Atypical combined immunodeficiency due to Artemis defect: a case presenting as hyperimmunoglobulin M syndrome and with LGLL.

abstract：:Anti-human C1s monoclonal antibody H1532, a mouse gamma-1-immunoglobulin elicited by a C1r2C1s2 immunogen, appeared to bind to the beta-domain of C1s by electron microscopy. In agreement with this observation, Western blotting demonstrated good binding to unreduced C1s, but no binding to the alpha or gamma-B domains. ...

journal_title：Molecular immunology

authors： Tseng Y,Phillips ML,Schumaker VN

更新日期：1997-06-01 00:00:00

abstract：:In the host a diverse collection of endogenous danger signals is constantly generated consisting of waste material as protein aggregates or crystalline materials that are recognized and handled by soluble pattern recognition receptors and phagocytic cells of the innate immune system. These signals may under certain ci...

journal_title：Molecular immunology

authors： Niyonzima N,Halvorsen B,Sporsheim B,Garred P,Aukrust P,Mollnes TE,Espevik T

更新日期：2017-04-01 00:00:00

abstract：:Mus m 1.0102 is a member of the mouse Major Urinary Protein family, belonging to the Lipocalins superfamily. Major Urinary Proteins (MUPs) are characterized by highly conserved structural motifs. These include a disulphide bond, involved in protein oxidative folding and protein structure stabilization, and a free cyst...

journal_title：Molecular immunology

authors： Ferrari E,Corsini R,Burastero SE,Tanfani F,Spisni A

更新日期：2020-04-01 00:00:00

abstract：:When mouse dendritic cells (DCs) are isolated from tissues, purified and placed in a nutritive culture they die more rapidly than would be expected from their normal turnover in vivo. This can distort culture assays of DC function. We therefore tested several approaches to prolonging DC survival in culture. Of several...

journal_title：Molecular immunology

authors： Vremec D,Hansen J,Strasser A,Acha-Orbea H,Zhan Y,O'Keeffe M,Shortman K

更新日期：2015-02-01 00:00:00

abstract：:Artificial Salmonella serogroup B, D or Cl-specific glycolipids were prepared by covalently linking oligosaccharides corresponding to two O-antigen repeating units, obtained by phage enzyme hydrolysis of native O-antigenic polysaccharides, to octyl residues. Sheep erythrocytes coated with the artificial glycolipids we...

journal_title：Molecular immunology

authors： Grossman N,Svenson SB,Leive L,Lindberg AA

更新日期：1990-09-01 00:00:00

abstract：:A sheep cDNA library was screened with a human C mu probe, and the complete nucleotide sequence of a 1923 nt cDNA was determined. It contains sequences corresponding to all the exons (VH, DH, JH, CH1, CH2, CH3 and CH4) characteristic of the immunoglobulin mu heavy chain regions. The deduced amino acid sequence shows a...

journal_title：Molecular immunology

authors： Patri S,Nau F

更新日期：1992-07-01 00:00:00

abstract：:Macrophage migration is mediated by complex cellular signaling processes and cytoskeleton re-arrangement. In particular, recent advances indicate that the innate immunity signaling process plays a key role in the regulation of macrophage migration. In this report, we have provided evidence demonstrating the involvemen...

journal_title：Molecular immunology

authors： Gan L,Li L

更新日期：2010-03-01 00:00:00

abstract：:Immunoglobulin heavy chain (Igh) locus rearrangements are controlled in part by an approximately 30 b complex 3' regulatory region located 3' of C alpha: this region contains several enhancers. We report here the comparison of the genomic sequences of the 3' regulatory region and further downstream sequences from mous...

journal_title：Molecular immunology

authors： Sepulveda MA,Garrett FE,Price-Whelan A,Birshtein BK

更新日期：2005-03-01 00:00:00

abstract：:Comparative interactions of purified rabbit C1q with 18-2-3, a high affinity (2-3 X 10(10) M-1) anti-fluorescein (anti-F1) murine monoclonal IgM antibody (pentamer) and constitutive monomeric subunits (IgMs) were studied. Using a solid phase radioimmunoassay (SPRIA), based on immobilized polyvalent antigen, it was sho...

journal_title：Molecular immunology

authors： Swanson SM,Dombrink-Kurtzman MA,Voss EW Jr

更新日期：1988-06-01 00:00:00

abstract：:Fibrates, which function by binding and activating peroxisome proliferator-activated receptor alpha (PPARalpha), have been used successfully to treat hyperlipidemia and atherosclerosis. Increasing evidence suggests that in addition to their lipid lowering activities these medications also function as immunosuppressive...

