Localisation of the monocyte-binding region on human immunoglobulin G.

abstract：BACKGROUND:Ethanol feeding in mice activates complement via C1q binding to apoptotic cells in the liver; complement contributes to ethanol-induced inflammation and injury. Despite the critical role of C1q in ethanol-induced injury, the mechanism by which ethanol activates C1q remains poorly understood. Secretory IgM (s...

journal_title：Molecular immunology

authors： Smathers RL,Chiang DJ,McMullen MR,Feldstein AE,Roychowdhury S,Nagy LE

更新日期：2016-04-01 00:00:00

abstract：:Cimetidine, a histamine type-2 receptor antagonist, is known to inhibit the growth of several tumors in human and animals, however the mechanism of action underlying this effect remains largely unknown. Here, in the mice model of 3LL lung tumor, cimetidine showed significant inhibition of tumor growth. However, an in ...

journal_title：Molecular immunology

authors： Zheng Y,Xu M,Li X,Jia J,Fan K,Lai G

更新日期：2013-05-01 00:00:00

abstract：:Although the lambda-bearing antibodies represent only 5% of the total mouse serum immunoglobulins, some antigens such as B1355 dextran (alpha (1-3)Dex), the 4-hydroxy-3-nitrophenyl acetyl (NP) and 2,4-dinitro or 2,4,6-trinitrophenyl (DNP/TNP) antigens can induce lambda-positive immune responses. In contrast to the lam...

journal_title：Molecular immunology

authors： Sanchez P,Juy D,Cazenave PA

更新日期：1988-02-01 00:00:00

abstract：:Invertebrate cells lack the p53 recombination checkpoint but contain mobile DNA sequences that transpose by a mechanism in part shared with excision of the V(D)J recombination signal sequences (RSS). In this work, inversion, deletion, and duplication of sequences associated with an invertebrate C. elegans Tc6 element ...

journal_title：Molecular immunology

authors： Dreyfus DH,Gelfand EW

更新日期：1999-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are now recognized as important regulators of all cellular processes, including immune function and cancer survival. These evolutionary preserved, single-stranded, non-coding RNA molecules mediate important functional effects primarily through post-transcriptional regulation of protein expression. M...

journal_title：Molecular immunology

authors： Saultz JN,Freud AG,Mundy-Bosse BL

更新日期：2019-11-01 00:00:00

abstract：:It is well established that many cell functions are controlled by the PI-3K signaling pathway and the signaling lipid, phosphatidylinositol-3,4,5-triphosphate (PIP3). This is particularly true for mast cells which play a key regulatory role in allergy and inflammation through activation via high-affinity IgE receptors...

journal_title：Molecular immunology

authors： Shenker BJ,Boesze-Battaglia K,Zekavat A,Walker L,Besack D,Ali H

更新日期：2010-11-01 00:00:00

abstract：:Heparin and two dextran sulphate preparations with a low or high average molecular mass (M(r) 5000 and 5 x 10(5), respectively) enhanced binding of radioactively labelled complement factor H to the complement protein C3b, coupled to Sepharose 4B, maximally 2.5-4-fold within a polyanion concn range of 12.5-400 microgra...

journal_title：Molecular immunology

authors： Koistinen V

更新日期：1993-02-01 00:00:00

abstract：:Interferon (IFN)-γ is highly upregulated during heart inflammation and enhances the production of pro-inflammatory cytokines. Absent in Melanoma 2 (AIM2) is an IFN-inducible protein implicated as a component of the inflammasome. Here we seek to determine the role of AIM2 during inflammation in cardiac cells. We found ...

journal_title：Molecular immunology

authors： Furrer A,Hottiger MO,Valaperti A

更新日期：2016-06-01 00:00:00

abstract：:The goal of this study was to identify potential transcriptomic markers in developing asthma by an integrative analysis of multiple public microarray data sets. Using the R software and bioconductor packages, we performed a statistical analysis to identify differentially expressed (DE) genes in asthma, and further per...

journal_title：Molecular immunology

authors： Fang F,Pan J,Li Y,Li Y,Feng X,Wang J

更新日期：2017-12-01 00:00:00

abstract：:LMIR5/CD300b is an activating immunoglobulin-like receptor whose extracellular domain (LMIR5-Fc) is constitutively released from immune cells. The release of LMIR5-Fc is augmented upon stimulation with TLR agonists. LMIR5-Fc is reported to possess inflammatory activity and amplify LPS-induced lethal inflammation; howe...

