Molecular characterization of the dimer formation of Fcα/μ receptor (CD351).

abstract：:Immunoglobulin heavy chain (Igh) locus rearrangements are controlled in part by an approximately 30 b complex 3' regulatory region located 3' of C alpha: this region contains several enhancers. We report here the comparison of the genomic sequences of the 3' regulatory region and further downstream sequences from mous...

journal_title：Molecular immunology

authors： Sepulveda MA,Garrett FE,Price-Whelan A,Birshtein BK

更新日期：2005-03-01 00:00:00

abstract：:Amyloid-beta (Aβ) plaque accumulation in the brain is one of the hallmarks of Alzheimer's disease (AD). Immunotherapy against Aβ was considered a potential strategy for reducing the Aβ load in the brain. However, none of the Aβ immunotherapies have produced clinically meaningful results to date, due to poor safety or ...

journal_title：Molecular immunology

authors： Fu L,Guo Y,Sun Y,Dong Y,Wu J,Yu B,Zhang H,Yu X,Wu H,Kong W

更新日期：2018-09-01 00:00:00

abstract：:Mice deficient for SPI-group ETS transcription factors PU.1 or SPI-B fail to generate lymphocytes or do not mount normal antibody mediated immune responses, respectively. PU.1 expression is restricted to B-, T-lymphocytes and macrophages, while SPI-B is expressed in B- and T-lymphocytes. SPI-C is an ETS transcription ...

journal_title：Molecular immunology

authors： Carlsson R,Persson C,Leanderson T

更新日期：2003-06-01 00:00:00

abstract：:HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 is expressed at the cell surface of antigen presenting cells (APC) both as canonical β2m-associated and non-canonical β2m-free heavy chain (FHC) forms which include B27 dimers (termed B272). B27 FHC forms arise in an endosomal compartment from recy...

journal_title：Molecular immunology

authors： Shaw J,Hatano H,Kollnberger S

更新日期：2014-01-01 00:00:00

abstract：:Recently, basophils have been suggested to produce inflammatory mediators in response to IgE in the absence of allergens. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the initiation of inflammatory responses by recruiting various immune cells to the site of allergic inflammation. In the presen...

journal_title：Molecular immunology

authors： Ahn KB,Jeon JH,Kang SS,Chung DK,Yun CH,Han SH

更新日期：2014-11-01 00:00:00

abstract：:Affinity-purified major histocompatibility complex (MHC) class II molecules are known to bind antigenic peptides in vitro. The percentage of MHC class II molecules occupied with such peptides is usually very low and varies significantly depending upon the sequence and size of a given antigenic peptide. The present stu...

journal_title：Molecular immunology

authors： Nag B,Mukku PV,Arimilli S,Phan D,Deshpande SV,Winkelhake JL

更新日期：1994-10-01 00:00:00

abstract：:The cell surface co-stimulatory protein CD154 (CD40L) is a target for monoclonal antibody (mAb) inhibitors of T-cell mediated immune diseases. This protein, like most other members of the TNF ligand family, forms homotrimeric complexes on the cell surface and in solution, with a three-fold axis of symmetry. We find th...

journal_title：Molecular immunology

authors： Ferrant JL,Wilson CA,Benjamin CD,Hess DM,Hsu YM,Karpusas M,Roux KH,Taylor FR

更新日期：2002-09-01 00:00:00

abstract：:Selection of specific antibodies from large repertoires is of importance in generating antibodies to specific structural determinants and in studying structure-function relationships. Alkaline phosphatase (AP) has several isozymes with various degrees of homology and a range of common synthetic substrates. We have pre...

journal_title：Molecular immunology

authors： Jain V,Saini D,Goswami P,Sinha S

更新日期：2007-01-01 00:00:00

abstract：:The T-cell surface proteins CD4 (L3T4) and CD8 (Lyt2) are first expressed on thymocytes as they undergo maturation in the thymus. Two immature T-lymphoma cell clones SL12.4 and RS4.2 which constitutively express low or undetectable levels of CD4 and CD8 were used to investigate the activation of CD4 and CD8 gene expre...

journal_title：Molecular immunology

authors： Wilkinson MF,Fong AM,Huynh H,Hays EF,MacLeod CL

更新日期：1991-01-01 00:00:00

abstract：:The isolation and characterization of two human serum proteins, RHP and N-RHP, are described. N-RHP appears to be the normal counterpart of RHP which is found at elevated levels in sera of patients with rheumatoid arthritis [Rosano et al. (1988b) Inflammation 12, 351 - 360]. Although both proteins crossreact with anti...

