Circular Dichroism reveals evidence of coupling between immunoglobulin constant and variable region secondary structure.

abstract：:Since secretion of IgE antibodies is known to be blocked by tunicamycin, the first aim of the present study was to determine at which step of glycosylation or processing secretion was restored. For this purpose, murine hybridoma cells secreting an anti beta-lactoglobulin IgE were incubated either in the presence of in...

journal_title：Molecular immunology

authors： Granato DA,Neeser JR

更新日期：1987-08-01 00:00:00

abstract：:Dendritic cells (DCs) serve to maintain peripheral tolerance under steady state conditions. Upon triggering by activation signals they initiate strong immune responses. The activation of DCs is accompanied by a rapid upregulation of proinflammatory cytokines, which were shown in other cell types to be regulated by mec...

journal_title：Molecular immunology

authors： Bros M,Wiechmann N,Besche V,Art J,Pautz A,Grabbe S,Kleinert H,Reske-Kunz AB

更新日期：2010-02-01 00:00:00

abstract：:Tumors exploit immunoregulatory checkpoints that serve to attenuate T cell responses as a means of circumventing immunologic rejection. Programmed death ligand 1 (PD-L1) is a negative regulator of T cell function and is frequently expressed by solid tumors. By engaging programmed death 1 (PD-1) on activated T cells, P...

journal_title：Molecular immunology

authors： Prosser ME,Brown CE,Shami AF,Forman SJ,Jensen MC

更新日期：2012-07-01 00:00:00

abstract：:The expression levels of three commonly used housekeeping genes, EF1-alpha, RPS20 and Beta-Actin, were examined in seven different tissues and leucocytes from non-stimulated Atlantic salmon (Salmo salar L.). The tissues analysed by quantitative real-time PCR were gill, liver, intestine, muscle, spleen, head kidney leu...

journal_title：Molecular immunology

authors： Ingerslev HC,Pettersen EF,Jakobsen RA,Petersen CB,Wergeland HI

更新日期：2006-03-01 00:00:00

abstract：:We have examined the properties of soluble guanylate cyclase activity in the human neutrophil. The enzyme showed complex regulation by metal ions. A 10-fold higher activity was observed in the presence of Mn2+ than Mg2+, while Ca2+ caused an increase in activity only in the presence of Mg2+ ion. Sodium nitroprusside (...

journal_title：Molecular immunology

authors： Lad PM,Glovsky MM,Richards JH,Smiley PA,Backstrom B

更新日期：1985-07-01 00:00:00

abstract：:We describe the entire immunoglobulin heavy chain (IgH) locus from the reptile Anolis carolinensis. The heavy chain constant (C(H)) region includes C mu, C delta and C upsilon genes. This is the first description of a C upsilon gene in the reptilian class. Variable (V(H)), diversity (D(H)) and joining (J(H)) genes are...

journal_title：Molecular immunology

authors： Gambón Deza F,Sánchez Espinel C,Magadán Mompó S

更新日期：2009-05-01 00:00:00

abstract：:The capability of NK lymphocytes to kill tumor cells depends on different receptors/ligands interactions. In order to identify the cellular ligands recognized by "orphan" triggering receptors, mice were immunized with NK susceptible target cells. mAbs were selected that inhibited NK cytotoxicity and recognized two dif...

journal_title：Molecular immunology

authors： Pende D,Bottino C,Castriconi R,Cantoni C,Marcenaro S,Rivera P,Spaggiari GM,Dondero A,Carnemolla B,Reymond N,Mingari MC,Lopez M,Moretta L,Moretta A

更新日期：2005-02-01 00:00:00

abstract：:In this paper we report a chemometric approach to Quantitative Structure-Activity Relationship (QSAR) analysis applied to a study of the binding of peptides to Major Histocompatibility Complex (MHC) class I proteins. Peptides which possess the known primary anchor residue motif for HLA-B27 binding do not necessarily b...

journal_title：Molecular immunology

authors： Rovero P,Riganelli D,Fruci D,Viganò S,Pegoŕaro S,Revoltella R,Greco G,Butler R,Clementi S,Tanigaki N

更新日期：1994-05-01 00:00:00

abstract：:Cathepsin L protease belongs to the papain-like cysteine proteases family, plays indispensable roles in animals' pathological and physiological processes. However, little is known about Cathepsin L in silkworm, Bombyx mori. Herein, a novel Cathepsin L-like (Cat L-like) was cloned and identified from silkworm by the ra...

journal_title：Molecular immunology

authors： Pan G,Zhang K,Li C,Hu X,Kausar S,Gu H,Yang L,Cui H

更新日期：2020-12-26 00:00:00

abstract：:The structural and functional integrity of the cell is largely maintained by protein-protein interactions. Recently, we demonstrated that multiple antigenic peptides (MAPs) constructed from 60 kDa Ro sequence could be used to show intramolecular and intermolecular protein-protein interaction within the 60 kDa Ro ribon...

