Linkage of a tumor immune function and cell cycle de-regulation via a gene regulatory network subcircuit.


:Gene regulatory network (GRN) subcircuits have been described for cell fate progressions in animal development. The hallmark of these subcircuits is the integration of promoters, and positive- and negative-acting promoter binding proteins, such that an alteration in function of any one member of the defined subcircuit, occurring with a change in cell fate, defines a change in status for all other members of the subcircuit. Here we describe a GRN subcircuit that links a tumor immune function with cell cycle de-regulation. All members of this subcircuit have a predictable status change in response to rescue of the growth-controlled phenotype. Given the similarities between the molecular mechanisms underlying cell status changes in tumorigenesis and development, application of GRN paradigms to tumor progression is particularly apt and offers the hope of providing a more concise, reliable, and therapeutically useful series of predictions linking gene regulation and tumor progression.


Mol Immunol


Molecular immunology


Xu L,Niesen MI,Blanck G




Has Abstract


2009-02-01 00:00:00














  • Human myeloma light chains with increased molecular weight: high frequency among lambda chains.

    abstract::The discovery of a human myeloma protein comprising a kappa L-chain with an increased mol. wt of 30,000) (Bouvet et. al., 1980) prompted investigations on the incidence of such heavier L-chains among other human myeloma proteins. In 105 samples examined, 34 were found to have L-chains heavier than normal (23,000-24,00...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Bouvet JP,Pillot J,Liacopoulos P

    更新日期:1983-04-01 00:00:00

  • Low level formation of potent catalytic IgG fragments mediated by disulfide bond instability.

    abstract::A highly purified preparation of a monoclonal antibody to vasoactive intestinal peptide (VIP) was analysed by gel filtration. Three peaks of VIP hydrolysing activity were observed, corresponding to the 150 kDa tetramer IgG, 80 kDa dimer of the heavy and light chains (H-L dimer) and 25 kDa L chain monomer. The hydrolyt...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Li L,Sun M,Gao QS,Paul S

    更新日期:1996-05-01 00:00:00

  • Cloning and characterization of murine CD6.

    abstract::The lymphocyte antigen CD6 has been extensively studied in humans, but has not been reported in mouse. Here we describe the isolation and characterization of a cDNA clone encoding the murine homologue of the human lymphocyte antigen CD6. Comparison of the predicted amino acid sequence of human and murine CD6 shows tha...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Whitney G,Bowen M,Neubauer M,Aruffo A

    更新日期:1995-01-01 00:00:00

  • Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses.

    abstract::Bacterial lipopolysaccharide (LPS) activates the innate immune system by forming a complex with myeloid differentiation factor 2 (MD-2) and Toll-like receptor 4 (TLR4), which is present on antigen presenting cells. MD-2 plays an essential role in this activation of the innate immune system as a member of the ternary c...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Mattis DM,Chervin AS,Ranoa DR,Kelley SL,Tapping RI,Kranz DM

    更新日期:2015-12-01 00:00:00

  • Cathepsin S inhibition changes regulatory T-cell activity in regulating bladder cancer and immune cell proliferation and apoptosis.

    abstract::Regulatory T cells (Tregs) are immune suppressive cells, but their roles in tumor growth have been elusive, depending on tumor type or site. Our prior study demonstrated a role of cathepsin S (CatS) in reducing Treg immunosuppressive activity. Therefore, CatS inhibition in Tregs may exacerbate tumor growth. Using mous...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Yan X,Wu C,Chen T,Santos MM,Liu CL,Yang C,Zhang L,Ren J,Liao S,Guo H,Sukhova GK,Shi GP

    更新日期:2017-02-01 00:00:00

  • Cloning and expression analysis of two pro-inflammatory cytokines, IL-1 beta and IL-8, in haddock (Melanogrammus aeglefinus).

    abstract::This paper reports the cloning and sequencing of two pro-inflammatory cytokines, interleukin (IL)-1beta and IL-8, in haddock (Melanogrammus aeglefinus) by homology cloning. The complete transcript of the haddock IL-1beta was sequenced and contained 1043 bp, including a 762 bp open reading frame. The 3' end of the gene...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Corripio-Miyar Y,Bird S,Tsamopoulos K,Secombes CJ

