Role of MAIT cells in metabolic diseases.

abstract：:Epithelial surfaces constitute natural immunobarriers against environmental threats. These barriers are brimming with fluids that bind, transport, cleave or degrade bacterial cells and their endotoxic by-products. Saliva and the airway surface-lining fluid (ASL) comprise the important fluid constituents. Short palate,...

journal_title：Molecular immunology

authors： Zhou HD,Li GY,Yang YX,Li XL,Sheng SR,Zhang WL,Zhao J

更新日期：2006-04-01 00:00:00

abstract：:Many T cell responses are dominated by restricted TCR expression and can range from repeated usage of particular TCR Vbeta- and/or Valpha-elements, to the preferential usage of both V- and J-elements, often in conjunction with conserved V-D-J or V-J junctional sequences. Cytotoxic T lymphocytes specific for a Kb-restr...

journal_title：Molecular immunology

authors： Turner SJ,Carbone FR

更新日期：1998-04-01 00:00:00

abstract：:The insect gut participates in initial local immune responses by producing reactive oxygen and nitrogen species as well as anti-microbial peptides to resist pathogenic invasions. Nitric oxide (NO), a signaling and an immune effector molecule synthesized by the enzyme NO synthase (NOS), mediates an early step of the si...

journal_title：Molecular immunology

authors： Liu W,Wang Y,Leng Z,Wang Q,Duan X,Luo Y,Jiang Y,Qin L

更新日期：2020-10-01 00:00:00

abstract：:Human leukocyte antigens (HLA) allele determination is becoming an increasingly important aspect in the field of transplantation as well as in the area of HLA association with a number of diseases. Through Lebanon's history, this country, situated at a crossroads between Europe, Asia and Africa, has been a host for va...

journal_title：Molecular immunology

authors： Samaha H,Rahal EA,Abou-Jaoude M,Younes M,Dacchache J,Hakime N

更新日期：2003-07-01 00:00:00

abstract：:The carbohydrate binding properties of a novel member of the subfamily of galactose-specific jacalin-related lectin isolated from the bark of black mulberry (Morus nigra) (Morniga G) was studied in detail by enzyme-linked lectinosorbent and inhibition assays using panels of monomeric saccharides, mammalian polyvalent ...

journal_title：Molecular immunology

authors： Singh T,Wu JH,Peumans WJ,Rougé P,Van Damme EJ,Wu AM

更新日期：2007-01-01 00:00:00

abstract：:Recent studies have shown that aberrant activation of the complement system plays an important role in the pathogenesis of preeclampsia. There is evidence to suggest that aberrant activation of the complement system may already be present during the first trimester. Here, we performed a prospective study in which peri...

journal_title：Molecular immunology

authors： He YD,Xu BN,Wang ML,Wang YQ,Yu F,Chen Q,Zhao MH

更新日期：2020-04-16 00:00:00

abstract：:The etiology of multiple sclerosis (MS), particularly the environmental component of the disease, remains speculative. Recent reports have suggested that alterations in the gut microbiota of MS patients could contribute to the etiology or pathophysiology of the disease. In this Viewpoint, using PICRUSt (Phylogenetic I...

journal_title：Molecular immunology

authors： Montassier E,Berthelot L,Soulillou JP

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Spinal cord injury (SCI) is a neurological disease with high incidence and disability. In this paper, we made a foundational study in long non-coding RNA paternally expressed gene 10 (lncRNA PEG10) at PC-12 cells. METHODS:We used CCK8, flow cytometry, migration and invasion assay to detect changes at the cel...

journal_title：Molecular immunology

authors： Niu S,Ni Y,Niu T,Gao J

更新日期：2020-02-01 00:00:00

abstract：:The recovery of VDJ rearrangement is most often accomplished by PCR amplification of DNA extracted from mixtures of B-cells. Using this procedure in swine, VDJs containing chimeric V(H) genes that resemble gene-conversion products, are frequently encountered. To examine whether these chimeras could be the result of PC...

journal_title：Molecular immunology

authors： Sinkora M,Sun J,Butler JE

更新日期：2000-12-01 00:00:00

abstract：:The myobacterial factors and the associated mechanism by which Mycobacterium tuberculosis (Mtb) evades the host immune surveillance system remain widely unexplored. Here, we found that overexpressing Rv1016c, a mannosylated protein of M. tuberculosis in BCG (rBCG-Rv1016c) led to increased virulence of the recombined B...

journal_title：Molecular immunology

authors： Su H,Peng B,Zhang Z,Liu Z,Zhang Z

更新日期：2019-05-01 00:00:00

abstract：:Fibroblast-like synoviocyte (FLS) is the ultimate effectual cells in the pathogenesis of rheumatoid arthritis (RA). The current study was undertaken to investigate whether a proliferation-inducing ligand (APRIL) mediates the function of FLS in an animal model of RA. Rat adjuvant-induced arthritis (AA) was induced by i...

