Evolution of low molecular weight immunoglobulins--IV. IgY-like immunoglobulins of birds, reptiles and amphibians, precursors of mammalian IgA.


:Radioimmunochemical studies on the comparison of the immunological cross-reactivity between the 7-S Igs of birds, reptiles and amphibians (IgY-like Igs) and the IgA of mammals (man and pig) using 125I-chicken IgY and anti-chicken IgY(Fc) or anti-chicken IgY(H) antibodies from rabbits and carp for the detection led to the conclusion that there are close antigenic relationships between them. Therefore, the IgY-like Igs seem to be the precursors for the IgA class of mammals. From that, we give a phylogenetic tree of Igs in accordance with the evolutionary development of vertebrates.


Mol Immunol


Molecular immunology


Hädge D,Ambrosius H




Has Abstract


1984-08-01 00:00:00












  • Role of MAIT cells in metabolic diseases.

    abstract::MAIT cells are innate-like T cells that are enriched in mucosal sites and tissues including adipose tissue and liver. They play an important role in immunity against microbial pathogens. Recently, it has been reported that MAIT cells could also be important in metabolic diseases and can be involved in setting up and m...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Toubal A,Lehuen A

    更新日期:2021-02-01 00:00:00

  • Cyanogen bromide cleaves Fc fragments of pooled human IgG at both methionine and tryptophan residues.

    abstract::An attempt was made to obtain fragments containing the C gamma 2 region by selectively cleaving human Fc fragments prepared from pooled IgG at Met residues using cyanogen bromide. Based on the known locations of Met residues in the Fc regions of human IgG subclasses, fragments between Met 252 and 358, comprising the C...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Boulware DW,Goldsworthy PD,Nardella FA,Mannik M

    更新日期:1985-12-01 00:00:00

  • Molecular analysis of induced idiotypes associated with autoanti-thyroglobulin.

    abstract::Idiotype (Id) and autoanti-thyroglobulin were induced in different strains of mice by priming with anti-Id to monoclonal anti-thyroglobulins (D8 and G4) and challenged with a subimmunogenic dose of thyroglobulin (Tg). Both D8.Id and G4.Id were induced in CBA mice by priming with the appropriate anti-Id, but only primi...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Male D,Pryce G,Roitt I

    更新日期:1985-03-01 00:00:00

  • Cathepsin S inhibition changes regulatory T-cell activity in regulating bladder cancer and immune cell proliferation and apoptosis.

    abstract::Regulatory T cells (Tregs) are immune suppressive cells, but their roles in tumor growth have been elusive, depending on tumor type or site. Our prior study demonstrated a role of cathepsin S (CatS) in reducing Treg immunosuppressive activity. Therefore, CatS inhibition in Tregs may exacerbate tumor growth. Using mous...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Yan X,Wu C,Chen T,Santos MM,Liu CL,Yang C,Zhang L,Ren J,Liao S,Guo H,Sukhova GK,Shi GP

    更新日期:2017-02-01 00:00:00

  • The binding of anti-DNA antibodies to phosphorothioate oligonucleotides in a solid phase immunoassay.

    abstract::Phosphorothioate oligonucleotides (S-oligos) are nucleic acid derivatives that are commonly used as antisense agents. These compounds, similar to bacterial DNA and CpG oligonucleotides, display a variety of immunological activities in vitro and in vivo. To assess further these activities, the antigenicity of a series ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Pisetsky DS,Reich CF 3rd

    更新日期:1998-12-01 00:00:00

  • A unique Vgamma5-T-cell population in the murine mammary gland.

    abstract::Mammary epithelia and the epidermis share a common embryologic origin. Like resident epidermal T cells (ETC), a significant number of murine mammary gland T cells (MTC) express Vgamma5-T-cell receptors (TCR). MTC were assessed to see if they express the same invariant Vgamma5/Vdelta1-TCRs as those of ETC. MTC-derived ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Reardon C,Born WK,O'Brien RL

    更新日期:2006-03-01 00:00:00

  • N-substituted benzamides inhibit nuclear factor-kappaB and nuclear factor of activated T cells activity while inducing activator protein 1 activity in T lymphocytes.

    abstract::N-substituted benzamides are compounds that have recently been reported to inhibit nuclear factor-kappaB (NF-kappaB) activity and induce apoptosis in a pre-B cell line. In this study, we focused on the effects of N-substituted benzamides on transcriptional regulation in Jurkat T cells. We used a model system where the...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Lindgren H,Pero RW,Ivars F,Leanderson T