    更新日期:2007-02-01 00:00:00

  • Design, synthesis, and characterization of a 39 amino acid peptide mimic of the main immunogenic region of the Torpedo acetylcholine receptor.

    abstract::We have designed a 39 amino acid peptide mimic of the conformation-dependent main immunogenic region (MIR) of the Torpedo acetylcholine receptor (TAChR) that joins three discontinuous segments of the Torpedo α-subunit, α(1-12), α(65-79), and α(110 - 115) with two GS linkers: This 39MIR-mimic was expressed in E. coli a...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Trinh VB,Foster AJ,Fairclough RH

    更新日期:2014-05-01 00:00:00

  • Functional maturation of murine B lymphocyte precursors--III. Soluble factors involved in the regulation of growth and differentiation.

    abstract::When 5-fluorouracil (5-FU) resistant bone marrow (BM) cells are depleted of B-cells and then cultured in insert chambers [separated from a layer of adherent BM (aBM) cells by a nucleopore membrane], no mature, lipopolysaccharide (LPS) reactive B-cells are formed. Factors acting on B-cell precursors are not produced un...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Gisler RH,Schlienger C,Söderberg A,Ledermann F,Lambris JD

    更新日期:1988-11-01 00:00:00

  • An unusual inhibitory receptor--the mast cell function-associated antigen (MAFA).

    abstract::The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein that was first identified on the surface of rat mucosal-type mast cells of the RBL-2H3 line. A C-type lectin domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) are located in the extracellular and intracellular domain...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Abramson J,Xu R,Pecht I

    更新日期:2002-09-01 00:00:00

  • DNA immunization via intramuscular and intradermal routes using a gene gun provides different magnitudes and durations on immune response.

    abstract::We investigated the antibody (Ab) and cytotoxic T lymphocyte (CTL) responses to gene gun (GG)-mediated DNA immunization via the intramuscular (i.m.) and intradermal (i.d.) routes. BALB/c mice were immunized five times at weekly intervals with plasmid DNA encoding enhanced green fluorescent protein (EGFP). EGFP product...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Ito K,Ito K,Shinohara N,Kato S

    更新日期:2003-05-01 00:00:00

  • A novel dendritic cell-targeted lentiviral vector, encoding Ag85A-ESAT6 fusion gene of Mycobacterium tuberculosis, could elicit potent cell-mediated immune responses in mice.

    abstract::Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), leading to high mortality worldwide. It is well-established that cellular immunity plays a critical role to control Mtb infection. Dendritic Cells (DCs) are potent antigen presenting cells, which play an important role to prime cell...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Shakouri M,Moazzeni SM,Ghanei M,Arashkia A,Etemadzadeh MH,Azadmanesh K

    更新日期:2016-07-01 00:00:00

  • MicroRNA-146a promotes IgE class switch in B cells via upregulating 14-3-3σ expression.

    abstract::B cells play a critical role in immune responses both in physiological and pathological conditions, and microRNAs have been shown to play important roles in regulating B cell proliferation and function. MiR-146a has been shown to modulate T cell immunity, but its function in regulating B cell response remains partiall...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Li F,Huang Y,Huang YY,Kuang YS,Wei YJ,Xiang L,Zhang XJ,Jia ZC,Jiang S,Li JY,Wan Y

    更新日期:2017-12-01 00:00:00

  • Comparative molecular modelling of the Fas-ligand and other members of the TNF family.

    abstract::A number of proteins with significant similarity to the tumour necrosis factor (TNF) have been identified over the last years. Upon interaction with their cognate receptor (members of the TNF-receptor family), all members of this protein family induce either cell death or proliferation/differentiation of the receptor-...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Peitsch MC,Tschopp J

    更新日期:1995-07-01 00:00:00

  • Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization.

    abstract::The interferon (IFN)-inducible p200-protein family includes structurally related murine (for example, p202a, p202b, p204, and Aim2) and human (for example, AIM2 and IFI16) proteins. All proteins in the family share a partially conserved repeat of 200-amino acid residues (also called HIN-200 domain) in the C-terminus. ...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Veeranki S,Choubey D

    更新日期:2012-01-01 00:00:00

  • Are the decrease in circulating anti-α1,3-Gal IgG and the lower content of galactosyl transferase A1 in the microbiota of patients with multiple sclerosis a novel environmental risk factor for the disease?

