当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > The Jak-STAT pathway.

The Jak-STAT pathway.

Abstract：

:A variety of important cellular functions are regulated by cytokines. The Jak-STAT pathway is one of the important signaling pathways downstream of cytokine receptors. Following binding of a ligand to its cognate receptor, receptor-associated Jaks are activated. STAT proteins are then in turn activated by tyrosine phosphorylation by Jak kinases, allowing their dimerization and subsequent translocation into the nucleus, where they modulate expression of target genes. Indispensable functions of Jaks and STATs in cytokine signaling in vivo have been revealed through knockout mouse studies. Moreover, the recent discovery of the CIS/SOCS/JAB/SSI family of inhibitors has contributed to understanding how this pathway is negatively regulated.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Imada K,Leonard WJ

doi

10.1016/s0161-5890(00)00018-3

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

1-11

issue

1-2

eissn

0161-5890

issn

1872-9142

pii

S0161589000000183

journal_volume

37

pub_type

杂志文章,评审

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • Differences in endocytosis mediated by FcγRIIA and FcγRIIB2.

    abstract：:An important function of Fcγ receptors is the removal of IgG-containing immune complexes from the circulation. The activating receptor FcγRIIA and inhibitory receptor FcγRIIB2 are both expressed on human myeloid cells, and are both capable of mediating endocytosis of immune complexes. We studied endocytosis of these t...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2011.09.003

    authors： Zhang CY,Booth JW

    更新日期：2011-10-01 00:00:00

  • The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus.

    abstract：:Cattle antibodies have unusually long CDR3 loops in their heavy chains (HCs), and limited light chain (LC) diversity, raising the question of whether these mask the effect of LC variation on antigen recognition. We have investigated the role of the LC in the structure and activity of two neutralizing cattle antibodies...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.04.026

    authors： Ren J,Nettleship JE,Harris G,Mwangi W,Rhaman N,Grant C,Kotecha A,Fry E,Charleston B,Stuart DI,Hammond J,Owens RJ

    更新日期：2019-08-01 00:00:00

  • A priori delineation of a peptide which mimics a discontinuous antigenic determinant.

    abstract：:A technique was developed for identifying peptides with high affinity for a given antibody. By testing a monoclonal antibody directed against a discontinuous antigenic determinant on foot-and-mouth disease virus, peptides mimicking the determinant were identified even though the tertiary structure of the proteins comp...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90081-7

    authors： Geysen HM,Rodda SJ,Mason TJ

    更新日期：1986-07-01 00:00:00

  • HLA class II allele frequencies in the Lebanese population.

    abstract：:Human leukocyte antigens (HLA) allele determination is becoming an increasingly important aspect in the field of transplantation as well as in the area of HLA association with a number of diseases. Through Lebanon's history, this country, situated at a crossroads between Europe, Asia and Africa, has been a host for va...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(03)00073-7

    authors： Samaha H,Rahal EA,Abou-Jaoude M,Younes M,Dacchache J,Hakime N

    更新日期：2003-07-01 00:00:00

  • The TNFα converting enzyme (TACE) from ayu (Plecoglossus altivelis) exhibits TNFα shedding activity.

    abstract：:TNFα converting enzyme (TACE) is responsible for converting membrane-anchored TNFα to its soluble form in mammalian. However, the function and characteristics of TACE in teleosts is unclear. In this study, we report the cloning of a cDNA sequence of the PaTACE from ayu, Plecoglossus altivelis. PaTACE encodes an 865-aa...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2014.10.010

    authors： Lu XJ,Chen Q,Yang GJ,Chen J

    更新日期：2015-02-01 00:00:00

  • Src-family kinases: rheostats of immune cell signaling.

    abstract：:In immune cells, Src-family kinases have been implicated as critical regulators of a large number of intracellular signaling pathways. Studies of gene knockout mice lacking various family members have both confirmed the requirement for these kinases in some pathways and provided surprising insight into their roles in ...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2004.04.010

    authors： Lowell CA

    更新日期：2004-07-01 00:00:00

  • Activation of NF-κB induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque.

