当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals.

CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals.

Abstract：

:Interleukin (IL)-23 is a heterodimeric cytokine composed of the IL-23-specific subunit p19 and the p40 subunit which also constitutes part of IL-12. IL-23 propagates development of Th17 cells, a novel T cell subset which produces IL-17 but no interferon-gamma or IL-4. For both, IL-23 and IL-23-driven IL-17, a crucial role in autoimmune diseases such as experimental autoimmune encephalomyelitis, collagen-induced arthritis, and colitis is well accepted. Recent studies indicate that there is also a role for IL-23 and IL-17 in tumorigenesis, promoting tumor growth and vascularization, and affecting tumor incidence. We show that human CD14(+) peripheral blood monocyte-derived dendritic cells (DC), as used for clinical applications in anti-tumor immunization strategies, produce high amounts of IL-23. CD40-triggering of immature and mature DC but not of primary monocytes induced a rapid expression of high levels of IL-23, free p40, and minor levels of IL-12. Upon stimulation of DC subsets with a variety of different danger signals such as single stranded and double stranded RNA, bacterial components or viral infections, IL-23 expression pattern was analyzed. Interestingly, co-stimulation with CD40L enabled IL-23 expression by DC subsets towards danger signals to which they have been unresponsive upon single stimulation. Furthermore, we detected two novel splice variants of the IL-23-specific subunit p19 that could be associated with the regulation of IL-23 expression. Data presented here might have an impact on DC-based cancer vaccination strategies and contribute to a better understanding of the complex regulation of the heterodimeric cytokine IL-23.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Sender LY,Gibbert K,Suezer Y,Radeke HH,Kalinke U,Waibler Z

doi

10.1016/j.molimm.2009.12.008

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

1255-61

issue

6

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(09)00864-5

journal_volume

47

pub_type

杂志文章

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • A monoclonal antibody recognizing a conserved epitope in a group of phospholipases A2.

    abstract：:Notexin and nigexine are monomeric phospholipases A2(PLA2s) from the venoms of Notechis scutatus scutatus and Naja nigricollis, respectively. Polyclonal antibodies raised in mice against these antigenic proteins displayed non-reciprocal cross-reactivity; anti-notexin antibodies recognized notexin but not nigexine, whe...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(90)90055-5

    authors： Mollier P,Chwetzoff S,Ménez A

    更新日期：1990-01-01 00:00:00

  • Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a.

    abstract：:The host response to intravascular, Gram-negative bacteria includes profound immunologic, hematologic and physiologic changes. Numerous host defense mechanisms are activated by Gram-negative bacteria, including the complement system. Activation of the complement system leads to cleavage of C5 with subsequent generatio...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.10.037

    authors： Hollmann TJ,Mueller-Ortiz SL,Braun MC,Wetsel RA

    更新日期：2008-04-01 00:00:00

  • Immunochemical studies on alpha-lactalbumin.

    abstract：:The antigenic structural features of alpha-lactalbumin have been investigated using a radioimmunoassay, peptide inhibition of the quantitative precipitin reaction, and by immunodiffusion analysis after chemical modification of the molecule. Antigenic activity (in rabbits) was localized to several peptic fragments and ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90192-4

    authors： Hopp TP,Woods KR

    更新日期：1982-11-01 00:00:00

  • IL-12 and IL-23 modulate plasticity of FoxP3+ regulatory T cells in human Leprosy.

    abstract：:Leprosy is a bacterial disease caused by M. leprae. Its clinical spectrum reflects the host's immune response to the M. leprae and provide an ideal model to investigate the host pathogen interaction and immunological dysregulation. Tregs are high in leprosy patients and responsible for immune suppression of the host b...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.01.008

    authors： Tarique M,Saini C,Naqvi RA,Khanna N,Sharma A,Rao DN

    更新日期：2017-03-01 00:00:00

  • IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism.

    abstract：:We have recently isolated and characterized human and mouse genes of a putative natural killer (NK) cell tumour-recognition protein (NK-TR) that is specifically expressed in NK cells. This gene codes for a 150 kD protein with a cyclophilin-related amino terminus followed by several positively charged domains. We repor...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90047-f

    authors： Rinfret A,Anderson SK

    更新日期：1993-10-01 00:00:00

  • Inhibition of phosphatidylserine synthesis induced by triggering CD2 or the CD3-TCR complex in a human T cell line. Relationships with G proteins and receptors modulation.

