Cloning and characterization of murine CD6.

abstract：:The T-dependent BALB/c murine immune response to fluorescein (F1) is characterized by structural heterogeneity at the protein level exemplified in part by a significantly wide range of affinities (Ka), and apparent lack of dominant idiotypes. In order to generate an idiotype family, xenogenic anti-idiotype (anti-ID) a...

journal_title：Molecular immunology

authors： Bates RM,Ballard DW,Voss EW Jr

更新日期：1985-08-01 00:00:00

abstract：:A Brucella abortus protein with a molecular weight of 50 kDa has been shown to bind bovine immunoglobulin G from healthy, brucellosis-free animals. The Brucella immunoglobulin G binding molecule appears to be a protein, since it is susceptible to proteolysis. The protein is presumed to be located on the cell surface, ...

journal_title：Molecular immunology

authors： Bricker BJ,Tabatabai LB,Mayfield JE

更新日期：1991-01-01 00:00:00

abstract：:The antigen-limiting nature of microtiter ELISAs predicts that antibodies of minor classes may be underestimated when the same specimen contains large amounts of IgG antibodies specific for the same antigen. Such competitive inhibition can be diagnosed from ELISA titration plots. A method is described to eliminate the...

journal_title：Molecular immunology

authors： Butler JE,Heo Y,Adams P,Richerson HB

更新日期：1990-04-01 00:00:00

abstract：:Serum levels of IgA1 and IgA2 were measured by solid phase radioimmunoassay in samples from 110 children between 3 months and 10 years of age. Both IgA1 and IgA2 were detectable in all samples, and both IgA1 and IgA2 increased with increasing age. The percent of total serum IgA that was IgA2 did not change with age an...

journal_title：Molecular immunology

authors： Conley ME,Arbeter A,Douglas SD

更新日期：1983-09-01 00:00:00

abstract：:The mechanisms of each subset of immune cells contributing to the pathogenesis of viral hepatitis remain incompletely understood. In this study, we examined the role of liver CD4(-) CD8(-) (double negative, DN) T cells during murine hepatitis virus strain 3 (MHV-3)-induced hepatitis in C3H/HeJ mice. We demonstrate tha...

journal_title：Molecular immunology

authors： Lu Y,Wang X,Yan W,Wang H,Wang M,Wu D,Zhu L,Luo X,Ning Q

更新日期：2012-10-01 00:00:00

abstract：:Increasing evidence suggests that inflammation and apoptosis are involved in the development of acute myocardial ischemia (AMI). Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) have recently been identified as key mediators of inflammatory responses. The aim of this study was to explore the speci...

journal_title：Molecular immunology

authors： Li H,Zhang S,Li F,Qin L

更新日期：2016-08-01 00:00:00

abstract：:Mice were immunized with a purified preparation of human alpha-foetoprotein (AFP) and their spleen cells were hybridized with mouse myeloma cells. Eleven hybridoma cell lines secreting antibody to AFP were obtained. These antibodies were classified into two groups on the basis of different antigenic determinants they ...

journal_title：Molecular immunology

authors： Nomura M,Imai M,Nakamura T,Miyakawa Y,Mayumi M

更新日期：1982-12-01 00:00:00

abstract：:Bla g 1 is a major allergen from Blatella germanica and one of the primary allergens used to assess cockroach allergen exposure. The epitope of an anti-Bla g 1 scFv was mapped in order to better understand cross reactivity with other group 1 cockroach allergens and patient IgE epitopes. X-ray crystallography was used ...

journal_title：Molecular immunology

authors： Mueller GA,Ankney JA,Glesner J,Khurana T,Edwards LL,Pedersen LC,Perera L,Slater JE,Pomés A,London RE

更新日期：2014-06-01 00:00:00

abstract：:The cDNA coding for a hybridoma anti Shigella dysenteriae type 1 antibody (3707 E9) has been cloned, and sequenced. Binding patterns with fragments of the bacterial polysaccharide antigen had already been studied in detail. The VH sequence utilizes the VH441 gene, first identified amongst beta-(1,6)galactan-binding an...

journal_title：Molecular immunology

authors： Miller CE,Huppi K,Siwarski D,Karpas A,Newman A,Mainhart C,Glaudemans CP

更新日期：1995-06-01 00:00:00

abstract：:The development and maintenance of thymic microenvironments depends on sustained crosstalk signals derived from developing thymocytes. However, the molecular basis for the initial phase in the lymphoid dependent development of thymic epithelial cells (TECs) remains unclear. Here we show that similarly to regular thymo...

journal_title：Molecular immunology

authors： Masuda K,Germeraad WT,Satoh R,Itoi M,Ikawa T,Minato N,Katsura Y,van Ewijk W,Kawamoto H