    abstract：:TRIMCyp generated by retrotransposition of a cyclophilin A inserting into TRIM5 locus, has been identified in owl monkey and most of Old World monkeys (OWM). Owl monkey TRIMCyp (omTRIMCyp) inhibits HIV-1 infection by direct interaction with viral capsid and indirect innate immune induction, whereas most of TRIMCyps fr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2018.08.001

    authors： Zhu JW,Mu D,Liu FL,Luo MT,Luo RH,Zheng YT

    更新日期：2018-09-01 00:00:00

  • The interaction between C/EBPβ and TFAM promotes acute kidney injury via regulating NLRP3 inflammasome-mediated pyroptosis.

    abstract：:Sepsis-induced inflammatory damage is a crucial cause of acute kidney injury (AKI), and AKI is an ecumenical fearful complication in approximately half of patients with sepsis. CCAAT/enhancer-binding protein β (C/EBPβ) plays roles in regulating acute phase responses and inflammation. However, the role and mechanism of...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.08.023

    authors： Dai XG,Li Q,Li T,Huang WB,Zeng ZH,Yang Y,Duan ZP,Wang YJ,Ai YH

    更新日期：2020-11-01 00:00:00

  • Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses.

    abstract：:Bacterial lipopolysaccharide (LPS) activates the innate immune system by forming a complex with myeloid differentiation factor 2 (MD-2) and Toll-like receptor 4 (TLR4), which is present on antigen presenting cells. MD-2 plays an essential role in this activation of the innate immune system as a member of the ternary c...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2015.08.008

    authors： Mattis DM,Chervin AS,Ranoa DR,Kelley SL,Tapping RI,Kranz DM

    更新日期：2015-12-01 00:00:00

  • MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement.

    abstract：:Mannose-binding lectin (MBL) and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pa...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2009.05.005

    authors： Garred P,Honoré C,Ma YJ,Munthe-Fog L,Hummelshøj T

    更新日期：2009-09-01 00:00:00

  • Cloning and expression analysis of two pro-inflammatory cytokines, IL-1 beta and IL-8, in haddock (Melanogrammus aeglefinus).

    abstract：:This paper reports the cloning and sequencing of two pro-inflammatory cytokines, interleukin (IL)-1beta and IL-8, in haddock (Melanogrammus aeglefinus) by homology cloning. The complete transcript of the haddock IL-1beta was sequenced and contained 1043 bp, including a 762 bp open reading frame. The 3' end of the gene...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.05.010

    authors： Corripio-Miyar Y,Bird S,Tsamopoulos K,Secombes CJ

    更新日期：2007-02-01 00:00:00

  • RIP2-beta: a novel alternative mRNA splice variant of the receptor interacting protein kinase RIP2.

    abstract：:RIP2/RICK/CARDIAK is a member of the receptor interacting protein kinase (RIP) family. RIP2 promotes NF-kappaB activation as well as activation of the MAPKs JNK, ERK1/2 and p38 MAPK, thereby playing an emergent role in the innate immune response and NOD signaling. Moreover, RIP2 has been shown to interact with the CAR...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.11.002

    authors： Krieg A,Le Negrate G,Reed JC

    更新日期：2009-03-01 00:00:00

  • Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies.

    abstract：:Peptide gpMBP72-85, containing amino acids 72-85 of guinea pig myelin basic protein is commonly used to induce experimental autoimmune encephalomyelitis in Lewis rats. The N-terminal glutamine in this peptide can cyclize to pyroglutamic acid, leading to loss of the first MHC anchor for binding to MHC class II. Acetyla...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2003.10.015

    authors： de Haan EC,Wauben MH,Wagenaar-Hilbers JP,Grosfeld-Stulemeyer MC,Rijkers DT,Moret EE,Liskamp RM

    更新日期：2004-02-01 00:00:00

  • Knockdown PEG10 deteriorates H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX.

    abstract：OBJECTIVE:Spinal cord injury (SCI) is a neurological disease with high incidence and disability. In this paper, we made a foundational study in long non-coding RNA paternally expressed gene 10 (lncRNA PEG10) at PC-12 cells. METHODS:We used CCK8, flow cytometry, migration and invasion assay to detect changes at the cel...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.11.012

    authors： Niu S,Ni Y,Niu T,Gao J

    更新日期：2020-02-01 00:00:00

  • IL-12 and IL-23 modulate plasticity of FoxP3+ regulatory T cells in human Leprosy.