journal_title：Molecular immunology

authors： Hurwitz C,Rosano CL,Hechemy KE,Weber P,Parhami N

更新日期：1995-11-01 00:00:00

abstract：:IFN-gamma plays an essential role in the IL-12/IL-23/IFN-gamma pathway that is required for the defense against intracellular pathogens. In the IFN-gammaR1 several amino acid substitutions have been reported that abrogate IFN-gamma signaling. These substitutions can lead to a null phenotype and enhanced susceptibility...

journal_title：Molecular immunology

authors： van de Wetering D,de Paus RA,van Dissel JT,van de Vosse E

更新日期：2010-02-01 00:00:00

abstract：:In Drosophila the synthesis of antimicrobial peptides in response to microbial infections is under the control of the Toll and immune deficiency (Imd) signaling pathways. The Toll signaling pathway responds mainly to Gram-positive bacterial and fungal infection while the Imd pathway mediates the response to Gram-negat...

journal_title：Molecular immunology

authors： Leone P,Bischoff V,Kellenberger C,Hetru C,Royet J,Roussel A

更新日期：2008-05-01 00:00:00

abstract：:The architecture of lymphoid microenvironments depends upon complex interactions between several stromal cell types. We describe in this report the cloning of a cDNA which encodes a novel membrane molecule containing two external Ig-like domains. It is expressed at the junction between endothelial cells including HEV....

journal_title：Molecular immunology

authors： Malergue F,Galland F,Martin F,Mansuelle P,Aurrand-Lions M,Naquet P

更新日期：1998-12-01 00:00:00

abstract：:Large quantities of antibodies are transported into the yolk of the chicken's egg. We have identified several regions within the antibody molecule important for its uptake into the egg yolk. An intact Fc and hinge region but not the Fc-associated carbohydrate are required for transport. Our data suggest that the C(H)2...

journal_title：Molecular immunology

authors： Morrison SL,Mohammed MS,Wims LA,Trinh R,Etches R

更新日期：2002-01-01 00:00:00

abstract：:The generation of T cell receptor (TCR) sequence diversity can produce 'forbidden' clones able to recognize self-antigens. Here, the structure of the complex between a myelin basic protein peptide (MBP85-99), human leukocyte antigen (HLA)-DR2 (DRB1*1501/DRA) and TCR-Ob.2F3, the dominant autoimmune clone obtained from ...

journal_title：Molecular immunology

authors： Kato Z,Stern JN,Nakamura HK,Miyashita N,Kuwata K,Kondo N,Strominger JL

更新日期：2010-11-01 00:00:00

abstract：:MTX is an effective therapy for autoimmune-inflammatory diseases. The mechanisms that mediate these actions are not completely clear. It is accepted that many of these effects are mediated through the release of adenosine with the activation of the adenosine receptor A2. MTX is used as a steroid sparing agent. An impr...

journal_title：Molecular immunology

authors： Goecke IA,Alvarez C,Henríquez J,Salas K,Molina ML,Ferreira A,Gatica H

更新日期：2007-03-01 00:00:00

abstract：:The characterization of the site on the IgE molecule which accommodates the high affinity receptor for IgE (Fc epsilon RI) should allow the design of IgE analogues which can be utilized to block allergic responses. Using chimeric human IgE molecules in which different constant region domains were exchanged with their ...

journal_title：Molecular immunology

authors： Nissim A,Eshhar Z

更新日期：1992-09-01 00:00:00

abstract：:Previous investigation have demonstrated the presence of the Rho(D) antigen in Rh negative erythrocytes. The intact Rh negative cell, however, does not bind anti-D IgG. Presently we have shown that an anti-D binding antigen resides on the cytoplasmic surface of Rh negative erythrocyte membranes. Unsealed Rh negative m...

journal_title：Molecular immunology

authors： Evans JP,Brown PJ,Sinor LT,Tilzer LL,Beck M,Plapp FV

更新日期：1983-05-01 00:00:00

abstract：:The disialoganglioside GalAcbeta1-4(NeuAcalpha2-8NeuAcalpha2-3)Galbeta1-4Glcbeta1-1Cer (GD2) is expressed on various tumors, including neuroblastoma, and was defined as a relevant tumor antigen. The monoclonal anti-GD2 antibody 14.18 is widely used for diagnostic purposes in neuroblastoma, and in its mouse/human chime...

journal_title：Molecular immunology

authors： Förster-Waldl E,Riemer AB,Dehof AK,Neumann D,Brämswig K,Boltz-Nitulescu G,Pehamberger H,Zielinski CC,Scheiner O,Pollak A,Lode H,Jensen-Jarolim E

更新日期：2005-02-01 00:00:00

abstract：:Amino acid sequences encoded by exon 8 of the H-2K and H-2D/L genes appear to be locus specific. The majority of H-2Kb molecules contain 10 amino acids that are derived from exon 8. In contrast, the H-2Db, -Dd and -Ld molecules contain only one amino acid which is encoded by exon 8, even though the genetic information...

