Molecular comparison of mouse Thy-1 and its human homologue.


:Physicochemical techniques were used to verify previous immunochemical studies showing homology of the human Thy-1 (formerly p25) antigen and the murine Thy-1 or theta antigen. Peptide maps and amino acid compositions showed close similarity between these two proteins; however, they were not identical. These data confirm that the p25 antigen is the human homologue of mouse Thy-1.


Mol Immunol


Molecular immunology


Bonewald L,Wang AC,Terry E,Zwerner R,Balch CM,Ades EW




Has Abstract


1982-03-01 00:00:00












  • Humanization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen.

    abstract::Humanization of monoclonal antibodies by complementary determinant region (CDR)-grafting has become a standard procedure to improve the clinical usage of animal antibodies. However, antibody humanization may result in loss of activity that has been attributed to structural constraints in the framework structure. In th...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Caldas C,Coelho V,Kalil J,Moro AM,Maranhão AQ,Brígido MM

    更新日期:2003-05-01 00:00:00

  • Autophagy and MHC-restricted antigen presentation.

    abstract::Major histocompatibility complex (MHC) molecules present peptide antigens to T lymphocytes and initiate immune responses. The peptides loaded onto MHC class I or MHC class II molecules can be derived from cytosolic proteins, both self and foreign. A variety of cellular processes, including endocytosis, vesicle traffic...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Valečka J,Almeida CR,Su B,Pierre P,Gatti E

    更新日期:2018-07-01 00:00:00

  • Helper role of NK cells during the induction of anticancer responses by dendritic cells.

    abstract::Recent reports demonstrate that natural killer (NK) cells and dendritic cells (DC) support each other's activity in a positive feedback. We observed that activated NK cells induce the maturation of DCs into stable type-1 polarized DCs (DC1), characterized by up to 100-fold enhanced ability to produce IL-12p70 in respo...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Kalinski P,Giermasz A,Nakamura Y,Basse P,Storkus WJ,Kirkwood JM,Mailliard RB

    更新日期:2005-02-01 00:00:00

  • Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells.

    abstract::In most cases, cytotoxic T cell activation is dependent on the interaction of the T cell receptor (TCR) and CD8 with MHC class I molecules. In the CD8(+) T cell system based on the mouse cytotoxic T cell clone 2C, recognition of the allogeneic MHC L(d) exhibits a less significant role for CD8 than recognition of the s...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Lee PU,Kranz DM

    更新日期:2003-01-01 00:00:00

  • The anti-oxidative, anti-inflammatory, and protective effect of S100A8 in endotoxemic mice.

    abstract::Polymorphonuclear neutrophils (PMNs) produce and release copious amounts of reactive oxygen species (ROS) which target potential bacterial invaders but also contribute to the inflammation-associated organ injuries seen in sepsis. Calprotectin is an immune regulatory protein complex made of S100A8 and S100A9 that inhib...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Sun Y,Lu Y,Engeland CG,Gordon SC,Sroussi HY

    更新日期:2013-04-01 00:00:00

  • The activation of the TLR2/p38 pathway by sodium butyrate in bovine mammary epithelial cells is involved in the reduction of Staphylococcus aureus internalization.

    abstract::Staphylococcus aureus is an etiological agent of human and animal diseases, and it is able to internalize into non-professional phagocytic cells (i.e. bovine mammary epithelial cells, bMECs), which is an event that is related to chronic and recurrent infections. bMECs contribute to host innate immune responses (IIR) t...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Alva-Murillo N,Medina-Estrada I,Báez-Magaña M,Ochoa-Zarzosa A,López-Meza JE

    更新日期:2015-12-01 00:00:00

  • Cathepsin S inhibition changes regulatory T-cell activity in regulating bladder cancer and immune cell proliferation and apoptosis.

    abstract::Regulatory T cells (Tregs) are immune suppressive cells, but their roles in tumor growth have been elusive, depending on tumor type or site. Our prior study demonstrated a role of cathepsin S (CatS) in reducing Treg immunosuppressive activity. Therefore, CatS inhibition in Tregs may exacerbate tumor growth. Using mous...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Yan X,Wu C,Chen T,Santos MM,Liu CL,Yang C,Zhang L,Ren J,Liao S,Guo H,Sukhova GK,Shi GP