    更新日期:2001-08-01 00:00:00

  • The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice.

    abstract::Increasing indication is unveiling a role for poly(ADP-ribose) polymerase (PARP)-1 in the regulation of inflammatory/immune responses. The aim of the present study was to determine the potential anti-inflammatory effects of PARP-1 inhibitor 5-aminoisoquinolinone (5-AIQ) to explore the role of PARP-1 inhibitor in a mou...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Ahmad SF,Zoheir KM,Ansari MA,Korashy HM,Bakheet SA,Ashour AE,Al-Shabanah OA,Al-harbi MM,Attia SM

    更新日期:2015-02-01 00:00:00

  • Specificity of ganglioside binding to rat macrophages.

    abstract::The binding specificity of rat alveolar macrophages (AM phi) for sheep erythrocytes (E) coated with gangliosides GM1, GM2, GM3, GD1a, GD1b or GT1b was analyzed in a rosette assay by studying the inhibitory effect of gangliosides, various carbohydrates, IgG, C3b-like C3, and fibronectin in this assay. The uptake of gan...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Förster O,Boltz-Nitulescu G,Holzinger C,Wiltschke C,Riedl M,Ortel B,Fellinger A,Bernheimer H

    更新日期:1986-11-01 00:00:00

  • 2-Methoxyestradiol protects against IgG immune complex-induced acute lung injury by blocking NF-κB and CCAAT/enhancer-binding protein β activities.

    abstract::Increasing evidences indicate that 2-Methoxyestradiol (2ME2) plays an essential role in protecting against inflammatory responses. However, its effect on IgG immune complex (IC)-induced acute lung injury (ALI) remains enigmatic. In the study, by using i.p. administration of 2ME2, we evaluated its influence on IgG IC-i...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Yan C,Shen Y,Sun Q,Yuan D,Tang H,Gao H

    更新日期:2017-05-01 00:00:00

  • Antibody repertoire development in fetal and neonatal piglets. V. VDJ gene chimeras resembling gene conversion products are generated at high frequency by PCR in vitro.

    abstract::The recovery of VDJ rearrangement is most often accomplished by PCR amplification of DNA extracted from mixtures of B-cells. Using this procedure in swine, VDJs containing chimeric V(H) genes that resemble gene-conversion products, are frequently encountered. To examine whether these chimeras could be the result of PC...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Sinkora M,Sun J,Butler JE

    更新日期:2000-12-01 00:00:00

  • Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells.

    abstract::Antigen-stimulated B lymphocytes undergo genetic and phenotypic changes in germinal centers (GCs), including affinity maturation of immunoglobulin (Ig) genes and Ig heavy chain isotype switching. Expression of the Germinal Center Expressed Transcript (GCET) gene is up-regulated in murine GC B cells. The human homolog ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Steinke JW,Hodsdon W,Parenti S,Ostraat R,Lutz R,Borish L,Hagman J

    更新日期:2004-11-01 00:00:00

  • Of mice and men: The factor H protein family and complement regulation.

    abstract::For decades immunological research has relied, with variable success, on mouse models to investigate diseases and possible therapeutic interventions. With the approval of the first therapeutic antibody targeting complement, called eculizumab, as therapy in paroxysmal nocturnal hemoglobinuria (PNH) and more recently at...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Pouw RB,Vredevoogd DW,Kuijpers TW,Wouters D

    更新日期:2015-09-01 00:00:00

  • Kinetics of the precipitation of cryoimmunoglobulins.

    abstract::The kinetics of the cryoprecipitation of two monoclonal IgG and two monoclonal IgM cryoimmunoglobulins, two IgM/IgG mixed cryoglobulins and a series of cold soluble monoclonal IgG and IgM immunoglobulins in the presence of polyethylene glycol have been compared by time dependent turbidity measurements. The effects of ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Lawson EQ,Brandau DT,Trautman PA,Aziz SE,Middaugh CR

    更新日期:1987-09-01 00:00:00

  • Protein 4.1G binds to a unique motif within the Fc gamma RI cytoplasmic tail.

