当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > Interleukin 1 activation of the AP-1 transcription complex in murine T cells is regulated at the level of Jun B protein accumulation.

Interleukin 1 activation of the AP-1 transcription complex in murine T cells is regulated at the level of Jun B protein accumulation.

Abstract：

:We have examined the regulation of the AP-1 DNA transcription complex during T cell activation in response to interleukin 1 (IL-1) and phorbol ester (TPA) treatment of the IL-1 responsive murine thymoma T cell line, EL4 6.1 C 10. IL-1 synergistically enhances the stimulatory effect of TPA on AP-1-mediated gene expression in this cell line. To elucidate the mechanism(s) by which IL-1 enhances AP-1-mediated gene expression, we examined the effect of IL-1 on the synthesis and turnover of Jun B, the member of the jun gene family that is present in AP-1 complexes in EL4 cells. We found that IL-1 + TPA-treated cells contain significantly higher Jun B protein levels than cells treated with TPA alone. IL-1 promotes the prolonged accumulation of Jun B, whereas the cellular content of Jun B decreases dramatically after 6 hr in cells treated with only TPA. IL-1 enhancement of Jun B protein levels is not the result of a change in the turnover rate of the Jun B protein, but rather results from the maintenance of sufficient jun B mRNA to support continued accumulation of newly synthesized protein. In addition to Jun B, we found that the T cell AP-1 complex contains the Fra-1 protein, a member of the fos gene family. Although IL-1 dramatically increases Jun B accumulation, it does not enhance TPA-induced Fra-1 protein levels in EL4 cells. Thus, the stimulation of AP-1-mediated gene expression by IL-1 in EL4 cells is due to the promotion of Jun B protein accumulation that, in turn, facilitates Jun B heterodimerization with TPA-induced Fra-1 protein, thereby forming an active AP-1 complex.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Brooks JW,Yoza BK,Mizel SB

doi

10.1016/0161-5890(95)00055-j

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

779-88

issue

11

eissn

0161-5890

issn

1872-9142

pii

016158909500055J

journal_volume

32

pub_type

杂志文章

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement.

    abstract：:Mannose-binding lectin (MBL) and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pa...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2009.05.005

    authors： Garred P,Honoré C,Ma YJ,Munthe-Fog L,Hummelshøj T

    更新日期：2009-09-01 00:00:00

  • Antigen specificity and cross-reactivity of monoclonal anti-lysozyme antibodies.

    abstract：:Twenty-seven murine monoclonal anti-hen egg-white lysozyme (HEL) antibodies were tested with a panel of nine antigens; eight avian lysozymes and human lysozyme. The antibodies were arranged into 10 groups based on their antigen specificity and cross-reactivity. Antigenic determinants recognized by each group of antibo...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(87)90081-2

    authors： Harper M,Lema F,Boulot G,Poljak RJ

    更新日期：1987-02-01 00:00:00

  • Differential ICAM-1 isoform expression regulates the development and progression of experimental autoimmune encephalomyelitis.

    abstract：:Intercellular adhesion molecule-1 (ICAM-1) functions in leukocyte trafficking, activation, and the formation of the immunological synapse. ICAM-1 is a member of the immunoglobulin superfamily of adhesion proteins, which share a similar structure of repeating Ig-like domains. Many genes in this family, including ICAM-1...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2010.03.005

    authors： Hu X,Barnum SR,Wohler JE,Schoeb TR,Bullard DC

    更新日期：2010-05-01 00:00:00

  • Human monoclonal antibodies produced in transgenic BABkappa,lambda mice recognising idiotypic immunoglobulins of human lymphoma cells.

    abstract：:Clonal idiotypic immunoglobulins of follicular lymphomas can be isolated by somatic fusion procedures. Idiotypic IgMs (Id-IgM) were isolated from two patients and used to immunise a strain of mice, deficient in mouse antibody production and engineered with yeast artificial chromosomes (YAC) containing fragments of the...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2004.03.035

    authors： Suárez E,Yáñez R,Barrios Y,Díaz-Espada F

    更新日期：2004-07-01 00:00:00

  • TWEAK/Fn14 promotes pro-inflammatory cytokine secretion in hepatic stellate cells via NF-κB/STAT3 pathways.

    abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) have been associated with liver disease. Hepatic stellate cells (HSCs) play a critical role in the hepatic wound-healing response after liver injury, but there is little information available on t...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.04.003

    authors： Wang A,Zhang F,Xu H,Xu M,Cao Y,Wang C,Xu Y,Su M,Zhang M,Zhuge Y

    更新日期：2017-07-01 00:00:00

  • Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity.

