Abstract：
:Mastocytosis is an incurable and sometimes fatal haematological disorder grossly described as the accumulation of abnormal mast cells in the bone marrow and other organs causing tissue and organ damage. The clinical manifestations of this disease are extremely variable; disease phenotypes range from indolent to aggressive, and often present with associated non-mast cell haematological disorders (AHNMD), mainly myeloproliferative neoplasm and myelodysplastic syndromes. Recent efforts to genetically dissect the mechanisms that define aggressive and non-aggressive mastocytosis have generated a list of recurrent somatic mutations in mastocytosis patients that are associated with and may predict the evolution towards aggressive disease phenotypes. Here we review these mutations and discuss the molecular mechanisms associated with these mutations in an effort to better understand the biology of this disease and to predict its onset and evolution, with the ultimate goal of devising new and improved treatment strategies.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Soucie E,Brenet F,Dubreuil Pdoi
10.1016/j.molimm.2014.03.013subject
Has Abstractpub_date
2015-01-01 00:00:00pages
55-60issue
1eissn
0161-5890issn
1872-9142pii
S0161-5890(14)00075-3journal_volume
63pub_type
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