    abstract::The C-terminal domain of protein 4.1G was identified to interact with the cytosolic tail of the high affinity IgG receptor, Fc gamma RI, in yeast two-hybrid screens. Proteins of the 4.1 family have previously been found to mediate receptor/cytoskeleton interactions. In the study presented here, we show an alternativel...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Beekman JM,Bakema JE,van der Poel CE,van der Linden JA,van de Winkel JG,Leusen JH

    更新日期:2008-04-01 00:00:00

  • Differential ICAM-1 isoform expression regulates the development and progression of experimental autoimmune encephalomyelitis.

    abstract::Intercellular adhesion molecule-1 (ICAM-1) functions in leukocyte trafficking, activation, and the formation of the immunological synapse. ICAM-1 is a member of the immunoglobulin superfamily of adhesion proteins, which share a similar structure of repeating Ig-like domains. Many genes in this family, including ICAM-1...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Hu X,Barnum SR,Wohler JE,Schoeb TR,Bullard DC

    更新日期:2010-05-01 00:00:00

  • The heterogeneity of bovine IgG2--VIII. The complete cDNA sequence of bovine IgG2a (A2) and an IgG1.

    abstract::The complete cDNA sequences of two bovine IgGs were obtained by RT-PCR cloning. The first-strand cDNA was prepared from an animal homozygous (A2/A2) for IgG2a; the resulting sequences of the two bovine IgGs reported here were identified as IgG2a(A2) and IgG1. These sequences, and their deduced amino acid sequences, ar...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Kacskovics I,Butler JE

    更新日期:1996-02-01 00:00:00

  • A model system for T-lymphocyte differentiation: regulation of CD4 and CD8 gene expression in SL12.4 T-lymphoma cell clones.

    abstract::The T-cell surface proteins CD4 (L3T4) and CD8 (Lyt2) are first expressed on thymocytes as they undergo maturation in the thymus. Two immature T-lymphoma cell clones SL12.4 and RS4.2 which constitutively express low or undetectable levels of CD4 and CD8 were used to investigate the activation of CD4 and CD8 gene expre...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Wilkinson MF,Fong AM,Huynh H,Hays EF,MacLeod CL

    更新日期:1991-01-01 00:00:00

  • Cloning of a crustin-like, single whey-acidic-domain, antibacterial peptide from the haemocytes of the European lobster, Homarus gammarus, and its response to infection with bacteria.

    abstract::Degenerate PCR was used to isolate a 221-base pair nucleotide sequence of a new crustin-like antibacterial peptide from the haemocytes of the European lobster, Homarus gammarus. Rapid amplification of cDNA ends was used to extend the sequence to determine the complete open reading frame and un-translated regions. The ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Hauton C,Brockton V,Smith VJ

    更新日期:2006-03-01 00:00:00

  • The synthesis and expression of HLA-A and -B antigens in Xenopus laevis oocytes.

    abstract::Purified mRNA's encoding the HLA-A and -B antigen heavy chains or beta 2-microglobulin were prepared from human B lymphoid cells by positive hybridization selection procedures. The role of chain association in the biosynthesis and intracellular transport of HLA-A and -B antigens was investigated by injecting these mRN...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Kinnon C,Owen MJ

    更新日期:1986-05-01 00:00:00

  • Liver stroma enhances activation of TLR3-triggered NK cells through fibronectin.

    abstract::Recent studies demonstrate that tissue microenvironments may regulate development and functions of immune cells including dendritic cells, monocytes and T cells. However, there is no report about functional regulation of innate NK cells by tissue microenvironment. The liver is an organ abundant in NK cells and suscept...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Xia S,Guo Z,Yao Y,Xu X,Yi H,Xia D,Cao X

    更新日期:2008-05-01 00:00:00

  • Autoreactive B-cell repertoire in mice with chronic graft versus host disease.

    abstract::A quantitative analysis of the frequencies of autoantibody producing B-cells has been undertaken by producing and analyzing random hybridoma collections generated in fusions with activated B-cells. Activated B-cells were derived from mice injected with LPS and SRBC and normal mice. They were compared to those derived ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Rolink AG,Thalmann P,Berger C,Radaszkiewicz T,Melchers F

    更新日期:1988-11-01 00:00:00

  • Glycosaminoglycans enhance complement hemolytic efficiency: theoretical considerations for GAG-complement-saliva interactions.

