Identification of novel non-pathogenic mutation in SH3 domain of Btk in an XLA patient.

abstract：:The DNA vaccine based on the glycoprotein gene of Infectious hematopoietic necrosis virus induces a non-specific anti-viral immune response and long-term specific immunity against IHNV. This study characterized gene expression responses associated with the early anti-viral response. Homozygous rainbow trout were injec...

journal_title：Molecular immunology

authors： Purcell MK,Nichols KM,Winton JR,Kurath G,Thorgaard GH,Wheeler P,Hansen JD,Herwig RP,Park LK

更新日期：2006-05-01 00:00:00

abstract：:Recombinant IL-2 (rIL-2) produced in prokaryotes, is widely used in lieu of native IL-2, which is secreted by T cells, to assess the functional profile of this cytokine. We provide evidence that a naturally occurring species of post-translationally modified IL-2 (moIL-2) exhibits enhanced bioactivity compared to rIL-2...

journal_title：Molecular immunology

authors： Denis MC,Huber BT

更新日期：2003-09-01 00:00:00

abstract：:Recent studies suggest that CD8(+) T cells with down-regulated CD8 expression (CD3(+)CD8(low) T cells) represented as a distinct phenotype of CD8(+) T cells are increased and linked to disease severity in some chronically persistent infection, such as chronic HIV and parasite infection. However, the role of CD3(+)CD8(...

journal_title：Molecular immunology

authors： Ouyang L,Li X,Liang Z,Yang D,Gong F,Shen G,Weng X,Wu X

更新日期：2013-12-01 00:00:00

abstract：:Quiescent T lymphocytes reorganize the actin cytoskeleton subsequent to interaction with antigen presenting cells bearing the appropriate peptide antigen. Although both biochemical and genetic evidence indicate that T cell receptor-dependent cytoskeletal reorganization is critical to T cell activation, the mechanisms ...

journal_title：Molecular immunology

authors： Lu Q,Liu X,Trama J,Roti MA,Go WY,Ho SN

更新日期：2004-06-01 00:00:00

abstract：:GK-1 is an immunomodulatory, 18-aa-long peptide that has been proved to promote the activation of mouse peritoneal macrophages and LPS-pulsed mouse bone marrow-derived dendritic cells (BM-DCs). This study is aimed to explore the mechanisms underlying the activation of these antigen-presenting cells (APCs) by GK-1. In ...

journal_title：Molecular immunology

authors： Montero L,Cervantes-Torres J,Sciutto E,Fragoso G

更新日期：2020-12-01 00:00:00

abstract：:Dendritic cells(DCs) were once considered as a single cell type closely related developmentally to macrophages. Now we recognise several subtypes of DCs and have outlined several different pathways that potentially lead to their development. This article outlines some of the research findings that led to these changes...

journal_title：Molecular immunology

authors： Shortman K

更新日期：2020-03-01 00:00:00

abstract：:Human IgE antibodies from nine allergic subjects were found to react with poly-L-lysine (PLL) and other polyamines. Radioimmunoassay inhibition studies indicated that the two amino groups, but not the carboxyl, in lysine contributed to the antibody binding and 4-aminomethyl-1,8-octanediamine, a compound containing thr...

journal_title：Molecular immunology

authors： Zhao Z,Baldo BA,O'Brien RM,Plomley RF

更新日期：2000-04-01 00:00:00

abstract：:Lysozyme is an important component of the insect non-specific immune response against bacteria that is characterized by its ability to break down bacterial cell-walls. By searching an EST database from the fall armyworm, Spodoptera frugiperda (Negre et al., 2006), we identified five sequences encoding proteins of the ...

journal_title：Molecular immunology

authors： Chapelle M,Girard PA,Cousserans F,Volkoff NA,Duvic B

更新日期：2009-12-01 00:00:00

abstract：:The porcine complement proteins C3 and C4 have been isolated and then characterized using small-angle scattering methods. Within the limits of experimental errors, the porcine proteins are virtually identical with the corresponding human proteins as measured in terms of mol. wt, Mr and radius of gyration, R,: Mr(C3) =...

journal_title：Molecular immunology

authors： Osterberg R,Malmensten B,Boive T,Nilsson U,Stigbrand T,Mortensen K

更新日期：1991-09-01 00:00:00

abstract：:We describe several proteins that are components of the rabbit B cell receptor complex. Two proteins (37 kDa and 42 kDa) were found in non-covalent association with IgM expressed on B cells from peripheral blood. These proteins were also immunoprecipitated by anti-B29 (Ig-beta) and anti-mb1 (Ig-alpha) monoclonal antib...

