Abstract：
:A bovine papilloma virus-derived vector was used to direct the high level expression in mouse C127 cells of three different cDNAs encoding the human interleukin-2 receptor. These were: the previously described cDNA clone isolated from the T-cell lymphoma, HUT-102; a cDNA clone isolated from mitogen-activated, normal peripheral blood T cells; and an altered version of the HUT-102 receptor in which Ser247, believed to be the site of protein kinase C-mediated phosphorylation, has been changed to an Ala residue. Fluorescence-activated cell-sorting using a monoclonal antibody directed against the human IL-2 receptor was used to derive stable lines of C127 cells expressing from 2-6 X 10(6) IL-2 binding sites per cell. However, all of these receptors bound IL-2 with low affinity.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Cosman D,Wignall J,Lewis A,Alpert A,Cerretti DP,Park L,Dower SK,Gillis S,Urdal DLdoi
10.1016/0161-5890(86)90123-9subject
Has Abstractpub_date
1986-09-01 00:00:00pages
935-41issue
9eissn
0161-5890issn
1872-9142journal_volume
23pub_type
杂志文章abstract：:The innate immune system is the first line of defense against infection and responses are initiated by pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs). PRRs also detect endogenous danger-associated molecular patterns (DAMPs) that are released by damaged or dying cells. T...
journal_title：Molecular immunology
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abstract：:Class switch DNA recombination (CSR) substitutes an immunoglobulin (Ig) constant heavy chain (C(H)) region with a different C(H) region, thereby endowing an antibody with different biological effector functions. CSR requires activation-induced cytidine deaminase (AID) and occurrence of double-strand DNA breaks (DSBs) ...
journal_title：Molecular immunology
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journal_title：Molecular immunology
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abstract：:The globular C1q heterotrimer is a subunit of the C1 complement factor. Binding of the C1q subunit to the constant (Fc) part of antibody molecules is a first step and key event of complement activation. Although three-dimensional structures of C1q and antibody Fc subunits have been determined experimentally no atomic ...
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更新日期：1992-10-01 00:00:00
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journal_title：Molecular immunology
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journal_title：Molecular immunology
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journal_title：Molecular immunology
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更新日期：2011-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1986-11-01 00:00:00
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更新日期：1987-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2010.01.013
更新日期：2010-04-01 00:00:00
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更新日期：2009-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(94)90115-5
更新日期：1994-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(86)90015-5
更新日期：1986-12-01 00:00:00
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更新日期：2003-01-01 00:00:00
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更新日期：1995-12-01 00:00:00
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journal_title：Molecular immunology
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journal_title：Molecular immunology
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更新日期：2017-12-01 00:00:00
