Abstract：
:The S100A12 gene belongs to the S100 family of genes, which are specific to vertebrates. It is involved in many inflammatory diseases of human and has been considered as a powerful diagnostic gene. In the present study, we identified the porcine S100A12 (pS100A12) gene, provided evidence that pS100A12 is located on chromosome 4 and is closely linked to SW512. We show that pS100A12 is expressed preferentially in immune organs/tissues, e.g., bone marrow, spleen, and inguinal lymph nodes. Expression of the pS100A12 gene is dramatically induced in porcine whole blood cultures by both lipopolysaccharide (LPS) and polyinosine-polycytidylic acid (Poly(I:C)). Elevated expression of pS100A12 is also correlated with in vivo infection with porcine circovirus type 2 (PCV-2) from at least 48h post infection. By analyzing a series of pS100A12 promoter reporter constructs, we have defined two crucial regions (-1013 to -590, -135 to -50) that are responsible for LPS- and Poly(I:C)-induced transcriptional activation, and demonstrated that the LPS/Poly(I:C)-PKC-C/EBPb-pS100A12 pathway may play a critical role in the transcription of the pS100A12.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Chen H,Cheng L,Yang S,Liu X,Liu Y,Tang J,Li X,He Q,Zhao Sdoi
10.1016/j.molimm.2010.01.024subject
Has Abstractpub_date
2010-04-01 00:00:00pages
1601-7issue
7-8eissn
0161-5890issn
1872-9142pii
S0161-5890(10)00036-2journal_volume
47pub_type
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