Abstract：
:Recent studies suggest that CD8(+) T cells with down-regulated CD8 expression (CD3(+)CD8(low) T cells) represented as a distinct phenotype of CD8(+) T cells are increased and linked to disease severity in some chronically persistent infection, such as chronic HIV and parasite infection. However, the role of CD3(+)CD8(low) T cells in the context of chronic HBV infection is poorly understood. In this study, peripheral blood samples of 47 chronic hepatitis B patients and 19 healthy controls were collected and tested for the frequency and phenotype of CD8(low) T cells. The circulating CD8(low) T cells were significantly more frequent in the patients compared to those in healthy controls, and the CD8(low) T cells in the patients expressed less IFN-γ and more mTGF-β1 than those in the controls, suggesting their type-2 polarized and suppressive properties. Meanwhile, the concentrations of plasma soluble HLA class I molecules were found elevated in the patients, and positively associated with the frequencies of CD8(low) T cells. Furthermore, the CD8(low) T-cell frequency in the HLA-A2-positive patients (n=21) was found negatively correlated with the T-cell responsiveness against the HBc₁₈₋₂₇ peptide, the latter was impaired as revealed by IFN-γ Elispot assay. Our findings suggested that a better understanding of the involvement of CD8(low) T cells in chronically persistent HBV infection would add to our knowledge of the impaired T-cell response in the patients.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Ouyang L,Li X,Liang Z,Yang D,Gong F,Shen G,Weng X,Wu Xdoi
10.1016/j.molimm.2013.07.003subject
Has Abstractpub_date
2013-12-01 00:00:00pages
698-704issue
4eissn
0161-5890issn
1872-9142pii
S0161-5890(13)00450-1journal_volume
56pub_type
杂志文章abstract：:A 30,000 mol. wt component (beta) is associated in a 1:1 ratio with the 50,000 mol. wt glycoprotein (alpha) which binds immunoglobulin E (IgE) on mast cells and related tumor cells. We show that alpha and beta are associated in membrane preparations. This is consistent with previous results which showed labeling of be...
journal_title：Molecular immunology
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0161-5890(94)00150-y
更新日期：1995-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2014.06.028
更新日期：2014-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2020.07.018
更新日期：2020-10-01 00:00:00
abstract：:In human peripheral blood, most of the CD3+ cells express the alpha/beta T cell receptor. A smaller fraction of CD3+ T cells express the gamma/delta T cell receptor (from 1 to 10% depending the individuals, with an average of 3-5%). Interestingly, although the alpha/beta + T cells never express the gamma chain at the ...
journal_title：Molecular immunology
pub_type： 杂志文章,评审
doi：10.1016/0161-5890(92)90001-e
更新日期：1992-04-01 00:00:00
