Immunodominant structures in the aminoterminal portion of human interferon alpha 1.

abstract：:Complement factor H (CFH) protein is an inhibitor of the alternative pathway of complement (AP) both in the fluid phase and on the surface of host cells. Mouse and human complement factor H-related (CFHR) proteins also belong to the fH family of plasma glycoproteins. The main goal of the current study was to compare t...

journal_title：Molecular immunology

authors： Mehta G,Ferreira VP,Skerka C,Zipfel PF,Banda NK

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Complement activation involved in the innate immunity and adaptive immunity and further contributed to the development of tumor growth. This study aimed to investigate the association of genetic variants in complement 3 (C3) and decay-accelerating factor (DAF) genes with the risk of gastric cancer. METHODS:...

journal_title：Molecular immunology

authors： Song Q,Zhang Z,Liu Y,Han S,Zhang X

更新日期：2015-02-01 00:00:00

abstract：:The immune system protects from infections primarily by detecting and eliminating invading pathogens. This is predominantly mediated by innate immune cells like neutrophils, monocytes and dendritic cells (DCs) expressing specific receptors recognizing pathogen-associated molecular patterns. DC activation by pathogens ...

journal_title：Molecular immunology

authors： Bieber K,Autenrieth SE

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Using multiplex microarray-based component resolved diagnosis (CRD) to investigate the allergen sensitization profile of allergic asthma patients in southern China. METHOD:Serum samples from 57 polysensitized mite allergic asthmatic patients in a tertiary referral centre of southern China were tested with mu...

journal_title：Molecular immunology

authors： Hu H,Luo W,Wu Z,Cai C,Huang H,Sun B

更新日期：2019-01-01 00:00:00

abstract：:Glycosylation is an important protein post-translational modification. In this process, the intermediate product, Tn antigen, arises from somatic mutations in core1β3-galactosyltransferase-specific molecular chaperone (Cosmc), which is required for the formation of active core1β3-galactosyltransferase (T-synthase). As...

journal_title：Molecular immunology

authors： Shi C,Xu X,Yu X,Du Z,Luan X,Liu D,Hu T

更新日期：2017-10-01 00:00:00

abstract：:Syngeneic polyclonal antibodies were elicited to an affinity labeled high affinity (2-3 X 10(10) M-1) anti-fluorescein murine IgG2a monoclonal antibody. Hyperimmune ascites fluid was tested for reactivity with homologous liganded, affinity labeled and non-liganded Fab fragments derived from the high affinity antibody....

journal_title：Molecular immunology

authors： Voss EW Jr,Miklasz SD,Petrossian A,Dombrink-Kurtzman MA

更新日期：1988-08-01 00:00:00

abstract：:Mutations in the RAS family of oncogenes are highly prevalent in human cancer and, amongst its manifold effects, oncogenic RAS impairs the expression of components of the antigen presentation pathway. This allows evasion of cytotoxic T lymphocytes (CTL). CTL and natural killer (NK) cells are reciprocally regulated by ...

journal_title：Molecular immunology

authors： El-Jawhari JJ,El-Sherbiny YM,Scott GB,Morgan RS,Prestwich R,Bowles PA,Blair GE,Tanaka T,Rabbitts TH,Meade JL,Cook GP

更新日期：2014-04-01 00:00:00

abstract：:In humans, the CD4 molecule is expressed on a subset of T-cells and at various levels on myeloid and lymphoid cells. The mechanisms regulating human CD4 gene expression are yet poorly understood. We speculated that the CD4 silencer, which operates in CD8+ T-cells to repress CD4 expression, could be responsible for CD4...

journal_title：Molecular immunology

authors： Mouly E,Dorival C,Pflumio F,Baillou C,Coulombel L,Levy Y,Lemoine FM,Klatzmann D,Marodon G

更新日期：2007-01-01 00:00:00

abstract：:In human peripheral blood, most of the CD3+ cells express the alpha/beta T cell receptor. A smaller fraction of CD3+ T cells express the gamma/delta T cell receptor (from 1 to 10% depending the individuals, with an average of 3-5%). Interestingly, although the alpha/beta + T cells never express the gamma chain at the ...

journal_title：Molecular immunology

authors： Alexandre D,Lefranc MP

更新日期：1992-04-01 00:00:00

abstract：:This study aimed to co-culture Jurkat T lymphocytes with inactivated Mycobacterium tuberculosis (Mtb H37Ra), explore whether T lymphocytes could phagocytose H37Ra cells, and determine the underlying mechanism. Jurkat T lymphocytes were co-cultured with H37Ra cells, and confocal laser scanning microscopy, electron micr...

journal_title：Molecular immunology

authors： Zhang M,Zhu Q,Shi M,Liu Y,Ma L,Yang Y,Feng D,Dai W,Zhang L,Kang T,Chen P,He Y,Liu T,Zhao Q,Wang W,Zhi J,Feng G,Zhao G