更新日期：2009-05-01 00:00:00

abstract：:Staphylococcus aureus is an etiological agent of human and animal diseases, and it is able to internalize into non-professional phagocytic cells (i.e. bovine mammary epithelial cells, bMECs), which is an event that is related to chronic and recurrent infections. bMECs contribute to host innate immune responses (IIR) t...

journal_title：Molecular immunology

authors： Alva-Murillo N,Medina-Estrada I,Báez-Magaña M,Ochoa-Zarzosa A,López-Meza JE

更新日期：2015-12-01 00:00:00

abstract：:Human gastrointestinal glycoproteins (mucins), isolated by pepsin digestion from foetal stomachs and meconia, and from paired tumour and non-neoplastic mucosal samples of patients with gastric and colorectal carcinomas, were tested for precipitating reactions with peanut lectin (PNL) and four anti-carbohydrate antibod...

journal_title：Molecular immunology

authors： Picard JK,Feizi T

更新日期：1983-11-01 00:00:00

abstract：:C3 glomerulopathy (C3G) is an ultra-rare complement-mediated renal disease characterized histologically by the predominance of C3 deposition within in the glomerulus. Familial cases of C3G are extremely uncommon and offer unique insight into the genetic drivers of complement dysregulation. In this report, we describe ...

journal_title：Molecular immunology

authors： Xiao X,Ghossein C,Tortajada A,Zhang Y,Meyer N,Jones M,Borsa NG,Nester CM,Thomas CP,de Córdoba SR,Smith RJ

更新日期：2016-09-01 00:00:00

abstract：:The purpose of the present work was to determine the ability of BgTX peptides, corresponding to the various loops and exposed regions of alpha-bungarotoxin (BgTX) and representing regions that are recognized by B and/or T cells, to stimulate protective immunity in mice against in vivo challenge with BgTX. The BgTX LD5...

journal_title：Molecular immunology

authors： Dolimbek BZ,Atassi MZ

更新日期：1996-05-01 00:00:00

abstract：:Naturally developing human antibodies to the Epstein-Barr nuclear antigen recognize synthetic peptides containing sequences from the unusual glycine-alanine region of this protein. We tested antibody binding to a series of peptides of from five to 20 amino acids in length. Peptides as small as seven amino acids could ...

journal_title：Molecular immunology

authors： Rhodes G,Houghten R,Taulane JP,Carson D,Vaughan J

更新日期：1984-11-01 00:00:00

abstract：:Increasing indication is unveiling a role for poly(ADP-ribose) polymerase (PARP)-1 in the regulation of inflammatory/immune responses. The aim of the present study was to determine the potential anti-inflammatory effects of PARP-1 inhibitor 5-aminoisoquinolinone (5-AIQ) to explore the role of PARP-1 inhibitor in a mou...

journal_title：Molecular immunology

authors： Ahmad SF,Zoheir KM,Ansari MA,Korashy HM,Bakheet SA,Ashour AE,Al-Shabanah OA,Al-harbi MM,Attia SM

更新日期：2015-02-01 00:00:00

abstract：:Interleukin 10 (IL-10)-producing regulatory B-cells (Bregs) suppress inflammatory responses that mediate autoimmune diseases. However, it is unknown whether Bregs derive from a pre-existing dedicated B-cell lineage or if any B-cell can differentiate into Bregs in response to BCR or TLR activation. GL7(+) B-cells are a...

journal_title：Molecular immunology

authors： Wang X,Wei Y,Xiao H,Liu X,Zhang Y,Han G,Chen G,Hou C,Zhang L,Ma N,Shen B,Li Y,Egwuagu CE,Wang R

更新日期：2016-03-01 00:00:00

abstract：:Cutaneous leishmaniasis (CL) mainly caused by Leishmania braziliensis is a chronic inflammatory disease widely spread in Brazil. Genetic variant strains of this parasite have been associated with atypical clinical manifestations of CL in an endemic area in Brazil. Furthermore, these strains have presented distinct bio...

journal_title：Molecular immunology

authors： Rêgo FD,Fradico JRB,Teixeira-Carvalho A,Gontijo CMF

更新日期：2019-02-01 00:00:00

abstract：:Natural resistance to infection with intracellular parasites, such as Leishmania, Salmonella, and Mycobacterium, is controlled in mice by the expression of a single dominant gene locus designated Lsh/Ity/Bcg. Natural resistance-associated macrophage protein gene 1 (NRAMP1) was isolated as a candidate gene. NRAMP1 enco...

journal_title：Molecular immunology

authors： Kishi F,Yoshida T,Aiso S

更新日期：1996-11-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein that was first identified on the surface of rat mucosal-type mast cells of the RBL-2H3 line. A C-type lectin domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) are located in the extracellular and intracellular domain...

