Activation-induced apoptosis in Jurkat cells through a myc-independent mechanism.

abstract：:Subunits of the mitochondrial ATP synthase complex are expressed on the surface of tumors, bind the TCR of human Vgamma9/Vdelta2 lymphocytes and promote their cytotoxicity. Present experiments show that detection of the complex (called ecto-F1-ATPase) at the cell surface by immunofluorescence correlates with low MHC-c...

journal_title：Molecular immunology

authors： Vantourout P,Martinez LO,Fabre A,Collet X,Champagne E

更新日期：2008-01-01 00:00:00

abstract：:The DNA vaccine based on the glycoprotein gene of Infectious hematopoietic necrosis virus induces a non-specific anti-viral immune response and long-term specific immunity against IHNV. This study characterized gene expression responses associated with the early anti-viral response. Homozygous rainbow trout were injec...

journal_title：Molecular immunology

authors： Purcell MK,Nichols KM,Winton JR,Kurath G,Thorgaard GH,Wheeler P,Hansen JD,Herwig RP,Park LK

更新日期：2006-05-01 00:00:00

abstract：:Noxiustoxin (NTX) is a short-chain toxin from the venom of the scorpion Centruroides noxius Hoffmann, whose molecular structure and physiological effects have been characterized in detail, whereas the antigenic properties of this and other K(+) channel-blocking toxins are poorly studied. A monoclonal antibody against ...

journal_title：Molecular immunology

authors： Gazarian T,Selisko B,Hérion P,Gazarian K

更新日期：2000-08-01 00:00:00

abstract：:Helminths, as well as their secretory/excretory products, induce a tolerogenic immune microenvironment. High molecular weight components (PI) from Ascaris suum extract down-modulate the immune response against ovalbumin (OVA). The PI exerts direct effect on dendritic cells (DCs) independent of TLR 2, 4 and MyD88 molec...

journal_title：Molecular immunology

authors： Favoretto BC,Casabuono AAC,Portes-Junior JA,Jacysyn JF,Couto AS,Faquim-Mauro EL

更新日期：2017-07-01 00:00:00

abstract：:Human complement components C6 and C7 have been purified and characterized. Component C6 is a single-chain plasma protein of mol. wt 104,800 containing 3.8% carbohydrate and it has alanine as the amino terminal residue. Component C7 is a single-chain plasma protein of mol. wt 92,400 containing 6.4% carbohydrate and it...

journal_title：Molecular immunology

authors： Discipio RG,Gagnon J

更新日期：1982-11-01 00:00:00

abstract：:The immunoglobulin JHC mu intron was cloned from genomic DNA of a VHa3 rabbit and a 1257 bp sequence which contains conserved enhancer and splice sites was determined. From positions 315 to 1257, there is approximately 72 and 67% similarity to available sequences of man and mouse, respectively (counting gaps as single...

journal_title：Molecular immunology

authors： Mage RG,Newman BA,Harindranath N,Bernstein KE,Becker RS,Knight KL

更新日期：1989-10-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (S. Typhimurium) changes the structure of its lipopolysaccharide (LPS) in response to the environment. The two main LPS variants found in S. Typhimurium correspond to LPS with a hepta-acylated lipid A (LPS 430) and LPS with modified phosphate groups on its lipid A (LPS 435). We ...

journal_title：Molecular immunology

authors： Aldapa-Vega G,Moreno-Eutimio MA,Berlanga-Taylor AJ,Jiménez-Uribe AP,Nieto-Velazquez G,López-Ortega O,Mancilla-Herrera I,Cortés-Malagón EM,Gunn JS,Isibasi A,Wong-Baeza I,López-Macías C,Pastelin-Palacios R

更新日期：2019-07-01 00:00:00

abstract：:Dendritic cells (DC) are capable of capturing and processing antigens and can stimulate co-cultured effector cells in a specific manner. Here, we pulsed DC with apoptotic bodies (apb) from colorectal carcinoma. For enhancement of the immunogenic potential of apb, we transduced the tumor cells with the MHC class II gen...

journal_title：Molecular immunology

authors： Märten A,Renoth S,Schmidt-Wolf IG

更新日期：2002-11-01 00:00:00

abstract：:The mechanism by which heparin inhibits the alternative complement pathway (ACP) by a fluid-phase activator, CoVF, has been studied. Results presented here indicate that heparin's major (rate-limiting) effect on the fluid-phase activation of the ACP was to potentiate Factor H activity. Such an effect results in a very...

