Differences in endocytosis mediated by FcγRIIA and FcγRIIB2.

abstract：:Factor I (C3b/C4b inactivator) is a regulatory protein of the classical and alternative complement pathways. In this paper, we report the sequence of Xenopus factor I cDNA and the deduced protein structure. The basic structure of human preprofactor I, NH2-heavy chain-cleavage peptide-light chain-COOH, is conserved in ...

journal_title：Molecular immunology

authors： Kunnath-Muglia LM,Chang GH,Sim RB,Day AJ,Ezekowitz RA

更新日期：1993-10-01 00:00:00

abstract：:The analysis of the antigenic structure of human interferon (IFN)-alpha 1 with a panel of monoclonal antibodies revealed four immunodominant regions. Three of them, recognized by 12 of 14 antibodies were mapped into the aminoterminal portion of IFN-alpha 1 around residues 31-38, 43-53 and 63-85. The region 31-85 prove...

journal_title：Molecular immunology

authors： Kontsek P,Borecký L,Kontseková E,Kolcunová A,Novák M,Zav'yalov VP,Maiorov VA

更新日期：1992-07-01 00:00:00

abstract：:The host response to intravascular, Gram-negative bacteria includes profound immunologic, hematologic and physiologic changes. Numerous host defense mechanisms are activated by Gram-negative bacteria, including the complement system. Activation of the complement system leads to cleavage of C5 with subsequent generatio...

journal_title：Molecular immunology

authors： Hollmann TJ,Mueller-Ortiz SL,Braun MC,Wetsel RA

更新日期：2008-04-01 00:00:00

abstract：:Concanavalin A (Con A)section-binding proteins from mouse spleen leukocytes were characterised by two-dimensional electrophoresis of material precipitated, by Con A plus anti-Con A, from lysates of biosynthetically-labelled cells. Although most cell surface (iodinatable) proteins are known to bind Con A, some of the m...

journal_title：Molecular immunology

authors： Pink JR,Hoessli D,Tartakoff A,Hooghe R

更新日期：1983-04-01 00:00:00

abstract：:The transcription factor NF-kappaB plays critical roles in immune and inflammatory responses. Here we show that filarial parasitic sheath proteins cause activation of NF-kappaB in the airway epithelial HEp-2 cell line. This activation was transient and saturable, and involved degradation of the cytoplasmic inhibitor p...

journal_title：Molecular immunology

authors： Narayanan K,Balakrishnan A,Miyamoto S

更新日期：2000-02-01 00:00:00

abstract：:The recognition structure responsible for binding to conventional antigen on target cells has not previously been described for nonspecific cytotoxic cells (NCC) or for mammalian natural killer (NK) cells. Although several biochemical pathways may be available for initiation of the lytic cycle in NCC, evidence present...

journal_title：Molecular immunology

authors： Jaso-Friedmann L,Leary JH 3rd,Evans DL

更新日期：1997-08-01 00:00:00

abstract：:Interleukin (IL)-23 is a heterodimeric cytokine composed of the IL-23-specific subunit p19 and the p40 subunit which also constitutes part of IL-12. IL-23 propagates development of Th17 cells, a novel T cell subset which produces IL-17 but no interferon-gamma or IL-4. For both, IL-23 and IL-23-driven IL-17, a crucial ...

journal_title：Molecular immunology

authors： Sender LY,Gibbert K,Suezer Y,Radeke HH,Kalinke U,Waibler Z

更新日期：2010-03-01 00:00:00

abstract：:C-reactive protein (CRP) binds to chromatin, histones, and small nuclear ribonucleoproteins (snRNPs) through a phosphocholine (PC)-inhibitable, calcium-dependent binding site. snRNPs process pre-mRNA to mature mRNA and are composed of small uridine-rich RNAs (designated U1, U2, U5 and U4/U6) and associated proteins. W...

journal_title：Molecular immunology

authors： Jewell WS,Marnell LL,Rokeach LA,Du Clos TW

更新日期：1993-06-01 00:00:00

abstract：:The objective of this study was to characterize the in vitro and in vivo activity of a novel afucosylated rituximab (BLX-300) expressed in a Lemna aquatic plant-based system free of zoonotic pathogens. The glycosylation of BLX-300 was shown to be homogeneous, composed of a single major N-glycan species without detecta...

journal_title：Molecular immunology

authors： Gasdaska JR,Sherwood S,Regan JT,Dickey LF

更新日期：2012-03-01 00:00:00

abstract：:Mice deficient for SPI-group ETS transcription factors PU.1 or SPI-B fail to generate lymphocytes or do not mount normal antibody mediated immune responses, respectively. PU.1 expression is restricted to B-, T-lymphocytes and macrophages, while SPI-B is expressed in B- and T-lymphocytes. SPI-C is an ETS transcription ...

