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MYC inhibition increases PD-L1 expression induced by IFN-γ in hepatocellular carcinoma cells.

Abstract：

:The effectiveness of immunotherapy targeting the immune checkpoint PD-L1/PD-1 pathway highlights importance of elucidating the regulatory mechanisms of PD-L1 expression in cancer cells. Previous studies demonstrate that oncogene MYC up-regulates PD-L1 expression in lymphomas. In the present study, we investigated the regulatory role of MYC in the PD-L1 expression induced by IFN-γ in HCC cells. Unexpectedly, knockdown of MYC expression using siRNA assay increased the inducible expression of PD-L1 both at mRNA and protein levels. Mechanistically, the inhibition of MYC elevated expression of STAT1, a critical component of IFN-γ signaling pathway, leading to the elevation of PD-L1 expression in HCC cells exposed to IFN-γ. These results suggest that MYC may down-regulate PD-L1 expression in the context of HCC. This study implicates that a combination therapy targeting MYC function and PD-L1/PD-1 pathway might be effective for treatment of HCC.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Zou J,Zhuang M,Yu X,Li N,Mao R,Wang Z,Wang J,Wang X,Zhou H,Zhang L,Shi Y

doi

10.1016/j.molimm.2018.07.006

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

203-209

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(18)30536-4

journal_volume

101

pub_type

杂志文章

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