journal_title：Molecular immunology

authors： Boackle RJ,Caughman GB,Vesely J,Medgyesi G,Fudenberg HH

更新日期：1983-11-01 00:00:00

abstract：:The interaction between a single-chain Fv (sFv) of the monoclonal antibody 3A21 and its antigen, bovine pancreatic ribonuclease A (RNase A), was studied by site-directed mutagenesis of the hypervariable regions and fluorescence polarization analysis. The affinity constants of wild-type sFv and a mutant sFv D31A (Asp31...

journal_title：Molecular immunology

authors： Katakura Y,Kumamoto T,Iwai Y,Kurokawa Y,Omasa T,Suga K

更新日期：1997-07-01 00:00:00

abstract：:Peripheral blood B lymphocytes have been isolated from healthy individuals who were immunized with lymphocytes from HLA-incompatible donors and transformed with Epstein-Barr virus to produce human monoclonal cell lines specific for human HLA molecules. The cell lines have been previously characterized and are known to...

journal_title：Molecular immunology

authors： Andris JS,Abraham SR,Pascual V,Pistillo MP,Mantero S,Ferrara GB,Capra JD

更新日期：1995-10-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) contribute to the regulation of gastrointestinal (GI) homeostasis. Over the past 15 years, there has been a large effort to dissect the mechanisms required for GI homeostasis, with a major focus on different immune cell populations and the cytokines that they produce. In contrast to T-help...

journal_title：Molecular immunology

authors： Fung KY,Nguyen PM,Putoczki T

更新日期：2019-06-01 00:00:00

abstract：:The immunological role of exosomes in autoimmune encephalitis (AE) remains uncharacterized and not examined. In this study we ought to determine whether exosomes are generated in AE and to define the presence of cell surface neuronal autoantigens (autoAgs) in the cargo. Exosomes were isolated from cerebrospinal fluid ...

journal_title：Molecular immunology

authors： Gu J,Jin T,Li Z,Chen H,Xia H,Xu X,Gui Y

更新日期：2021-01-11 00:00:00

abstract：:Renal transplantation is the treatment of choice for patients with end-stage renal disease. The vital role of the complement system in renal transplantation is widely recognized. This review discusses the role of complement in the different phases of renal transplantation: in the donor, during preservation, in reperfu...

journal_title：Molecular immunology

authors： Jager NM,Poppelaars F,Daha MR,Seelen MA

更新日期：2017-09-01 00:00:00

abstract：:Although granulocyte colony-stimulating factor(G-CSF) has pathogenic roles in several immune inflammatory diseases, its role in periodontitis has not been investigated. Here we detected local expression of G-CSF using public datasets in the Gene Expression Omnibus (GEO) database, and immune cell infiltration into ging...

journal_title：Molecular immunology

authors： Zhang Z,Yuan W,Deng J,Wang D,Zhang T,Peng L,Tian H,Wang Z,Ma J

更新日期：2020-01-01 00:00:00

abstract：:Optineurin (Optn) is an adaptor protein with homology to NF-κB essential modulator (NEMO), the regulatory subunit of the IκB kinase (IKK) complex. Dysregulation of Optn has been linked to neurodegenerative, autoimmune and bone diseases. Optn shares a high degree of homology with NEMO, but is not part of the same high-...

journal_title：Molecular immunology

authors： Montecalvo A,Watkins SC,Orange J,Kane LP

更新日期：2017-05-01 00:00:00

abstract：:Human beta defensin-1 (hBD1) is a component of the immune system which links the innate and adaptive immune responses. We have demonstrated that hBD1 induces rapid cytolysis of prostate cancer cells and that it may also possess tumor suppressive abilities. In addition, there is a high frequency of cancer-specific loss...

journal_title：Molecular immunology

authors： Bose SK,Gibson W,Bullard RS,Donald CD

更新日期：2009-03-01 00:00:00

abstract：:Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-E(k) revealed an interesting localization of negatively charged residues within the P6 pocket, which may have implications in the pH dependency...

journal_title：Molecular immunology

authors： Dao CT,Weber DA,Jensen PE

更新日期：2002-06-01 00:00:00

abstract：:Recently, basophils have been suggested to produce inflammatory mediators in response to IgE in the absence of allergens. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the initiation of inflammatory responses by recruiting various immune cells to the site of allergic inflammation. In the presen...

journal_title：Molecular immunology

authors： Ahn KB,Jeon JH,Kang SS,Chung DK,Yun CH,Han SH

更新日期：2014-11-01 00:00:00

abstract：:Glycosylation is an important protein post-translational modification. In this process, the intermediate product, Tn antigen, arises from somatic mutations in core1β3-galactosyltransferase-specific molecular chaperone (Cosmc), which is required for the formation of active core1β3-galactosyltransferase (T-synthase). As...

