Abstract：
:The common variant in the human complement Factor H gene (CFH), with Tyr402His, is linked to age-related macular degeneration (AMD), a prevalent disorder leading to visual impairment and irreversible blindness in elderly patients. Here we show that the risk variant CFH 402His displays reduced binding to C reactive protein (CRP), heparin and retinal pigment epithelial cells. This reduced binding can cause inefficient complement regulation at the cell surface, particularly when CRP is recruited to injured sites and tissue. In addition, we identify the Factor H-like protein 1 (FHL-1), an alternative splice product of the CFH gene as an additional protein that includes the risk residue 402, and thus confers risk for AMD. FHL-1 is expressed in the eye and the FHL-1 402His risk variant shows similar reduced cell binding and likely reduced complement regulatory functions on the cell surface. CFH and FHL-1 may act in concert in the eye and the reduced surface binding may result in inappropriate local complement control, which in turn can lead to inflammation, disturbance of local physiological homeostasis and progression to cell damage. As a consequence, these processes may lead to AMD pathogenesis.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Skerka C,Lauer N,Weinberger AA,Keilhauer CN,Sühnel J,Smith R,Schlötzer-Schrehardt U,Fritsche L,Heinen S,Hartmann A,Weber BH,Zipfel PFdoi
10.1016/j.molimm.2007.02.012subject
Has Abstractpub_date
2007-07-01 00:00:00pages
3398-406issue
13eissn
0161-5890issn
1872-9142pii
S0161-5890(07)00085-5journal_volume
44pub_type
杂志文章abstract：:Here we present the gene structure and expression data on two Atlantic salmon TNF-alpha genes. Both genes are approximately 2.0kb in length and organized into four exons and three introns. The open reading frame of both genes translates into 246 amino acid putative peptides, being 91.5% identical at the amino acid lev...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2006.08.015
更新日期：2007-03-01 00:00:00
abstract：:We have developed a method for use in investigating factors controlling the binding and cross-linking by bivalent haptens of immunoglobulin E (IgE) bound to receptors on rat basophilic leukemia (RBL) cells. This method employs monoclonal anti-2,4-dinitrophenyl (DNP) IgE that is labeled with fluorescein-5-isothiocyanat...
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pub_type： 杂志文章
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doi：10.1016/s0161-5890(98)00079-0
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abstract：:To investigate the IL-6/IL-6 receptor system, we obtained five murine monoclonal antibodies against human IL-6, which neutralize its biological activity. We classified them into two groups (Type I mAb and Type II mAb) according to the epitopes they recognized. These two types of antibodies showed no difference in the ...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1991-11-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2019.09.012
更新日期：2019-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(92)90010-u
更新日期：1992-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/s0161-5890(97)00024-2
更新日期：1997-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2016.12.005
更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2014.02.019
更新日期：2014-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2020.03.021
更新日期：2020-04-16 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(92)90015-p
更新日期：1992-03-01 00:00:00
abstract：:During B and T lymphocyte development, immunoglobulin and T cell receptor genes are assembled from the germline V, (D) and J gene segments (Lewis, S.M., 1994. The mechanism of V(D)J joining: lessons from molecular, immunological and comparative analyses. Adv. Immunol. 56, 27-150). These DNA rearrangements, responsible...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1999-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2007.01.009
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journal_title：Molecular immunology
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2006.07.300
更新日期：2007-03-01 00:00:00
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journal_title：Molecular immunology
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更新日期：2016-11-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.02.032
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abstract：:The synovial sarcoma X breakpoint (SSX) gene family contains nine members. The SSX proteins are CT (cancer/testis) antigens and can be expressed in many tumor types. T cell immune response against SSX protein can be detected in tumor patients and mice expressing any SSX. Screening predominant protective epitopes might...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2008.01.014
更新日期：2008-05-01 00:00:00
