Isolation and structural analysis of peptide mimotopes for the disialoganglioside GD2, a neuroblastoma tumor antigen.

abstract：:The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) suppresses T-cell responses and promotes immune tolerance in tumor resistance. A previous study determined that IDO inhibits Vav1 mRNA expression and the activation of Vav1 and its downstream targets in T cells in the guanine exchange factor (GEF)-independe...

journal_title：Molecular immunology

authors： Li R,Li H,Sun Q,Liu L,Zhang C,Ren X

更新日期：2017-01-01 00:00:00

abstract：:The immunological role of exosomes in autoimmune encephalitis (AE) remains uncharacterized and not examined. In this study we ought to determine whether exosomes are generated in AE and to define the presence of cell surface neuronal autoantigens (autoAgs) in the cargo. Exosomes were isolated from cerebrospinal fluid ...

journal_title：Molecular immunology

authors： Gu J,Jin T,Li Z,Chen H,Xia H,Xu X,Gui Y

更新日期：2021-01-11 00:00:00

abstract：:C-reactive protein (CRP) is a pattern recognition molecule that binds several microbial and host ligands. Ligand-bound CRP activates the complement system via the classical pathway. Previously, we identified human complement factor H-related protein 4 (CFHR4), a member of the factor H protein family, as a CRP binding ...

journal_title：Molecular immunology

authors： Hebecker M,Okemefuna AI,Perkins SJ,Mihlan M,Huber-Lang M,Józsi M

更新日期：2010-03-01 00:00:00

abstract：:The T cell receptor (TCR) detects the presence of infectious pathogens and activates numerous intracellular signaling pathways. Protein tyrosine phosphorylation and ubiquitination serve as key regulatory mechanisms downstream of the TCR. Negative regulation of TCR signaling pathways is important in controlling the imm...

journal_title：Molecular immunology

authors： Carpino N,Chen Y,Nassar N,Oh HW

更新日期：2009-10-01 00:00:00

abstract：:We have previously developed a number of monoclonal antibodies (Mabs) that bind to protamine. One of these antibodies, Hup1N, binds to human protamine 1 but not to protamine 2. In contrast, Mab HupA binds both protamine 1 and protamine 2. The epitopes for these two Mabs were observed to overlap, and were localized to ...

journal_title：Molecular immunology

authors： Stanker LH,Wyrobek A,McKeown C,Balhorn R

更新日期：1993-12-01 00:00:00

abstract：:During the last years, intensive research has shed light in the transcriptional networks that shape the invariant NKT (iNKT) cell lineage and guide the choices towards functionally distinct iNKT cell subsets (Constantinides and Bendelac, 2013; Engel and Kronenberg, 2014; Gapin, 2016; Kim et al., 2015). However, the ep...

journal_title：Molecular immunology

authors： Tsagaratou A

更新日期：2018-09-01 00:00:00

abstract：:Natural resistance to infection with intracellular parasites, such as Leishmania, Salmonella, and Mycobacterium, is controlled in mice by the expression of a single dominant gene locus designated Lsh/Ity/Bcg. Natural resistance-associated macrophage protein gene 1 (NRAMP1) was isolated as a candidate gene. NRAMP1 enco...

journal_title：Molecular immunology

authors： Kishi F,Yoshida T,Aiso S

更新日期：1996-11-01 00:00:00

abstract：:Invertebrate cells lack the p53 recombination checkpoint but contain mobile DNA sequences that transpose by a mechanism in part shared with excision of the V(D)J recombination signal sequences (RSS). In this work, inversion, deletion, and duplication of sequences associated with an invertebrate C. elegans Tc6 element ...

journal_title：Molecular immunology

authors： Dreyfus DH,Gelfand EW

更新日期：1999-05-01 00:00:00

abstract：:Serotonin release from rat basophilic leukemia (RBL) cells, sensitized with a DNP-binding monoclonal IgE, was stimulated with solid surface (polystyrene)-bound DNP-amino acids. The stimulatory potency of DNP-amino acids was dependent on the structure of amino acid attached to DNP. Generally, DNP-amino acids with high ...

journal_title：Molecular immunology

authors： Varga JM,Kalchschmid G,Klein GF,Fritsch P

更新日期：1991-06-01 00:00:00

abstract：:Reduced expression of Erythrocyte Complement Receptor 1 (E-CR1) is envisaged to contribute significantly to the pathophysiology of systemic lupus erythematosus (SLE). We determined the levels of CR1 transcript in the neutrophils from 25 untreated patients with active SLE and 25 normal healthy individuals and, studied ...