更新日期：2015-08-01 00:00:00

abstract：:The potential biochemical mechanisms that mediate the 'shedding' of soluble IL-6 RI (80-kDa) receptor fragments in populations of adherent macrophages were explored. Stimulated macrophages displayed proportional increases in both the expression of membrane-associated IL-6 RI (80-kDa) and the release of soluble recepto...

journal_title：Molecular immunology

authors： Coyne CP,Howell T 3rd,Baravick J,Baravick E,Willetto C,Fenwick BW

更新日期：2001-09-01 00:00:00

abstract：:Mutation of microphthalmia transcription factor (MITF) results in deafness, bone loss, small eyes, and poorly pigmented eyes and skin. The primary cell types affected in MITF-deficient mice are melanocytes, osteoclasts and mast cells. A search for MITF-associated proteins, using a mast cell library that was screened w...

journal_title：Molecular immunology

authors： Nechushtan H,Razin E

更新日期：2002-09-01 00:00:00

abstract：:Interleukin-12 (IL-12) is a heterodimeric cytokine produced by macrophages in response to intracellular pathogens and provides an obligatory signal for the differentiation of T-helper-1 cells. p300 is an important histone acetyltransferase (HAT) and has been implicated in the regulation of gene expression. Whether p30...

journal_title：Molecular immunology

authors： Sun H,Lu J,Wei L,Wang X,Xu X,Dong M,Huang B

更新日期：2004-11-01 00:00:00

abstract：:The host response to intravascular, Gram-negative bacteria includes profound immunologic, hematologic and physiologic changes. Numerous host defense mechanisms are activated by Gram-negative bacteria, including the complement system. Activation of the complement system leads to cleavage of C5 with subsequent generatio...

journal_title：Molecular immunology

authors： Hollmann TJ,Mueller-Ortiz SL,Braun MC,Wetsel RA

更新日期：2008-04-01 00:00:00

abstract：:Fibroblast-like synoviocyte (FLS) is the ultimate effectual cells in the pathogenesis of rheumatoid arthritis (RA). The current study was undertaken to investigate whether a proliferation-inducing ligand (APRIL) mediates the function of FLS in an animal model of RA. Rat adjuvant-induced arthritis (AA) was induced by i...

journal_title：Molecular immunology

authors： Chang Y,Jia X,Sun X,Xu S,Wu Y,Zhang L,Wei W

更新日期：2015-03-01 00:00:00

abstract：:T cell responses are determined by the environment in which antigen is encountered. In the absence of proper costimulation, anergizing stimuli induce the activation of a specific program of gene expression. Proteins encoded by these genes impose a state of functional unresponsiveness in anergic T cells through the act...

journal_title：Molecular immunology

authors： Duré M,Macian F

更新日期：2009-02-01 00:00:00

abstract：:Increasing lines of evidence indicate that arsenic may be associated with immune related problems, but its detailed effects on immune organs are poorly understood. The objective of this study was to explore inflammatory responses and T cell differentiation of arsenic exposure in spleen and thymus. Female C57BL/6 mice ...

journal_title：Molecular immunology

authors： Duan X,Gao S,Li J,Wu L,Zhang Y,Li W,Zhao L,Chen J,Yang S,Sun G,Li B

更新日期：2017-01-01 00:00:00

abstract：:Egr-1 is an immediate early gene that is rapidly upregulated in response to mitogenic signals induced by antigen receptor crosslinking on murine B lymphocytes. It has been shown that levels of Egr-1 expression are closely correlated with B cell proliferation in several models of B cell activation and tolerance. We com...

journal_title：Molecular immunology

authors： Klaus SJ,Phillips NE,Parker DC

更新日期：1993-11-01 00:00:00

abstract：:PKZ, protein kinase containing Z-DNA binding domains, is a novel member of eIF2α kinase in fish. PKZ can be up-regulated in response to Poly I:C or heat stress, and it has a typical eIF2α kinase activity. However, the relationship between fish PKZ and apoptosis remains unclear. In the present study, effects of PKZ on ...

journal_title：Molecular immunology

authors： Wu C,Hu Y,Fan L,Wang H,Sun Z,Deng S,Liu Y,Hu C

更新日期：2016-01-01 00:00:00

abstract：:C3 glomerulopathy (C3G) is an ultra-rare complement-mediated renal disease characterized histologically by the predominance of C3 deposition within in the glomerulus. Familial cases of C3G are extremely uncommon and offer unique insight into the genetic drivers of complement dysregulation. In this report, we describe ...

journal_title：Molecular immunology

authors： Xiao X,Ghossein C,Tortajada A,Zhang Y,Meyer N,Jones M,Borsa NG,Nester CM,Thomas CP,de Córdoba SR,Smith RJ