    abstract：:Activation of Jurkat T cells with phytohemagglutinin, CD3 or CD2 mAbs results in a marked inhibition of phosphatidylserine (PS) synthesis. Monitoring PS synthesis in T cells shows that: (i) after modulation of CD3 molecules the cells become refractory to further treatment with CD3 mAbs as well as to a further challeng...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(89)90072-2

    authors： Pelassy C,Dallanegra A,Aussel C,Fehlmann M

    更新日期：1989-11-01 00:00:00

  • Antibodies against glutaraldehyde-modified albumin in normal mouse sera.

    abstract：:An antigen-coated plate radioimmunoassay was used to detect antibodies against homologous glutaraldehyde-modified albumin (in monomeric or polymeric form) in normal mouse sera. Mouse antibodies reacted also with heterologous glutaraldehyde-treated albumin; for instance human albumin. Immunoelectrophoresis of purified ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90310-8

    authors： Onică D,Mărgineanu I,Medeşan C,Călugăru A,Manciulea M

    更新日期：1982-08-01 00:00:00

  • The antigen-limited nature of microtiter ELISAs requires partial depletion of IgG to permit reliable determination of rabbit serum IgA antibody activity.

    abstract：:The antigen-limiting nature of microtiter ELISAs predicts that antibodies of minor classes may be underestimated when the same specimen contains large amounts of IgG antibodies specific for the same antigen. Such competitive inhibition can be diagnosed from ELISA titration plots. A method is described to eliminate the...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(90)90044-z

    authors： Butler JE,Heo Y,Adams P,Richerson HB

    更新日期：1990-04-01 00:00:00

  • Interactions of multilamellar phospholipid vesicles with bovine lymphocytes: effects of alpha-tocopherol on lymphocyte blastogenesis.

    abstract：:Multilamellar lipid vesicles (MLV) composed of egg yolk lecithin (EYL) suppressed the response of bovine peripheral blood lymphocytes (BPBL) to phytohemagglutinin (PHA). EYL contains 18:1 and 18:2 as the major unsaturated phospholipids. Dioleoyllecithin (DOL; cis 9) MLV did not suppress BPBL blastogenesis. Dilinoeylle...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90195-x

    authors： Fountain MW,Dees C,Weete JD,Schultz RD

    更新日期：1982-11-01 00:00:00

  • cDNA cloning and eukaryotic expression of feline CD9.

    abstract：:A monoclonal antibody (vpg15) has been described which can block infection with feline immunodeficiency virus (FIV) and which recognizes the feline homologue of CD9. In order to study the role of feline CD9 in infection with FIV we have molecularly cloned a cDNA encoding feline CD9 by R.A.C.E (rapid amplification of c...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00008-3

    authors： Willett BJ,Neil JC

    更新日期：1995-04-01 00:00:00

  • Regulation of NKG2D-ligand cell surface expression by intracellular calcium after HDAC-inhibitor treatment.

    abstract：:In this study we demonstrate that histone deacetylase (HDAC)-inhibitor mediated cell surface expression of the structural different NKG2D-ligands MICA/B and ULBP2 is calcium-dependent. Treatment with the calcium chelator EGTA inhibited constitutive as well as HDAC-inhibitor induced MICA/B and ULBP2 cell surface expres...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2012.08.011

    authors： Jensen H,Hagemann-Jensen M,Lauridsen F,Skov S

    更新日期：2013-03-01 00:00:00

  • Discerning the kinetics of autoimmune manifestations in a model of Sjögren's syndrome.

    abstract：:Ectopic follicles are non-encapsulated organized lymphoid structures that form at sites of inflammation and presumably contribute to the activation and differentiation of cells with autoreactive potential within target tissues. As such, directed targeting of ectopic follicles in settings of autoimmunity may provide a ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2014.05.006

    authors： Karnell JL,Mahmoud TI,Herbst R,Ettinger R

    更新日期：2014-12-01 00:00:00

  • Evidence that the hinge region plays a role in maintaining serum levels of the murine IgG1 molecule.

    abstract：:The site of the murine IgG1 molecule that regulates catabolism has recently been shown to encompass amino acids that are located at the CH2-CH3 domain interface. The CH2 and CH3 domains are connected to each other by a relatively flexible "mini-hinge" region, and flexibility in this region could clearly affect the ori...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00019-b

    authors： Kim JK,Tsen MF,Ghetie V,Ward ES

    更新日期：1995-05-01 00:00:00

  • Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions.

