The expanding role of innate lymphoid cells and their T-cell counterparts in gastrointestinal cancers.

abstract：:The mammalian interleukin (IL)-6 family of cytokines consist of eight class-I helical cytokines and are major players in hematopoiesis, as well as in neuroendocrine and immune systems, and have pro- and anti-inflammatory properties. We have identified a novel fish CNTF-like molecule, for the first time, as well as the...

journal_title：Molecular immunology

authors： Wang T,Secombes CJ

更新日期：2009-07-01 00:00:00

abstract：:TNFα converting enzyme (TACE) is responsible for converting membrane-anchored TNFα to its soluble form in mammalian. However, the function and characteristics of TACE in teleosts is unclear. In this study, we report the cloning of a cDNA sequence of the PaTACE from ayu, Plecoglossus altivelis. PaTACE encodes an 865-aa...

journal_title：Molecular immunology

authors： Lu XJ,Chen Q,Yang GJ,Chen J

更新日期：2015-02-01 00:00:00

abstract：:Individually amplified kappa cDNA molecules from single B lymphocytes revealed sequence heterogeneity and aberrantly spliced products. The nature and frequency of the base changes and their absence from similarly amplified beta2 microglobulin transcripts indicate that they were not derived by Taq polymerase misincorpo...

journal_title：Molecular immunology

authors： Jena PK,Liu AH,Smith DS,Aviszus K,Wysocki LJ

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:A T cell subtype with the CD4+CD25-FoxP3+ phenotype was recently described. We aimed to investigate the frequency of these cells and their ability to produce cytokines in tumor-draining lymph nodes from patients with breast cancer (BC). MATERIALS AND METHODS:Mononuclear cells from lymph nodes of 20 patients...

journal_title：Molecular immunology

authors： Niakan A,Faghih Z,Talei AR,Ghaderi A

更新日期：2019-12-01 00:00:00

abstract：:Inhibitory antibodies directed against blood coagulation factor VIII (FVIII) impair FVIII replacement therapy, constituting a serious complication in haemophilic and autoimmune patients. Identifying B-cell FVIII epitopes and mapping them on the molecule remain important challenges. Using a combination of different alg...

journal_title：Molecular immunology

authors： Di Giambattista M,Branckaert T,Hougardy V,Kemball-Cook G,Laub R

更新日期：2007-03-01 00:00:00

abstract：:The site of the murine IgG1 molecule that regulates catabolism has recently been shown to encompass amino acids that are located at the CH2-CH3 domain interface. The CH2 and CH3 domains are connected to each other by a relatively flexible "mini-hinge" region, and flexibility in this region could clearly affect the ori...

journal_title：Molecular immunology

authors： Kim JK,Tsen MF,Ghetie V,Ward ES

更新日期：1995-05-01 00:00:00

abstract：:In this paper, we performed further biochemical characterization of the CD26 antigen, as defined by the mAbs in anti-1F7 and anti-Ta1, in order to clarify the observed functional differences among these mAbs. For this purpose, we developed a mAb, anti-5F8, which recognizes yet another epitope on the CD26 antigen diffe...

journal_title：Molecular immunology

authors： Torimoto Y,Dang NH,Tanaka T,Prado C,Schlossman SF,Morimoto C

更新日期：1992-02-01 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, challenges host defense mechanism by impairing the signal transduction of T cells which leads to downregulation of T cell proliferation, mainly as a consequence of interference with IL-2 production. In this study we sought to identify how soluble forms of M. leprae...

journal_title：Molecular immunology

authors： Chattree V,Khanna N,Rao DN

更新日期：2007-03-01 00:00:00

abstract：:A number of fragments derived from acid-treated rabbit IgG by digestion with plasmin have been separated by high-resolution gel filtration. Fragments isolated included a dimer and monomer Facb, named F(acb)2 and Facb, respectively and a heterodimer composed of Facb and Fab subunits, named F(acb)(ab). A C gamma 2 fragm...

journal_title：Molecular immunology

authors： Utsumi S,Okada M,Udaka K,Amano T

更新日期：1985-07-01 00:00:00

abstract：:Optineurin (Optn) is an adaptor protein with homology to NF-κB essential modulator (NEMO), the regulatory subunit of the IκB kinase (IKK) complex. Dysregulation of Optn has been linked to neurodegenerative, autoimmune and bone diseases. Optn shares a high degree of homology with NEMO, but is not part of the same high-...

journal_title：Molecular immunology

authors： Montecalvo A,Watkins SC,Orange J,Kane LP

更新日期：2017-05-01 00:00:00

abstract：:Mast cells have a clear-cut pathologic role in allergy, participating in a number of chronic inflammatory conditions, in helmintic parasitosis, and in some solid tumor reactions, but also in physiological situations, such as wound healing and innate immunity. Mast cells release a large number of proinflammatory, immun...

