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The function of MITF and associated proteins in mast cells.

Abstract：

:Mutation of microphthalmia transcription factor (MITF) results in deafness, bone loss, small eyes, and poorly pigmented eyes and skin. The primary cell types affected in MITF-deficient mice are melanocytes, osteoclasts and mast cells. A search for MITF-associated proteins, using a mast cell library that was screened with a construct that encodes the basic helix-loop-helix leucine zipper (bHLH-Zip) domain of MITF, resulted in the isolation of the protein kinase C interacting (PKCI) protein 1 and protein inhibitor of activated STAT3 (PIAS3). We have accumulated clear evidence of a function for these two proteins as repressors of MITF-induced transcriptional activity. Here, we describe this evidence and ideas that give some insight into the cellular network of interactions between various transcription factors and MITF.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Nechushtan H,Razin E

doi

10.1016/s0161-5890(02)00059-7

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

1177-80

issue

16-18

eissn

0161-5890

issn

1872-9142

pii

S0161589002000597

journal_volume

38

pub_type

杂志文章,评审

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