    abstract::The etiology of multiple sclerosis (MS), particularly the environmental component of the disease, remains speculative. Recent reports have suggested that alterations in the gut microbiota of MS patients could contribute to the etiology or pathophysiology of the disease. In this Viewpoint, using PICRUSt (Phylogenetic I...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Montassier E,Berthelot L,Soulillou JP

    更新日期:2018-01-01 00:00:00

  • Sequence analysis of porcine immunoglobulin light chain cDNAs.

    abstract::A porcine cDNA library was constructed using poly(A)+ RNA isolated from the spleen of an adult Minnesota miniature swine. Screening the library with antisera specific for porcine immunoglobulin light chains resulted in the selection and isolation of two recombinant clones, PLC18 and PLC3, which encode for kappa and la...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Lammers BM,Beaman KD,Kim YB

    更新日期:1991-08-01 00:00:00

  • Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure.

    abstract::Most cells are believed to be capable of producing type I interferons (IFN I) as part of an innate immune response against, for instance, viral infections. In macrophages, IFN I is potently induced upon cytoplasmic exposure to foreign nucleic acids. Infection of these cells with herpesviruses leads to triggering of th...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Gram AM,Sun C,Landman SL,Oosenbrug T,Koppejan HJ,Kwakkenbos MJ,Hoeben RC,Paludan SR,Ressing ME

    更新日期:2017-11-01 00:00:00

  • Chemokine-mediated inflammation: Identification of a possible regulatory role for CCR2.

    abstract::The chemokine receptor CCR2 binds four pro-inflammatory monocyte chemoattractant proteins, designated MCP1/CCL2, MCP2/CCL8, MCP3/CCL7 and MCP4/CCL13. This study demonstrates the important biology of this receptor during the response to the chemokine milieu. Competitive chemotaxis and calcium flux assays were performed...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: O'Boyle G,Brain JG,Kirby JA,Ali S

    更新日期:2007-03-01 00:00:00

  • C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation.

    abstract:UNLABELLED:C5L2, a G-protein-coupled receptor (GPCR), has been identified as an ASP (C3adesArg) and C5a receptor. Controversy exists regarding both ligand binding and functionality. ASP activation of C5L2 is proposed to regulate fat storage. C5L2 is also proposed as a decoy receptor for C5a, an inflammatory mediator, b...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Cui W,Simaan M,Laporte S,Lodge R,Cianflone K

    更新日期:2009-09-01 00:00:00

  • Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome.

    abstract::Several mutations in the CFH gene have been described in non-Shiga-toxin-associated haemolytic uraemic syndrome (non-Stx-HUS), a rare syndrome characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. Mutations in genes encoding other complement regulatory proteins, membrane cofactor protein (CD46...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Monteferrante G,Brioschi S,Caprioli J,Pianetti G,Bettinaglio P,Bresin E,Remuzzi G,Noris M

    更新日期:2007-03-01 00:00:00

  • Protective KIR-HLA interactions for HCV infection in intravenous drug users.

    abstract::Intravenous drug use has become the principal route of hepatitis C virus (HCV) transmission due to the sharing of infected needles. In this study, we analyzed the distribution of HLA-KIR genotypes among 160 Puerto Rican intravenous drug users (IDUs) with HCV infection and 92 HCV-negative Puerto Rican IDUs. We found a ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Zúñiga J,Romero V,Azocar J,Terreros D,Vargas-Rojas MI,Torres-García D,Jiménez-Alvarez L,Vargas-Alarcón G,Granados-Montiel J,Husain Z,Chung RT,Alper CA,Yunis EJ

    更新日期:2009-08-01 00:00:00

  • Translation in Xenopus laevis oocytes of hybrid selected LEW rat RT1.B alpha- and beta-chain transcripts results in serologically discrete class II polypeptide chain complexes.

    abstract::Using the non-crossreactive mAb MRC-OX3 and MRC-OX6, two serologically distinct RT1.B-specific (I-A equivalent) alpha, beta heterodimers have previously been described by us as residing at the cell surface of LEW rat spleen cells. The two-chain elements were suggested to represent stable conformation isomers, diverged...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Henkes W,Reske K

