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A novel immunoglobulin superfamily junctional molecule expressed by antigen presenting cells, endothelial cells and platelets.

Abstract：

:The architecture of lymphoid microenvironments depends upon complex interactions between several stromal cell types. We describe in this report the cloning of a cDNA which encodes a novel membrane molecule containing two external Ig-like domains. It is expressed at the junction between endothelial cells including HEV. It is also expressed by platelets and MHC class II+ antigen presenting cells in thymic medulla and T-cell areas in peripheral lymphoid organs. These cells which lack in RelB-deficient mice include tissue-derived dendritic, epithelial cells and macrophages. Thus, this molecule might contribute to the organization of cell junctions in different microenvironments.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Malergue F,Galland F,Martin F,Mansuelle P,Aurrand-Lions M,Naquet P

doi

10.1016/s0161-5890(98)00102-3

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

1111-9

issue

17

eissn

0161-5890

issn

1872-9142

pii

S0161589098001023

journal_volume

35

pub_type

杂志文章

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