Abstract：
:T-cell activation requires interaction of T-cell receptors (TCR) with peptide epitopes bound by major histocompatibility complex (MHC) proteins. This interaction occurs at a special cell-cell junction known as the immune or immunological synapse. Fluorescence microscopy has shown that the interplay among one agonist peptide-MHC (pMHC), one TCR and one CD4 provides the minimum complexity needed to trigger transient calcium signalling. We describe a computational approach to the study of the immune synapse. Using molecular dynamics simulation, we report here on a study of the smallest viable model, a TCR-pMHC-CD4 complex in a membrane environment. The computed structural and thermodynamic properties are in fair agreement with experiment. A number of biomolecules participate in the formation of the immunological synapse. Multi-scale molecular dynamics simulations may be the best opportunity we have to reach a full understanding of this remarkable supra-macromolecular event at a cell-cell junction.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Wan S,Flower DR,Coveney PVdoi
10.1016/j.molimm.2007.09.022subject
Has Abstractpub_date
2008-03-01 00:00:00pages
1221-30issue
5eissn
0161-5890issn
1872-9142pii
S0161-5890(07)00770-5journal_volume
45pub_type
杂志文章abstract：:The complement system is important for protection from invading pathogens, removal of waste products and guidance of the immune response. Furthermore, complement can be also targeted to cancer cells. However, membrane-bound inhibitors over-expressed by certain types of tumor cells restrict the cytotoxic activity of co...
journal_title：Molecular immunology
pub_type： 杂志文章
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abstract：:Recognition of double-stranded RNA (dsRNA) activates interferon-regulatory factor 3 (IRF3)-dependent expression of anti-viral factors. The innate immune system recognizes viral dsRNA through two distinct pathways. First, the Toll-like receptor 3 (TLR3) detects dsRNA phagocytosed in endosomes. In addition, the helicase...
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pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1993-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2018.07.023
更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2013.07.003
更新日期：2013-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(92)90154-p
更新日期：1992-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2008.01.031
更新日期：2008-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2011.05.027
更新日期：2011-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2008.09.034
更新日期：2009-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1997-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2008.02.006
更新日期：2008-05-01 00:00:00
