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Modulation of CR1 transcript in systemic lupus erythematosus (SLE) by IFN-gamma and immune complex.

Abstract：

:Reduced expression of Erythrocyte Complement Receptor 1 (E-CR1) is envisaged to contribute significantly to the pathophysiology of systemic lupus erythematosus (SLE). We determined the levels of CR1 transcript in the neutrophils from 25 untreated patients with active SLE and 25 normal healthy individuals and, studied the effect of interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and immune complexes (IC) on the same. The study revealed a marked decline in the levels of neutrophil CR1 (N-CR1) transcript in the patients with SLE, and differential pattern of IFN-gamma and IL-4 expression in the neutrophils from normals and patients. Opsonized immune complexes down regulated CR1 transcript in patients and IFN-gamma up regulated the same both in normals and patients. Immune complexes suppressed this effect of IFN-gamma. IL-4 also suppressed the effect of IFN-gamma but effect confined only to the normals. This is the first real-time RT-PCR data comparing the neutrophil CR1 expression in normals and patients with SLE and its modulation by IFN-gamma, IL-4 and immune complexes. IFN-gamma and immune complexes, respectively, emerged as the positive and negative modulators of neutrophil CR1 transcript in SLE.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Arora V,Mondal AM,Grover R,Kumar A,Chattopadhyay P,Das N

doi

10.1016/j.molimm.2006.07.300

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

1722-8

issue

7

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(06)00548-7

journal_volume

44

pub_type

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