Hypoallergenic and T cell reactive analogue peptides of bovine serum albumin, the major beef allergen.

abstract：:The synovial sarcoma X breakpoint (SSX) gene family contains nine members. The SSX proteins are CT (cancer/testis) antigens and can be expressed in many tumor types. T cell immune response against SSX protein can be detected in tumor patients and mice expressing any SSX. Screening predominant protective epitopes might...

journal_title：Molecular immunology

authors： He Y,Mao L,Lin Z,Deng Y,Tang Y,Jiang M,Li W,Jia Z,Wang J,Ni B,Wu Y

更新日期：2008-05-01 00:00:00

abstract：:Activation of p38 MAP kinase in T cells leads to increased interferon-gamma production in CD4+ and CD8+ T cells, and the selective cell death of CD8+ T cells. To address the role of p38 MAP kinase activation in T cells during an in vivo immune response, we examined the response against the influenza virus in transgeni...

journal_title：Molecular immunology

authors： Conze D,Lumsden J,Enslen H,Davis RJ,Le Gros G,Rincón M

更新日期：2000-06-01 00:00:00

abstract：:Myeloid differentiation protein 2 (MD-2) is required in the recognition of lipopolysaccharide (LPS) by toll-like receptor 4 (TLR4), and participates in LPS-induced alveolar macrophage (AM) inflammation during acute lung injury (ALI). Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflamm...

journal_title：Molecular immunology

authors： Luo M,Hu L,Li D,Wang Y,He Y,Zhu L,Ren W

更新日期：2017-10-01 00:00:00

abstract：:Stimulation of cells of the rat basophilic leukemia line RBL-2H3, which are used as a model in biochemical studies of mast cells, by antigen or by the calcium ionophore ionomycin, are known to cause secretion of mediators of inflammation. These stimuli have now been found to cause a decrease in the cells' cytosolic pH...

journal_title：Molecular immunology

authors： Gertler R,Pecht I

更新日期：1988-11-01 00:00:00

abstract：:During acute lung injury, a large number of monocytes are recruited into the pulmonary tissue, which is mainly mediated by local production of monocyte chemotactic protein 1 (MCP-1). As an essential component of the lung tissues, alveolar type II epithelial cells are one of the major sources of MCP-1. Therefore, uncov...

journal_title：Molecular immunology

authors： Yan C,Li B,Liu X,Deng C,Cai R,Shen Y,Tang H

更新日期：2019-07-01 00:00:00

abstract：:Three interferon regulatory factor (IRF) genes, CaIRF-1, CaIRF-2 and CaIRF-7, and their promoters of snakehead (Channa argus) were cloned and characterized. The CaIRF-1 gene consists of ten exons, spans 4.3 kb and encodes a putative peptide of 299 aa. The CaIRF-2 gene consists of nine exons, spans 8 kb and encodes a p...

journal_title：Molecular immunology

authors： Jia W,Guo Q

更新日期：2008-04-01 00:00:00

abstract：:The developmental regulation of antigen receptor gene transcription and recombination are mediated by cis regulatory elements. At the T cell receptor beta chain locus (TCRbeta), two DNase I hypersensitive sites within the Jbeta2-Cbeta2 intron contained binding sites for NF-kappaB and additional nuclear factors and wer...

journal_title：Molecular immunology

authors： Whitehurst CE,Hu H,Ryu CJ,Rajendran P,Schmidt T,Chen J

更新日期：2001-01-01 00:00:00

abstract：:Gene regulatory network (GRN) subcircuits have been described for cell fate progressions in animal development. The hallmark of these subcircuits is the integration of promoters, and positive- and negative-acting promoter binding proteins, such that an alteration in function of any one member of the defined subcircuit...

journal_title：Molecular immunology

authors： Xu L,Niesen MI,Blanck G

更新日期：2009-02-01 00:00:00

abstract：:We discovered that some bovine antibodies are amongst the largest known to exist due to the presence of an exceptionally long CDR3H (≥49 amino acids) with multiple cysteines that provide a unique knob and stalk structure to the antigen binding site. The large CDR3H size, unlike mouse and human, provides a suitable pla...

journal_title：Molecular immunology

authors： Pasman Y,Soliman C,Ramsland PA,Kaushik AK

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Allergen epitope characterization provides valuable information useful for the understanding of proteins as food allergens. It is believed that IgE epitopes in general are conformational, nevertheless, for food allergens known to sensitize through the gastrointestinal tract linear epitopes have been suggeste...

journal_title：Molecular immunology

authors： Bøgh KL,Nielsen H,Madsen CB,Mills EN,Rigby N,Eiwegger T,Szépfalusi Z,Roggen EL