    abstract：:Porcine deltacoronavirus (PDCoV) is an emerging swine coronavirus causing diarrhea and intestinal damage in nursing piglets. Previous work showed that PDCoV infection inhibits type I interferon (IFN) production. To further identify and characterize the PDCoV-encoded IFN antagonists will broaden our understanding of it...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.07.003

    authors： Liu X,Fang P,Fang L,Hong Y,Zhu X,Wang D,Peng G,Xiao S

    更新日期：2019-10-01 00:00:00

  • Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan.

    abstract：:In Drosophila the synthesis of antimicrobial peptides in response to microbial infections is under the control of the Toll and immune deficiency (Imd) signaling pathways. The Toll signaling pathway responds mainly to Gram-positive bacterial and fungal infection while the Imd pathway mediates the response to Gram-negat...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.01.015

    authors： Leone P,Bischoff V,Kellenberger C,Hetru C,Royet J,Roussel A

    更新日期：2008-05-01 00:00:00

  • Gene structures and promoter characteristics of interferon regulatory factor 1 (IRF-1), IRF-2 and IRF-7 from snakehead Channa argus.

    abstract：:Three interferon regulatory factor (IRF) genes, CaIRF-1, CaIRF-2 and CaIRF-7, and their promoters of snakehead (Channa argus) were cloned and characterized. The CaIRF-1 gene consists of ten exons, spans 4.3 kb and encodes a putative peptide of 299 aa. The CaIRF-2 gene consists of nine exons, spans 8 kb and encodes a p...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.11.011

    authors： Jia W,Guo Q

    更新日期：2008-04-01 00:00:00

  • A dominant V beta bias in the CTL response after HSV-1 infection is determined by peptide residues predicted to also interact with the TCR beta-chain CDR3.

    abstract：:Many T cell responses are dominated by restricted TCR expression and can range from repeated usage of particular TCR Vbeta- and/or Valpha-elements, to the preferential usage of both V- and J-elements, often in conjunction with conserved V-D-J or V-J junctional sequences. Cytotoxic T lymphocytes specific for a Kb-restr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(98)00051-0

    authors： Turner SJ,Carbone FR

    更新日期：1998-04-01 00:00:00

  • Production and characterization of monoclonal antibodies to staphylococcal enterotoxins: use in immunodetection and immunopurification.

    abstract：:Four cell lines producing monoclonal antibodies were obtained by fusion of NS1 myeloma cells with splenocytes of BALB/C mice immunized with only 1 microgram of each staphylococcal enterotoxin A, B, C1 and D by a modified technique of intrasplenic boosting. This procedure was considerably more efficient than the more c...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(87)90118-0

    authors： Lapeyre C,Kaveri SV,Janin F,Strosberg AD

    更新日期：1987-12-01 00:00:00

  • Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation.

    abstract：:The mis-regulation of nuclear factor-kappa B (NF-kappaB) signal pathway is involved in a variety of inflammatory diseases that leds to the production of inflammatory mediators. Our studies using human U937 promonocytes cells suggested that magnolol, a low molecular weight lignan isolated from the medicinal plant Magno...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.12.004

    authors： Tse AK,Wan CK,Zhu GY,Shen XL,Cheung HY,Yang M,Fong WF

    更新日期：2007-04-01 00:00:00

  • Characterizing the inhibitory action of zinc oxide nanoparticles on allergic-type mast cell activation.

    abstract：:The development of nanoparticles (NPs) for commercial products is undergoing a dramatic expansion. Many sunscreens and cosmetics now use zinc oxide (ZnO) or titania (TiO2) NPs, which are effective ultraviolet (UV) filters. Zinc oxide topical creams are also used in mild anti-inflammatory treatments. In this study we e...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2015.02.021

    authors： Feltis BN,Elbaz A,Wright PF,Mackay GA,Turney TW,Lopata AL

    更新日期：2015-08-01 00:00:00

  • The effect of fragment B of staphylococcal protein A on the binding of rabbit IgG to human granulocytes and monocytes.

    abstract：:The effect of fragment B of staphylococcal protein A on the binding of rabbit IgG to human granulocytes has been examined. When rabbit IgG sensitized sheep erythrocytes (EA) were preincubated with increasing amounts of fragment B, a dose dependent inhibition of rosette formation between the human granulocytes and the ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90206-1

    authors： Barnett Foster DE,Sjoquist J,Painter RH

    更新日期：1982-03-01 00:00:00

  • The heterogeneity of bovine IgG2--IV. Structural differences between IgG2a molecules of the A1 and A2 allotypes.

    abstract：:The major product of digestion of bovine IgG2a(A1) with immobilized pepsin is F(ab')2 while similar treatment of IgG2a(A2) yields Fab, Fc and other products. It is postulated that structural differences in the hinge region, including the absence of the most N-terminal disulfide bridge in IgG2a(A2) and a displacement o...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(87)90128-3

    authors： Heyermann H,Butler JE

    更新日期：1987-12-01 00:00:00

  • Cross-linking of IgE-receptor complexes at the cell surface: a fluorescence method for studying the binding of monovalent and bivalent haptens to IgE.

