A marker of human foetal endoderm defined by a monoclonal antibody involves Type 1 blood group chains.

abstract：:Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-E(k) revealed an interesting localization of negatively charged residues within the P6 pocket, which may have implications in the pH dependency...

journal_title：Molecular immunology

authors： Dao CT,Weber DA,Jensen PE

更新日期：2002-06-01 00:00:00

abstract：:Jackfruit lectin, jacalin, prepared from two batches of jackfruit seeds showed a different specificity in precipitating reaction in Agarose gel with various purified immunoglobulins and secretory components. Jacalin-P, extracted from jackfruit seeds from the Philippines, reacts only with serum IgA and secretory IgA of...

journal_title：Molecular immunology

authors： Kondoh H,Kobayashi K,Hagiwara K

更新日期：1987-11-01 00:00:00

abstract：:A number of fragments derived from acid-treated rabbit IgG by digestion with plasmin have been separated by high-resolution gel filtration. Fragments isolated included a dimer and monomer Facb, named F(acb)2 and Facb, respectively and a heterodimer composed of Facb and Fab subunits, named F(acb)(ab). A C gamma 2 fragm...

journal_title：Molecular immunology

authors： Utsumi S,Okada M,Udaka K,Amano T

更新日期：1985-07-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a chronic disease characterized by autoimmune-mediated destruction of pancreatic insulin-producing beta cells. Interleukin (IL)-18 is a pro-inflammatory cytokine implicated in the pathogenesis of a number of inflammatory diseases. Here, we analyzed IL-18 levels in the plasma of juveniles with ...

journal_title：Molecular immunology

authors： Harms RZ,Yarde DN,Guinn Z,Lorenzo-Arteaga KM,Corley KP,Cabrera MS,Sarvetnick NE

更新日期：2015-04-01 00:00:00

abstract：:Comparative interactions of purified rabbit C1q with 18-2-3, a high affinity (2-3 X 10(10) M-1) anti-fluorescein (anti-F1) murine monoclonal IgM antibody (pentamer) and constitutive monomeric subunits (IgMs) were studied. Using a solid phase radioimmunoassay (SPRIA), based on immobilized polyvalent antigen, it was sho...

journal_title：Molecular immunology

authors： Swanson SM,Dombrink-Kurtzman MA,Voss EW Jr

更新日期：1988-06-01 00:00:00

abstract：:We showed that nucleotide sequences coding for linear B-cell epitopes of human immunodeficiency virus type 1 (HIV1) gp120 protein are enriched with codons containing cytosine and guanine in their first and second codon positions. Guanine and cytosine are the most mutable nucleotides in HIV1 genes (due to APOBEC3 and A...

journal_title：Molecular immunology

authors： Khrustalev VV

更新日期：2010-04-01 00:00:00

abstract：:Natural killer (NK) cells express receptors that are specific for MHC class I molecules. These receptors play a crucial role in regulating the lytic and cytokine expression capabilities of NK cells. In humans, three distinct families of genes have been defined that encode for receptors of HLA class I molecules. The fi...

journal_title：Molecular immunology

authors： Borrego F,Kabat J,Kim DK,Lieto L,Maasho K,Peña J,Solana R,Coligan JE

更新日期：2002-02-01 00:00:00

abstract：:PKZ, protein kinase containing Z-DNA binding domains, is a novel member of eIF2α kinase in fish. PKZ can be up-regulated in response to Poly I:C or heat stress, and it has a typical eIF2α kinase activity. However, the relationship between fish PKZ and apoptosis remains unclear. In the present study, effects of PKZ on ...

journal_title：Molecular immunology

authors： Wu C,Hu Y,Fan L,Wang H,Sun Z,Deng S,Liu Y,Hu C

更新日期：2016-01-01 00:00:00

abstract：:Myeloid differentiation protein 2 (MD-2) is required in the recognition of lipopolysaccharide (LPS) by toll-like receptor 4 (TLR4), and participates in LPS-induced alveolar macrophage (AM) inflammation during acute lung injury (ALI). Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflamm...

journal_title：Molecular immunology

authors： Luo M,Hu L,Li D,Wang Y,He Y,Zhu L,Ren W

更新日期：2017-10-01 00:00:00

abstract：:Although the lambda-bearing antibodies represent only 5% of the total mouse serum immunoglobulins, some antigens such as B1355 dextran (alpha (1-3)Dex), the 4-hydroxy-3-nitrophenyl acetyl (NP) and 2,4-dinitro or 2,4,6-trinitrophenyl (DNP/TNP) antigens can induce lambda-positive immune responses. In contrast to the lam...