journal_title：Molecular immunology

authors： Fitts MG,Metzger DW,Hendershot LM,Mage RG

更新日期：1995-07-01 00:00:00

abstract：:ASF1a (anti-silencing function 1a), an evolutionarily conserved protein and a histone chaperone, is required for a variety of chromatin-mediated cellular processes. However, the function of ASF1a in innate immune response remains unclear. Here, we find that ASF1a is induced in Vesicular Stomatitis Virus (VSV)-infected...

journal_title：Molecular immunology

authors： Liu Z,Yang L,Sun Y,Xie X,Huang J

更新日期：2016-10-01 00:00:00

abstract：:Interleukin 10 (IL-10)-producing regulatory B-cells (Bregs) suppress inflammatory responses that mediate autoimmune diseases. However, it is unknown whether Bregs derive from a pre-existing dedicated B-cell lineage or if any B-cell can differentiate into Bregs in response to BCR or TLR activation. GL7(+) B-cells are a...

journal_title：Molecular immunology

authors： Wang X,Wei Y,Xiao H,Liu X,Zhang Y,Han G,Chen G,Hou C,Zhang L,Ma N,Shen B,Li Y,Egwuagu CE,Wang R

更新日期：2016-03-01 00:00:00

abstract：:One of the major obstacles in the successful clinical application of monoclonal antibodies has been the development of host immune responses to murine Ig constant and variable regions. While the CDR grafting of MAbs may alleviate many of these problems, the potential remains that one or more murine CDRs on the human I...

journal_title：Molecular immunology

authors： Iwahashi M,Milenic DE,Padlan EA,Bei R,Schlom J,Kashmiri SV

更新日期：1999-10-01 00:00:00

abstract：:Amyloid-beta (Aβ) plaque accumulation in the brain is one of the hallmarks of Alzheimer's disease (AD). Immunotherapy against Aβ was considered a potential strategy for reducing the Aβ load in the brain. However, none of the Aβ immunotherapies have produced clinically meaningful results to date, due to poor safety or ...

journal_title：Molecular immunology

authors： Fu L,Guo Y,Sun Y,Dong Y,Wu J,Yu B,Zhang H,Yu X,Wu H,Kong W

更新日期：2018-09-01 00:00:00

abstract：:The effect of fragment B of staphylococcal protein A on the binding of rabbit IgG to human granulocytes has been examined. When rabbit IgG sensitized sheep erythrocytes (EA) were preincubated with increasing amounts of fragment B, a dose dependent inhibition of rosette formation between the human granulocytes and the ...

journal_title：Molecular immunology

authors： Barnett Foster DE,Sjoquist J,Painter RH

更新日期：1982-03-01 00:00:00

abstract：:The structural and functional integrity of the cell is largely maintained by protein-protein interactions. Recently, we demonstrated that multiple antigenic peptides (MAPs) constructed from 60 kDa Ro sequence could be used to show intramolecular and intermolecular protein-protein interaction within the 60 kDa Ro ribon...

journal_title：Molecular immunology

authors： Scofield RH,Kurien BT,Gross JK,Reed NB,Taylor AK,Dominguez N,Mehta P,Guthridge JM,Bachmann M

更新日期：2004-07-01 00:00:00

abstract：:The general thinking about the phylogenic distribution of vertebrate Ig classes is that fish and urodele amphibians are only able to synthesize polymeric IgM-like molecules and that the emergence of a new class of LMW Ig occurs for the first time in anouran species. Following immunization of the Mexican axolotl (Ambys...

journal_title：Molecular immunology

authors： Fellah JS,Charlemagne J

更新日期：1988-12-01 00:00:00

abstract：:UL16 binding proteins (ULBPs) are ligands for the NK cell activating receptor NKG2D. A cDNA encoding a porcine ULBP-like protein (PULBP) was cloned and the predicted amino acid sequence exhibited 35-52% identity to human ULBPs. Southern blot analysis suggested that there is only one ULBP-like gene in the pig genome. T...

journal_title：Molecular immunology

authors： García-Borges CN,Phanavanh B,Saraswati S,Dennis RA,Crew MD

更新日期：2005-04-01 00:00:00

abstract：:In periodontal disease, IgG1 and IgA1 antibodies produced in situ deposit on antigens in the affected tissues. Thus, there is an interest in the effect of co-deposited IgA1 antibodies on complement activation by IgG1-immune complexes. In the present study, we first analyzed the effect of IgA1-immune complexes on compl...

journal_title：Molecular immunology

authors： Boackle RJ,Nguyen QL,Leite RS,Yang X,Vesely J

更新日期：2006-02-01 00:00:00

abstract：:The five-year survival rate of melanoma worsens significantly with advancing tumor stage. We hypothesized that regulatory B cells (Breg) might have participated in the pathogenesis of melanoma. In this study, the PD-L1+ Breg cells were investigated. The expression of PD-L1 by circulating B cells was very low in health...