journal_title：Molecular immunology

authors： Maloy WL,Lew AM,Anderson RW,Coligan JE

更新日期：1988-05-01 00:00:00

abstract：:During B and T lymphocyte development, immunoglobulin and T cell receptor genes are assembled from the germline V, (D) and J gene segments (Lewis, S.M., 1994. The mechanism of V(D)J joining: lessons from molecular, immunological and comparative analyses. Adv. Immunol. 56, 27-150). These DNA rearrangements, responsible...

journal_title：Molecular immunology

authors： Sun T,Ezekiel UR,Erskine L,Agulo R,Bozek G,Roth D,Storb U

更新日期：1999-06-01 00:00:00

abstract：:Macrophages are the most abundant cells in tumor stroma and their polarization within tumor microenvironment exert the key roles in tumorigenesis. Astragaloside IV is a natural extract from traditional Chinese herbal Radix Astragali, and fulfills pleiotropic function in several cancers. Nevertheless, its function in o...

journal_title：Molecular immunology

authors： Wang X,Gao S,Song L,Liu M,Sun Z,Liu J

更新日期：2021-02-01 00:00:00

abstract：:A high affinity C5 convertase is generated when a C3 convertase deposits additional C3b molecules on and around itself thereby switching the substrate specificity of C3 convertase from C3 to C5. In the present study the role of the additional C3b molecules in influencing the regulation of classical pathway C5 converta...

journal_title：Molecular immunology

authors： Rawal N,Pangburn MK

更新日期：2007-02-01 00:00:00

abstract：:Accumulating evidence suggests a role for the complement system in the pathogenesis of diabetes and the vascular complications that characterise this condition. Complement proteins contribute to the development of type 1 diabetes (T1D) by enhancing the underlying organ-specific autoimmune processes. Complement upregul...

journal_title：Molecular immunology

authors： Ajjan RA,Schroeder V

更新日期：2019-10-01 00:00:00

abstract：:Evidence suggests that immune dysregulation is associated with autism spectrum disorder (ASD). T cell immunoglobulin and mucin domain-3 (TIM-3) has a critical role in several inflammatory disorders; however, the role of TIM-3 signaling has not been demonstrated in ASD. In the present study, we assessed the role of TIM...

journal_title：Molecular immunology

authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alotaibi MR,Alhoshani AR,Alshammari MA,Attia SM

更新日期：2019-02-01 00:00:00

abstract：:Sepsis-induced inflammatory damage is a crucial cause of acute kidney injury (AKI), and AKI is an ecumenical fearful complication in approximately half of patients with sepsis. CCAAT/enhancer-binding protein β (C/EBPβ) plays roles in regulating acute phase responses and inflammation. However, the role and mechanism of...

journal_title：Molecular immunology

authors： Dai XG,Li Q,Li T,Huang WB,Zeng ZH,Yang Y,Duan ZP,Wang YJ,Ai YH

更新日期：2020-11-01 00:00:00

abstract：:The xenotransplantation research is driven by the shortage of allografts for transplantation of patients with end-stage organ failure and by lack of success in developing suitable artificial organs. Pigs are now generally accepted to be the donor species of choice, although a possible risk for transmission of xenozoon...

journal_title：Molecular immunology

authors： Mollnes TE,Fiane AE

更新日期：1999-03-01 00:00:00

abstract：:Aberrant O-glycosylation of cell surface mucin antigens is characteristic of epithelial cancer cells. For example, Thomsen-Friedenreich disaccharide (TFD) is a chemically well-defined carbohydrate antigen with a documented link to malignancy. There have been many attempts to improve immune response to carbohydrate ant...

journal_title：Molecular immunology

authors： Irazoqui FJ,Lopez PH,Mandel U,Nores GA

更新日期：2002-03-01 00:00:00

abstract：:The complement system is very tightly regulated by fluid-phase and membrane-bound factors that prevent injury to self-tissues. The study of genetically engineered animals with targeted deletion or gain of function mutations has highlighted the important role that many of the complement inhibitors play in vivo. The adv...

journal_title：Molecular immunology

authors： Turnberg D,Botto M

更新日期：2003-09-01 00:00:00

abstract：:The Class II Transactivator (CIITA) is the master regulator of Major Histocompatibility Class II (MHC II) genes. Transcription of CIITA through the IFN-γ inducible CIITA promoter IV (CIITA pIV) during activation is characterized by a decrease in trimethylation of histone H3 lysine 27 (H3K27me3), catalyzed by the histo...

journal_title：Molecular immunology

authors： Boyd NH,Morgan JE,Greer SF

更新日期：2015-10-01 00:00:00