journal_title：Molecular immunology

authors： Scofield RH,Kurien BT,Gross JK,Reed NB,Taylor AK,Dominguez N,Mehta P,Guthridge JM,Bachmann M

更新日期：2004-07-01 00:00:00

abstract：:Spondyloarthritis is the second most common form of chronic inflammatory arthritis and a unique hallmark of the disease is pathologic new bone formation. Several cytokine pathways have been genetically associated with ankylosing spondylitis (AS), the prototypic subtype of SpA, and additional evidence from human and an...

journal_title：Molecular immunology

authors： Hreggvidsdottir HS,Noordenbos T,Baeten DL

更新日期：2014-01-01 00:00:00

abstract：:Interleukin 1 receptor-associated kinase 4 (IRAK4) is a key factor in TLR-mediated host immune function. In this study, an IRAK4 homologue molecule was identified from Apostichopus japonicus (designated as AjIRAK4) by RACE approach. The full-length cDNA of AjIRAK4 was of 2024 bp containing an open reading frame of 131...

journal_title：Molecular immunology

authors： Cui Y,Jiang L,Xing R,Wang Z,Wang Z,Shao Y,Zhang W,Zhao X,Li C

更新日期：2018-09-01 00:00:00

abstract：:Pathogen-driven selection is believed to be important in the evolution and maintenance of the polymorphism of the major histocompatibility complex (MHC) genes but have been tested for very few vertebrates. In this study, we first investigate by SSCP (single strand conformational polymorphism) the diversity found at th...

journal_title：Molecular immunology

authors： Croisetière S,Tarte PD,Bernatchez L,Belhumeur P

更新日期：2008-06-01 00:00:00

abstract：:Most cells are believed to be capable of producing type I interferons (IFN I) as part of an innate immune response against, for instance, viral infections. In macrophages, IFN I is potently induced upon cytoplasmic exposure to foreign nucleic acids. Infection of these cells with herpesviruses leads to triggering of th...

journal_title：Molecular immunology

authors： Gram AM,Sun C,Landman SL,Oosenbrug T,Koppejan HJ,Kwakkenbos MJ,Hoeben RC,Paludan SR,Ressing ME

更新日期：2017-11-01 00:00:00

abstract：:Aberrant O-glycosylation of cell surface mucin antigens is characteristic of epithelial cancer cells. For example, Thomsen-Friedenreich disaccharide (TFD) is a chemically well-defined carbohydrate antigen with a documented link to malignancy. There have been many attempts to improve immune response to carbohydrate ant...

journal_title：Molecular immunology

authors： Irazoqui FJ,Lopez PH,Mandel U,Nores GA

更新日期：2002-03-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection afflicts over 350 million people worldwide and is a leading cause of hepatitis, cirrhosis and hepatocellular carcinoma. HBV replicates noncytopathically in hepatocytes, and most of the hepatic injury is caused by the immune response to the virus. While most studies focused on the adap...

journal_title：Molecular immunology

authors： Qu Z,Liang X,Liu Y,Du J,Liu S,Sun W

更新日期：2009-12-01 00:00:00

abstract：:We have previously developed a number of monoclonal antibodies (Mabs) that bind to protamine. One of these antibodies, Hup1N, binds to human protamine 1 but not to protamine 2. In contrast, Mab HupA binds both protamine 1 and protamine 2. The epitopes for these two Mabs were observed to overlap, and were localized to ...

journal_title：Molecular immunology

authors： Stanker LH,Wyrobek A,McKeown C,Balhorn R

更新日期：1993-12-01 00:00:00

abstract：:Effective use of adenovirus-5 (Ad5) in cancer therapy is heavily dependent on the degree to which the virus's natural tropism can be subverted to one that favours tumour cells. This is normally achieved through either engineering of the viral fiber knob or the use of bispecific adaptors that display both adenovirus an...

journal_title：Molecular immunology

authors： Vasiljevic S,Beale EV,Bonomelli C,Easthope IS,Pritchard LK,Seabright GE,Caputo AT,Scanlan CN,Dalziel M,Crispin M

更新日期：2015-12-01 00:00:00

abstract：:Grass pollens are amongst the most important aeroallergen sources world-wide triggering allergic rhinoconjunctivitis and asthma in sensitised patients. Much of what we know about the allergen components of grasses is informed by research on pollen of temperate (Pooideae) species that are abundant in the temperate clim...

journal_title：Molecular immunology

authors： Kailaivasan T,Davies JM

更新日期：2018-08-01 00:00:00

abstract：:A number of studies have showed that High mobility group box-1 (HMGB1), which played key role in inflammation activation by triggering the toll like receptor 4 (TLR4) signaling axis in hepatic fibrogenesis, may share similar inflammation stimulating mechanism with LPS. Herein, we introduced a recently established anti...