    abstract：:Although the beneficial effects of probiotics on wide variety of diseases have been shown, little is known about how probiotics modulate the immune system. In this study we elucidated the underlying mechanisms how Lactobacillus casei (L. casei) protects against rheumatoid arthritis (RA) progression by investigating th...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.12.010

    authors： So JS,Kwon HK,Lee CG,Yi HJ,Park JA,Lim SY,Hwang KC,Jeon YH,Im SH

    更新日期：2008-05-01 00:00:00

  • Cytokine profile of CD4+CD25-FoxP3+ T cells in tumor-draining lymph nodes from patients with breast cancer.

    abstract：BACKGROUND:A T cell subtype with the CD4+CD25-FoxP3+ phenotype was recently described. We aimed to investigate the frequency of these cells and their ability to produce cytokines in tumor-draining lymph nodes from patients with breast cancer (BC). MATERIALS AND METHODS:Mononuclear cells from lymph nodes of 20 patients...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.10.007

    authors： Niakan A,Faghih Z,Talei AR,Ghaderi A

    更新日期：2019-12-01 00:00:00

  • Inactivation of the KSRP gene modifies collagen antibody induced arthritis.

    abstract：:The KH type splicing regulatory protein (KSRP) is a nucleic acid binding protein, which negatively regulates the stability and/or translatability of many mRNA species encoding immune-relevant proteins. As KSRP is expressed in immune cells including T and B cells, neutrophils, macrophages and dendritic cells, we wanted...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.05.003

    authors： Käfer R,Schrick K,Schmidtke L,Montermann E,Hobernik D,Bros M,Chen CY,Kleinert H,Pautz A

    更新日期：2017-07-01 00:00:00

  • A dominant V beta bias in the CTL response after HSV-1 infection is determined by peptide residues predicted to also interact with the TCR beta-chain CDR3.

    abstract：:Many T cell responses are dominated by restricted TCR expression and can range from repeated usage of particular TCR Vbeta- and/or Valpha-elements, to the preferential usage of both V- and J-elements, often in conjunction with conserved V-D-J or V-J junctional sequences. Cytotoxic T lymphocytes specific for a Kb-restr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(98)00051-0

    authors： Turner SJ,Carbone FR

    更新日期：1998-04-01 00:00:00

  • Fugu, Takifugu ruberipes, mucus keratins act as defense molecules against fungi.

    abstract：:Keratin is a cytoskeletal protein that constitutes the intermediate filament. Its distribution is restricted to epithelial tissues in mammals, but is wider in fish. An interesting feature of fish keratin is that it is abundant in the cutaneous mucus. However, the biological function of keratin in the mucus has not bee...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.09.012

    authors： Shibuya K,Tsutsui S,Nakamura O

    更新日期：2019-12-01 00:00:00

  • Human C-reactive protein: expression, structure, and function.

    abstract：:C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Expression of CRP is regulated mainly at the transcriptional level with interleukin-6 being the principal inducer of the gene during the acute phase. The crystal structure of CRP...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-5890(01)00042-6

    authors： Volanakis JE

    更新日期：2001-08-01 00:00:00

  • Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor.

    abstract：:In addition to the antigen receptor, resting T cells express a number of receptors that can be stimulated to generate proliferative signals. These "accessory" receptors require co-expression of the T cell receptor (TCR), suggesting that they channel their signals via secondary activation of the signal transduction fun...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(94)00160-3

    authors： Zhang XM,Berland R,Rosoff PM

    更新日期：1995-04-01 00:00:00

  • Redirecting adenoviruses to tumour cells using therapeutic antibodies: Generation of a versatile human bispecific adaptor.

    abstract：:Effective use of adenovirus-5 (Ad5) in cancer therapy is heavily dependent on the degree to which the virus's natural tropism can be subverted to one that favours tumour cells. This is normally achieved through either engineering of the viral fiber knob or the use of bispecific adaptors that display both adenovirus an...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2015.08.014

    authors： Vasiljevic S,Beale EV,Bonomelli C,Easthope IS,Pritchard LK,Seabright GE,Caputo AT,Scanlan CN,Dalziel M,Crispin M

    更新日期：2015-12-01 00:00:00

  • pH dependent binding of high and low affinity myelin basic protein peptides to purified HLA-DR2.

    abstract：:Major histocompatibility complex (MHC) class II molecules are cell surface glycoproteins and are known to display processed antigens on the surface of antigen presenting cells (APC). Within the APC, the loading of processed antigenic peptides to MHC class II molecules is known to take place in the endosomal compartmen...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00030-i

    authors： Mukku PV,Passmore D,Phan D,Nag B

    更新日期：1995-06-01 00:00:00

  • Isolation and structural analysis of peptide mimotopes for the disialoganglioside GD2, a neuroblastoma tumor antigen.