journal_title：Molecular immunology

authors： Abramson J,Xu R,Pecht I

更新日期：2002-09-01 00:00:00

abstract：:Antigens related to the carcinoembryonic antigen (CEA) were isolated from normal human plasma by perchloric acid extraction, gel permeation chromatography and immunoaffinity chromatography using a monoclonal antibody with broad specificity and high affinity. The antigens were separated by SDS-polyacrylamide gel electr...

journal_title：Molecular immunology

authors： Neumaier M,Fenger U,Wagener C

更新日期：1985-11-01 00:00:00

abstract：:We have sequenced the TCRs from Ld-specific alloreactive T cell hybridomas, whose reactivities we have found to be quite representative of those of a primary dm2 anti-BALB/cJ mixed lymphocyte reaction. We find V beta 6, V beta 7, V beta 8 and V beta 10 gene segments. V alpha usage is diverse, although closely related ...

journal_title：Molecular immunology

authors： Louie KA,Ochoa-Garay J,Chen PJ,McKinney D,Groshen S,McMillan M

更新日期：1996-06-01 00:00:00

abstract：:The Class II Transactivator (CIITA) is the master regulator of Major Histocompatibility Class II (MHC II) genes. Transcription of CIITA through the IFN-γ inducible CIITA promoter IV (CIITA pIV) during activation is characterized by a decrease in trimethylation of histone H3 lysine 27 (H3K27me3), catalyzed by the histo...

journal_title：Molecular immunology

authors： Boyd NH,Morgan JE,Greer SF

更新日期：2015-10-01 00:00:00

abstract：:Major histocompatibility complex (MHC) has a profound influence on disease resistance or susceptibility, productivity and important economic traits in chicken. Association of the MHC with a wide range of immune responses makes it a valuable predictive factor for the disease pathogenesis and outcome. The tandem repeat ...

journal_title：Molecular immunology

authors： Esmailnejad A,Nikbakht Brujeni G,Badavam M

更新日期：2017-10-01 00:00:00

abstract：:The expression and ligand binding activity of Fc receptors for IgG (Fc gamma R) on guinea-pig peripheral blood polymorphonuclear leukocytes (blood PMN) have been compared with those on casein-elicited peritoneal PMN (exudate PMN). Both the PMN were found to express two distinct types of Fc gamma R, one specific for Ig...

journal_title：Molecular immunology

authors： Fukuchi Y,Sato M,Yamashita T,Koyama J

更新日期：1992-05-01 00:00:00

abstract：:Phosphocholine (PC)-specific antibodies that arise in the mouse in response to Proteus morganii (PM) and use V1-DFL16.1-JH1 are characterized by a number of recurring mutations. Most striking is an invariant A for G substitution in codon 95 of VH which results in an asparagine instead of aspartate at that position. Be...

journal_title：Molecular immunology

authors： George J,Sheehan KM,Brodeur PH,Claflin JL

更新日期：1993-03-01 00:00:00

abstract：:The immunosuppressive cyclic undecapeptide cyclosporine (Cs) represents a useful model for studying the molecular basis of antibody-antigen interactions. The three-dimensional structure of the Cs molecule is known and a large panel of monoclonal antibodies (mAbs) to Cs has been well characterized by cross-reactivity s...

journal_title：Molecular immunology

authors： Schmitter D,Poch O,Zeder G,Heinrich GF,Kocher HP,Quesniaux VF,Van Regenmortel MH

更新日期：1990-10-01 00:00:00

abstract：:Major histocompatibility complex class I proteins (MHC-I) load short peptides derived from proteolytic cleavage of endogenous proteins in any cell of the body, in a process termed antigen processing and presentation. When the source proteins are altered self or encoded by a pathogen, recognition of peptide/MHC-I compl...

journal_title：Molecular immunology

authors： Lázaro S,Gamarra D,Del Val M

更新日期：2015-12-01 00:00:00

abstract：:Humanization of rodent mAbs by CDR-grafting (also called "reshaping") is now a standard procedure for reducing immunogenicity and recruiting human effector functions. However, the design of the humanized mAb can sometimes prove circuitous. Attempts were made to humanize L-25, a mouse antibody against the human alpha-4...

journal_title：Molecular immunology

authors： Saldanha JW,Martin AC,Léger OJ

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Ethanol feeding in mice activates complement via C1q binding to apoptotic cells in the liver; complement contributes to ethanol-induced inflammation and injury. Despite the critical role of C1q in ethanol-induced injury, the mechanism by which ethanol activates C1q remains poorly understood. Secretory IgM (s...

journal_title：Molecular immunology

authors： Smathers RL,Chiang DJ,McMullen MR,Feldstein AE,Roychowdhury S,Nagy LE

更新日期：2016-04-01 00:00:00