journal_title：Molecular immunology

authors： Zhang H,Liu Z,Liu S

更新日期：2016-01-01 00:00:00

abstract：:The disialoganglioside GalAcbeta1-4(NeuAcalpha2-8NeuAcalpha2-3)Galbeta1-4Glcbeta1-1Cer (GD2) is expressed on various tumors, including neuroblastoma, and was defined as a relevant tumor antigen. The monoclonal anti-GD2 antibody 14.18 is widely used for diagnostic purposes in neuroblastoma, and in its mouse/human chime...

journal_title：Molecular immunology

authors： Förster-Waldl E,Riemer AB,Dehof AK,Neumann D,Brämswig K,Boltz-Nitulescu G,Pehamberger H,Zielinski CC,Scheiner O,Pollak A,Lode H,Jensen-Jarolim E

更新日期：2005-02-01 00:00:00

abstract：:Cutaneous leishmaniasis (CL) mainly caused by Leishmania braziliensis is a chronic inflammatory disease widely spread in Brazil. Genetic variant strains of this parasite have been associated with atypical clinical manifestations of CL in an endemic area in Brazil. Furthermore, these strains have presented distinct bio...

journal_title：Molecular immunology

authors： Rêgo FD,Fradico JRB,Teixeira-Carvalho A,Gontijo CMF

更新日期：2019-02-01 00:00:00

abstract：:A computerized method for predicting the locations of protein antigenic determinants is presented, which requires only the amino acid sequence of a protein, and no other information. This procedure has been used to predict the major antigenic determinant of the hepatitis B surface antigen, as well as antigenic sites o...

journal_title：Molecular immunology

authors： Hopp TP,Woods KR

更新日期：1983-04-01 00:00:00

abstract：:When mouse dendritic cells (DCs) are isolated from tissues, purified and placed in a nutritive culture they die more rapidly than would be expected from their normal turnover in vivo. This can distort culture assays of DC function. We therefore tested several approaches to prolonging DC survival in culture. Of several...

journal_title：Molecular immunology

authors： Vremec D,Hansen J,Strasser A,Acha-Orbea H,Zhan Y,O'Keeffe M,Shortman K

更新日期：2015-02-01 00:00:00

abstract：:The KH type splicing regulatory protein (KSRP) is a nucleic acid binding protein, which negatively regulates the stability and/or translatability of many mRNA species encoding immune-relevant proteins. As KSRP is expressed in immune cells including T and B cells, neutrophils, macrophages and dendritic cells, we wanted...

journal_title：Molecular immunology

authors： Käfer R,Schrick K,Schmidtke L,Montermann E,Hobernik D,Bros M,Chen CY,Kleinert H,Pautz A

更新日期：2017-07-01 00:00:00

abstract：:This paper reports the cloning and sequencing of two pro-inflammatory cytokines, interleukin (IL)-1beta and IL-8, in haddock (Melanogrammus aeglefinus) by homology cloning. The complete transcript of the haddock IL-1beta was sequenced and contained 1043 bp, including a 762 bp open reading frame. The 3' end of the gene...

journal_title：Molecular immunology

authors： Corripio-Miyar Y,Bird S,Tsamopoulos K,Secombes CJ

更新日期：2007-02-01 00:00:00

abstract：:A common feature of human IgG1 antibodies used for cancer treatment is that their anti-tumour efficacy requires high serum trough levels and continued therapy for several months. Treatment cycles, thereby, consume several grams of IgG1 translating into significant drug needs and costs. The basis for the low in vivo ef...

journal_title：Molecular immunology

authors： Preithner S,Elm S,Lippold S,Locher M,Wolf A,da Silva AJ,Baeuerle PA,Prang NS

更新日期：2006-03-01 00:00:00

abstract：:Fibroblast-like synoviocyte (FLS) is the ultimate effectual cells in the pathogenesis of rheumatoid arthritis (RA). The current study was undertaken to investigate whether a proliferation-inducing ligand (APRIL) mediates the function of FLS in an animal model of RA. Rat adjuvant-induced arthritis (AA) was induced by i...

journal_title：Molecular immunology

authors： Chang Y,Jia X,Sun X,Xu S,Wu Y,Zhang L,Wei W

更新日期：2015-03-01 00:00:00

abstract：:The cell-surface receptor ST2L triggers cytokine release by immune cells upon exposure to its ligand IL-33. To study the effect of ST2L-dependent signaling in different cell types, we generated antagonist antibodies that bind different receptor domains. We sought to characterize their activities in vitro using both tr...

journal_title：Molecular immunology

authors： Fursov N,Lu J,Healy C,Wu SJ,Lacy E,Filer A,Li Y,Liu C,Lamb R,Jones B,Reddy R,Petley T,Duffy K

更新日期：2016-07-01 00:00:00

abstract：:Maspin (mammary serine protease inhibitor) is a non-inhibitory member of the serine protease inhibitor superfamily and a tumor suppressor in several cancers due to its ability to inhibit cell invasion, angiogenesis, and promote apoptosis. However, its immunomodulatory function remains largely unexplored. Thus, we expl...

journal_title：Molecular immunology

authors： Wang Y,Sun L,Song Z,Wang D,Bao Y,Li Y

更新日期：2017-02-01 00:00:00