    abstract：:Leprosy is a bacterial disease caused by M. leprae. Its clinical spectrum reflects the host's immune response to the M. leprae and provide an ideal model to investigate the host pathogen interaction and immunological dysregulation. Tregs are high in leprosy patients and responsible for immune suppression of the host b...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.01.008

    authors： Tarique M,Saini C,Naqvi RA,Khanna N,Sharma A,Rao DN

    更新日期：2017-03-01 00:00:00

  • NF-kappaB is essential for induction of pro-inflammatory cytokine genes by filarial parasitic sheath proteins.

    abstract：:The transcription factor NF-kappaB plays critical roles in immune and inflammatory responses. Here we show that filarial parasitic sheath proteins cause activation of NF-kappaB in the airway epithelial HEp-2 cell line. This activation was transient and saturable, and involved degradation of the cytoplasmic inhibitor p...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(00)00039-0

    authors： Narayanan K,Balakrishnan A,Miyamoto S

    更新日期：2000-02-01 00:00:00

  • Selection of human antibodies against cell surface-associated oligomeric anthrax protective antigen.

    abstract：:The protective antigen (PA(83)) of Bacillus anthracis is the dominant antigen in natural and vaccine-induced immunity to anthrax infection. Three human single-chain variable fragments (scFvs) against cell bound PA were isolated from an antibody phage display library. Specifically, the antibodies were evaluated for the...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.11.011

    authors： Steiniger SC,Altobell LJ 3rd,Zhou B,Janda KD

    更新日期：2007-04-01 00:00:00

  • The expanding role of innate lymphoid cells and their T-cell counterparts in gastrointestinal cancers.

    abstract：:Innate lymphoid cells (ILCs) contribute to the regulation of gastrointestinal (GI) homeostasis. Over the past 15 years, there has been a large effort to dissect the mechanisms required for GI homeostasis, with a major focus on different immune cell populations and the cytokines that they produce. In contrast to T-help...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2017.11.013

    authors： Fung KY,Nguyen PM,Putoczki T

    更新日期：2019-06-01 00:00:00

  • Identification of potential transcriptomic markers in developing asthma: An integrative analysis of gene expression profiles.

    abstract：:The goal of this study was to identify potential transcriptomic markers in developing asthma by an integrative analysis of multiple public microarray data sets. Using the R software and bioconductor packages, we performed a statistical analysis to identify differentially expressed (DE) genes in asthma, and further per...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.09.021

    authors： Fang F,Pan J,Li Y,Li Y,Feng X,Wang J

    更新日期：2017-12-01 00:00:00

  • Targeting STAT3 phosphorylation by neem leaf glycoprotein prevents immune evasion exerted by supraglottic laryngeal tumor induced M2 macrophages.

    abstract：:Tumor-associated macrophages (TAMs) are preferentially M2 skewed and promote tumor growth, angiogenesis, invasion, and/or metastasis. In this study, we have analyzed the in vitro immunomodulatory potential of a non-toxic neem leaf glycoprotein (NLGP) in reprogramming Stage III supraglottic laryngeal tumor cell lysate ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2014.01.015

    authors： Goswami KK,Barik S,Sarkar M,Bhowmick A,Biswas J,Bose A,Baral R

    更新日期：2014-06-01 00:00:00

  • The RNA binding protein tristetraprolin influences the activation state of murine dendritic cells.

    abstract：:Dendritic cells (DCs) serve to maintain peripheral tolerance under steady state conditions. Upon triggering by activation signals they initiate strong immune responses. The activation of DCs is accompanied by a rapid upregulation of proinflammatory cytokines, which were shown in other cell types to be regulated by mec...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.11.002

    authors： Bros M,Wiechmann N,Besche V,Art J,Pautz A,Grabbe S,Kleinert H,Reske-Kunz AB

    更新日期：2010-02-01 00:00:00

  • PECAM-1-regulated signalling thresholds control tolerance in anergic transgenic B-cells.

    abstract：:Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) is an immunoglobulin (Ig)-immunoreceptor tyrosine based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, predominantly SHP-2 and to a lesser extent, SHP-1. Previously, we have shown that deletion of PEC...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.09.024

    authors： Wong MX,Hayball JD,Jackson DE

    更新日期：2008-03-01 00:00:00

  • Site A of the MCP-1 distal regulatory region functions as a transcriptional modulator through the transcription factor NF1.