journal_title：Molecular immunology

authors： Selim E,Frkanec JT,Cunard R

更新日期：2007-02-01 00:00:00

abstract：:The ragweed allergens Amb t 5 and Amb a 5 are among the smallest inhaled protein allergens known, containing a single, immunodominant T-cell epitope. In this study we analyzed the B-cell epitope structure of Amb t 5. The three-dimensional structures of Amb t 5 and Amb a 5 have been determined by NMR spectroscopy, prov...

journal_title：Molecular immunology

authors： Rafnar T,Brummet ME,Bassolino-Klimas D,Metzler WJ,Marsh DG

更新日期：1998-06-01 00:00:00

abstract：:Evidence suggests that immune dysregulation is associated with autism spectrum disorder (ASD). T cell immunoglobulin and mucin domain-3 (TIM-3) has a critical role in several inflammatory disorders; however, the role of TIM-3 signaling has not been demonstrated in ASD. In the present study, we assessed the role of TIM...

journal_title：Molecular immunology

authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alotaibi MR,Alhoshani AR,Alshammari MA,Attia SM

更新日期：2019-02-01 00:00:00

abstract：:We have recently developed an in vitro culture model enabling the large-scale expansion of switched-memory B lymphocytes, producing a polyclonal human IgG repertoire. Given the importance of glycosylation for the functions of immunoglobulins, we analyzed the N-glycosylation profiles of the immunoglobulin G (IgG) in th...

journal_title：Molecular immunology

authors： Ritamo I,Cloutier M,Valmu L,Néron S,Räbinä J

更新日期：2014-02-01 00:00:00

abstract：:The purpose of the present work was to determine the ability of BgTX peptides, corresponding to the various loops and exposed regions of alpha-bungarotoxin (BgTX) and representing regions that are recognized by B and/or T cells, to stimulate protective immunity in mice against in vivo challenge with BgTX. The BgTX LD5...

journal_title：Molecular immunology

authors： Dolimbek BZ,Atassi MZ

更新日期：1996-05-01 00:00:00

abstract：:The recovery of VDJ rearrangement is most often accomplished by PCR amplification of DNA extracted from mixtures of B-cells. Using this procedure in swine, VDJs containing chimeric V(H) genes that resemble gene-conversion products, are frequently encountered. To examine whether these chimeras could be the result of PC...

journal_title：Molecular immunology

authors： Sinkora M,Sun J,Butler JE

更新日期：2000-12-01 00:00:00

abstract：:The S100A12 gene belongs to the S100 family of genes, which are specific to vertebrates. It is involved in many inflammatory diseases of human and has been considered as a powerful diagnostic gene. In the present study, we identified the porcine S100A12 (pS100A12) gene, provided evidence that pS100A12 is located on ch...

journal_title：Molecular immunology

authors： Chen H,Cheng L,Yang S,Liu X,Liu Y,Tang J,Li X,He Q,Zhao S

更新日期：2010-04-01 00:00:00

abstract：:Previous data suggested that constitutive expression of the transcription factor Bright (B cell regulator of immunoglobulin heavy chain transcription), normally tightly regulated during B cell differentiation, was associated with autoantibody production. Here we show that constitutive Bright expression results in skew...

journal_title：Molecular immunology

authors： Oldham AL,Miner CA,Wang HC,Webb CF

更新日期：2011-10-01 00:00:00

abstract：:The thermal effects associated with the binding reaction of concanavalin A and immunoglobulins have been measured by calorimetry. IgG solutions do not generate heat on mixing with concanavalin A, confirming the low reactivity of IgG for the lectin molecule. IgM solutions, on the other hand, show a substantial enthalpi...

journal_title：Molecular immunology

authors： Dani M,Manca F,Rialdi G

更新日期：1982-07-01 00:00:00

abstract：:The migration of dendritic cells (DCs) from the site of antigen-encounter to regional lymphoid organs is crucial for DCs to function as potent antigen-presenting cells. Matrix metalloproteinase-9 (MMP-9) is critically for DCs migration across extracellular matrix (ECM). We verified in previous studies that hypoxia dim...

journal_title：Molecular immunology

authors： Zhao P,Li XG,Yang M,Shao Q,Wang D,Liu S,Song H,Song B,Zhang Y,Qu X

更新日期：2008-04-01 00:00:00

abstract：:In this paper we report a chemometric approach to Quantitative Structure-Activity Relationship (QSAR) analysis applied to a study of the binding of peptides to Major Histocompatibility Complex (MHC) class I proteins. Peptides which possess the known primary anchor residue motif for HLA-B27 binding do not necessarily b...