journal_title：Molecular immunology

authors： Shi C,Xu X,Yu X,Du Z,Luan X,Liu D,Hu T

更新日期：2017-10-01 00:00:00

abstract：:Adiponectin can protect against inflammation; one of the mechanisms involves direct, inhibition of macrophages (MΦ). We postulated that adiponectin anti-sense transgenic (AsTg) mice raised in our laboratory are prone to inflammation because of systemic low adiponectin levels. The writhing response to acetic acid was u...

journal_title：Molecular immunology

authors： Negoro T,Kin M,Takuma A,Saito K,Shimizu S,Nakano Y

更新日期：2014-02-01 00:00:00

abstract：:Rabbit antisera specific for horseradish peroxidase inhibit the catalytic activity of the enzyme. All antibodies prepared against the holoenzyme react with the peroxidase apoenzyme. However, only a minority (30-45%) of the total antiperoxidase pool cross react with reduced and alkylated apoenzymes. The antibodies inhi...

journal_title：Molecular immunology

authors： Conroy JM,Salter RD

更新日期：1982-05-01 00:00:00

abstract：:Pathogenic micro-organisms employ a broad range of strategies to survive in and to persistently infect the human host. Far from being completely understood by which highly sophisticated means invading pathogens overcome the host's destructive immune defence, there is a growing body of evidence on particular mechanisms...

journal_title：Molecular immunology

authors： Kraiczy P,Würzner R

更新日期：2006-01-01 00:00:00

abstract：:It is well established that aggregation of cell surface immunoglobulin is involved in signal transduction by cells of the immune system. It is less well understood what special properties of these cell surface aggregates are important in initiating the signal cascade. Several authors have proposed that cells respond t...

journal_title：Molecular immunology

authors： Posner RG,Dembo M

更新日期：1994-12-01 00:00:00

abstract：:N-Acetylcysteine (NAC) has been widely used as an antioxidant in research, however, it has also been found to reduce the binding of TNF to its receptor independent of its antioxidative role. In this study, we investigated the effect of NAC on NF-kappaB activation. In HeLa cells, Hep3B cells, and A549 cells, DNA-bindin...

journal_title：Molecular immunology

authors： Liu J,Yoshida Y,Yamashita U

更新日期：2008-09-01 00:00:00

abstract：:In addition to the antigen receptor, resting T cells express a number of receptors that can be stimulated to generate proliferative signals. These "accessory" receptors require co-expression of the T cell receptor (TCR), suggesting that they channel their signals via secondary activation of the signal transduction fun...

journal_title：Molecular immunology

authors： Zhang XM,Berland R,Rosoff PM

更新日期：1995-04-01 00:00:00

abstract：:Age-related macular degeneration (AMD) and membranoproliferative glomerulonephritis type II (MPGN2) are dense deposit diseases that share a genetic association with complement genes and have complement proteins as important components of the dense deposits. Here, we present the case of a 64-year-old smoker male who de...

journal_title：Molecular immunology

authors： Montes T,Goicoechea de Jorge E,Ramos R,Gomà M,Pujol O,Sánchez-Corral P,Rodríguez de Córdoba S

更新日期：2008-05-01 00:00:00

abstract：:Pathogen-driven selection is believed to be important in the evolution and maintenance of the polymorphism of the major histocompatibility complex (MHC) genes but have been tested for very few vertebrates. In this study, we first investigate by SSCP (single strand conformational polymorphism) the diversity found at th...

journal_title：Molecular immunology

authors： Croisetière S,Tarte PD,Bernatchez L,Belhumeur P

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Previous studies have suggested the importance of somatic mutations and arginine, asparagine and lysine residues in the complementarity determining regions (CDRs) of antiphospholipid antibodies (aPL) implicated in the pathogenesis of the antiphospholipid antibody syndrome. The relative contributions of the...

journal_title：Molecular immunology

authors： Giles IP,Haley J,Nagl S,Latchman DS,Chen PP,Chukwuocha RU,Isenberg DA,Rahman A

更新日期：2003-09-01 00:00:00

abstract：:In immune cells, Src-family kinases have been implicated as critical regulators of a large number of intracellular signaling pathways. Studies of gene knockout mice lacking various family members have both confirmed the requirement for these kinases in some pathways and provided surprising insight into their roles in ...

journal_title：Molecular immunology

authors： Lowell CA

更新日期：2004-07-01 00:00:00