    abstract：:The monocyte chemoattractant protein-1 (MCP-1) functions to recruit monocytes and macrophages to areas of inflammation and is a prototypic chemokine subjected to coordinate regulation by immunomodulatory agents. TNF mediated regulation of MCP-1 occurs through a distal regulatory region located 2.5 kb upstream of the t...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(00)00097-3

    authors： Kumar SN,Boss JM

    更新日期：2000-08-01 00:00:00

  • Molecular patterns in the isotype-specific antibody responses to the major cedar aeroallergen Jun a 1.

    abstract：:Most studies of the immune responses in allergic rhinitis have focused on IgE antibodies to mixtures of allergenic proteins. Based on our previous studies of the major mountain cedar allergen Jun a 1, we sought to describe a broader assessment of the humoral immune responses to a single, dominant allergen, in three gr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2018.08.007

    authors： Goldblum RM,Madagoda-Desilva RS,Zhang Y,van Bavel J,Midoro-Horiuti T

    更新日期：2018-09-01 00:00:00

  • Inactivation of the KSRP gene modifies collagen antibody induced arthritis.

    abstract：:The KH type splicing regulatory protein (KSRP) is a nucleic acid binding protein, which negatively regulates the stability and/or translatability of many mRNA species encoding immune-relevant proteins. As KSRP is expressed in immune cells including T and B cells, neutrophils, macrophages and dendritic cells, we wanted...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.05.003

    authors： Käfer R,Schrick K,Schmidtke L,Montermann E,Hobernik D,Bros M,Chen CY,Kleinert H,Pautz A

    更新日期：2017-07-01 00:00:00

  • Identification and characterisation of human Junctional Adhesion Molecule (JAM).

    abstract：:It is widely believed that migrating immune cells utilise the intercellular junctions as routes of passage, and in doing so cause the transient disruption of junctional structures. Thus there is much interest in the molecules that have been identified at cell-cell contact points and their potential involvement in the ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(99)00122-4

    authors： Williams LA,Martin-Padura I,Dejana E,Hogg N,Simmons DL

    更新日期：1999-12-01 00:00:00

  • Dendritic cell development in infection.

    abstract：:The immune system protects from infections primarily by detecting and eliminating invading pathogens. This is predominantly mediated by innate immune cells like neutrophils, monocytes and dendritic cells (DCs) expressing specific receptors recognizing pathogen-associated molecular patterns. DC activation by pathogens ...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2020.02.015

    authors： Bieber K,Autenrieth SE

    更新日期：2020-05-01 00:00:00

  • Mapping and characterization of antigenic epitopes of arginine kinase of Scylla paramamosain.

    abstract：:Arginine kinase (AK) is a panallergen present in crustaceans, which can induce an immunoglobulin (Ig) E-mediated immune response in humans. The aim of this work was to map and characterize the antigenic epitopes of Scylla paramamosain AK. Specific-protein-A-enriched IgG raised in rabbits against purified S. paramamosa...

    journal_title：Molecular immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.molimm.2015.02.010

    authors： Yang Y,Cao MJ,Alcocer M,Liu QM,Fei DX,Mao HY,Liu GM

    更新日期：2015-06-01 00:00:00

  • Molecular comparison of mouse Thy-1 and its human homologue.

    abstract：:Physicochemical techniques were used to verify previous immunochemical studies showing homology of the human Thy-1 (formerly p25) antigen and the murine Thy-1 or theta antigen. Peptide maps and amino acid compositions showed close similarity between these two proteins; however, they were not identical. These data conf...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90216-4

    authors： Bonewald L,Wang AC,Terry E,Zwerner R,Balch CM,Ades EW

    更新日期：1982-03-01 00:00:00

  • Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity.

    abstract：:The potency of a T cell is determined in large part by two interactions, binding of a cognate peptide to the MHC, and binding of the T cell receptor (TCR) to this pepMHC. Various studies have attempted to assess the relative importance of these interactions, and to correlate the corresponding binding parameters with t...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.06.012

    authors： Bowerman NA,Crofts TS,Chlewicki L,Do P,Baker BM,Christopher Garcia K,Kranz DM

    更新日期：2009-09-01 00:00:00