    更新日期:1989-02-01 00:00:00

  • C-mip interacts physically with RelA and inhibits nuclear factor kappa B activity.

    abstract::The fine regulation of NF-kappaB activity is crucial for both resting and stimulated cells and relies on complex balance between multiple activators and inhibitors. We report here that c-mip, a recently identified pleckstrin homology (PH) and leucine-rich repeat (LRR)-domain-containing protein, inactivates GSKbeta and...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Kamal M,Valanciute A,Dahan K,Ory V,Pawlak A,Lang P,Guellaen G,Sahali D

    更新日期:2009-02-01 00:00:00

  • ANCA associated vasculitis: The journey to complement-targeted therapies.

    abstract::ANCA associated vasculitis is a serious, very often recurrent disease that despite the current standard treatment with high-dose glucocorticoids and either cyclophosphamide or rituximab, patients have a nine-fold increased mortality risk in the first year compared with healthy controls, attributed to infections, vascu...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Quintana LF,Kronbichler A,Blasco M,Zhao MH,Jayne D

    更新日期:2019-08-01 00:00:00

  • Effects of surfactant protein D on growth, adhesion and epithelial invasion of intestinal Gram-negative bacteria.

    abstract::Surfactant protein D (SP-D) interacts with various different microorganisms and plays an important role in pulmonary innate immunity. SP-D expression has also been detected in extrapulmonary tissues, including the gastro-intestinal tract. However, its function in the intestine is unknown and may differ considerably fr...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Hogenkamp A,Herías MV,Tooten PC,Veldhuizen EJ,Haagsman HP

    更新日期:2007-07-01 00:00:00

  • Quasi-elastic light scattering of antigen-antibody complexes.

    abstract::Many biological properties of immune complexes (IC) depend upon their size. Quasi-elastic light scattering (QLS) was used to measure a mean equivalent hydrodynamic radius (Rh) and variance of the distribution of model IC composed of bovine serum albumin (BSA) as antigen (Ag) and combinations of two or three well-chara...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Yarmush DM,Murphy RM,Colton CK,Fisch M,Yarmush ML

    更新日期:1988-01-01 00:00:00

  • Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells.

    abstract::Neutrophil migration is essential for battling against infections but also drives chronic inflammation. Since primary neutrophils are terminally differentiated and not genetically tractable, leukemia cells such as HL-60 are differentiated into neutrophil-like cells to study mechanisms underlying neutrophil migration. ...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Hsu AY,Liu S,Syahirah R,Brasseale KA,Wan J,Deng Q

    更新日期:2019-08-01 00:00:00

  • Design and expression of a stable bispecific scFv dimer with affinity for both glycophorin and N9 neuraminidase.

    abstract::We have designed and produced a stable bispecific scFv dimer (bisFv) by non-covalent association of two hybrid VH-VL pairs derived from an anti-neuraminidase antibody (NC10) and an anti-glycophorin antibody (1C3). The bisFv dimer was demonstrated to have binding activity to the two respective target antigens and was e...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Atwell JL,Pearce LA,Lah M,Gruen LC,Kortt AA,Hudson PJ

    更新日期:1996-12-01 00:00:00

  • SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells.

    abstract::Emerging evidence has indicated that vascular endothelial cells (ECs) not only form the barrier between blood and the vessel wall but also serve as conditional innate immune cells. Our previous study found that SIRT1, a class III histone deacetylase, inhibits the inflammatory response in ECs. Recent studies revealed t...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Li Y,Wang P,Yang X,Wang W,Zhang J,He Y,Zhang W,Jing T,Wang B,Lin R

    更新日期:2016-09-01 00:00:00

  • Vγ1+γδT, early cardiac infiltrated innate population dominantly producing IL-4, protect mice against CVB3 myocarditis by modulating IFNγ+ T response.

    abstract::Viral myocarditis (VMC) is an inflammation of the myocardium closely associated with Coxsackievirus B3 (CVB3) infection. Vγ1+γδT cells, one of early cardiac infiltrated innate population, were reported to protect CVB3 myocarditis while the precise mechanism not fully addressed. To explore cytokine profiles and kinetic...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Wan F,Yan K,Xu D,Qian Q,Liu H,Li M,Xu W

    更新日期:2017-01-01 00:00:00