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Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction.

Abstract：

:Interleukin 1β (IL-1β) is a pro-inflammatory cytokine secreted by activated macrophages and monocytes. Previously, we have reported that bone morphogenetic protein-6 (BMP-6) induces inducible nitric oxide synthase (iNOS) expression via IL-1β in macrophages. In the present study, we demonstrate that BMP-6 increases IL-1β expression in macrophages via the receptors ALK3 and BMPRII as well as the downstream signaling protein Smad1. Surprisingly though, inhibition of the ERK and JNK non-Smad pathways also completely blocked the induction of IL-1β by BMP-6 in macrophages. Further analysis revealed that a physical interaction between the transcription factor PU.1 and Smad 1 is necessary for the upregulation of IL-1β expression by BMP-6 in macrophages. Taken together, these results demonstrate that BMP-6-induced IL-1β expression in macrophages is mediated via a cross-talk between the Smad and the non-Smad pathways through Smad1 and PU.1.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Lee GT,Jung YS,Lee JH,Kim WJ,Kim IY

doi

10.1016/j.molimm.2011.04.019

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

1540-7

issue

12-13

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(11)00148-9

journal_volume

48

pub_type

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