The TNFα converting enzyme (TACE) from ayu (Plecoglossus altivelis) exhibits TNFα shedding activity.

abstract：:Viral myocarditis (VMC) is an inflammation of the myocardium closely associated with Coxsackievirus B3 (CVB3) infection. Vγ1+γδT cells, one of early cardiac infiltrated innate population, were reported to protect CVB3 myocarditis while the precise mechanism not fully addressed. To explore cytokine profiles and kinetic...

journal_title：Molecular immunology

authors： Wan F,Yan K,Xu D,Qian Q,Liu H,Li M,Xu W

更新日期：2017-01-01 00:00:00

abstract：:The RING finger type E3 ubiquitin ligase, Cbl-b, is abundantly expressed in bone marrow-derived mast cells (BMMCs) and functions as a potent negative regulator of signalling responses from the high-affinity IgE receptor (FcvarepsilonRI). To determine the contribution of Cbl-b E3 ligase activity we generated knockin mi...

journal_title：Molecular immunology

authors： Oksvold MP,Dagger SA,Thien CB,Langdon WY

更新日期：2008-02-01 00:00:00

abstract：:We have developed a method for use in investigating factors controlling the binding and cross-linking by bivalent haptens of immunoglobulin E (IgE) bound to receptors on rat basophilic leukemia (RBL) cells. This method employs monoclonal anti-2,4-dinitrophenyl (DNP) IgE that is labeled with fluorescein-5-isothiocyanat...

journal_title：Molecular immunology

authors： Erickson J,Kane P,Goldstein B,Holowka D,Baird B

更新日期：1986-07-01 00:00:00

abstract：:We investigated the structure and expression of immunoglobulin genes in the pufferfish, Takifugu rubripes, a highly prized and economically important fish species. The cDNA fragment that partially encodes the constant region of the IgM heavy chain was isolated in these animals by RACE using degenerate primers after wh...

journal_title：Molecular immunology

authors： Saha NR,Suetake H,Suzuki Y

更新日期：2005-01-01 00:00:00

abstract：:Interferon (IFN)-γ is highly upregulated during heart inflammation and enhances the production of pro-inflammatory cytokines. Absent in Melanoma 2 (AIM2) is an IFN-inducible protein implicated as a component of the inflammasome. Here we seek to determine the role of AIM2 during inflammation in cardiac cells. We found ...

journal_title：Molecular immunology

authors： Furrer A,Hottiger MO,Valaperti A

更新日期：2016-06-01 00:00:00

abstract：:The xenotransplantation research is driven by the shortage of allografts for transplantation of patients with end-stage organ failure and by lack of success in developing suitable artificial organs. Pigs are now generally accepted to be the donor species of choice, although a possible risk for transmission of xenozoon...

journal_title：Molecular immunology

authors： Mollnes TE,Fiane AE

更新日期：1999-03-01 00:00:00

abstract：:The structural and functional integrity of the cell is largely maintained by protein-protein interactions. Recently, we demonstrated that multiple antigenic peptides (MAPs) constructed from 60 kDa Ro sequence could be used to show intramolecular and intermolecular protein-protein interaction within the 60 kDa Ro ribon...

journal_title：Molecular immunology

authors： Scofield RH,Kurien BT,Gross JK,Reed NB,Taylor AK,Dominguez N,Mehta P,Guthridge JM,Bachmann M

更新日期：2004-07-01 00:00:00

abstract：:Many infections are associated with diabetes, as the ability of the body to fight pathogens is impaired. Recently, altered levels of defensins and polymorphism in Toll-like receptors (TLRs), two crucial components of the innate immune system, have been associated with diabetes. To study the functionality of the innate...

journal_title：Molecular immunology

authors： Froy O,Hananel A,Chapnik N,Madar Z

更新日期：2007-02-01 00:00:00

abstract：:The interaction between a single-chain Fv (sFv) of the monoclonal antibody 3A21 and its antigen, bovine pancreatic ribonuclease A (RNase A), was studied by site-directed mutagenesis of the hypervariable regions and fluorescence polarization analysis. The affinity constants of wild-type sFv and a mutant sFv D31A (Asp31...

journal_title：Molecular immunology

authors： Katakura Y,Kumamoto T,Iwai Y,Kurokawa Y,Omasa T,Suga K

更新日期：1997-07-01 00:00:00

abstract：:The T cell receptor (TCR) detects the presence of infectious pathogens and activates numerous intracellular signaling pathways. Protein tyrosine phosphorylation and ubiquitination serve as key regulatory mechanisms downstream of the TCR. Negative regulation of TCR signaling pathways is important in controlling the imm...

