Abstract:
:The development and progression of systemic lupus erythematosus (SLE) is strongly associated with complement activation and deposition. The anaphylatoxin C3a is a product of complement activation with immunomodulatory properties, and the receptor for C3a (C3aR) is not only expressed by granulocytes and antigen presenting cell populations, but it is also strongly up-regulated in lupus prone mice with active nephritis. In order to characterize the role of the C3aR in inflammatory nephritis, we bred C3aR knock out mice onto the MRL/lpr genetic background (C3aR KO MRL). Compared to control MRL/lpr mice, C3aR KO MRL mice had elevated auto-antibody titers and an earlier onset of renal injury. At 8 weeks, renal expression of a wide range of chemokines and chemokine receptors was increased in C3aR KO MRL kidneys compared to controls. Only the expression of MCP-1 was significantly decreased in the C3aR KO MRL mice. The increased chemokine and chemokine receptor expression seen in the C3aR KO MRL mice was associated with a more rapid rise in serum creatinine and the acceleration of renal fibrosis. However, loss of the C3aR had little impact on long-term kidney injury and did not alter survival. These findings suggest that activation of the C3aR plays a protective, not pathologic, role in the early phase of inflammatory nephritis in the MRL/lpr model of SLE.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Wenderfer SE,Wang H,Ke B,Wetsel RA,Braun MCdoi
10.1016/j.molimm.2008.12.004subject
Has Abstractpub_date
2009-04-01 00:00:00pages
1397-404issue
7eissn
0161-5890issn
1872-9142pii
S0161-5890(08)00774-8journal_volume
46pub_type
杂志文章abstract::The diagnosis and therapy of allergic disorders are usually performed with crude extracts which are a heterogeneous mixture of proteins with different allergenic potency. The knowledge of the allergenic composition is a key step for diagnostic and therapeutic options. Parietaria judaica pollen represents one of the ma...
journal_title:Molecular immunology
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journal_title:Molecular immunology
pub_type: 杂志文章,评审
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journal_title:Molecular immunology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Molecular immunology
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pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2009.09.009
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journal_title:Molecular immunology
pub_type: 杂志文章
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journal_title:Molecular immunology
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pub_type: 杂志文章
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journal_title:Molecular immunology
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journal_title:Molecular immunology
pub_type: 杂志文章
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