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A murine antibody to Shigella dysenteriae type 1 employs V-genes that contain a rearranged codon for the lambda light chain.

Abstract：

:The cDNA coding for a hybridoma anti Shigella dysenteriae type 1 antibody (3707 E9) has been cloned, and sequenced. Binding patterns with fragments of the bacterial polysaccharide antigen had already been studied in detail. The VH sequence utilizes the VH441 gene, first identified amongst beta-(1,6)galactan-binding antibodies, while the VL is closely related to the V lambda 1 gene. We found that the VL3707 E9 gene employed a VL-J combinatorial joining leading to a rare Trp-->Leu substitution at position L96.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Miller CE,Huppi K,Siwarski D,Karpas A,Newman A,Mainhart C,Glaudemans CP

doi

10.1016/0161-5890(95)00072-m

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

679-82

issue

9

eissn

0161-5890

issn

1872-9142

pii

016158909500072M

journal_volume

32

pub_type

杂志文章

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