    更新日期:2017-02-01 00:00:00

  • Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities.

    abstract::Chicken host defense peptide cathelicidin-2 (CATH-2) is known to exert antimicrobial and immunomodulatory activities and consists of two alpha-helices connected by a hinge region. Here we report the biological properties of the separate alpha-helical segments and the importance of the proline residue in the hinge regi...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: van Dijk A,Molhoek EM,Veldhuizen EJ,Bokhoven JL,Wagendorp E,Bikker F,Haagsman HP

    更新日期:2009-08-01 00:00:00

  • Possible use of similar framework region amino acid sequences between human and mouse immunoglobulins for humanizing mouse antibodies.

    abstract::We have previously noted that a specific amino acid sequence could form the second framework region of human, mouse and rabbit immunoglobulin light chains, suggesting that this sequence has been preserved for 80 million years. Through divergent evolution, each species has acquired a different set of framework region s...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Wu TT,Kabat EA

    更新日期:1992-09-01 00:00:00

  • Processing of DR1-restricted determinants from the fusion protein of measles virus following two distinct pathways.

    abstract::A panel of human T cell clones specific for measles virus was characterized and among them fusion protein-specific, DR1-and DP-restricted T cell clones were selected to study the processing and presentation of determinants borne by a viral membrane protein. Using two independent methods to assess the activation of T c...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Demotz S,Péléraux A

    更新日期:1996-03-01 00:00:00

  • A new enzymatic method to obtain high-yield F(ab)2 suitable for clinical use from mouse IgGl.

    abstract::Four different proteases were screened for their capability of selectively digesting murine monoclonal IgGl to obtain active F(ab)2. For the screening, a series of five different mouse monoclonal antibodies (IgGl, k) was used, recognizing different tumor-associated antigens and currently used for radioimmunoimaging st...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Mariani M,Camagna M,Tarditi L,Seccamani E

    更新日期:1991-01-01 00:00:00

  • PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.

    abstract::The capability of NK lymphocytes to kill tumor cells depends on different receptors/ligands interactions. In order to identify the cellular ligands recognized by "orphan" triggering receptors, mice were immunized with NK susceptible target cells. mAbs were selected that inhibited NK cytotoxicity and recognized two dif...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Pende D,Bottino C,Castriconi R,Cantoni C,Marcenaro S,Rivera P,Spaggiari GM,Dondero A,Carnemolla B,Reymond N,Mingari MC,Lopez M,Moretta L,Moretta A

    更新日期:2005-02-01 00:00:00

  • Potentiated macrophage activation by acid sensing under low adiponectin levels.

    abstract::Adiponectin can protect against inflammation; one of the mechanisms involves direct, inhibition of macrophages (MΦ). We postulated that adiponectin anti-sense transgenic (AsTg) mice raised in our laboratory are prone to inflammation because of systemic low adiponectin levels. The writhing response to acetic acid was u...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Negoro T,Kin M,Takuma A,Saito K,Shimizu S,Nakano Y

    更新日期:2014-02-01 00:00:00

  • Kinetics of the precipitation of cryoimmunoglobulins.

    abstract::The kinetics of the cryoprecipitation of two monoclonal IgG and two monoclonal IgM cryoimmunoglobulins, two IgM/IgG mixed cryoglobulins and a series of cold soluble monoclonal IgG and IgM immunoglobulins in the presence of polyethylene glycol have been compared by time dependent turbidity measurements. The effects of ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Lawson EQ,Brandau DT,Trautman PA,Aziz SE,Middaugh CR

    更新日期:1987-09-01 00:00:00

  • Complement deficiencies and dysregulation: Pathophysiological consequences, modern analysis, and clinical management.

    abstract::Complement defects are associated with an enhanced risk of a broad spectrum of infectious as well as systemic or local inflammatory and thrombotic disorders. Inherited complement deficiencies have been described for virtually all complement components but can be mimicked by autoantibodies, interfering with the activit...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Schröder-Braunstein J,Kirschfink M