更新日期：2016-09-01 00:00:00

abstract：:Very sensitive assays of IgE are required for determining prevalence of allergic reactions in children. In order to develop a sensitive two-site IRMA two kinds of mAb were produced. Antibodies specific for D epsilon 1 determinants were derived from immunization with a 40 kDa papain Fc fragment. They bound equally nati...

journal_title：Molecular immunology

authors： Anfosso F,Demeure C,Delaage M,Cheballah R,Bellot F,Bourgois A

更新日期：1987-11-01 00:00:00

abstract：:Arginine kinase (AK) is a panallergen present in crustaceans, which can induce an immunoglobulin (Ig) E-mediated immune response in humans. The aim of this work was to map and characterize the antigenic epitopes of Scylla paramamosain AK. Specific-protein-A-enriched IgG raised in rabbits against purified S. paramamosa...

journal_title：Molecular immunology

authors： Yang Y,Cao MJ,Alcocer M,Liu QM,Fei DX,Mao HY,Liu GM

更新日期：2015-06-01 00:00:00

abstract：:The murine pre-B cell line R2-bfl, which can be induced to differentiate in vitro, was used to study germline transcription of variable regions of the light chain loci. RNA from these cells was subjected to a 3'-RACE and germline transcripts from 17 individual Vkappa gene segments belonging to 12 Vkappa families were ...

journal_title：Molecular immunology

authors： Düber S,Engel H,Rolink A,Kretschmer K,Weiss S

更新日期：2003-12-01 00:00:00

abstract：:Interplay between complement factors, regulatory proteins, anaphylatoxins and cytokines could be involved in tendon healing and scar formation. The expression and regulation of complement factors by cytokines or anaphylatoxins are completely unclear in tendon. Hence, the gene expression of the anaphylatoxin receptors ...

journal_title：Molecular immunology

authors： Busch C,Girke G,Kohl B,Stoll C,Lemke M,Krasnici S,Ertel W,Silawal S,John T,Schulze-Tanzil G

更新日期：2013-04-01 00:00:00

abstract：:Monoclonal antibodies to cyclosporine A (Cs), a potent immunosuppressant, were generated in BALB/c mice using a novel antigen prepared by linking Cs to a protein carrier via a photoactive cross-linking reagent, 4-benzoylbenzoic acid (BBa). Twenty-two monoclonal anti-Cs antibodies were generated, using Cs-BBa-bovine se...

journal_title：Molecular immunology

authors： Cacalano NA,Aggarwal R,Quesniaux VF,Cleveland WL,Erlanger BF

更新日期：1992-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a family of highly conserved germline-encoded pattern-recognition receptors (PRRs) and are essential for host immune response. Little is known regarding the activation mechanism of TLRs especially of the TLR7/8/9 subfamily. Here we cloned and characterized bovine TLR8 (bTLR8) and found t...

journal_title：Molecular immunology

authors： Zhu J,Brownlie R,Liu Q,Babiuk LA,Potter A,Mutwiri GK

更新日期：2009-02-01 00:00:00

abstract：:Dendritic cells (DC) are comprised of several subsets with distinct functions, differing in their capacity to respond to pathogen products. To gain novel insights into their pathogen specificity, we compared the protein composition of the plasma membrane of CD8+ and CD8- DC, directly isolated from mouse spleens. Diffe...

journal_title：Molecular immunology

authors： Segura E,Kapp E,Gupta N,Wong J,Lim J,Ji H,Heath WR,Simpson R,Villadangos JA

更新日期：2010-05-01 00:00:00

abstract：:For decades immunological research has relied, with variable success, on mouse models to investigate diseases and possible therapeutic interventions. With the approval of the first therapeutic antibody targeting complement, called eculizumab, as therapy in paroxysmal nocturnal hemoglobinuria (PNH) and more recently at...

journal_title：Molecular immunology

authors： Pouw RB,Vredevoogd DW,Kuijpers TW,Wouters D

更新日期：2015-09-01 00:00:00

abstract：:Mevalonate kinase deficiency (MKD) is a hereditary syndrome characterized by recurring episodes of fever and inflammation. Peripheral blood mononuclear cells from MKD patients secrete high levels of interleukin (IL)-1beta when stimulated with lipopolysaccharide (LPS), which is thought to be a primary cause of the infl...

journal_title：Molecular immunology

authors： Kuijk LM,Mandey SH,Schellens I,Waterham HR,Rijkers GT,Coffer PJ,Frenkel J

更新日期：2008-04-01 00:00:00

abstract：:We investigated the structure and expression of immunoglobulin genes in the pufferfish, Takifugu rubripes, a highly prized and economically important fish species. The cDNA fragment that partially encodes the constant region of the IgM heavy chain was isolated in these animals by RACE using degenerate primers after wh...

journal_title：Molecular immunology

authors： Saha NR,Suetake H,Suzuki Y

更新日期：2005-01-01 00:00:00