journal_title：Molecular immunology

authors： Piliponsky AM,Gleich GJ,Bar I,Levi-Schaffer F

更新日期：2002-09-01 00:00:00

abstract：:The peptide editor HLA-DM (DM) catalyzes the exchange of peptides bound to MHC class II molecules within antigen presenting cells by generating a "peptide-receptive" MHC class II conformation (MHC(receptive)) to which peptides readily bind and rapidly unbind. While recent work has uncovered the determinants of DM reco...

journal_title：Molecular immunology

authors： Narayan K,Su KW,Chou CL,Khoruzhenko S,Sadegh-Nasseri S

更新日期：2009-09-01 00:00:00

abstract：:Although the lambda-bearing antibodies represent only 5% of the total mouse serum immunoglobulins, some antigens such as B1355 dextran (alpha (1-3)Dex), the 4-hydroxy-3-nitrophenyl acetyl (NP) and 2,4-dinitro or 2,4,6-trinitrophenyl (DNP/TNP) antigens can induce lambda-positive immune responses. In contrast to the lam...

journal_title：Molecular immunology

authors： Sanchez P,Juy D,Cazenave PA

更新日期：1988-02-01 00:00:00

abstract：:Tehranolide named as new type of a sesquiterpene lactone with an endoperoxide group which purified from Artemisia diffusa and having similar structure to Artemisinin. Tehranolide is hypothesized to possess effects akin to Artemisinin, which is active against cancer cells. In the present research we emphasized on the d...

journal_title：Molecular immunology

authors： Noori S,Taghikhani M,Hassan ZM,Allameha A,Mostafaei A

更新日期：2010-04-01 00:00:00

abstract：:The anti-cytokeratin (CK) 8 monoclonal antibody (mab) TS1 has been shown to efficiently bind to CK8 expressed in carcinomas in vivo. The anti-idiotypic antibody of TS1, alphaTS1, can be used to regulate the tumor:non-tumor ratio of TS1 by clearing non-tumor binding TS1 from the circulation. If the interaction of TS1 t...

journal_title：Molecular immunology

authors： Holm P,Jafari R,Sundström BE

更新日期：2007-02-01 00:00:00

abstract：:Endogenous mouse mammary tumor proviruses (MMTV; Mtv loci) deletes Vbeta6 expressing T cells in the thymus of Mtv-7(+) DBA/2 (H2(d)) mice through negative selection. We found that in Mtv-7(-) BALB/c (H2(d)) mice, Vbeta6 is a dominant V gene used in T cell responses to an 18 amino acid long peptide antigen: EYKEYAEYAEY...

journal_title：Molecular immunology

authors： Kilgannon P,Novak Z,Fotedar A,Singh B

更新日期：2010-02-01 00:00:00

abstract：:Signal transduction by the B cell receptor (BCR) is an absolute requirement for the selection and development of B lymphocytes at multiple checkpoints. Binding to antigen via the BCR is complemented by a co-stimulus delivered through accessory and co-stimulatory cell surface molecules that regulate the signalling thre...

journal_title：Molecular immunology

authors： Galloway TS,Ray K,Malhotra R

更新日期：2003-01-01 00:00:00

abstract：:Infectious salmon anaemia virus (ISAV) is a marine orthomyxovirus of significant interest not only as a cause of a fatal disease of farmed Atlantic salmon resulting in severe economic losses to the aquaculture industry, but also as the only poikilothermic orthomyxovirus. ISAV targets vascular endothelial cells and mac...

journal_title：Molecular immunology

authors： Workenhe ST,Hori TS,Rise ML,Kibenge MJ,Kibenge FS

更新日期：2009-09-01 00:00:00

abstract：:Withanolide, coagulin-H (1), was evaluated for its effect on various cellular functions related to immune response including lymphocyte proliferation, and expression of interleukin-2 (IL-2) cytokine, and results were compared with prednisolone (2), a commonly used immune modulating drug. Coagulin-H (1) was found to ha...

journal_title：Molecular immunology

authors： Mesaik MA,Zaheer-Ul-Haq,Murad S,Ismail Z,Abdullah NR,Gill HK,Atta-Ur-Rahman,Yousaf M,Siddiqui RA,Ahmad A,Choudhary MI

更新日期：2006-04-01 00:00:00

abstract：:Mammals have evolved a special cellular mechanism for killing invading microbes, which is called the phagocytosis. Neutrophils are the first phagocytosing cells that migrate into the site of infection. In these cells, hypochlorite (HOCl) and other hypohalites, generated in the myeloperoxidase (MPO)-hydrogen peroxide (...