journal_title：Molecular immunology

authors： Sanchez P,Juy D,Cazenave PA

更新日期：1988-02-01 00:00:00

abstract：:We have developed two distinct solid-phase immunoassays for the detection of antigen binding activity by products of antigen binding T cell hybridomas in the absence of MHC. Two suppressor T cell hybridomas studied (34s-18 and 34s-704) are specific for keyhole limpet hemocyanin, a protein antigen, and the other suppre...

journal_title：Molecular immunology

authors： Bristow CL,Marchalonis JJ

更新日期：1989-07-01 00:00:00

abstract：:Previous studies showed that P2 receptors are involved in neutrophil migration via stimulation of chemokine release and by facilitating chemoattractant gradient sensing. Here, we have investigated whether these receptors are involved in LPS-induced neutrophil transendothelial migration (TEM) using a Boyden chamber whe...

journal_title：Molecular immunology

authors： Kukulski F,Ben Yebdri F,Bahrami F,Fausther M,Tremblay A,Sévigny J

更新日期：2010-02-01 00:00:00

abstract：:It is well established that aggregation of cell surface immunoglobulin is involved in signal transduction by cells of the immune system. It is less well understood what special properties of these cell surface aggregates are important in initiating the signal cascade. Several authors have proposed that cells respond t...

journal_title：Molecular immunology

authors： Posner RG,Dembo M

更新日期：1994-12-01 00:00:00

abstract：:Human gastrointestinal glycoproteins (mucins), isolated by pepsin digestion from foetal stomachs and meconia, and from paired tumour and non-neoplastic mucosal samples of patients with gastric and colorectal carcinomas, were tested for precipitating reactions with peanut lectin (PNL) and four anti-carbohydrate antibod...

journal_title：Molecular immunology

authors： Picard JK,Feizi T

更新日期：1983-11-01 00:00:00

abstract：:We considered the possibility that the greater the distance between an immune receptor V and J, the more likely the V usage. Such a hypothesis is supported by results from mouse experiments. And, such a hypothesis is consistent with the fundamental nature of recombination and genomic distance: the further the distance...

journal_title：Molecular immunology

authors： Pakasticali N,Gill T,Chobrutskiy BI,Tong WL,Ramsamooj M,Blanck G

更新日期：2019-12-01 00:00:00

abstract：:The ragweed allergens Amb t 5 and Amb a 5 are among the smallest inhaled protein allergens known, containing a single, immunodominant T-cell epitope. In this study we analyzed the B-cell epitope structure of Amb t 5. The three-dimensional structures of Amb t 5 and Amb a 5 have been determined by NMR spectroscopy, prov...

journal_title：Molecular immunology

authors： Rafnar T,Brummet ME,Bassolino-Klimas D,Metzler WJ,Marsh DG

更新日期：1998-06-01 00:00:00

abstract：:Peptide fragments of pertussis toxin subunit 1 (PT-S1) have been synthesized in order to investigate their antigenic and immunogenic activity, and to evaluate their possible use as components of a new vaccine. Two peptides (sequence 73-82, EAERAGRGTG and sequence 107-116, YVDTYGDNAG) were selected for their predictabl...

journal_title：Molecular immunology

authors： Presentini R,Perin F,Ancilli G,Nucci D,Bartoloni A,Rappuoli R,Antoni G

更新日期：1989-01-01 00:00:00

abstract：:Mast cells have a clear-cut pathologic role in allergy, participating in a number of chronic inflammatory conditions, in helmintic parasitosis, and in some solid tumor reactions, but also in physiological situations, such as wound healing and innate immunity. Mast cells release a large number of proinflammatory, immun...

journal_title：Molecular immunology

authors： Piliponsky AM,Gleich GJ,Bar I,Levi-Schaffer F

更新日期：2002-09-01 00:00:00

abstract：:Using a combinatorial chemistry approach, we identified a tetrameric tripeptide, denoted Protein A Mimetic (PAM) or TG19318, able to bind to immunoglobulins of different classes and species. The inverso variant, with the tripeptide in the all-D configuration (D-PAM or TG19320), is described as retaining binding proper...

journal_title：Molecular immunology

authors： Rossi M,Ruvo M,Marasco D,Colombo M,Cassani G,Verdoliva A

更新日期：2008-01-01 00:00:00

abstract：:Spondyloarthritis is the second most common form of chronic inflammatory arthritis and a unique hallmark of the disease is pathologic new bone formation. Several cytokine pathways have been genetically associated with ankylosing spondylitis (AS), the prototypic subtype of SpA, and additional evidence from human and an...