journal_title：Molecular immunology

authors： Carpino N,Chen Y,Nassar N,Oh HW

更新日期：2009-10-01 00:00:00

abstract：:Members of the genus Ebolavirus cause fulminating outbreaks of disease in human and non-human primate populations with a mortality rate up to 90%. To facilitate rapid detection of these pathogens in clinical and environmental samples, robust reagents capable of providing sensitive and specific detection are required. ...

journal_title：Molecular immunology

authors： Goodchild SA,Dooley H,Schoepp RJ,Flajnik M,Lonsdale SG

更新日期：2011-09-01 00:00:00

abstract：:Egr-1 is an immediate early gene that is rapidly upregulated in response to mitogenic signals induced by antigen receptor crosslinking on murine B lymphocytes. It has been shown that levels of Egr-1 expression are closely correlated with B cell proliferation in several models of B cell activation and tolerance. We com...

journal_title：Molecular immunology

authors： Klaus SJ,Phillips NE,Parker DC

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Angioedema diagnosis classically targets the complement system (via C1 inhibitor (C1Inh) function and antigenic C4 level) and contact phase activation (via amidase activity). Bradykinin is responsible for angioedema attacks and is produced from contact phase activation secondary to failed C1Inh control. OBJ...

journal_title：Molecular immunology

authors： Charignon D,Ghannam A,Ponard D,Drouet C

更新日期：2017-05-01 00:00:00

abstract：:Human promyelocytic leukemia (HL-60) cells were induced by 1,25-dihydroxyvitamin D3 (calcitriol) to differentiate and examined using a panel of monoclonal antibodies (MoAbs) and functional assays. Although morphologically and histochemically these cells appeared to be of the monocyte-macrophage phenotype, there was a ...

journal_title：Molecular immunology

authors： Rigby WF,Shen L,Ball ED,Fanger MW

更新日期：1985-05-01 00:00:00

abstract：:Evidence suggests that immune dysregulation is associated with autism spectrum disorder (ASD). T cell immunoglobulin and mucin domain-3 (TIM-3) has a critical role in several inflammatory disorders; however, the role of TIM-3 signaling has not been demonstrated in ASD. In the present study, we assessed the role of TIM...

journal_title：Molecular immunology

authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alotaibi MR,Alhoshani AR,Alshammari MA,Attia SM

更新日期：2019-02-01 00:00:00

abstract：:Because of its lethal effects, ease of preparation, and ability to be delivered by aerosolization, ricin has been developed as a lethal weapon by various terrorist groups. When introduced into the pulmonary system of rodents, ricin causes pathological changes in the lung that are known to occur in acute respiratory di...

journal_title：Molecular immunology

authors： Korcheva V,Wong J,Lindauer M,Jacoby DB,Iordanov MS,Magun B

更新日期：2007-04-01 00:00:00

abstract：:Recognition of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs) is important in innate immune signaling. Toll-like receptors (TLRs) are well-characterized PRRs and are pivotal in antiviral and antitumor host defense. TIR domain-containing adaptor molecule 1 (TICAM-1, also called T...

journal_title：Molecular immunology

authors： Funami K,Matsumoto M,Obuse C,Seya T

更新日期：2016-05-01 00:00:00

abstract：:Anti-DNP activity was found in normal human immunoglobulins with average affinities (10(4)-10(6) l/mole) and frequencies (15-2%) that correlate well with those expected from multispecific binding sites. ...

journal_title：Molecular immunology

authors： Ortega E,Kostovetzky M,Larralde C

更新日期：1984-10-01 00:00:00

abstract：:The capacity of α-galactosylceramide (α-GalCer) to act as an anti-cancer agent in mice through the specific stimulation of type I NKT (iNKT) cells has prompted extensive investigation to translate this finding to the clinic. However, low frequencies of iNKT cells in cancer patients and their hypo-responsiveness to rep...

journal_title：Molecular immunology

authors： Painter GF,Burn OK,Hermans IF

更新日期：2021-02-01 00:00:00

abstract：:The genetic complexity of the H-2D region includes haplotype disparities in apparent gene and product number. To probe the genetic basis of this complexity, the products of two independently derived mouse strains (STU and B10.SAA48) that express Dw3 antigens were compared. Serologic, fluorometric and peptide map compa...

