The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.

Abstract:

:Previous data suggested that constitutive expression of the transcription factor Bright (B cell regulator of immunoglobulin heavy chain transcription), normally tightly regulated during B cell differentiation, was associated with autoantibody production. Here we show that constitutive Bright expression results in skewing of mature B lineage subpopulations toward marginal zone cells at the expense of the follicular subpopulation. C57Bl/6 transgenic mice constitutively expressing Bright in B lineage cells generated autoantibodies that were not the result of global increases in immunoglobulin or of breaches in key tolerance checkpoints typically defective in other autoimmune mouse models. Rather, autoimmunity correlated with increased numbers of marginal zone B cells and alterations in the phenotype and gene expression profiles of lymphocytes within the follicular B cell compartment. These data suggest a novel role for Bright in the normal development of mature B cell subsets and in autoantibody production.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Oldham AL,Miner CA,Wang HC,Webb CF

doi

10.1016/j.molimm.2011.09.008

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

367-79

issue

1-2

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(11)00748-6

journal_volume

49

pub_type

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