Abstract：
:Abs reactive to DNA and DNA/histone complexes are a distinguished characteristic of primary immunoglobulin repertoires in autoimmune B6.MRL-Faslpr and MRL/MpJ-Faslpr mice. These mice are defective in Fas receptor, which is critical for the apoptosis of autoreactive B cells by an extrinsic pathway. In the present study, we explored the possibility that bone marrow small pre-B and immature B cells from adult B6.MRL-Faslpr mice and MRL/MpJ-Faslpr mice respectively, which contain autoreactive B-cell antigen receptors (BCR) and manifest autoimmune syndromes, exhibit enhanced receptor editing patterns. Indeed, FASlpr pre B and immature B cells were shown to possess more ongoing replacements of non-productive (nP) than productive (P) primary VκJκ rearrangements. Significantly, the P vs nP ratios of these replaced primary rearrangements were 1:2, thus indicating that κ light-chain production appears not to inhibit secondary rearrangements. In addition, we identified multiple atypical rearrangements, such as Vκ cRS (cryptic recombination signals) cleavages. These results suggest that the onset of light chain secondary rearrangements persists similarly as a non-selected mode and independent of BCR autoreactivity during certain developmental windows of bone marrow B cells in lupus-prone mice and control, and leads us to propose the function of secondary, de novo Igκ rearrangements to increase BCR diversity.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Li S,Liu W,Li Y,Zhao S,Liu C,Hu M,Yue W,Liu Y,Wang Y,Yang R,Xiang R,Liu Fdoi
10.1016/j.molimm.2016.09.006subject
Has Abstractpub_date
2016-10-01 00:00:00pages
193-206eissn
0161-5890issn
1872-9142pii
S0161-5890(16)30178-Xjournal_volume
78pub_type
杂志文章abstract：:The NLRP3 inflammasome constitutes a major antiviral host defense mechanism during influenza virus infection. Inflammasome assembly in virus-infected cells facilitates autocatalytic processing of pro-caspase-1 and subsequent cleavage and secretion of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome is...
journal_title：Molecular immunology
pub_type： 杂志文章
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abstract：:Most cells are believed to be capable of producing type I interferons (IFN I) as part of an innate immune response against, for instance, viral infections. In macrophages, IFN I is potently induced upon cytoplasmic exposure to foreign nucleic acids. Infection of these cells with herpesviruses leads to triggering of th...
journal_title：Molecular immunology
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更新日期：2018-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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abstract：:The ectodomain of matrix protein 2 (M2e) has remained remarkably conserved amongst human influenza A viruses and is a target for Abs with protective activity. For these reasons, M2e is being investigated for its potential as a broadly protective influenza A virus vaccine. Here, we report on the fine specificity and se...
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.06.015
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2010-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2004.05.013
更新日期：2004-11-01 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2005.08.003
更新日期：2006-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.05.014
更新日期：2009-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2010.01.026
更新日期：2010-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(87)90122-2
更新日期：1987-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2006.04.025
更新日期：2007-02-01 00:00:00
abstract：:Host-derived macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infection, especially in malarial anemia. Although two Plasmodium parasite-derived MIF orthologs, Plasmodium falciparum MIF and P. berghei MIF were identified recently, the crystal structure and the precise rol...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.10.037
更新日期：2010-01-01 00:00:00
