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Identification of MHC class IIbeta resistance/susceptibility alleles to Aeromonas salmonicida in brook charr (Salvelinus fontinalis).

Abstract：

:Pathogen-driven selection is believed to be important in the evolution and maintenance of the polymorphism of the major histocompatibility complex (MHC) genes but have been tested for very few vertebrates. In this study, we first investigate by SSCP (single strand conformational polymorphism) the diversity found at the MHC class IIbeta gene in a population of brook charr (Salvelinus fontinalis) from the Rupert River (Québec, Canada). Secondly, to explore the survival performances conferred by specific alleles and genotypes, individuals from 23 half- and full-sibling families were infected with Aeromonas salmonicida, the causative agent of furonculosis. From the initial brook charr population, a total of six MHC class IIbeta alleles were identified; four complete and two partial coding sequences that include the complete polymorphic beta1 domain. One allele, Safo-DAB*0101, was significantly associated with resistance against A. salmonicida. In addition to homozygotes for this allele, its resistance effect was also detected in heterozygotes for two specific genotypes. Other allelic combinations, namely heterozygous genotypes Safo-DAB*0201/*0301 and Safo-DAB*0301/*0401 were significantly associated with increased susceptibility to furonculosis. Given that its frequency was relatively low (0.0873), the negative frequency-dependent selection hypothesis could explain the advantage associated with the allele Safo-DAB*0101 over the other alleles and highlight the importance of this mechanism to sustain variation at the MHC in brook charr.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Croisetière S,Tarte PD,Bernatchez L,Belhumeur P

doi

10.1016/j.molimm.2008.03.007

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

3107-16

issue

11

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(08)00125-9

journal_volume

45

pub_type

杂志文章

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