Abstract:
:Previous data suggested that constitutive expression of the transcription factor Bright (B cell regulator of immunoglobulin heavy chain transcription), normally tightly regulated during B cell differentiation, was associated with autoantibody production. Here we show that constitutive Bright expression results in skewing of mature B lineage subpopulations toward marginal zone cells at the expense of the follicular subpopulation. C57Bl/6 transgenic mice constitutively expressing Bright in B lineage cells generated autoantibodies that were not the result of global increases in immunoglobulin or of breaches in key tolerance checkpoints typically defective in other autoimmune mouse models. Rather, autoimmunity correlated with increased numbers of marginal zone B cells and alterations in the phenotype and gene expression profiles of lymphocytes within the follicular B cell compartment. These data suggest a novel role for Bright in the normal development of mature B cell subsets and in autoantibody production.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Oldham AL,Miner CA,Wang HC,Webb CFdoi
10.1016/j.molimm.2011.09.008subject
Has Abstractpub_date
2011-10-01 00:00:00pages
367-79issue
1-2eissn
0161-5890issn
1872-9142pii
S0161-5890(11)00748-6journal_volume
49pub_type
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