journal_title：Molecular immunology

authors： Arora V,Mondal AM,Grover R,Kumar A,Chattopadhyay P,Das N

更新日期：2007-03-01 00:00:00

abstract：:A variety of important cellular functions are regulated by cytokines. The Jak-STAT pathway is one of the important signaling pathways downstream of cytokine receptors. Following binding of a ligand to its cognate receptor, receptor-associated Jaks are activated. STAT proteins are then in turn activated by tyrosine pho...

journal_title：Molecular immunology

authors： Imada K,Leonard WJ

更新日期：2000-01-01 00:00:00

abstract：:The MHC class II transactivator (CIITA) acts in the cell nucleus as the master regulator of MHC class II (MHC II) gene expression. It is important to study CIITA regulation in multiple myeloma since MHC expression is central to ability of myeloma cells to present antigen and to the ability of the immune system to reco...

journal_title：Molecular immunology

authors： Zhao M,Flynt FL,Hong M,Chen H,Gilbert CA,Briley NT,Bolick SC,Wright KL,Piskurich JF

更新日期：2007-04-01 00:00:00

abstract：:Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be classified as MBL deficient, underlining the redundancy of the immune syste...

journal_title：Molecular immunology

authors： Thiel S,Frederiksen PD,Jensenius JC

更新日期：2006-01-01 00:00:00

abstract：:This study describes serological and biochemical properties of a novel MHC class I molecule. The mutant H-2Ksm1 molecule was discovered in a mouse because of loss of reactivity of its peripheral blood lymphocytes to monoclonal antibodies. This mutation in the H-2Ks molecule is the first in vivo mutation described that...

journal_title：Molecular immunology

authors： Hasenkrug KJ,Kesari KV,Nathenson SG

更新日期：1992-12-01 00:00:00

abstract：:Using the non-crossreactive mAb MRC-OX3 and MRC-OX6, two serologically distinct RT1.B-specific (I-A equivalent) alpha, beta heterodimers have previously been described by us as residing at the cell surface of LEW rat spleen cells. The two-chain elements were suggested to represent stable conformation isomers, diverged...

journal_title：Molecular immunology

authors： Henkes W,Reske K

更新日期：1989-02-01 00:00:00

abstract：:RIP2/RICK/CARDIAK is a member of the receptor interacting protein kinase (RIP) family. RIP2 promotes NF-kappaB activation as well as activation of the MAPKs JNK, ERK1/2 and p38 MAPK, thereby playing an emergent role in the innate immune response and NOD signaling. Moreover, RIP2 has been shown to interact with the CAR...

journal_title：Molecular immunology

authors： Krieg A,Le Negrate G,Reed JC

更新日期：2009-03-01 00:00:00

abstract：:the SC5b-8 complex of human complement is a hydrophilic molecule of mol. wt 800,000-850,000 that is seen in the electron microscope as an elongated, straight or curved structure of 50-55 nm total length and 8-9 nm width. Tryptic attack on the fluid-phase complex exposes lipid-binding surfaces on the molecule. The tryp...

journal_title：Molecular immunology

authors： Bhakdi S,Tranum-Jensen J

更新日期：1982-09-01 00:00:00

abstract：:Interplay between complement factors, regulatory proteins, anaphylatoxins and cytokines could be involved in tendon healing and scar formation. The expression and regulation of complement factors by cytokines or anaphylatoxins are completely unclear in tendon. Hence, the gene expression of the anaphylatoxin receptors ...

journal_title：Molecular immunology

authors： Busch C,Girke G,Kohl B,Stoll C,Lemke M,Krasnici S,Ertel W,Silawal S,John T,Schulze-Tanzil G

更新日期：2013-04-01 00:00:00

abstract：:An important function of Fcγ receptors is the removal of IgG-containing immune complexes from the circulation. The activating receptor FcγRIIA and inhibitory receptor FcγRIIB2 are both expressed on human myeloid cells, and are both capable of mediating endocytosis of immune complexes. We studied endocytosis of these t...

journal_title：Molecular immunology

authors： Zhang CY,Booth JW

更新日期：2011-10-01 00:00:00

abstract：:Four cell lines producing monoclonal antibodies were obtained by fusion of NS1 myeloma cells with splenocytes of BALB/C mice immunized with only 1 microgram of each staphylococcal enterotoxin A, B, C1 and D by a modified technique of intrasplenic boosting. This procedure was considerably more efficient than the more c...

journal_title：Molecular immunology

authors： Lapeyre C,Kaveri SV,Janin F,Strosberg AD

更新日期：1987-12-01 00:00:00

abstract：:Nine monoclonal antibodies (MAbs) directed against crystallized human adenovirus type 1 (Ad h 1) hexon were tested with purified homologous and heterologous hexon preparations by gel diffusion. Six MAbs formed a single line with the homologous hexon in a 2-well pattern, and 3 MAbs formed lines only in biclonal combina...

