Abstract：
:For decades immunological research has relied, with variable success, on mouse models to investigate diseases and possible therapeutic interventions. With the approval of the first therapeutic antibody targeting complement, called eculizumab, as therapy in paroxysmal nocturnal hemoglobinuria (PNH) and more recently atypical hemolytic uremic syndrome (aHUS), the viability of targeting the complement system was demonstrated. The potent, endogenous complement regulators have become of increasing interest as templates for designing and developing new therapeutics. Recently, complement inhibitors based on (parts of) the human complement regulator factor H (FH) are being examined for therapeutic intervention in inflammatory conditions. The first step to evaluate the potency of a new drug is often testing it in a mouse model for the target disease. However, translating results to human conditions requires a good understanding of similarities and, more importantly, differences between the human and mouse complement system and particularly regulation. This review will provide a comprehensive overview of the complement regulator FH and its closely related proteins and current views on their role in mice and men.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Pouw RB,Vredevoogd DW,Kuijpers TW,Wouters Ddoi
10.1016/j.molimm.2015.03.011subject
Has Abstractpub_date
2015-09-01 00:00:00pages
12-20issue
1eissn
0161-5890issn
1872-9142pii
S0161-5890(15)00115-7journal_volume
67pub_type
杂志文章,评审abstract：:Different proteins, even without sequence similarity, still can contain similar surface regions involved in protein-protein interactions with common target. These regions can serve as structural determinants of cross-reactivity and molecular mimicry. Molecular mimicry, defined as the process in which structural proper...
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1991-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2019.04.026
更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2009-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0161-5890(00)00043-2
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pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1996-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