journal_title：Molecular immunology

authors： Lee DR,Lillehoj EP,Myers NB,Coligan JE,Hansen TH

更新日期：1986-10-01 00:00:00

abstract：:To investigate the interaction of DNA and anti-DNA antibodies in the immune complex disease of systemic lupus erythematosus, the fine specificity of binding of a monoclonal anti-DNA antibody was determined. This antibody, termed Cll, was derived from the fusion of spleen cells from an autoimmune MRL-lpr/lpr mouse with...

journal_title：Molecular immunology

authors： Pisetsky DS,Caster SA

更新日期：1982-05-01 00:00:00

abstract：:Recently, basophils have been suggested to produce inflammatory mediators in response to IgE in the absence of allergens. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the initiation of inflammatory responses by recruiting various immune cells to the site of allergic inflammation. In the presen...

journal_title：Molecular immunology

authors： Ahn KB,Jeon JH,Kang SS,Chung DK,Yun CH,Han SH

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:C5L2, a G-protein-coupled receptor (GPCR), has been identified as an ASP (C3adesArg) and C5a receptor. Controversy exists regarding both ligand binding and functionality. ASP activation of C5L2 is proposed to regulate fat storage. C5L2 is also proposed as a decoy receptor for C5a, an inflammatory mediator, b...

journal_title：Molecular immunology

authors： Cui W,Simaan M,Laporte S,Lodge R,Cianflone K

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Spinal cord injury (SCI) is a neurological disease with high incidence and disability. In this paper, we made a foundational study in long non-coding RNA paternally expressed gene 10 (lncRNA PEG10) at PC-12 cells. METHODS:We used CCK8, flow cytometry, migration and invasion assay to detect changes at the cel...

journal_title：Molecular immunology

authors： Niu S,Ni Y,Niu T,Gao J

更新日期：2020-02-01 00:00:00

abstract：:In human peripheral blood, most of the CD3+ cells express the alpha/beta T cell receptor. A smaller fraction of CD3+ T cells express the gamma/delta T cell receptor (from 1 to 10% depending the individuals, with an average of 3-5%). Interestingly, although the alpha/beta + T cells never express the gamma chain at the ...

journal_title：Molecular immunology

authors： Alexandre D,Lefranc MP

更新日期：1992-04-01 00:00:00

abstract：:The innate immune system is the first line of defense against infection and responses are initiated by pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs). PRRs also detect endogenous danger-associated molecular patterns (DAMPs) that are released by damaged or dying cells. T...

journal_title：Molecular immunology

authors： Vajjhala PR,Ve T,Bentham A,Stacey KJ,Kobe B

更新日期：2017-06-01 00:00:00

abstract：:The Pms2 gene is involved in DNA mismatch repair in mammalian cells, and has recently been shown to affect hypermutation of mammalian immunoglobulin genes. We have studied hypermutation of a lambda1 transgene in chronically stimulated Peyer's patch B cells of both young and old mice deficient in function of Pms2. In y...

journal_title：Molecular immunology

authors： Kong Q,Maizels N

更新日期：1999-02-01 00:00:00

abstract：:Four different proteases were screened for their capability of selectively digesting murine monoclonal IgGl to obtain active F(ab)2. For the screening, a series of five different mouse monoclonal antibodies (IgGl, k) was used, recognizing different tumor-associated antigens and currently used for radioimmunoimaging st...

journal_title：Molecular immunology

authors： Mariani M,Camagna M,Tarditi L,Seccamani E

更新日期：1991-01-01 00:00:00

abstract：:Placental growth factor (PlGF), a member of vascular endothelial growth factors (VEGF) family, is considered as an important antigen associated with pathological conditions such as cancer cell growth, and metastasis. PlGF-targeting via nanobody (Nb) therefore could be beneficial to modulate these pathologies. In this ...

journal_title：Molecular immunology

authors： Arezumand R,Mahdian R,Zeinali S,Hassanzadeh-Ghassabeh G,Mansouri K,Khanahmad H,Namvar-Asl N,Rahimi H,Behdani M,Cohan RA,Eavazalipour M,Ramazani A,Muyldermans S

更新日期：2016-10-01 00:00:00

abstract：:The complement system is very tightly regulated by fluid-phase and membrane-bound factors that prevent injury to self-tissues. The study of genetically engineered animals with targeted deletion or gain of function mutations has highlighted the important role that many of the complement inhibitors play in vivo. The adv...

journal_title：Molecular immunology

authors： Turnberg D,Botto M

更新日期：2003-09-01 00:00:00