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Dendritic cell development in infection.

Abstract：

:The immune system protects from infections primarily by detecting and eliminating invading pathogens. This is predominantly mediated by innate immune cells like neutrophils, monocytes and dendritic cells (DCs) expressing specific receptors recognizing pathogen-associated molecular patterns. DC activation by pathogens leads to the initiation of antigen-specific adaptive immune responses, thereby bridging the innate and adaptive immune systems. However, various pathogens have evolved immune evasion strategies to ensure their survival. In this review, we highlight recent findings on how various microorganisms or their structural features affect or modulate DC development and whether this has any consequences for a protective immune response.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Bieber K,Autenrieth SE

doi

10.1016/j.molimm.2020.02.015

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

111-117

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(19)30706-0

journal_volume

121

pub_type

杂志文章,评审

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