journal_title：Molecular immunology

authors： Carlsson R,Persson C,Leanderson T

更新日期：2003-06-01 00:00:00

abstract：:Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be classified as MBL deficient, underlining the redundancy of the immune syste...

journal_title：Molecular immunology

authors： Thiel S,Frederiksen PD,Jensenius JC

更新日期：2006-01-01 00:00:00

abstract：:Pulmonary exposure to innocuous aeroallergens is a common event leading to inhalation tolerance. Distinct subsets of pulmonary dendritic cells (DC) and regulatory T cells (T(Reg)) play critical roles in mediating and maintaining such tolerance. In asthmatics, the same aeroallergens drive a maladaptive, Th2-biased immu...

journal_title：Molecular immunology

authors： Köhl J,Wills-Karp M

更新日期：2007-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF) has been implicated in the pathogenesis of a variety of human diseases including septic shock, cachexia, graft-versus-host disease and several autoimmune diseases. Monoclonal antibodies directed against TNF provide an attractive mode of therapeutic intervention in these diseases. We h...

journal_title：Molecular immunology

authors： Knight DM,Trinh H,Le J,Siegel S,Shealy D,McDonough M,Scallon B,Moore MA,Vilcek J,Daddona P

更新日期：1993-11-01 00:00:00

abstract：:The antigen-limiting nature of microtiter ELISAs predicts that antibodies of minor classes may be underestimated when the same specimen contains large amounts of IgG antibodies specific for the same antigen. Such competitive inhibition can be diagnosed from ELISA titration plots. A method is described to eliminate the...

journal_title：Molecular immunology

authors： Butler JE,Heo Y,Adams P,Richerson HB

更新日期：1990-04-01 00:00:00

abstract：:During T-cell regulation, T-cell receptors and CD28 lead to signaling activation, while T-lymphocyte antigen 4 (CTLA-4) is known to lead to downregulation, similar to programmed cell death-1 (PD-1). In the cytoplasmic tails of CD28 and CTLA-4, phosphoinositide 3-kinase (PI3K) binds to the consensus sequence including ...

journal_title：Molecular immunology

authors： Iiyama M,Numoto N,Ogawa S,Kuroda M,Morii H,Abe R,Ito N,Oda M

更新日期：2020-12-29 00:00:00

abstract：:Monoclonal antibodies (mAbs) to the hinge region of human IgG1 immunoglobulins were prepared by immunization with a proteolytic fragment of hinge segment coupled to keyhole limpet hemocyanin. A mAb, 4G3, was obtained capable of binding to intact IgG but not to partially reduced IgG. Using this mAb, inter-heavy (H) cha...

journal_title：Molecular immunology

authors： Azuma T,Takeda J,Motoyama N,Okada H

更新日期：1992-01-01 00:00:00

abstract：:Antibodies (Ab) are bifunctional molecules with two domains, a constant region (C) that confers effector properties and a variable (V) region responsible of antigen (Ag) binding. Historically the C and V regions were considered to be functionally independent, with Ag specificity being solely determined by the V region...

journal_title：Molecular immunology

authors： Janda A,Casadevall A

更新日期：2010-04-01 00:00:00

abstract：:In an attempt to understand the relationship of amino acid sequence to the formation of primary or multiple myeloma-related amyloid (AL amyloid), we have determined the complete amino acid sequence of amyloid protein BAN. This protein belongs to the kappa I immunoglobulin light chain subgroup and has a polypeptide cha...

journal_title：Molecular immunology

authors： Dwulet FE,O'Connor TP,Benson MD

更新日期：1986-01-01 00:00:00

abstract：:The binding of CD40 ligand on activated T cells to CD40 on resting B cells induces the expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86). The induction of B7 molecules by CD40 ligand-CD40 interaction represents a critical step in rendering B cells competent for antigen presentation. The CBA/N mouse has...

journal_title：Molecular immunology

authors： Goldstein MD,Debenedette MA,Hollenbaugh D,Watts TH

更新日期：1996-04-01 00:00:00

abstract：:N-Acetylcysteine (NAC) has been widely used as an antioxidant in research, however, it has also been found to reduce the binding of TNF to its receptor independent of its antioxidative role. In this study, we investigated the effect of NAC on NF-kappaB activation. In HeLa cells, Hep3B cells, and A549 cells, DNA-bindin...

