Polyclonal antibodies specific for liganded active site (metatype) of a high affinity anti-hapten monoclonal antibody.

abstract：:Antibodies that recognize Xenopus class II molecules have been developed. Mouse monoclonal antibodies were prepared by immunizing BALB/c mice with frog MHC antigens that had been partially purified with alloantisera, and by immunizing mouse spleen cells in vitro with activated Xenopus T lymphocytes. In addition, five ...

journal_title：Molecular immunology

authors： Flajnik MF,Ferrone S,Cohen N,Du Pasquier L

更新日期：1990-05-01 00:00:00

abstract：:The T-dependent BALB/c murine immune response to fluorescein (F1) is characterized by structural heterogeneity at the protein level exemplified in part by a significantly wide range of affinities (Ka), and apparent lack of dominant idiotypes. In order to generate an idiotype family, xenogenic anti-idiotype (anti-ID) a...

journal_title：Molecular immunology

authors： Bates RM,Ballard DW,Voss EW Jr

更新日期：1985-08-01 00:00:00

abstract：:The mechanism by which heparin inhibits the alternative complement pathway (ACP) by a fluid-phase activator, CoVF, has been studied. Results presented here indicate that heparin's major (rate-limiting) effect on the fluid-phase activation of the ACP was to potentiate Factor H activity. Such an effect results in a very...

journal_title：Molecular immunology

authors： Boackle RJ,Caughman GB,Vesely J,Medgyesi G,Fudenberg HH

更新日期：1983-11-01 00:00:00

abstract：:The three-dimensional structure of the Mcg lambda-type Bence-Jones dimer crystallized in ammonium sulfate is known at 2.3-A resolution. A series of nine other human lambda-chains and two kappa-chains did not crystallize under the same conditions. After these proteins were hybridized with the Mcg light chain by the met...

journal_title：Molecular immunology

authors： Ely KR,Peabody DS,Holm TR,Cheson BD,Edmundson AB

更新日期：1985-02-01 00:00:00

abstract：:Activation-induced cell death (AICD) in T lymphocytes depends on the expression of Fas-ligand, which triggers the apoptotic process after binding to its receptor Fas. This leads to the activation of cysteine proteases of the caspase family and especially of caspase-3, a critical effector protein during AICD. We have p...

journal_title：Molecular immunology

authors： Sabbagh L,Bourbonnière M,Sékaly RP,Cohen LY

更新日期：2005-07-01 00:00:00

abstract：:Interleukin 1 receptor-associated kinase 4 (IRAK4) is a key factor in TLR-mediated host immune function. In this study, an IRAK4 homologue molecule was identified from Apostichopus japonicus (designated as AjIRAK4) by RACE approach. The full-length cDNA of AjIRAK4 was of 2024 bp containing an open reading frame of 131...

journal_title：Molecular immunology

authors： Cui Y,Jiang L,Xing R,Wang Z,Wang Z,Shao Y,Zhang W,Zhao X,Li C

更新日期：2018-09-01 00:00:00

abstract：:Human beta defensin-1 (hBD1) is a component of the immune system which links the innate and adaptive immune responses. We have demonstrated that hBD1 induces rapid cytolysis of prostate cancer cells and that it may also possess tumor suppressive abilities. In addition, there is a high frequency of cancer-specific loss...

journal_title：Molecular immunology

authors： Bose SK,Gibson W,Bullard RS,Donald CD

更新日期：2009-03-01 00:00:00

abstract：:To date, although a promising anti-inflammatory activity of oligomeric proanthocyanidins (OPCs) has been observed in asthma, the mechanism responsible for these immunomodulatory properties remains obscure. Dendritic cells (DCs) that reside in the airway have been widely perceived as an important contributor to asthma....

journal_title：Molecular immunology

authors： Li Y,Yu Q,Zhao W,Zhang J,Liu W,Huang M,Zeng X

更新日期：2017-11-01 00:00:00

abstract：:When 5-fluorouracil (5-FU) resistant bone marrow (BM) cells are depleted of B-cells and then cultured in insert chambers [separated from a layer of adherent BM (aBM) cells by a nucleopore membrane], no mature, lipopolysaccharide (LPS) reactive B-cells are formed. Factors acting on B-cell precursors are not produced un...

journal_title：Molecular immunology

authors： Gisler RH,Schlienger C,Söderberg A,Ledermann F,Lambris JD

更新日期：1988-11-01 00:00:00

abstract：:In most cases, cytotoxic T cell activation is dependent on the interaction of the T cell receptor (TCR) and CD8 with MHC class I molecules. In the CD8(+) T cell system based on the mouse cytotoxic T cell clone 2C, recognition of the allogeneic MHC L(d) exhibits a less significant role for CD8 than recognition of the s...