journal_title：Molecular immunology

authors： Hreggvidsdottir HS,Noordenbos T,Baeten DL

更新日期：2014-01-01 00:00:00

abstract：:Abs reactive to DNA and DNA/histone complexes are a distinguished characteristic of primary immunoglobulin repertoires in autoimmune B6.MRL-Faslpr and MRL/MpJ-Faslpr mice. These mice are defective in Fas receptor, which is critical for the apoptosis of autoreactive B cells by an extrinsic pathway. In the present study...

journal_title：Molecular immunology

authors： Li S,Liu W,Li Y,Zhao S,Liu C,Hu M,Yue W,Liu Y,Wang Y,Yang R,Xiang R,Liu F

更新日期：2016-10-01 00:00:00

abstract：:It has been developed an HIV type 1 transgenic rat model (HIV-1 Tg Rat) which contains a gag-pol-deleted HIV-1 provirus regulated by the viral LTR promoter. Although it harbors a non infectious provirus, efficient viral expression occurs in different tissues and disease manifestations as well as immune-response altera...

journal_title：Molecular immunology

authors： Mazzucchelli R,Amadio M,Curreli S,Denaro F,Bemis K,Reid W,Bryant J,Riva A,Galli M,Zella D

更新日期：2004-08-01 00:00:00

abstract：:The thermal effects associated with the binding reaction of concanavalin A and immunoglobulins have been measured by calorimetry. IgG solutions do not generate heat on mixing with concanavalin A, confirming the low reactivity of IgG for the lectin molecule. IgM solutions, on the other hand, show a substantial enthalpi...

journal_title：Molecular immunology

authors： Dani M,Manca F,Rialdi G

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:The complement system is well known for its role in innate immunity via the classical, the alternative and the lectin pathways, although recent investigations suggest expanding roles in adipose tissue. Properdin stabilizes C3 convertase following alternative complement activation. Properdin is also present i...

journal_title：Molecular immunology

authors： Gauvreau D,Roy C,Tom FQ,Lu H,Miegueu P,Richard D,Song WC,Stover C,Cianflone K

更新日期：2012-05-01 00:00:00

abstract：:Antibodies (Ab) are bifunctional molecules with two domains, a constant region (C) that confers effector properties and a variable (V) region responsible of antigen (Ag) binding. Historically the C and V regions were considered to be functionally independent, with Ag specificity being solely determined by the V region...

journal_title：Molecular immunology

authors： Janda A,Casadevall A

更新日期：2010-04-01 00:00:00

abstract：:Although the beneficial effects of probiotics on wide variety of diseases have been shown, little is known about how probiotics modulate the immune system. In this study we elucidated the underlying mechanisms how Lactobacillus casei (L. casei) protects against rheumatoid arthritis (RA) progression by investigating th...

journal_title：Molecular immunology

authors： So JS,Kwon HK,Lee CG,Yi HJ,Park JA,Lim SY,Hwang KC,Jeon YH,Im SH

更新日期：2008-05-01 00:00:00

abstract：:Human complement components C6 and C7 have been purified and characterized. Component C6 is a single-chain plasma protein of mol. wt 104,800 containing 3.8% carbohydrate and it has alanine as the amino terminal residue. Component C7 is a single-chain plasma protein of mol. wt 92,400 containing 6.4% carbohydrate and it...

journal_title：Molecular immunology

authors： Discipio RG,Gagnon J

更新日期：1982-11-01 00:00:00

abstract：:Humanization of rodent mAbs by CDR-grafting (also called "reshaping") is now a standard procedure for reducing immunogenicity and recruiting human effector functions. However, the design of the humanized mAb can sometimes prove circuitous. Attempts were made to humanize L-25, a mouse antibody against the human alpha-4...

journal_title：Molecular immunology

authors： Saldanha JW,Martin AC,Léger OJ

更新日期：1999-08-01 00:00:00

abstract：:Artificial Salmonella serogroup B, D or Cl-specific glycolipids were prepared by covalently linking oligosaccharides corresponding to two O-antigen repeating units, obtained by phage enzyme hydrolysis of native O-antigenic polysaccharides, to octyl residues. Sheep erythrocytes coated with the artificial glycolipids we...

journal_title：Molecular immunology

authors： Grossman N,Svenson SB,Leive L,Lindberg AA

更新日期：1990-09-01 00:00:00

abstract：:Low molecular weight hemorrhagins were purified from crude Bothrops atrox snake venom by gel filtration followed by ionic strength chromatography. The protein fractions obtained, designated HI-1 to HI-8, contained proteins with molecular masses lower than 30 kDa. HI-5, the most representative among of these fractions,...

journal_title：Molecular immunology

authors： Rodrigues FG,Petretski JH,Kanashiro MM,Lemos L,da Silva WD,Kipnis TL

更新日期：2004-03-01 00:00:00