journal_title：Molecular immunology

authors： Phongsisay V,Iizasa E,Hara H,Yamasaki S

更新日期：2014-11-01 00:00:00

abstract：:C3 glomerulopathy (C3G) is an ultra-rare complement-mediated renal disease characterized histologically by the predominance of C3 deposition within in the glomerulus. Familial cases of C3G are extremely uncommon and offer unique insight into the genetic drivers of complement dysregulation. In this report, we describe ...

journal_title：Molecular immunology

authors： Xiao X,Ghossein C,Tortajada A,Zhang Y,Meyer N,Jones M,Borsa NG,Nester CM,Thomas CP,de Córdoba SR,Smith RJ

更新日期：2016-09-01 00:00:00

abstract：:Antigens related to the carcinoembryonic antigen (CEA) were isolated from normal human plasma by perchloric acid extraction, gel permeation chromatography and immunoaffinity chromatography using a monoclonal antibody with broad specificity and high affinity. The antigens were separated by SDS-polyacrylamide gel electr...

journal_title：Molecular immunology

authors： Neumaier M,Fenger U,Wagener C

更新日期：1985-11-01 00:00:00

abstract：:The complement system plays a central role in a number of human inflammatory diseases, and there is a significant need for development of complement-directed therapies. The discovery of an arsenal of anti-complement proteins secreted by the pathogen Staphylococcus aureus brought with it the potential for harnessing th...

journal_title：Molecular immunology

authors： Summers BJ,Garcia BL,Woehl JL,Ramyar KX,Yao X,Geisbrecht BV

更新日期：2015-10-01 00:00:00

abstract：:Hybridomas producing anti-histone monoclonal antibodies were generated from a 2-month old MRL lpr/lpr mouse. Five IgM antibodies showed binding to histone H3 and three of these IgM antibodies also bound histone H1. Two IgG2a antibodies (MRA3 and MRA12) were specific for histone H1 and their binding was further charact...

journal_title：Molecular immunology

authors： Monestier M,Fasy TM,Böhm L

更新日期：1989-08-01 00:00:00

abstract：:Some IgM cattle antibodies are amongst the largest known to exist in jawed vertebrates where CDR3H size may extend up to 61 amino acids. To understand the origin of such an exceptionally long CDR3H, bovine D(H) gene locus was completely characterized from Holstein cattle that revealed the presence of a total of eight ...

journal_title：Molecular immunology

authors： Koti M,Kataeva G,Kaushik AK

更新日期：2010-07-01 00:00:00

abstract：:The complement (C) inflammatory cascade is part of the phylogenetically ancient innate immune response and is crucial to our natural ability to ward off infection. It has three critical physiologic activities: (i) defending against microbial infections by triggering the generation of a membranolytic complex (C5b9 comp...

journal_title：Molecular immunology

authors： Gasque P

更新日期：2004-11-01 00:00:00

abstract：:In contrast to normal B lymphocytes, splenic B cells from autoimmune NZB mice express on their surface greater amounts of IgM than IgD. We have found that the predominant mu chain species present on these cells is derived from pentameric secretory IgM which can be radioiodinated during transient association with the c...

journal_title：Molecular immunology

authors： Yuan D,Goldings EA

更新日期：1988-04-01 00:00:00

abstract：:Rearrangements in reading frame 2 promote the expression of a truncated heavy chain, the Dmu protein. Dmu can assemble into a pre-B cell receptor like complex that appears to induce a subset of signals elicited by full length mu, but cannot promote the pro-B to pre-B cell transition of Rag-/- B cells. In order to dete...

journal_title：Molecular immunology

authors： Wikström I,Bergqvist I,Holmberg D,Forssell J

更新日期：2006-03-01 00:00:00

abstract：:We investigated the antibody (Ab) and cytotoxic T lymphocyte (CTL) responses to gene gun (GG)-mediated DNA immunization via the intramuscular (i.m.) and intradermal (i.d.) routes. BALB/c mice were immunized five times at weekly intervals with plasmid DNA encoding enhanced green fluorescent protein (EGFP). EGFP product...

journal_title：Molecular immunology

authors： Ito K,Ito K,Shinohara N,Kato S

更新日期：2003-05-01 00:00:00

abstract：:We have determined the cDNA sequence encoding J chain, a polypeptide accessory molecule associated with polymeric Ig, from the anuran amphibian, Xenopus laevis (South African clawed frog). The translated polypeptide consists of 164 amino acid residues, including the signal sequence, and is somewhat longer than the cor...