    更新日期:2019-10-01 00:00:00

  • Molecular analysis of induced idiotypes associated with autoanti-thyroglobulin.

    abstract::Idiotype (Id) and autoanti-thyroglobulin were induced in different strains of mice by priming with anti-Id to monoclonal anti-thyroglobulins (D8 and G4) and challenged with a subimmunogenic dose of thyroglobulin (Tg). Both D8.Id and G4.Id were induced in CBA mice by priming with the appropriate anti-Id, but only primi...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Male D,Pryce G,Roitt I

    更新日期:1985-03-01 00:00:00

  • Prohibitin binds to C3 and enhances complement activation.

    abstract::Prohibitin (PHB1) is a multifunction protein that is released in lipid droplets from adipocytes and possibly other cells and is detectable in the circulation. We used crosslinking, immunoprecipitation and proteomic analysis to investigate binding partners for circulating PHB1. Crosslinking of PHB1 to serum resulted in...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Mishra S,Moulik S,Murphy LJ

    更新日期:2007-03-01 00:00:00

  • The immune response to synthetic peptides of human protamines HP1 and HP2.

    abstract::Peptides representing the amino-terminal sequence of protamines HP1 (sequence 1-12) and HP2 (sequence 1-11), the two major nuclear proteins of human sperm, have been synthesized. Rabbits were immunized either with peptide conjugated with a carrier or with free peptide. The resulting antisera were examined for their ca...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Rousseaux-Prevost R,Hublau P,Sautiere P,Rousseaux J

    更新日期:1991-09-01 00:00:00

  • Protective KIR-HLA interactions for HCV infection in intravenous drug users.

    abstract::Intravenous drug use has become the principal route of hepatitis C virus (HCV) transmission due to the sharing of infected needles. In this study, we analyzed the distribution of HLA-KIR genotypes among 160 Puerto Rican intravenous drug users (IDUs) with HCV infection and 92 HCV-negative Puerto Rican IDUs. We found a ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Zúñiga J,Romero V,Azocar J,Terreros D,Vargas-Rojas MI,Torres-García D,Jiménez-Alvarez L,Vargas-Alarcón G,Granados-Montiel J,Husain Z,Chung RT,Alper CA,Yunis EJ

    更新日期:2009-08-01 00:00:00

  • TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent.

    abstract::In addition to classic Smad signaling pathways, the pleiotropic immunoregulatory cytokine TGF-beta1 can activate MAP kinases, but a role for TGF-beta1-MAP kinase pathways in T cells has not been defined heretofore. We have shown previously that TGF-beta1 inhibits Th1 development by inhibiting IFN-gamma's induction of ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Park IK,Letterio JJ,Gorham JD

    更新日期:2007-07-01 00:00:00

  • Targeted inhibition of GATA-6 attenuates airway inflammation and remodeling by regulating caveolin-1 through TLR2/MyD88/NF-κB in murine model of asthma.

    abstract::The purpose of this study was to evaluate the effects of GATA-6 on airway inflammation and remodeling and the underlying mechanisms in a murine model of chronic asthma. Female BALB/c mice were randomly divided into four groups: phosphate-buffered saline control (PBS), ovalbumin (OVA)-induced asthma group (OVA), OVA+ s...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Fang P,Shi HY,Wu XM,Zhang YH,Zhong YJ,Deng WJ,Zhang YP,Xie M

    更新日期:2016-07-01 00:00:00

  • Theoretical analysis of the accuracy of calibrated immunoassays for measuring antibody concentration.

    abstract::The accuracy of calibrated immunoassays for measuring antibody concentration was analysed from a theoretical perspective. The study shows that there are theoretical limits on the accuracy of antibody immunoassays, which are determined by the affinity of the standard and unknown antibodies and the conditions chosen for...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Griswold WR,Chalquest RR

    更新日期:1991-07-01 00:00:00

  • A murine antibody to Shigella dysenteriae type 1 employs V-genes that contain a rearranged codon for the lambda light chain.

