Abstract:
:SOCS3 is well known to negatively regulate various cytokine-mediated signaling responses, but its direct role in the expression of specific cytokines has not been clearly elucidated. To understand the role of SOCS3 in the expression of IL-4, one of the key Th2 cytokines, RBL-2H3 cells (a rat mast cell line) were engineered to express SOCS3 constitutively at a high level or at a lower level using shRNA. In RBL-2H3 cells stably expressing SOCS3, the RNA and protein levels of IL-4 were significantly decreased, while it was opposite in RBL-2H3 cells containing shRNA for SOCS3. Overexpression of SOCS3 was found to reduce the level of calcium ionophore-induced phosphorylation of ERK1/2 and c-Jun transcription factor. Consistent with this data, knockdown of SOCS3 increased the level of phosphorylated ERK1 and ERK2. Taken together, SOCS3 appears to play an important role as a negative feedback inhibitor in the expression of IL-4 by inhibiting serine phosphorylation of c-Jun via the ERK signaling pathway.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Kim D,Kim SH,Cho SH,Shin K,Kim Sdoi
10.1016/j.molimm.2010.11.005subject
Has Abstractpub_date
2011-02-01 00:00:00pages
776-81issue
5eissn
0161-5890issn
1872-9142pii
S0161-5890(10)00622-Xjournal_volume
48pub_type
杂志文章abstract::Anti-human C1s monoclonal antibody H1532, a mouse gamma-1-immunoglobulin elicited by a C1r2C1s2 immunogen, appeared to bind to the beta-domain of C1s by electron microscopy. In agreement with this observation, Western blotting demonstrated good binding to unreduced C1s, but no binding to the alpha or gamma-B domains. ...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(97)00039-4
更新日期:1997-06-01 00:00:00
abstract::Type 2 Diabetes (T2D) is a disease of increasing importance and represents a growing burden on global healthcare and human health. In T2D, loss of effectiveness of insulin signaling in peripheral tissues cannot be compensated for by adequate insulin secretion, leading to hyperglycemia and resultant complications. In r...
journal_title:Molecular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.molimm.2016.12.009
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abstract::A number of studies have showed that High mobility group box-1 (HMGB1), which played key role in inflammation activation by triggering the toll like receptor 4 (TLR4) signaling axis in hepatic fibrogenesis, may share similar inflammation stimulating mechanism with LPS. Herein, we introduced a recently established anti...
journal_title:Molecular immunology
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更新日期:2016-01-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2015.04.022
更新日期:2015-08-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(92)90010-u
更新日期:1992-04-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2015.02.013
更新日期:2015-06-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2008.05.001
更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(89)90057-6
更新日期:1989-12-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0161-5890(02)00142-6
更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0161-5890(99)00027-9
更新日期:1999-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2013.05.230
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(93)90074-l
更新日期:1993-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(94)00150-y
更新日期:1995-03-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2007.12.008
更新日期:2008-04-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2009.03.008
更新日期:2009-06-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1982-11-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(02)00117-7
更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(00)00055-9
更新日期:2000-04-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(82)90192-4
更新日期:1982-11-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2007.09.022
更新日期:2008-03-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2016.09.005
更新日期:2016-11-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2008.01.031
更新日期:2008-05-01 00:00:00