journal_title：Molecular immunology

authors： Wu H,Xia L,Jia D,Zou H,Jin G,Qian W,Xu H,Li T

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Nuclear components targeted by autoantibodies are a characteristic feature of the autoimmune disease systemic lupus erythematosus (SLE). The nucleosome, a major autoantigen, is released in patients with SLE as a result of a disturbed apoptosis and/or an insufficient clearance of apoptotic debris. During apopt...

journal_title：Molecular immunology

authors： van Bavel CC,Dieker JW,Tamboer WP,van der Vlag J,Berden JH

更新日期：2010-11-01 00:00:00

abstract：:The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword t...

journal_title：Molecular immunology

authors： Mohlin C,Sandholm K,Ekdahl KN,Nilsson B

更新日期：2017-09-01 00:00:00

abstract：:The protective antigen (PA(83)) of Bacillus anthracis is the dominant antigen in natural and vaccine-induced immunity to anthrax infection. Three human single-chain variable fragments (scFvs) against cell bound PA were isolated from an antibody phage display library. Specifically, the antibodies were evaluated for the...

journal_title：Molecular immunology

authors： Steiniger SC,Altobell LJ 3rd,Zhou B,Janda KD

更新日期：2007-04-01 00:00:00

abstract：:Apo-1/Fas (CD95) is a transmembrane protein expressed on the cell surface that is involved in apoptosis and plays an important role in the function and regulation of the immune system. Aberrant expression of the Apo-1/Fas gene product has been reported in a number of immune-related disorders, such as autoimmune lympho...

journal_title：Molecular immunology

authors： Huang QR,Morris D,Manolios N

更新日期：1997-06-01 00:00:00

abstract：:Structurally diverse dextrans from Leuconostoc mesenteroides and related bacteria have been used extensively in fundamental immunochemical studies such as induction and characterization of anti-dextran antibodies, as well as in studies of their interaction with pneumococcal antisera, normal bovine serum, concanavalin ...

journal_title：Molecular immunology

authors： Jeanes A

更新日期：1986-09-01 00:00:00

abstract：:The primary structure of a human mu heavy chain (DAG) protein is described. The native protein is a circular decamer with a molecular weight (Mr) of 500 kDa, each decamer being constituted of the constant domains C mu 2, C mu 3 and C mu4 and interlinked by 15 disulfide bridges. At its NH2-terminal each monomeric chain...

journal_title：Molecular immunology

authors： Mihaesco C,Ferrara P,Guillemot JC,Congy N,Gendron MC,Roy JP,Sizaret PY,Mihaesco E

更新日期：1990-08-01 00:00:00

abstract：:The cDNA coding for a hybridoma anti Shigella dysenteriae type 1 antibody (3707 E9) has been cloned, and sequenced. Binding patterns with fragments of the bacterial polysaccharide antigen had already been studied in detail. The VH sequence utilizes the VH441 gene, first identified amongst beta-(1,6)galactan-binding an...

journal_title：Molecular immunology

authors： Miller CE,Huppi K,Siwarski D,Karpas A,Newman A,Mainhart C,Glaudemans CP

更新日期：1995-06-01 00:00:00

abstract：:Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the main pathogens that seriously affect the sustainable development of sericulture industry. Inhibition of Hsp90 by Hsp90 inhibitor, geldanamycin (GA) significantly suppresses BmNPV proliferation in Bombyx mori, while the functional mechanism is not clear. LncRNA has...

journal_title：Molecular immunology

authors： Yin H,Shang Q,Zhang S,Shen M,Huang H,Zhao W,Xijie G,Wu P

更新日期：2020-11-01 00:00:00

abstract：:Cimetidine, a histamine type-2 receptor antagonist, is known to inhibit the growth of several tumors in human and animals, however the mechanism of action underlying this effect remains largely unknown. Here, in the mice model of 3LL lung tumor, cimetidine showed significant inhibition of tumor growth. However, an in ...

journal_title：Molecular immunology

authors： Zheng Y,Xu M,Li X,Jia J,Fan K,Lai G

更新日期：2013-05-01 00:00:00

abstract：:The concomitant effects of trans-chromosomal allotype suppression of both an a VH and an n Cmu locus allotype in multiheterozygous rabbits were investigated. For example of the expression of the a2 VH and n81 Cmu allotypes were suppressed in a multiheterozygous rabbit having the a1 chi-y-n81de12,15f73g74/a2 chi 32y33n...

journal_title：Molecular immunology

authors： Horng WJ,Roux KH,Gilman-Sachs A,Dray S

更新日期：1982-01-01 00:00:00