IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism.

abstract：:Scygonadin is a novel antimicrobial peptide, which was originally isolated from the seminal plasma of the mud crab, Scylla serrata. Based on the partial 20-residue NH(2)-terminal sequence of the peptide, H-Gly-Gln-Ala-Leu-Asn-Lys-Leu-Met-Pro-Lys-Ile-Val-Ser-Ala-Ile-Ile-Tyr-Met-Val-Gly-OH, scygonadin was cloned from th...

journal_title：Molecular immunology

authors： Wang KJ,Huang WS,Yang M,Chen HY,Bo J,Li SJ,Wang GZ

更新日期：2007-03-01 00:00:00

abstract：:An attempt was made to obtain fragments containing the C gamma 2 region by selectively cleaving human Fc fragments prepared from pooled IgG at Met residues using cyanogen bromide. Based on the known locations of Met residues in the Fc regions of human IgG subclasses, fragments between Met 252 and 358, comprising the C...

journal_title：Molecular immunology

authors： Boulware DW,Goldsworthy PD,Nardella FA,Mannik M

更新日期：1985-12-01 00:00:00

abstract：:The protective antigen (PA(83)) of Bacillus anthracis is the dominant antigen in natural and vaccine-induced immunity to anthrax infection. Three human single-chain variable fragments (scFvs) against cell bound PA were isolated from an antibody phage display library. Specifically, the antibodies were evaluated for the...

journal_title：Molecular immunology

authors： Steiniger SC,Altobell LJ 3rd,Zhou B,Janda KD

更新日期：2007-04-01 00:00:00

abstract：:The thermal effects associated with the binding reaction of concanavalin A and immunoglobulins have been measured by calorimetry. IgG solutions do not generate heat on mixing with concanavalin A, confirming the low reactivity of IgG for the lectin molecule. IgM solutions, on the other hand, show a substantial enthalpi...

journal_title：Molecular immunology

authors： Dani M,Manca F,Rialdi G

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Complement activation involved in the innate immunity and adaptive immunity and further contributed to the development of tumor growth. This study aimed to investigate the association of genetic variants in complement 3 (C3) and decay-accelerating factor (DAF) genes with the risk of gastric cancer. METHODS:...

journal_title：Molecular immunology

authors： Song Q,Zhang Z,Liu Y,Han S,Zhang X

更新日期：2015-02-01 00:00:00

abstract：:Human CD63 has been reported to play a role either as an inhibitor or as a co-stimulator of T- cell responses, although the mechanism of this is unclear. In this study, an anti-human CD63 monoclonal antibody (mAb) COS3A was used to monitor the role of CD63 in T-cell activation. MAb COS3A could inhibit CD3-mediated T-c...

journal_title：Molecular immunology

authors： Wansook S,Mahasongkram K,Chruekamlow N,Pata S,Kasinrerk W,Khunkaewla P

更新日期：2019-10-01 00:00:00

abstract：:We discovered that some bovine antibodies are amongst the largest known to exist due to the presence of an exceptionally long CDR3H (≥49 amino acids) with multiple cysteines that provide a unique knob and stalk structure to the antigen binding site. The large CDR3H size, unlike mouse and human, provides a suitable pla...

journal_title：Molecular immunology

authors： Pasman Y,Soliman C,Ramsland PA,Kaushik AK

更新日期：2016-09-01 00:00:00

abstract：:V(D)J recombination is a mechanism peculiar to the somatic rearrangement of antigen receptor genes. It requires both expression of the RAG-1 and RAG-2 recombinases and accessibility of the substrate to its recombinase and post-cleavage/DNA repair stage. TCR revision is a genetic correction mechanism that changes T cel...

journal_title：Molecular immunology

authors： Lantelme E,Orlando L,Porcedda P,Turinetto V,De Marchi M,Amoroso A,Mantovani S,Giachino C

更新日期：2008-01-01 00:00:00

abstract：:The EGF receptor is an important target of cancer immunotherapies. The 7A7 monoclonal antibody has been raised against the murine EGFR, but it cross-reacts with the human receptor. The results from experiments using immune-competent mice can therefore, in principle, be extrapolated to the corresponding scenario in hum...

journal_title：Molecular immunology

authors： Talavera A,Mackenzie J,Garrido G,Friemann R,López-Requena A,Moreno E,Krengel U

更新日期：2011-07-01 00:00:00

abstract：:The alternative pathway of complement is receiving increasing attention as a therapeutic target because of recent findings in several animal models that support its essential role in tissue injury and disease pathogenesis. Although the contribution of alternative pathway activation to serum complement activation in vi...

