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The effect of fragment B of staphylococcal protein A on the binding of rabbit IgG to human granulocytes and monocytes.

Abstract：

:The effect of fragment B of staphylococcal protein A on the binding of rabbit IgG to human granulocytes has been examined. When rabbit IgG sensitized sheep erythrocytes (EA) were preincubated with increasing amounts of fragment B, a dose dependent inhibition of rosette formation between the human granulocytes and the treated EA was observed. In contrast, rosette formation between human monocytes and fragment B treated EA was not impaired. These results confirm previous findings which revealed differences in the specificities of the human Fc receptors of these cells. Rabbit IgG was used in place of human IgG for the preparation of the sensitized erythrocytes since human IgG coated human erythrocytes were agglutinated by fragment B, indicating the possibility of a secondary binding site for human IgG in this fragment.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Barnett Foster DE,Sjoquist J,Painter RH

doi

10.1016/0161-5890(82)90206-1

subject

Has Abstract

pub_date

1982-03-01 00:00:00

pages

407-12

issue

3

eissn

0161-5890

issn

1872-9142

journal_volume

19

pub_type

杂志文章

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