journal_title：Molecular immunology

authors： Chang Y,Jia X,Sun X,Xu S,Wu Y,Zhang L,Wei W

更新日期：2015-03-01 00:00:00

abstract：:Purified human C5 was converted non-enzymically to an activated form as defined by its ability to participate in reactive lysis. This conversion occurred following exposure to systems that generate oxygen radicals, namely addition of H2O2 in the presence of ascorbic acid and iron or the addition of xanthine oxidase, a...

journal_title：Molecular immunology

authors： Vogt W,Damerau B,von Zabern I,Nolte R,Brunahl D

更新日期：1989-12-01 00:00:00

abstract：:The C-terminal domain of protein 4.1G was identified to interact with the cytosolic tail of the high affinity IgG receptor, Fc gamma RI, in yeast two-hybrid screens. Proteins of the 4.1 family have previously been found to mediate receptor/cytoskeleton interactions. In the study presented here, we show an alternativel...

journal_title：Molecular immunology

authors： Beekman JM,Bakema JE,van der Poel CE,van der Linden JA,van de Winkel JG,Leusen JH

更新日期：2008-04-01 00:00:00

abstract：:Macrophages play an important role both in innate and adaptive immune responses. Treatment with interferon (IFN) γ together with lipopolysaccharide (LPS) activates pro-inflammatory macrophages which secrete various pro-inflammatory cytokines including IL-12. IL-12 promotes a Th1 type immune response by directly contro...

journal_title：Molecular immunology

authors： Boonyatecha N,Sangphech N,Wongchana W,Kueanjinda P,Palaga T

更新日期：2012-07-01 00:00:00

abstract：:CD8+ cytolytic T lymphocytes are essential players of anti-tumor immune responses. On tumors, they recognize peptides of about 8-to-10 amino acids that generally result from the degradation of cellular proteins by the proteasome. Until a decade ago, these peptides were thought to solely correspond to linear fragments ...

journal_title：Molecular immunology

authors： Vigneron N,Stroobant V,Ferrari V,Abi Habib J,Van den Eynde BJ

更新日期：2019-09-01 00:00:00

abstract：:A number of proteins with significant similarity to the tumour necrosis factor (TNF) have been identified over the last years. Upon interaction with their cognate receptor (members of the TNF-receptor family), all members of this protein family induce either cell death or proliferation/differentiation of the receptor-...

journal_title：Molecular immunology

authors： Peitsch MC,Tschopp J

更新日期：1995-07-01 00:00:00

abstract：:Lysozyme is an important component of the insect non-specific immune response against bacteria that is characterized by its ability to break down bacterial cell-walls. By searching an EST database from the fall armyworm, Spodoptera frugiperda (Negre et al., 2006), we identified five sequences encoding proteins of the ...

journal_title：Molecular immunology

authors： Chapelle M,Girard PA,Cousserans F,Volkoff NA,Duvic B

更新日期：2009-12-01 00:00:00

abstract：:Host-derived macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infection, especially in malarial anemia. Although two Plasmodium parasite-derived MIF orthologs, Plasmodium falciparum MIF and P. berghei MIF were identified recently, the crystal structure and the precise rol...

journal_title：Molecular immunology

authors： Shao D,Zhong X,Zhou YF,Han Z,Lin Y,Wang Z,Bu L,Zhang L,Su XD,Wang H

更新日期：2010-01-01 00:00:00

abstract：:Induction of the TCR signaling pathway terminates the expression of RAG genes, and a link between this pathway and their transcriptional control is evident from the recent demonstration of their re-expression if the TCR is subsequently lost or down-regulated. Since unstimulated T cells display a steady-state level of ...

journal_title：Molecular immunology

authors： Orlando L,Accomasso L,Circosta P,Turinetto V,Lantelme E,Porcedda P,Minieri V,Pautasso M,Willemsen RA,Cignetti A,Giachino C

更新日期：2011-07-01 00:00:00

abstract：:Amyloid-beta (Aβ) plaque accumulation in the brain is one of the hallmarks of Alzheimer's disease (AD). Immunotherapy against Aβ was considered a potential strategy for reducing the Aβ load in the brain. However, none of the Aβ immunotherapies have produced clinically meaningful results to date, due to poor safety or ...