journal_title：Molecular immunology

authors： Liu J,Yoshida Y,Yamashita U

更新日期：2008-09-01 00:00:00

abstract：:Glycosylation is an important protein post-translational modification. In this process, the intermediate product, Tn antigen, arises from somatic mutations in core1β3-galactosyltransferase-specific molecular chaperone (Cosmc), which is required for the formation of active core1β3-galactosyltransferase (T-synthase). As...

journal_title：Molecular immunology

authors： Shi C,Xu X,Yu X,Du Z,Luan X,Liu D,Hu T

更新日期：2017-10-01 00:00:00

abstract：:The high affinity receptor for IgE, which mediates allergic reactions, is found exclusively on mast cells, basophils and epidermal Langerhans cells. It is composed of an alpha, beta and two gamma-polypeptide chains, inserted as a complex into the plasma membrane. The alpha and beta-subunits are produced only by these ...

journal_title：Molecular immunology

authors： Witthuhn BA,Faust C

更新日期：1996-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating, neurodegenerative motor neuron disease. The aetiology of ALS remains an enigma which hinders the design of an effective treatment to prevent, postpone, or reverse the pathophysiological changes occurring during the aggressive progression of this disease. During the...

journal_title：Molecular immunology

authors： Kjældgaard AL,Pilely K,Olsen KS,Pedersen SW,Lauritsen AØ,Møller K,Garred P

更新日期：2018-10-01 00:00:00

abstract：:Age-related macular degeneration (AMD) and membranoproliferative glomerulonephritis type II (MPGN2) are dense deposit diseases that share a genetic association with complement genes and have complement proteins as important components of the dense deposits. Here, we present the case of a 64-year-old smoker male who de...

journal_title：Molecular immunology

authors： Montes T,Goicoechea de Jorge E,Ramos R,Gomà M,Pujol O,Sánchez-Corral P,Rodríguez de Córdoba S

更新日期：2008-05-01 00:00:00

abstract：:The structural characteristics of antigens recognized by a panel of monoclonal antibodies prepared against a rabbit T-lymphocyte cell line have been investigated. Those antigens which could be isolated using immunoadsorbents prepared from the monoclonal antibodies had mol. wts of 42,000, 90,000 and 120,000. The 42,000...

journal_title：Molecular immunology

authors： Wilkinson JM,Wetterskog DL,Sogn JA,Kindt TJ

更新日期：1984-01-01 00:00:00

abstract：:The complement system is an essential component of the innate immune system that participates in elimination of pathogens and altered host cells and comprises an essential link between the innate and adaptive immune system. Soluble and membrane-bound complement regulators protect cells and tissues from unintended comp...

journal_title：Molecular immunology

authors： Ferreira VP,Pangburn MK,Cortés C

更新日期：2010-08-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) has anti-inflammatory, anti-oxidant and immune-regulating properties, while the mechanism of DHEA actions remains unclear. The present study aims to investigate the effect and possible mechanism of DHEA on immune function of mice in vivo and in vitro. In vivo, a lipopolysaccharide (LPS)-i...

journal_title：Molecular immunology

authors： Cao J,Yu L,Zhao J,Ma H

更新日期：2019-08-01 00:00:00

abstract：:The collection of epitopes present within the variable regions of the tumor-specific clonal immunoglobulin expressed by B cell lymphomas (idiotype, Id) can serve as a target for active immunotherapy. Traditionally, tumor-derived Id protein is chemically conjugated to the immunogenic foreign carrier protein keyhole lim...

journal_title：Molecular immunology

authors： Kafi K,Betting DJ,Yamada RE,Bacica M,Steward KK,Timmerman JM

更新日期：2009-01-01 00:00:00

abstract：:ANCA associated vasculitis is a serious, very often recurrent disease that despite the current standard treatment with high-dose glucocorticoids and either cyclophosphamide or rituximab, patients have a nine-fold increased mortality risk in the first year compared with healthy controls, attributed to infections, vascu...

journal_title：Molecular immunology

authors： Quintana LF,Kronbichler A,Blasco M,Zhao MH,Jayne D

更新日期：2019-08-01 00:00:00

abstract：:This study analyzes the gene repertoire coding for antibodies to an evolutionary novel immunogenic carbohydrate antigen in mice. The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) is an autoantigen, abundantly expressed in wild type mice, but absent in alpha 1,3galactosyltransferase knock-out (KO) mice, where i...

journal_title：Molecular immunology

authors： Chen ZC,Radic MZ,Galili U

更新日期：2000-06-01 00:00:00