    abstract::The cDNA coding for a hybridoma anti Shigella dysenteriae type 1 antibody (3707 E9) has been cloned, and sequenced. Binding patterns with fragments of the bacterial polysaccharide antigen had already been studied in detail. The VH sequence utilizes the VH441 gene, first identified amongst beta-(1,6)galactan-binding an...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Miller CE,Huppi K,Siwarski D,Karpas A,Newman A,Mainhart C,Glaudemans CP

    更新日期:1995-06-01 00:00:00

  • Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies.

    abstract::Peptide gpMBP72-85, containing amino acids 72-85 of guinea pig myelin basic protein is commonly used to induce experimental autoimmune encephalomyelitis in Lewis rats. The N-terminal glutamine in this peptide can cyclize to pyroglutamic acid, leading to loss of the first MHC anchor for binding to MHC class II. Acetyla...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: de Haan EC,Wauben MH,Wagenaar-Hilbers JP,Grosfeld-Stulemeyer MC,Rijkers DT,Moret EE,Liskamp RM

    更新日期:2004-02-01 00:00:00

  • The effect of alternate substrates and substrate concentration on the antibody-mediated inhibition of horseradish peroxidase.

    abstract::Inhibition of the catalytic activity of horseradish peroxidase by rabbit antisera was measured using alternate enzyme substrates. The same general inhibition curve patterns were obtained regardless of the electron donor or hydroperoxide used. In all cases typical biphasic inhibition patterns were found and complete in...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Clark SK Jr,Conroy JM,Harris PJ

    更新日期:1983-12-01 00:00:00

  • The immune response towards beta-adrenergic ligands and their receptors--VII. Equilibrium and kinetic binding studies of l-alprenolol to a monoclonal anti-alprenolol antibody.

    abstract::Binding of the catecholamine beta-adrenergic antagonist, l-alprenolol, by the IgGl anti-alprenolol monoclonal antibody 37A4 was examined using the radioligand 3H-dihydroalprenolol as an extrinsic signal and the increase in antibody fluorescence upon l-alprenolol binding as intrinsic signal. Equilibrium binding studies...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Hoebeke J,Engelborghs Y,Chamat S,Strosberg AD

    更新日期:1987-06-01 00:00:00

  • pH dependent binding of high and low affinity myelin basic protein peptides to purified HLA-DR2.

    abstract::Major histocompatibility complex (MHC) class II molecules are cell surface glycoproteins and are known to display processed antigens on the surface of antigen presenting cells (APC). Within the APC, the loading of processed antigenic peptides to MHC class II molecules is known to take place in the endosomal compartmen...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Mukku PV,Passmore D,Phan D,Nag B

    更新日期:1995-06-01 00:00:00

  • IFRD1 regulates the asthmatic responses of airway via NF-κB pathway.

    abstract::Asthma is a chronic respiratory disease which is susceptible to children and causes great harm to them. Recently, Interferon-related developmental regulator 1 (IFRD1) was proved to be participant in regulating lung diseases, and its abnormal expression was shown in pathological airway tissues. Our study aimed to demon...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Chang M,Zhang Y,Hui Z,Wang D,Guo H

    更新日期:2020-11-01 00:00:00

  • Type III interferon gene expression in response to influenza virus infection in chicken and duck embryonic fibroblasts.

    abstract::Type III interferons (IFN-λs) comprise a group of newly identified antiviral cytokines that are functionally similar to type I IFNs and elicit first-line antiviral responses. Recently, type III IFNs were identified in several species; however, little information is available about type III IFNs in ducks. We compared t...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Zhang Z,Zou T,Hu X,Jin H

    更新日期:2015-12-01 00:00:00

  • Amino acid sequence of a light chain variable region of a human rheumatoid factor of the Wa idiotypic group, in part predicted by its reactivity with antipeptide antibodies.

    abstract::Antipeptide antisera were raised to the second and third complementarity-determining regions of the light chain derived from a human monoclonal IgM (Sie) which had antigammaglobulin activity and belonged to the Wa cross-reactive idiotypic group of human rheumatoid factors, two of whose members (Sie, Wo1) had been prev...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Newkirk M,Chen PP,Carson D,Posnett D,Capra JD

    更新日期:1986-03-01 00:00:00