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Mechanisms and functions of IL-17 signaling in renal autoimmune diseases.

Abstract：

:Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4+ T cells orchestrate the immune response and play a unique role in autoimmune and chronic inflammatory diseases. In particular, the characterization of a distinct, IL-17 cytokines producing CD4+ T cell subset named TH17 cells has significantly advanced the current understanding of the pathogenic mechanisms of organ-specific immunity. Our group and others have shown that the recruitment of TH17 cells to the inflamed kidney drives renal tissue injury in experimental and possibly human crescentic glomerulonephritis (GN), but much remains to be understood about the biological functions, regulation, and signaling pathways of the TH17/IL-17 axis leading to organ damage. Here we review our current knowledge about the mechanisms and functions of IL-17 signaling in renal autoimmune diseases, with a special focus on experimental and human crescentic GN.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Schmidt T,Luebbe J,Paust HJ,Panzer U

doi

10.1016/j.molimm.2018.09.005

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

90-99

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(18)30764-8

journal_volume

104

pub_type

杂志文章,评审

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