journal_title：Molecular immunology

authors： Rovero P,Riganelli D,Fruci D,Viganò S,Pegoŕaro S,Revoltella R,Greco G,Butler R,Clementi S,Tanigaki N

更新日期：1994-05-01 00:00:00

abstract：:Activation of p38 MAP kinase in T cells leads to increased interferon-gamma production in CD4+ and CD8+ T cells, and the selective cell death of CD8+ T cells. To address the role of p38 MAP kinase activation in T cells during an in vivo immune response, we examined the response against the influenza virus in transgeni...

journal_title：Molecular immunology

authors： Conze D,Lumsden J,Enslen H,Davis RJ,Le Gros G,Rincón M

更新日期：2000-06-01 00:00:00

abstract：:Recombinant DNA techniques now allow the production of "mini-antibodies" called Fv fragments. These have been produced either as the independent variable domains of the heavy and light chains non-covalently associated in one-to-one stoichiometry or as single-chain gene products with the two domains linked by an interv...

journal_title：Molecular immunology

authors： Webber KO,Reiter Y,Brinkmann U,Kreitman R,Pastan I

更新日期：1995-03-01 00:00:00

abstract：:A recent publication in Molecular Immunology by Leo and Goldman doi:10.1016/j.molimm.2009.02.024 has shown that the Escherichia coli immunoglobulin-binding (Eib) proteins are receptors for IgG and IgA. We would like to highlight important issues that were not addressed in their recent manuscript whilst providing possi...

journal_title：Molecular immunology

authors： Pleass RJ

更新日期：2009-07-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a recognition molecule of the complement (C) system and binds to carbohydrate ligands present on a wide range of pathogenic bacteria, viruses, fungi, and parasites. MBL has been detected in the cervico-vaginal cavity where it can provide a first-line defence against infectious agents co...

journal_title：Molecular immunology

authors： Bulla R,De Seta F,Radillo O,Agostinis C,Durigutto P,Pellis V,De Santo D,Crovella S,Tedesco F

更新日期：2010-11-01 00:00:00

abstract：:The complement system is important for protection from invading pathogens, removal of waste products and guidance of the immune response. Furthermore, complement can be also targeted to cancer cells. However, membrane-bound inhibitors over-expressed by certain types of tumor cells restrict the cytotoxic activity of co...

journal_title：Molecular immunology

authors： Okroj M,Hsu YF,Ajona D,Pio R,Blom AM

更新日期：2008-01-01 00:00:00

abstract：:Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-E(k) revealed an interesting localization of negatively charged residues within the P6 pocket, which may have implications in the pH dependency...

journal_title：Molecular immunology

authors： Dao CT,Weber DA,Jensen PE

更新日期：2002-06-01 00:00:00

abstract：:We have examined the properties of soluble guanylate cyclase activity in the human neutrophil. The enzyme showed complex regulation by metal ions. A 10-fold higher activity was observed in the presence of Mn2+ than Mg2+, while Ca2+ caused an increase in activity only in the presence of Mg2+ ion. Sodium nitroprusside (...

journal_title：Molecular immunology

authors： Lad PM,Glovsky MM,Richards JH,Smiley PA,Backstrom B

更新日期：1985-07-01 00:00:00

abstract：:During acute lung injury, a large number of monocytes are recruited into the pulmonary tissue, which is mainly mediated by local production of monocyte chemotactic protein 1 (MCP-1). As an essential component of the lung tissues, alveolar type II epithelial cells are one of the major sources of MCP-1. Therefore, uncov...

journal_title：Molecular immunology

authors： Yan C,Li B,Liu X,Deng C,Cai R,Shen Y,Tang H

更新日期：2019-07-01 00:00:00

abstract：:TRIMCyp generated by retrotransposition of a cyclophilin A inserting into TRIM5 locus, has been identified in owl monkey and most of Old World monkeys (OWM). Owl monkey TRIMCyp (omTRIMCyp) inhibits HIV-1 infection by direct interaction with viral capsid and indirect innate immune induction, whereas most of TRIMCyps fr...

journal_title：Molecular immunology

authors： Zhu JW,Mu D,Liu FL,Luo MT,Luo RH,Zheng YT

更新日期：2018-09-01 00:00:00

abstract：:The integral membrane protein flavocytochrome b (Cyt b) is the catalytic core of the NADPH oxidase complex, a multicomponent enzyme system that initiates a cascade of reactive oxygen species that play a critical role in innate immunity and vascular physiology. Epitope-mapped, monoclonal antibodies (mAb) that recognize...

journal_title：Molecular immunology

authors： Taylor RM,Maaty WS,Lord CI,Hamilton T,Burritt JB,Bothner B,Jesaitis AJ

更新日期：2007-01-01 00:00:00