journal_title：Molecular immunology

authors： Hohman VS,Stewart SE,Willett CE,Steiner LA

更新日期：1997-10-01 00:00:00

abstract：:Interplay between complement factors, regulatory proteins, anaphylatoxins and cytokines could be involved in tendon healing and scar formation. The expression and regulation of complement factors by cytokines or anaphylatoxins are completely unclear in tendon. Hence, the gene expression of the anaphylatoxin receptors ...

journal_title：Molecular immunology

authors： Busch C,Girke G,Kohl B,Stoll C,Lemke M,Krasnici S,Ertel W,Silawal S,John T,Schulze-Tanzil G

更新日期：2013-04-01 00:00:00

abstract：:Signal transduction by the B cell receptor (BCR) is an absolute requirement for the selection and development of B lymphocytes at multiple checkpoints. Binding to antigen via the BCR is complemented by a co-stimulus delivered through accessory and co-stimulatory cell surface molecules that regulate the signalling thre...

journal_title：Molecular immunology

authors： Galloway TS,Ray K,Malhotra R

更新日期：2003-01-01 00:00:00

abstract：:The DNA vaccine based on the glycoprotein gene of Infectious hematopoietic necrosis virus induces a non-specific anti-viral immune response and long-term specific immunity against IHNV. This study characterized gene expression responses associated with the early anti-viral response. Homozygous rainbow trout were injec...

journal_title：Molecular immunology

authors： Purcell MK,Nichols KM,Winton JR,Kurath G,Thorgaard GH,Wheeler P,Hansen JD,Herwig RP,Park LK

更新日期：2006-05-01 00:00:00

abstract：:Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(-/-)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with features of DDD, a ...

journal_title：Molecular immunology

authors： Paixão-Cavalcante D,Hanson S,Botto M,Cook HT,Pickering MC

更新日期：2009-06-01 00:00:00

abstract：:Interleukin 1β (IL-1β) is a pro-inflammatory cytokine secreted by activated macrophages and monocytes. Previously, we have reported that bone morphogenetic protein-6 (BMP-6) induces inducible nitric oxide synthase (iNOS) expression via IL-1β in macrophages. In the present study, we demonstrate that BMP-6 increases IL-...

journal_title：Molecular immunology

authors： Lee GT,Jung YS,Lee JH,Kim WJ,Kim IY

更新日期：2011-07-01 00:00:00

abstract：:Secreted glycoproteins generally contain oligosaccharides of the complex type. However, several molecules have been described in which individual glycans are processed differently from one another. Folding, assembly and oligomerization could affect the maturation of certain glycans by hindering them to the Golgi proce...

journal_title：Molecular immunology

authors： Cals MM,Guenzi S,Carelli S,Simmen T,Sparvoli A,Sitia R

更新日期：1996-01-01 00:00:00

abstract：:To investigate the IL-6/IL-6 receptor system, we obtained five murine monoclonal antibodies against human IL-6, which neutralize its biological activity. We classified them into two groups (Type I mAb and Type II mAb) according to the epitopes they recognized. These two types of antibodies showed no difference in the ...

journal_title：Molecular immunology

authors： Shimamura T,Taki S,Honda H,Yokota M,Ito S,Takahara Y

更新日期：1991-11-01 00:00:00

abstract：:Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-E(k) revealed an interesting localization of negatively charged residues within the P6 pocket, which may have implications in the pH dependency...

journal_title：Molecular immunology

authors： Dao CT,Weber DA,Jensen PE

更新日期：2002-06-01 00:00:00

abstract：:the SC5b-8 complex of human complement is a hydrophilic molecule of mol. wt 800,000-850,000 that is seen in the electron microscope as an elongated, straight or curved structure of 50-55 nm total length and 8-9 nm width. Tryptic attack on the fluid-phase complex exposes lipid-binding surfaces on the molecule. The tryp...

journal_title：Molecular immunology

authors： Bhakdi S,Tranum-Jensen J

更新日期：1982-09-01 00:00:00

abstract：:The specificity of a mouse anti-testicular cell monoclonal antibody, J1, was investigated. Previous studies suggested that N-acetyl-D-glucosamine (GlcNAc) was a constituent of the determinant recognized by J1. When the antibody was tested against a variety of purified glycolipids containing this saccharide in terminal...

journal_title：Molecular immunology

authors： Symington FW,Fenderson BA,Hakomori S

更新日期：1984-10-01 00:00:00