journal_title：Molecular immunology

authors： Atosuo J,Suominen E

更新日期：2019-12-01 00:00:00

abstract：:In two recent articles published in Molecular Immunology, Steere and colleagues continue their search for an autoimmune mechanism of arthritis in patients who have failed short-course antibiotic therapy for Borrelia burgdorferi, the spirochetal agent of Lyme disease. As in previous attempts, the authors fail to elucid...

journal_title：Molecular immunology

authors： Stricker RB,Johnson L

更新日期：2008-06-01 00:00:00

abstract：:Dendritic cells (DCs) are suspected to be involved in the development of atherogenesis, but their role is still unclear. The aim of this study was to characterize circulating DCs and monocyte-derived DCs (Mo-DCs) of obese and diabetic patients (T2D), and to study their interaction with human coronary smooth muscle cel...

journal_title：Molecular immunology

authors： Musilli C,Paccosi S,Pala L,Gerlini G,Ledda F,Mugelli A,Rotella CM,Parenti A

更新日期：2011-10-01 00:00:00

abstract：:Peptides representing the amino-terminal sequence of protamines HP1 (sequence 1-12) and HP2 (sequence 1-11), the two major nuclear proteins of human sperm, have been synthesized. Rabbits were immunized either with peptide conjugated with a carrier or with free peptide. The resulting antisera were examined for their ca...

journal_title：Molecular immunology

authors： Rousseaux-Prevost R,Hublau P,Sautiere P,Rousseaux J

更新日期：1991-09-01 00:00:00

abstract：:Interleukin 1β (IL-1β) is a pro-inflammatory cytokine secreted by activated macrophages and monocytes. Previously, we have reported that bone morphogenetic protein-6 (BMP-6) induces inducible nitric oxide synthase (iNOS) expression via IL-1β in macrophages. In the present study, we demonstrate that BMP-6 increases IL-...

journal_title：Molecular immunology

authors： Lee GT,Jung YS,Lee JH,Kim WJ,Kim IY

更新日期：2011-07-01 00:00:00

abstract：:Emerging evidence has indicated that vascular endothelial cells (ECs) not only form the barrier between blood and the vessel wall but also serve as conditional innate immune cells. Our previous study found that SIRT1, a class III histone deacetylase, inhibits the inflammatory response in ECs. Recent studies revealed t...

journal_title：Molecular immunology

authors： Li Y,Wang P,Yang X,Wang W,Zhang J,He Y,Zhang W,Jing T,Wang B,Lin R

更新日期：2016-09-01 00:00:00

abstract：:Rabbits hyperimmunized with fluorescyl-conjugated KLH exhibited bound ligand associated with a high affinity circulating IgG anti-fluorescein population. After cessation of immunogen administration the liganded complexes were eventually spontaneously cleared from the circulation. Individual rabbits synthesized autolog...

journal_title：Molecular immunology

authors： Voss EW Jr,Moore JK,Weidner-McGufficke KM,Denzin LK,Bedzyk WD,Voss VH

更新日期：1992-02-01 00:00:00

abstract：:Activation of Jurkat T cells with phytohemagglutinin, CD3 or CD2 mAbs results in a marked inhibition of phosphatidylserine (PS) synthesis. Monitoring PS synthesis in T cells shows that: (i) after modulation of CD3 molecules the cells become refractory to further treatment with CD3 mAbs as well as to a further challeng...

journal_title：Molecular immunology

authors： Pelassy C,Dallanegra A,Aussel C,Fehlmann M

更新日期：1989-11-01 00:00:00

abstract：:The protective antigen (PA(83)) of Bacillus anthracis is the dominant antigen in natural and vaccine-induced immunity to anthrax infection. Three human single-chain variable fragments (scFvs) against cell bound PA were isolated from an antibody phage display library. Specifically, the antibodies were evaluated for the...

journal_title：Molecular immunology

authors： Steiniger SC,Altobell LJ 3rd,Zhou B,Janda KD

更新日期：2007-04-01 00:00:00

abstract：:We have recently isolated and characterized human and mouse genes of a putative natural killer (NK) cell tumour-recognition protein (NK-TR) that is specifically expressed in NK cells. This gene codes for a 150 kD protein with a cyclophilin-related amino terminus followed by several positively charged domains. We repor...

journal_title：Molecular immunology

authors： Rinfret A,Anderson SK

更新日期：1993-10-01 00:00:00

abstract：:The interaction between a single-chain Fv (sFv) of the monoclonal antibody 3A21 and its antigen, bovine pancreatic ribonuclease A (RNase A), was studied by site-directed mutagenesis of the hypervariable regions and fluorescence polarization analysis. The affinity constants of wild-type sFv and a mutant sFv D31A (Asp31...

journal_title：Molecular immunology

authors： Katakura Y,Kumamoto T,Iwai Y,Kurokawa Y,Omasa T,Suga K

更新日期：1997-07-01 00:00:00