journal_title：Molecular immunology

authors： Fu L,Guo Y,Sun Y,Dong Y,Wu J,Yu B,Zhang H,Yu X,Wu H,Kong W

更新日期：2018-09-01 00:00:00

abstract：:Interplay between complement factors, regulatory proteins, anaphylatoxins and cytokines could be involved in tendon healing and scar formation. The expression and regulation of complement factors by cytokines or anaphylatoxins are completely unclear in tendon. Hence, the gene expression of the anaphylatoxin receptors ...

journal_title：Molecular immunology

authors： Busch C,Girke G,Kohl B,Stoll C,Lemke M,Krasnici S,Ertel W,Silawal S,John T,Schulze-Tanzil G

更新日期：2013-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a typical autoimmune disease with unclear etiology. Aberrant self-DNA recognition has been proven critical for the initiation of excessive immune responses in lupus. Consistently, we previously reported that a sort of self-DNA, activated lymphocyte-derived DNA (ALD-DNA) could pote...

journal_title：Molecular immunology

authors： Li X,Yue Y,Zhu Y,Xiong S

更新日期：2015-05-01 00:00:00

abstract：:The capability of NK lymphocytes to kill tumor cells depends on different receptors/ligands interactions. In order to identify the cellular ligands recognized by "orphan" triggering receptors, mice were immunized with NK susceptible target cells. mAbs were selected that inhibited NK cytotoxicity and recognized two dif...

journal_title：Molecular immunology

authors： Pende D,Bottino C,Castriconi R,Cantoni C,Marcenaro S,Rivera P,Spaggiari GM,Dondero A,Carnemolla B,Reymond N,Mingari MC,Lopez M,Moretta L,Moretta A

更新日期：2005-02-01 00:00:00

abstract：:Peptide fragments of pertussis toxin subunit 1 (PT-S1) have been synthesized in order to investigate their antigenic and immunogenic activity, and to evaluate their possible use as components of a new vaccine. Two peptides (sequence 73-82, EAERAGRGTG and sequence 107-116, YVDTYGDNAG) were selected for their predictabl...

journal_title：Molecular immunology

authors： Presentini R,Perin F,Ancilli G,Nucci D,Bartoloni A,Rappuoli R,Antoni G

更新日期：1989-01-01 00:00:00

abstract：:Linear IgE-binding epitopes identified in legumin allergens of peanut (Ara h 3) and other allergenic tree nuts (Jug r 4 of walnut, Cor a 9 of hazelnut, Ana o 2 cashew nut) were mapped on three-dimensional models of the proteins built up by homology modelling. A conformational analysis revealed that consensual surface-...

journal_title：Molecular immunology

authors： Barre A,Jacquet G,Sordet C,Culerrier R,Rougé P

更新日期：2007-05-01 00:00:00

abstract：:This study analyzes the gene repertoire coding for antibodies to an evolutionary novel immunogenic carbohydrate antigen in mice. The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) is an autoantigen, abundantly expressed in wild type mice, but absent in alpha 1,3galactosyltransferase knock-out (KO) mice, where i...

journal_title：Molecular immunology

authors： Chen ZC,Radic MZ,Galili U

更新日期：2000-06-01 00:00:00

abstract：:Autoimmunity is fundamentally a continuously evolving process. The autoimmune responses shift, drift and diversify with time not only to other epitopes in the original antigen but also to other related and sometimes to unrelated antigens. We have described a form of immune diversification--reciprocal T-B epitope sprea...

journal_title：Molecular immunology

authors： Singh RR

更新日期：2004-02-01 00:00:00

abstract：:ANCA associated vasculitis is a serious, very often recurrent disease that despite the current standard treatment with high-dose glucocorticoids and either cyclophosphamide or rituximab, patients have a nine-fold increased mortality risk in the first year compared with healthy controls, attributed to infections, vascu...

journal_title：Molecular immunology

authors： Quintana LF,Kronbichler A,Blasco M,Zhao MH,Jayne D

更新日期：2019-08-01 00:00:00

abstract：:Chicken and turkey beta 2-m were isolated from citrated plasma in sequential use of three chromatographic steps: affinity chromatography, gel filtration chromatography and anion-exchange chromatography. The purified protein was identified as beta 2-m by reaction with a beta 2-m specific monoclonal antibody and by the ...

journal_title：Molecular immunology

authors： Skjødt K,Welinder KG,Crone M,Verland S,Salomonsen J,Simonsen M

更新日期：1986-12-01 00:00:00

abstract：:A monoclonal antibody (vpg15) has been described which can block infection with feline immunodeficiency virus (FIV) and which recognizes the feline homologue of CD9. In order to study the role of feline CD9 in infection with FIV we have molecularly cloned a cDNA encoding feline CD9 by R.A.C.E (rapid amplification of c...

journal_title：Molecular immunology

authors： Willett BJ,Neil JC

更新日期：1995-04-01 00:00:00