    abstract：:We have developed a method for use in investigating factors controlling the binding and cross-linking by bivalent haptens of immunoglobulin E (IgE) bound to receptors on rat basophilic leukemia (RBL) cells. This method employs monoclonal anti-2,4-dinitrophenyl (DNP) IgE that is labeled with fluorescein-5-isothiocyanat...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90089-1

    authors： Erickson J,Kane P,Goldstein B,Holowka D,Baird B

    更新日期：1986-07-01 00:00:00

  • Activation of NF-κB induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque.

    abstract：:TRIMCyp generated by retrotransposition of a cyclophilin A inserting into TRIM5 locus, has been identified in owl monkey and most of Old World monkeys (OWM). Owl monkey TRIMCyp (omTRIMCyp) inhibits HIV-1 infection by direct interaction with viral capsid and indirect innate immune induction, whereas most of TRIMCyps fr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2018.08.001

    authors： Zhu JW,Mu D,Liu FL,Luo MT,Luo RH,Zheng YT

    更新日期：2018-09-01 00:00:00

  • Activation-induced apoptosis in Jurkat cells through a myc-independent mechanism.

    abstract：:Apoptosis can be induced in the human leukemic T-cell line Jurkat when these cells are stimulated by several known T-cell activators. Among the stimuli that activate Jurkat cells, calcium ionophore A23187, phytohemagglutinin and cross-linked monoclonal antibody anti-CD3 are the best inducers of apoptosis. The activato...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00059-n

    authors： Ruiz-Ruiz MC,Oliver FJ,Izquierdo M,López-Rivas A

    更新日期：1995-09-01 00:00:00

  • CD3/CD28 dynabeads induce expression of tn antigen in human t cells accompanied by hypermethylation of the cosmc promoter.

    abstract：:Glycosylation is an important protein post-translational modification. In this process, the intermediate product, Tn antigen, arises from somatic mutations in core1β3-galactosyltransferase-specific molecular chaperone (Cosmc), which is required for the formation of active core1β3-galactosyltransferase (T-synthase). As...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.06.250

    authors： Shi C,Xu X,Yu X,Du Z,Luan X,Liu D,Hu T

    更新日期：2017-10-01 00:00:00

  • Establishment of an ex vivo model of monocytes-derived macrophages differentiated from peripheral blood mononuclear cells (PBMCs) from HIV-1 transgenic rats.

    abstract：:It has been developed an HIV type 1 transgenic rat model (HIV-1 Tg Rat) which contains a gag-pol-deleted HIV-1 provirus regulated by the viral LTR promoter. Although it harbors a non infectious provirus, efficient viral expression occurs in different tissues and disease manifestations as well as immune-response altera...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2004.06.023

    authors： Mazzucchelli R,Amadio M,Curreli S,Denaro F,Bemis K,Reid W,Bryant J,Riva A,Galli M,Zella D

    更新日期：2004-08-01 00:00:00

  • Characterizations of CD4-1, CD4-2 and CD8β T cell subpopulations in peripheral blood leucocytes, spleen and head kidney of Japanese flounder (Paralichthys olivaceus).

    abstract：:In the previous study, antibodies against CD3 molecule have been produced and were used in labeling T cells in Japanese flounder (Paralichthys olivaceus). In this paper, CD4+ and CD8+ lymphocytes subpopulations in peripheral blood leucocytes (PBL), spleen and head kidney of flounder were investigated. The flounder CD4...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.02.015

    authors： Xing J,Ma J,Tang X,Sheng X,Zhan W

    更新日期：2017-05-01 00:00:00

  • Expression profiling and validation of reference gene candidates in immune relevant tissues and cells from Atlantic salmon (Salmo salar L.).

    abstract：:The expression levels of three commonly used housekeeping genes, EF1-alpha, RPS20 and Beta-Actin, were examined in seven different tissues and leucocytes from non-stimulated Atlantic salmon (Salmo salar L.). The tissues analysed by quantitative real-time PCR were gill, liver, intestine, muscle, spleen, head kidney leu...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.07.009

    authors： Ingerslev HC,Pettersen EF,Jakobsen RA,Petersen CB,Wergeland HI

    更新日期：2006-03-01 00:00:00

  • Identification and characterization of a novel nanobody against human placental growth factor to modulate angiogenesis.

    abstract：:Placental growth factor (PlGF), a member of vascular endothelial growth factors (VEGF) family, is considered as an important antigen associated with pathological conditions such as cancer cell growth, and metastasis. PlGF-targeting via nanobody (Nb) therefore could be beneficial to modulate these pathologies. In this ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2016.09.012

    authors： Arezumand R,Mahdian R,Zeinali S,Hassanzadeh-Ghassabeh G,Mansouri K,Khanahmad H,Namvar-Asl N,Rahimi H,Behdani M,Cohan RA,Eavazalipour M,Ramazani A,Muyldermans S

