The tag SNP rs10746463 in decay-accelerating factor is associated with the susceptibility to gastric cancer.


BACKGROUND:Complement activation involved in the innate immunity and adaptive immunity and further contributed to the development of tumor growth. This study aimed to investigate the association of genetic variants in complement 3 (C3) and decay-accelerating factor (DAF) genes with the risk of gastric cancer. METHODS:This case-control study included 500 gastric cancer patients and 500 cancer-free controls. Based on the Chinese population data from HapMap database, we used Haploview 4.2 program to select candidate tag SNPs. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression to evaluate the association of each genetic variant with the risk of gastric cancer. RESULTS:Among 12 tag SNPs of C3, no correlation was observed between C3 genetic variants and risk of gastric cancer. For tag SNPS of DAF, logistic regression analysis revealed that the carriers with DAF rs10746463 AA genotype had a significantly increased risk for developing gastric cancer (OR = 1.46, 95% CI = 1.01–2.10) when compared with GG genotype, but those carrying with rs10746463 AG genotype didn't (OR = 1.31, 95% CI = 0.98-1.75). When stratified by smoking status, we found that the risk of gastric cancer was associated with rs10746463 GA or AA genotype carriers among smoker with OR (95% CI) of 1.64 (1.06-2.54), but not among non-smoker (OR = 1.37, 95% CI = 0.97-1.94). CONCLUSION:DAF rs10746463 polymorphism effects on the risk of developing gastric cancer in Chinese population.


Mol Immunol


Molecular immunology


Song Q,Zhang Z,Liu Y,Han S,Zhang X




Has Abstract


2015-02-01 00:00:00














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    abstract::Human neutrophil peptides (HNPs) are cysteine-rich antimicrobial peptides stored in neutrophils. The similar structure of HNPs -1, -2, and -3 renders them impossible to study individually in biological samples. For the first time, we describe a method of individually identifying the HNPs -1-3 from exudative neutrophil...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Thompson L,Turko I,Murad F

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    journal_title:Molecular immunology

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    authors: Padlan EA

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    authors: Sarvas HO,Seppälä IJ,Tähtinen T,Péterfy F,Mäkelä O

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  • Targeted inhibition of GATA-6 attenuates airway inflammation and remodeling by regulating caveolin-1 through TLR2/MyD88/NF-κB in murine model of asthma.

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    journal_title:Molecular immunology

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    authors: Fang P,Shi HY,Wu XM,Zhang YH,Zhong YJ,Deng WJ,Zhang YP,Xie M

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    journal_title:Molecular immunology

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    authors: Petty HR

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Märten A,Renoth S,Schmidt-Wolf IG

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    pub_type: 杂志文章


    authors: Esmailnejad A,Nikbakht Brujeni G,Badavam M

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Kunnath-Muglia LM,Chang GH,Sim RB,Day AJ,Ezekowitz RA

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


    authors: Wilflingseder D,Banki Z,Dierich MP,Stoiber H

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    authors: Kepron MR,Conrad DH,Froese A

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    abstract::Apoptosis can be induced in the human leukemic T-cell line Jurkat when these cells are stimulated by several known T-cell activators. Among the stimuli that activate Jurkat cells, calcium ionophore A23187, phytohemagglutinin and cross-linked monoclonal antibody anti-CD3 are the best inducers of apoptosis. The activato...

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    authors: Ruiz-Ruiz MC,Oliver FJ,Izquierdo M,López-Rivas A

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    abstract::Abs reactive to DNA and DNA/histone complexes are a distinguished characteristic of primary immunoglobulin repertoires in autoimmune B6.MRL-Faslpr and MRL/MpJ-Faslpr mice. These mice are defective in Fas receptor, which is critical for the apoptosis of autoreactive B cells by an extrinsic pathway. In the present study...

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    authors: Li S,Liu W,Li Y,Zhao S,Liu C,Hu M,Yue W,Liu Y,Wang Y,Yang R,Xiang R,Liu F

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    authors: Li R,Li H,Sun Q,Liu L,Zhang C,Ren X

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    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Alexandre D,Lefranc MP

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Katakura Y,Kumamoto T,Iwai Y,Kurokawa Y,Omasa T,Suga K

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Yarmush DM,Murphy RM,Colton CK,Fisch M,Yarmush ML

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    authors: Avrameas A,Guillet JG,Chouchane L,Moraillon A,Sonigo P,Strosberg AD

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Rousseaux-Prevost R,Hublau P,Sautiere P,Rousseaux J

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  • Characterization of three novel beta-defensin antimicrobial peptides in rainbow trout (Oncorhynchus mykiss).

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    authors: Casadei E,Wang T,Zou J,González Vecino JL,Wadsworth S,Secombes CJ

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    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Kaartinen M,Rocca-Serra J,Mäkelä O

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Chen ZC,Radic MZ,Galili U

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    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


    authors: Yaneva R,Schneeweiss C,Zacharias M,Springer S

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Evans JP,Brown PJ,Sinor LT,Tilzer LL,Beck M,Plapp FV

    更新日期:1983-05-01 00:00:00