journal_title：Molecular immunology

authors： Holers VM,Thurman JM

更新日期：2004-06-01 00:00:00

abstract：:Type 2 Diabetes (T2D) is a disease of increasing importance and represents a growing burden on global healthcare and human health. In T2D, loss of effectiveness of insulin signaling in peripheral tissues cannot be compensated for by adequate insulin secretion, leading to hyperglycemia and resultant complications. In r...

journal_title：Molecular immunology

authors： King BC,Blom AM

更新日期：2017-04-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein that was first identified on the surface of rat mucosal-type mast cells of the RBL-2H3 line. A C-type lectin domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) are located in the extracellular and intracellular domain...

journal_title：Molecular immunology

authors： Abramson J,Xu R,Pecht I

更新日期：2002-09-01 00:00:00

abstract：:The expression levels of three commonly used housekeeping genes, EF1-alpha, RPS20 and Beta-Actin, were examined in seven different tissues and leucocytes from non-stimulated Atlantic salmon (Salmo salar L.). The tissues analysed by quantitative real-time PCR were gill, liver, intestine, muscle, spleen, head kidney leu...

journal_title：Molecular immunology

authors： Ingerslev HC,Pettersen EF,Jakobsen RA,Petersen CB,Wergeland HI

更新日期：2006-03-01 00:00:00

abstract：:The structural and functional integrity of the cell is largely maintained by protein-protein interactions. Recently, we demonstrated that multiple antigenic peptides (MAPs) constructed from 60 kDa Ro sequence could be used to show intramolecular and intermolecular protein-protein interaction within the 60 kDa Ro ribon...

journal_title：Molecular immunology

authors： Scofield RH,Kurien BT,Gross JK,Reed NB,Taylor AK,Dominguez N,Mehta P,Guthridge JM,Bachmann M

更新日期：2004-07-01 00:00:00

abstract：:A two-step purification procedure of Par j I from the whole Parietaria judaica pollen extract is described. The first step consisted of gel filtration HPLC using a TSKG 3000 SW column, and 0.1% trifluoroacetic acid as the eluant. By this method, proteins were separated from the highly colored material present in the e...

journal_title：Molecular immunology

authors： Polo F,Ayuso R,Carreira J

更新日期：1990-02-01 00:00:00

abstract：:Deficiencies in the classical pathway of complement activation have some common features but show also great differences. Deficiencies of each of the components (C1q, C1s, C1r, C4 and C2) imply increased susceptibility to bacterial infections. They are also associated with increased risk to develop systemic lupus eryt...

journal_title：Molecular immunology

authors： Truedsson L

更新日期：2015-11-01 00:00:00

abstract：:Mangiferin is the major bioactive ingredient in the leaves of Mangifera indica L., Aqueous extract of such leaves have been traditionally used as an indigenous remedy for respiratory diseases including cough and asthma in Traditional Chinese Medicine. Mangiferin was shown to exert its anti-asthmatic effect by modulati...

journal_title：Molecular immunology

authors： Yun C,Chang M,Hou G,Lan T,Yuan H,Su Z,Zhu D,Liang W,Li Q,Zhu H,Zhang J,Lu Y,Deng J,Guo H

更新日期：2019-10-01 00:00:00

abstract：:Malignant transformation of hepatocytes is frequently associated with upregulation of HLA-A expression. Currently there is no information available regarding the mechanisms underlying this phenotypic change. We investigated HLA-A expression in 165 paraffin embedded tissues and 21 fresh tissues from liver cancer patien...

journal_title：Molecular immunology

authors： Shen Y,Xia M,Zhang J,Xu L,Yang J,Chen A,Miao F,Ferrone S,Xie W

更新日期：2009-06-01 00:00:00

abstract：:Osteopontin (OPN) is a cytokine with multiple functions, including the regulation of innate immune response. However, the detailed function and mechanism of OPN in host defense against invaded microorganisms remain unclear. In this report, we revealed that OPN could affect the clearance of Propionibacterium acnes in k...

journal_title：Molecular immunology

authors： Yang H,Guo H,Fan K,Zhang B,Zhao L,Hou S,Qian W,Zhang D,Wang H,Dai J,Guo Y

更新日期：2011-09-01 00:00:00

abstract：:Activation-induced cell death (AICD) in T lymphocytes depends on the expression of Fas-ligand, which triggers the apoptotic process after binding to its receptor Fas. This leads to the activation of cysteine proteases of the caspase family and especially of caspase-3, a critical effector protein during AICD. We have p...