journal_title：Molecular immunology

authors： Adám E,Nász I,Lengyel A,Erdei J,Fachet J

更新日期：1985-08-01 00:00:00

abstract：:Of the antioxidant/prooxidant mechanisms mediating the regulation of inflammatory mediators, particularly cytokines, oxidative stress-related pathways remain a cornerstone. It is conspicuous that there is a strong association between free radical accumulation (ROS/RNS; oxidative stress) and the evolution of inflammati...

journal_title：Molecular immunology

authors： Haddad JJ,Harb HL

更新日期：2005-05-01 00:00:00

abstract：:To date, although a promising anti-inflammatory activity of oligomeric proanthocyanidins (OPCs) has been observed in asthma, the mechanism responsible for these immunomodulatory properties remains obscure. Dendritic cells (DCs) that reside in the airway have been widely perceived as an important contributor to asthma....

journal_title：Molecular immunology

authors： Li Y,Yu Q,Zhao W,Zhang J,Liu W,Huang M,Zeng X

更新日期：2017-11-01 00:00:00

abstract：:The site of the murine IgG1 molecule that regulates catabolism has recently been shown to encompass amino acids that are located at the CH2-CH3 domain interface. The CH2 and CH3 domains are connected to each other by a relatively flexible "mini-hinge" region, and flexibility in this region could clearly affect the ori...

journal_title：Molecular immunology

authors： Kim JK,Tsen MF,Ghetie V,Ward ES

更新日期：1995-05-01 00:00:00

abstract：:We designed the peptide (C3) mimetic carboxyl-terminus (Cterminus) of capsid protein of porcine circovirus type 2b (PCV2b-1A/1B) inducing humoral immunity and generating hybridomas. The positive reactivity of the mAbs to PCV2 capsid protein was demonstrated by Western blot assay. Those mAbs also showed positive signal...

journal_title：Molecular immunology

authors： Hung LC,Cheng IC

更新日期：2017-05-01 00:00:00

abstract：:Low molecular weight hemorrhagins were purified from crude Bothrops atrox snake venom by gel filtration followed by ionic strength chromatography. The protein fractions obtained, designated HI-1 to HI-8, contained proteins with molecular masses lower than 30 kDa. HI-5, the most representative among of these fractions,...

journal_title：Molecular immunology

authors： Rodrigues FG,Petretski JH,Kanashiro MM,Lemos L,da Silva WD,Kipnis TL

更新日期：2004-03-01 00:00:00

abstract：:Staphylococcus aureus is an etiological agent of human and animal diseases, and it is able to internalize into non-professional phagocytic cells (i.e. bovine mammary epithelial cells, bMECs), which is an event that is related to chronic and recurrent infections. bMECs contribute to host innate immune responses (IIR) t...

journal_title：Molecular immunology

authors： Alva-Murillo N,Medina-Estrada I,Báez-Magaña M,Ochoa-Zarzosa A,López-Meza JE

更新日期：2015-12-01 00:00:00

abstract：:Interferon (IFN)-γ is highly upregulated during heart inflammation and enhances the production of pro-inflammatory cytokines. Absent in Melanoma 2 (AIM2) is an IFN-inducible protein implicated as a component of the inflammasome. Here we seek to determine the role of AIM2 during inflammation in cardiac cells. We found ...

journal_title：Molecular immunology

authors： Furrer A,Hottiger MO,Valaperti A

更新日期：2016-06-01 00:00:00

abstract：:The protective antigen (PA(83)) of Bacillus anthracis is the dominant antigen in natural and vaccine-induced immunity to anthrax infection. Three human single-chain variable fragments (scFvs) against cell bound PA were isolated from an antibody phage display library. Specifically, the antibodies were evaluated for the...

journal_title：Molecular immunology

authors： Steiniger SC,Altobell LJ 3rd,Zhou B,Janda KD

更新日期：2007-04-01 00:00:00

abstract：:The migration of dendritic cells (DCs) from the site of antigen-encounter to regional lymphoid organs is crucial for DCs to function as potent antigen-presenting cells. Matrix metalloproteinase-9 (MMP-9) is critically for DCs migration across extracellular matrix (ECM). We verified in previous studies that hypoxia dim...

journal_title：Molecular immunology

authors： Zhao P,Li XG,Yang M,Shao Q,Wang D,Liu S,Song H,Song B,Zhang Y,Qu X

更新日期：2008-04-01 00:00:00