    abstract::When human serum is diluted and pre-incubated at 37 degrees C in low ionic strength buffer (LIS, u = 0.07; made iso-osmotic with dextrose), a spontaneous activation of complement (C) is observed as determined by C4 and C3 electrophoretic conversion. In this paper it is postulated that most species of glycosaminoglycan...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Chang NS,Boackle RJ

    更新日期:1986-08-01 00:00:00

  • Immunochemical studies on alpha-lactalbumin.

    abstract::The antigenic structural features of alpha-lactalbumin have been investigated using a radioimmunoassay, peptide inhibition of the quantitative precipitin reaction, and by immunodiffusion analysis after chemical modification of the molecule. Antigenic activity (in rabbits) was localized to several peptic fragments and ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Hopp TP,Woods KR

    更新日期:1982-11-01 00:00:00

  • A role for matrix metalloproteinases in granulocyte infiltration and testicular remodelation in a seasonal breeding teleost.

    abstract::The testicular cystic structure and the abrupt morphological changes that the fish testis undergoes during the reproductive cycle (RC) make it an interesting model for studying the regulation of spermatogenesis, in particular the role of matrix metalloproteinases (Mmps). The gilthead seabream is a seasonal breeding te...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Chaves-Pozo E,Castillo-Briceño P,García-Alcázar A,Meseguer J,Mulero V,García-Ayala A

    更新日期:2008-05-01 00:00:00

  • Translation in Xenopus laevis oocytes of hybrid selected LEW rat RT1.B alpha- and beta-chain transcripts results in serologically discrete class II polypeptide chain complexes.

    abstract::Using the non-crossreactive mAb MRC-OX3 and MRC-OX6, two serologically distinct RT1.B-specific (I-A equivalent) alpha, beta heterodimers have previously been described by us as residing at the cell surface of LEW rat spleen cells. The two-chain elements were suggested to represent stable conformation isomers, diverged...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Henkes W,Reske K

    更新日期:1989-02-01 00:00:00

  • Polyepitope protein incorporated the HIV-1 mimotope recognized by monoclonal antibody 2G12.

    abstract::A major goal in HIV-1 vaccine research is to develop an immunogen that can elicit broadly neutralizing antibodies that efficiently neutralize a wide range of the HIV-1 subtypes. Using biopanning procedure we have selected linear peptide VGAFGSFYRLSVLQS mimicking the structure of discontinuous binding sites of broadly ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Karpenko LI,Scherbakova NS,Chikaev AN,Tumanova OY,Lebedev LR,Shalamova LA,Pyankova OG,Ryzhikov AB,Ilyichev AA

    更新日期:2012-04-01 00:00:00

  • Astragaloside IV antagonizes M2 phenotype macrophage polarization-evoked ovarian cancer cell malignant progression by suppressing the HMGB1-TLR4 axis.

    abstract::Macrophages are the most abundant cells in tumor stroma and their polarization within tumor microenvironment exert the key roles in tumorigenesis. Astragaloside IV is a natural extract from traditional Chinese herbal Radix Astragali, and fulfills pleiotropic function in several cancers. Nevertheless, its function in o...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Wang X,Gao S,Song L,Liu M,Sun Z,Liu J

    更新日期:2021-02-01 00:00:00

  • Cross-linking of IgE-receptor complexes at the cell surface: a fluorescence method for studying the binding of monovalent and bivalent haptens to IgE.

    abstract::We have developed a method for use in investigating factors controlling the binding and cross-linking by bivalent haptens of immunoglobulin E (IgE) bound to receptors on rat basophilic leukemia (RBL) cells. This method employs monoclonal anti-2,4-dinitrophenyl (DNP) IgE that is labeled with fluorescein-5-isothiocyanat...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Erickson J,Kane P,Goldstein B,Holowka D,Baird B

    更新日期:1986-07-01 00:00:00

  • Impaired anti-leukemic immune response in PKCtheta-deficient mice.

    abstract::The cancer immunosurveillance hypothesis has found strong experimental support in recent years. It is believed that cytotoxic lymphocytes are important effectors in this process. PKCtheta plays an essential role in proliferation, activation and survival of these cells, but also proliferation and survival of leukemic T...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Garaude J,Kaminski S,Charni S,Aguilò JI,Jacquet C,Plays M,Hernandez J,Rodriguez F,Hipskind RA,Anel A,Villalba M

    更新日期:2008-07-01 00:00:00