journal_title：Molecular immunology

authors： Sabbagh L,Bourbonnière M,Sékaly RP,Cohen LY

更新日期：2005-07-01 00:00:00

abstract：:Helminths, as well as their secretory/excretory products, induce a tolerogenic immune microenvironment. High molecular weight components (PI) from Ascaris suum extract down-modulate the immune response against ovalbumin (OVA). The PI exerts direct effect on dendritic cells (DCs) independent of TLR 2, 4 and MyD88 molec...

journal_title：Molecular immunology

authors： Favoretto BC,Casabuono AAC,Portes-Junior JA,Jacysyn JF,Couto AS,Faquim-Mauro EL

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The complement system plays an important role in the development of acute coronary syndrome (ACS). Complement C1q is an important initial component of the classical complement pathway and closely related to many chronic inflammatory diseases, including atherosclerosis (AS). We aimed to determi...

journal_title：Molecular immunology

authors： Ni XN,Yan SB,Zhang K,Sai WW,Zhang QY,Ti Y,Wang ZH,Zhang W,Zheng CY,Zhong M

更新日期：2020-04-01 00:00:00

abstract：:The Pacific oyster (Crassostrea gigas) is farmed globally. Ostreid herpesvirus (OsHV-1) causes severe mortalities of farmed C. gigas. Management of OsHV-1 has proven difficult. Oysters treated with poly(I:C) exhibit enhanced protection (EP) against OsHV-1. This chemical treatment is highly effective, but it is not fea...

journal_title：Molecular immunology

authors： Green TJ,Helbig K,Speck P,Raftos DA

更新日期：2016-10-01 00:00:00

abstract：:Adiponectin can protect against inflammation; one of the mechanisms involves direct, inhibition of macrophages (MΦ). We postulated that adiponectin anti-sense transgenic (AsTg) mice raised in our laboratory are prone to inflammation because of systemic low adiponectin levels. The writhing response to acetic acid was u...

journal_title：Molecular immunology

authors： Negoro T,Kin M,Takuma A,Saito K,Shimizu S,Nakano Y

更新日期：2014-02-01 00:00:00

abstract：:The general thinking about the phylogenic distribution of vertebrate Ig classes is that fish and urodele amphibians are only able to synthesize polymeric IgM-like molecules and that the emergence of a new class of LMW Ig occurs for the first time in anouran species. Following immunization of the Mexican axolotl (Ambys...

journal_title：Molecular immunology

authors： Fellah JS,Charlemagne J

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:Nuclear components targeted by autoantibodies are a characteristic feature of the autoimmune disease systemic lupus erythematosus (SLE). The nucleosome, a major autoantigen, is released in patients with SLE as a result of a disturbed apoptosis and/or an insufficient clearance of apoptotic debris. During apopt...

journal_title：Molecular immunology

authors： van Bavel CC,Dieker JW,Tamboer WP,van der Vlag J,Berden JH

更新日期：2010-11-01 00:00:00

abstract：:Mice were immunized with a purified preparation of human alpha-foetoprotein (AFP) and their spleen cells were hybridized with mouse myeloma cells. Eleven hybridoma cell lines secreting antibody to AFP were obtained. These antibodies were classified into two groups on the basis of different antigenic determinants they ...

journal_title：Molecular immunology

authors： Nomura M,Imai M,Nakamura T,Miyakawa Y,Mayumi M

更新日期：1982-12-01 00:00:00

abstract：:The human monocyte-like cell line, U-937, was shown to synthesize and secrete C3 by hemolytic assays, radioimmunoassays and metabolic labeling experiments. The daily synthesis of antigenic C3 by unstimulated U-937 cells was low (about 3 ng/10(6) cells/24 hr) over a 3 day period. Induction of the cells to differentiate...

journal_title：Molecular immunology

authors： Minta JO,Isenman DE

更新日期：1987-10-01 00:00:00

abstract：:Human IgE antibodies from nine allergic subjects were found to react with poly-L-lysine (PLL) and other polyamines. Radioimmunoassay inhibition studies indicated that the two amino groups, but not the carboxyl, in lysine contributed to the antibody binding and 4-aminomethyl-1,8-octanediamine, a compound containing thr...

journal_title：Molecular immunology

authors： Zhao Z,Baldo BA,O'Brien RM,Plomley RF

更新日期：2000-04-01 00:00:00

abstract：:We recently identified IgE-binding epitopes of bovine serum albumin (BSA), the major beef allergen, and found that the major epitope structure contains an EXXV motif. Here we report hypoallergenic analogue peptides of BSA that preserve T cell reactivity to retain the capacity to induce immunotolerance. Substitution of...

journal_title：Molecular immunology

authors： Tanabe S,Shibata R,Nishimura T

更新日期：2004-07-01 00:00:00