    abstract：:The disialoganglioside GalAcbeta1-4(NeuAcalpha2-8NeuAcalpha2-3)Galbeta1-4Glcbeta1-1Cer (GD2) is expressed on various tumors, including neuroblastoma, and was defined as a relevant tumor antigen. The monoclonal anti-GD2 antibody 14.18 is widely used for diagnostic purposes in neuroblastoma, and in its mouse/human chime...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2004.07.011

    authors： Förster-Waldl E,Riemer AB,Dehof AK,Neumann D,Brämswig K,Boltz-Nitulescu G,Pehamberger H,Zielinski CC,Scheiner O,Pollak A,Lode H,Jensen-Jarolim E

    更新日期：2005-02-01 00:00:00

  • Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host.

    abstract：:Host-derived macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infection, especially in malarial anemia. Although two Plasmodium parasite-derived MIF orthologs, Plasmodium falciparum MIF and P. berghei MIF were identified recently, the crystal structure and the precise rol...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.10.037

    authors： Shao D,Zhong X,Zhou YF,Han Z,Lin Y,Wang Z,Bu L,Zhang L,Su XD,Wang H

    更新日期：2010-01-01 00:00:00

  • Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17.

    abstract：:Triptolide is an active component of extracts derived from the medicinal vine Tripterygium Wilfordii Hook. f. (TWHF) whose extracts have been used to treat inflammatory bowel disease (IBD). We have reported that triptolide showed therapeutic activity in a murine IBD model, but the potential mechanism of action of this...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2010.06.007

    authors： Li Y,Yu C,Zhu WM,Xie Y,Qi X,Li N,Li JS

    更新日期：2010-09-01 00:00:00

  • A novel mutation in the signal transducer and activator of transcription 3 (STAT3) gene, in hyper-IgE syndrome.

    abstract：:The hyper-IgE syndrome (HIES) is a rare primary immunodeficiency characterized by a highly elevated serum IgE, recurrent staphylococcal skin abscesses and cyst-forming pneumonia. Non-immunological abnormalities, including a distinctive facial appearance, hyperextensive joints, scoliosis, fracture following minor traum...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2010.01.010

    authors： Papanastasiou AD,Mantagos S,Papanastasiou DA,Zarkadis IK

    更新日期：2010-04-01 00:00:00

  • Analysis of human IgE epitope of Der f 2 with anti-Der f 2 mouse monoclonal antibodies.

    abstract：:Der f 2 is one of the major mite allergens recognized by human IgE antibodies of allergic patients. Using five anti-Der f 2 mouse monoclonal antibodies, human IgE epitopes of Der f 2 were analyzed. Among them, two monoclonal antibodies 15E11 and 13A4 inhibited the binding between Der f 2 and human IgE antibodies. To d...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(98)00112-6

    authors： Nishiyama C,Hatanaka H,Ichikawa S,Fukada M,Akagawa-Chihara M,Yuuki T,Yokota T,Inagaki F,Okumura Y

    更新日期：1999-01-01 00:00:00

  • NF-kappaB family of transcription factor facilitates gene conversion in chicken B cells.

    abstract：:Activation-induced cytidine deaminase (AID) is critical for immunoglobulin (Ig) diversification in B cells. The majority of evidence supports the model that AID modifies Ig genes at the DNA level by deaminating cytosines into uracils. The mutagenic activity is largely restricted to Ig genes to avoid genomic damage in ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.07.027

    authors： Kim Y,Tian M

    更新日期：2009-10-01 00:00:00

  • Anagliptin ameliorates high glucose- induced endothelial dysfunction via suppression of NLRP3 inflammasome activation mediated by SIRT1.

    abstract：:High glucose- induced endothelial dysregulation has been recognized as an initiation of vascular complications in Type 2 diabetes mellitus (T2DM). Anagliptin is a novel licensed dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of T2DM. The effects of anagliptin in high glucose- induced endothelial dysfunctio...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.01.006

    authors： Jiang T,Jiang D,Zhang L,Ding M,Zhou H

    更新日期：2019-03-01 00:00:00

  • Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease.

    abstract：:Complement per se has been shown to play an important role in demyelinating disease but controversy remains regarding the role of C3 in the development and progression of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. In this study, we used C3(-/-) mice to confirm previous fi...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.02.002

    authors： Szalai AJ,Hu X,Adams JE,Barnum SR

    更新日期：2007-05-01 00:00:00