journal_title：Molecular immunology

authors： Lee PU,Kranz DM

更新日期：2003-01-01 00:00:00

abstract：:PKZ, protein kinase containing Z-DNA binding domains, is a novel member of eIF2α kinase in fish. PKZ can be up-regulated in response to Poly I:C or heat stress, and it has a typical eIF2α kinase activity. However, the relationship between fish PKZ and apoptosis remains unclear. In the present study, effects of PKZ on ...

journal_title：Molecular immunology

authors： Wu C,Hu Y,Fan L,Wang H,Sun Z,Deng S,Liu Y,Hu C

更新日期：2016-01-01 00:00:00

abstract：:We have recently reported cellular growth arrest induced following crosslinking of surface IgM (sIgM) but not surface IgD (sIgD) in the WEHI-231 cell line, representative of the immature B cell stage, and its delta heavy chain (delta) transfectant. An initial report has indicated WEHI-231.7, a subclone of WEHI-231, fa...

journal_title：Molecular immunology

authors： Iwabuchi N,Williams DB,Nguyen HP,Hozumi N

更新日期：1992-05-01 00:00:00

abstract：:Structural similarities between two members of the immunoglobulin superfamily were explored by making chimeric immunoglobulin/CD4 antigen molecules. A crossover in the middle of the originally proposed J kappa homology unit of the first domain of the CD4 molecule was used to construct a chimeric molecule having human ...

journal_title：Molecular immunology

authors： Frey T,Estess P,Oi VT

更新日期：1993-06-01 00:00:00

abstract：:Antibacterial responses have been studied in Atlantic salmon following an acute intra peritoneal injection of a genetically attenuated (aroA(-)) strain of Aeromonas salmonicida known to elicit protective immunity. Three tissues were studied for transcriptional changes, the liver, head kidney and the gill. RNA was coll...

journal_title：Molecular immunology

authors： Martin SA,Blaney SC,Houlihan DF,Secombes CJ

更新日期：2006-04-01 00:00:00

abstract：:The monocyte chemoattractant protein-1 (MCP-1) functions to recruit monocytes and macrophages to areas of inflammation and is a prototypic chemokine subjected to coordinate regulation by immunomodulatory agents. TNF mediated regulation of MCP-1 occurs through a distal regulatory region located 2.5 kb upstream of the t...

journal_title：Molecular immunology

authors： Kumar SN,Boss JM

更新日期：2000-08-01 00:00:00

abstract：:The purpose of the present work was to determine the ability of BgTX peptides, corresponding to the various loops and exposed regions of alpha-bungarotoxin (BgTX) and representing regions that are recognized by B and/or T cells, to stimulate protective immunity in mice against in vivo challenge with BgTX. The BgTX LD5...

journal_title：Molecular immunology

authors： Dolimbek BZ,Atassi MZ

更新日期：1996-05-01 00:00:00

abstract：:Although the etiology of rheumatoid arthritis (RA) remains unknown, it has been widely suggested that RA has a genetic background. In humans, a copy number loss of 22q11.2, a region harboring the VPREB1 gene, has been suggested to be associated with several immunologic disorders, but there has been no study on the cop...

journal_title：Molecular immunology

authors： Yim SH,Chung YJ,Jin EH,Shim SC,Kim JY,Kim YS,Hu HJ,Shin SH,Pae HO,Zouali M,Chung HT

更新日期：2011-06-01 00:00:00

abstract：:Rainbow trout (Oncorhynchus mykiss) cells of a monocyte-macrophage lineage (rtMOCs) were used to characterize the ability of the trout innate immune system to recognize and respond to different pathogen associated molecular pattern (PAMP) bearing substances. Compared to what has been reported for mammalian macrophages...

journal_title：Molecular immunology

authors： Iliev DB,Liarte CQ,MacKenzie S,Goetz FW

更新日期：2005-06-01 00:00:00

abstract：:Age-related macular degeneration (AMD) and membranoproliferative glomerulonephritis type II (MPGN2) are dense deposit diseases that share a genetic association with complement genes and have complement proteins as important components of the dense deposits. Here, we present the case of a 64-year-old smoker male who de...

journal_title：Molecular immunology

authors： Montes T,Goicoechea de Jorge E,Ramos R,Gomà M,Pujol O,Sánchez-Corral P,Rodríguez de Córdoba S

更新日期：2008-05-01 00:00:00

abstract：:Many infections are associated with diabetes, as the ability of the body to fight pathogens is impaired. Recently, altered levels of defensins and polymorphism in Toll-like receptors (TLRs), two crucial components of the innate immune system, have been associated with diabetes. To study the functionality of the innate...