    更新日期：2016-10-01 00:00:00

  • Stylicins, a new family of antimicrobial peptides from the Pacific blue shrimp Litopenaeus stylirostris.

    abstract：:The present study reports the characterization of Ls-Stylicin1, a novel antimicrobial peptide from the penaeid shrimp, Litopenaeus stylirostris. The predicted mature peptide of 82 residues is negatively charged (theoretical pI=5.0) and characterized by a proline-rich N-terminal region and a C-terminal region containin...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.12.007

    authors： Rolland JL,Abdelouahab M,Dupont J,Lefevre F,Bachère E,Romestand B

    更新日期：2010-03-01 00:00:00

  • Selection of human antibodies against cell surface-associated oligomeric anthrax protective antigen.

    abstract：:The protective antigen (PA(83)) of Bacillus anthracis is the dominant antigen in natural and vaccine-induced immunity to anthrax infection. Three human single-chain variable fragments (scFvs) against cell bound PA were isolated from an antibody phage display library. Specifically, the antibodies were evaluated for the...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.11.011

    authors： Steiniger SC,Altobell LJ 3rd,Zhou B,Janda KD

    更新日期：2007-04-01 00:00:00

  • MicroRNA regulation of natural killer cell development and function in leukemia.

    abstract：:MicroRNAs (miRNAs) are now recognized as important regulators of all cellular processes, including immune function and cancer survival. These evolutionary preserved, single-stranded, non-coding RNA molecules mediate important functional effects primarily through post-transcriptional regulation of protein expression. M...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2018.07.022

    authors： Saultz JN,Freud AG,Mundy-Bosse BL

    更新日期：2019-11-01 00:00:00

  • Immunotoxins of Pseudomonas exotoxin A (PE): effect of linkage on conjugate yield, potency, selectivity and toxicity.

    abstract：:Conjugates of monoclonal antibodies and Pseudomonas exotoxin A (PE) were formed with disulfide or thioether bonds. Thioether conjugates which formed with succinimidyl 4-(N-maleimidomethyl)-cyclohexane-1-carboxylate (SMCC) modified PE and reduced antibody formed with an 80% yield of equimolar conjugate within 30 min wi...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(90)90140-u

    authors： Morgan AC Jr,Sivam G,Beaumier P,McIntyre R,Bjorn M,Abrams PG

    更新日期：1990-03-01 00:00:00

  • Mass spectrometry-based relative quantification of human neutrophil peptides 1, 2, and 3 from biological samples.

    abstract：:Human neutrophil peptides (HNPs) are cysteine-rich antimicrobial peptides stored in neutrophils. The similar structure of HNPs -1, -2, and -3 renders them impossible to study individually in biological samples. For the first time, we describe a method of individually identifying the HNPs -1-3 from exudative neutrophil...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.08.001

    authors： Thompson L,Turko I,Murad F

    更新日期：2006-03-01 00:00:00

  • Junctional diversification in the generation of the precursor of a discrete immune response.

    abstract：:Phosphocholine (PC)-specific antibodies that arise in the mouse in response to Proteus morganii (PM) and use V1-DFL16.1-JH1 are characterized by a number of recurring mutations. Most striking is an invariant A for G substitution in codon 95 of VH which results in an asparagine instead of aspartate at that position. Be...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90069-n

    authors： George J,Sheehan KM,Brodeur PH,Claflin JL

    更新日期：1993-03-01 00:00:00

  • Serum complement C1q level is associated with acute coronary syndrome.

    abstract：BACKGROUND AND OBJECTIVES:The complement system plays an important role in the development of acute coronary syndrome (ACS). Complement C1q is an important initial component of the classical complement pathway and closely related to many chronic inflammatory diseases, including atherosclerosis (AS). We aimed to determi...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.02.012

    authors： Ni XN,Yan SB,Zhang K,Sai WW,Zhang QY,Ti Y,Wang ZH,Zhang W,Zheng CY,Zhong M

    更新日期：2020-04-01 00:00:00

  • IgE epitopes of intact and digested Ara h 1: a comparative study in humans and rats.

    abstract：BACKGROUND:Allergen epitope characterization provides valuable information useful for the understanding of proteins as food allergens. It is believed that IgE epitopes in general are conformational, nevertheless, for food allergens known to sensitize through the gastrointestinal tract linear epitopes have been suggeste...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2012.04.002

    authors： Bøgh KL,Nielsen H,Madsen CB,Mills EN,Rigby N,Eiwegger T,Szépfalusi Z,Roggen EL

    更新日期：2012-07-01 00:00:00