

authors： Kim HY,Kim SK,Seo HS,Jeong S,Ahn KB,Yun CH,Han SH

更新日期：2018-09-01 00:00:00

abstract：:Activation-induced cell death (AICD) in T lymphocytes depends on the expression of Fas-ligand, which triggers the apoptotic process after binding to its receptor Fas. This leads to the activation of cysteine proteases of the caspase family and especially of caspase-3, a critical effector protein during AICD. We have p...

journal_title：Molecular immunology

authors： Sabbagh L,Bourbonnière M,Sékaly RP,Cohen LY

更新日期：2005-07-01 00:00:00

abstract：:In the present study, we report the activation of murine peritoneal macrophages in vitro on irradiation with sublethal dose of UVB (50 mJ/cm(2)). The activation involves enhanced expression of CD18 molecule and production of nitric oxide (NO), tumor necrosis factor (TNF-alpha) and interleukin-1 (IL-1). Production of N...

journal_title：Molecular immunology

authors： Sethi G,Sodhi A

更新日期：2004-04-01 00:00:00

abstract：:Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) is an immunoglobulin (Ig)-immunoreceptor tyrosine based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, predominantly SHP-2 and to a lesser extent, SHP-1. Previously, we have shown that deletion of PEC...

journal_title：Molecular immunology

authors： Wong MX,Hayball JD,Jackson DE

更新日期：2008-03-01 00:00:00

abstract：:Infectious salmon anaemia virus (ISAV) is a marine orthomyxovirus of significant interest not only as a cause of a fatal disease of farmed Atlantic salmon resulting in severe economic losses to the aquaculture industry, but also as the only poikilothermic orthomyxovirus. ISAV targets vascular endothelial cells and mac...

journal_title：Molecular immunology

authors： Workenhe ST,Hori TS,Rise ML,Kibenge MJ,Kibenge FS

更新日期：2009-09-01 00:00:00

abstract：:Although granulocyte colony-stimulating factor(G-CSF) has pathogenic roles in several immune inflammatory diseases, its role in periodontitis has not been investigated. Here we detected local expression of G-CSF using public datasets in the Gene Expression Omnibus (GEO) database, and immune cell infiltration into ging...

journal_title：Molecular immunology

authors： Zhang Z,Yuan W,Deng J,Wang D,Zhang T,Peng L,Tian H,Wang Z,Ma J

更新日期：2020-01-01 00:00:00

abstract：:The molecular interactions between the components of the C3 convertase of the alternative pathway (AP) of complement and its regulators, in both surface-bound and fluid-phase form, are still incompletely understood. The fact that the AP convertase is labile makes studies difficult to perform. According to the so calle...

journal_title：Molecular immunology

authors： Bexborn F,Andersson PO,Chen H,Nilsson B,Ekdahl KN

更新日期：2008-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of GATA-6 on airway inflammation and remodeling and the underlying mechanisms in a murine model of chronic asthma. Female BALB/c mice were randomly divided into four groups: phosphate-buffered saline control (PBS), ovalbumin (OVA)-induced asthma group (OVA), OVA+ s...

journal_title：Molecular immunology

authors： Fang P,Shi HY,Wu XM,Zhang YH,Zhong YJ,Deng WJ,Zhang YP,Xie M

更新日期：2016-07-01 00:00:00