journal_title：Molecular immunology

authors： Froy O,Hananel A,Chapnik N,Madar Z

更新日期：2007-02-01 00:00:00

abstract：:T-lymphocyte proliferative responses were determined with peripheral blood lymphocytes (PBL), peritoneal exudate lymphocytes (PEL) and lymph node lymphocytes (LNL) of guinea pigs immunized with horse cytochrome c (HCytc). The proliferative response of PBL activated by peptide 81-104 from animals immunized with HCytc w...

journal_title：Molecular immunology

authors： Wang KM,Reichlin M

更新日期：1988-08-01 00:00:00

abstract：:Antibodies (Ab) are bifunctional molecules with two domains, a constant region (C) that confers effector properties and a variable (V) region responsible of antigen (Ag) binding. Historically the C and V regions were considered to be functionally independent, with Ag specificity being solely determined by the V region...

journal_title：Molecular immunology

authors： Janda A,Casadevall A

更新日期：2010-04-01 00:00:00

abstract：:The maintenance of intestinal tissue homeostasis is vital for the resistance against inflammatory bowel diseases (IBDs). Necroptosis is identified as an alternative mode of regulated cell death, which plays a pivotal role in tissue homeostasis. Thus, the roles of RIP3-mediated necroptosis in intestinal inflammation ha...

journal_title：Molecular immunology

authors： Zhang J,Qin D,Yang YJ,Hu GQ,Qin XX,Du CT,Chen W

更新日期：2019-03-01 00:00:00

abstract：:The major product of digestion of bovine IgG2a(A1) with immobilized pepsin is F(ab')2 while similar treatment of IgG2a(A2) yields Fab, Fc and other products. It is postulated that structural differences in the hinge region, including the absence of the most N-terminal disulfide bridge in IgG2a(A2) and a displacement o...

journal_title：Molecular immunology

authors： Heyermann H,Butler JE

更新日期：1987-12-01 00:00:00

abstract：:MAIT cells are innate-like T cells that are enriched in mucosal sites and tissues including adipose tissue and liver. They play an important role in immunity against microbial pathogens. Recently, it has been reported that MAIT cells could also be important in metabolic diseases and can be involved in setting up and m...

journal_title：Molecular immunology

authors： Toubal A,Lehuen A

更新日期：2021-02-01 00:00:00

abstract：:We have previously shown that immunization with SIV-, SHIV-, or HA (influenza hemagglutinin)-virus-like particles (VLPs) elicits a strong humoral immune response in mice. However, little is known about the action VLPs exert on immune effector cells, including B cells. In this study, we found that all three types of VL...

journal_title：Molecular immunology

authors： Zhang S,Cubas R,Li M,Chen C,Yao Q

更新日期：2009-06-01 00:00:00

abstract：:By binding to T cell Ig mucin-3 (Tim-3) expressed on different cells, galectin-9 (Gal-9) mediates two important functions, triggering T cell death and activating innate immune cells. The mechanisms by which ligation of the same molecule on different cell types mediates different effects are largely unclear. Gal-9 cont...

journal_title：Molecular immunology

authors： Li Y,Feng J,Geng S,Geng S,Wei H,Chen G,Li X,Wang L,Wang R,Peng H,Han G,Shen B,Li Y

更新日期：2011-01-01 00:00:00

abstract：:This study analyzes the gene repertoire coding for antibodies to an evolutionary novel immunogenic carbohydrate antigen in mice. The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) is an autoantigen, abundantly expressed in wild type mice, but absent in alpha 1,3galactosyltransferase knock-out (KO) mice, where i...

journal_title：Molecular immunology

authors： Chen ZC,Radic MZ,Galili U

更新日期：2000-06-01 00:00:00

abstract：:DC-SIGN (dendritic cell-specific ICAM-3-grabbing non-integrin) is a myeloid pathogen-attachment factor C-type lectin which recognizes mannose- and fucose-containing oligosaccharide ligands on clinically relevant pathogens. Intracellular signaling initiated upon ligand engagement of DC-SIGN interferes with TLR-initiate...

journal_title：Molecular immunology

authors： Sierra-Filardi E,Estecha A,Samaniego R,Fernández-Ruiz E,Colmenares M,Sánchez-Mateos P,Steinman RM,Granelli-Piperno A,Corbí AL

更新日期：2010-01-01 00:00:00

abstract：:Ig production by splenic human B cells that express different surface Ig isotypes were analysed in limiting dilution cultures. Therefore, FACS sorted IgM+, IgG+ and IgA1+ B cells were stimulated with PMA-activated EL4 thymoma cells as helper cells in the presence of IL-2 and IL-4. We found that at least every second B...

journal_title：Molecular immunology

authors： Brinkmann V,Müller S,Heusser CH

更新日期：1992-10-01 00:00:00