更新日期：2012-07-01 00:00:00

abstract：:Human CD63 has been reported to play a role either as an inhibitor or as a co-stimulator of T- cell responses, although the mechanism of this is unclear. In this study, an anti-human CD63 monoclonal antibody (mAb) COS3A was used to monitor the role of CD63 in T-cell activation. MAb COS3A could inhibit CD3-mediated T-c...

journal_title：Molecular immunology

authors： Wansook S,Mahasongkram K,Chruekamlow N,Pata S,Kasinrerk W,Khunkaewla P

更新日期：2019-10-01 00:00:00

abstract：:Arginine kinase (AK) is a panallergen present in crustaceans, which can induce an immunoglobulin (Ig) E-mediated immune response in humans. The aim of this work was to map and characterize the antigenic epitopes of Scylla paramamosain AK. Specific-protein-A-enriched IgG raised in rabbits against purified S. paramamosa...

journal_title：Molecular immunology

authors： Yang Y,Cao MJ,Alcocer M,Liu QM,Fei DX,Mao HY,Liu GM

更新日期：2015-06-01 00:00:00

abstract：:As demonstrated by others, diisopropyl fluorophosphate (DFP) markedly inhibits the O2- generation from guinea-pig polymorphonuclear leukocytes (PMN) stimulated by an antibody complex with ovalbumin (Ag-Ab complex), and also the intracellular uptake of antibody-sensitized erythrocytes by the cells. However, when PMN we...

journal_title：Molecular immunology

authors： Kudoh M,Nakamura T,Koyama J

更新日期：1985-09-01 00:00:00

abstract：:Previously we reported that, early in the antibody response of BALB/c mice to several cytochromes c (CYT) coupled to ovalbumin (OVA), B cells responding to the self antigen mouse CYT recognized a single site on mouse CYT and were in much higher frequency than B cells responding to foreign CYT. In the present study the...

journal_title：Molecular immunology

authors： Mueller CM,Minnerath JM,Jemmerson R

更新日期：1997-08-01 00:00:00

abstract：:The dynamics of human antigen-specific immunoglobulin (Ig) responses in early life are not well characterized. We have previously observed an inverse relationship between allergen-specific Ig concentration and allergen-Ig-binding affinity in allergen-sensitive atopic adults, suggesting a possible feedback relationship...

journal_title：Molecular immunology

authors： Jackola DR,Liebeler CL,Lin CY,Chiu YK,Blumenthal MN,Rosenberg A

更新日期：2005-01-01 00:00:00

abstract：:Immunoglobulins (Ig) require correct folding and assembly of both heavy (H) and light (L) chains to form a functional H2L2 dimer that is secreted from plasma cells. This process is dependent upon the endoplasmic reticulum (ER) chaperone BiP, which targets improperly, folded or assembled Ig molecules for degradation. W...

journal_title：Molecular immunology

authors： McLean GR,Torres M,Trotter B,Noseda M,Bryson S,Pai EF,Schrader JW,Casadevall A

更新日期：2005-05-01 00:00:00

abstract：:A first report of an XLA patient with a polymorphism in Btk SH3 domain has been identified after sequencing of the entire gene. SH3 domain variants might not be detected due to well characterized mutations outside the domain. ...

journal_title：Molecular immunology

authors： Pérez de Diego R,Bravo J,Allende LM,López-Granados E,Rivera J,Ferreira A,Fontán G,García Rodríguez MC

更新日期：2008-01-01 00:00:00

abstract：:Antibodies (Ab) are bifunctional molecules with two domains, a constant region (C) that confers effector properties and a variable (V) region responsible of antigen (Ag) binding. Historically the C and V regions were considered to be functionally independent, with Ag specificity being solely determined by the V region...

journal_title：Molecular immunology

authors： Janda A,Casadevall A

更新日期：2010-04-01 00:00:00

abstract：:Four different proteases were screened for their capability of selectively digesting murine monoclonal IgGl to obtain active F(ab)2. For the screening, a series of five different mouse monoclonal antibodies (IgGl, k) was used, recognizing different tumor-associated antigens and currently used for radioimmunoimaging st...

journal_title：Molecular immunology

authors： Mariani M,Camagna M,Tarditi L,Seccamani E

更新日期：1991-01-01 00:00:00

abstract：:Despite the fact that was one of the first systems to be discovered and investigated in the innate immunity, Complement is continuing to receive growing attention by the scientific community. Complement is involved in several diseases such as diabetes, atherosclerosis or Systemic Lupus Erythematous. Successful therape...

journal_title：Molecular immunology

authors： Castellano G

更新日期：2015-11-01 00:00:00

abstract：:CD20 is a cell-surface marker expressed on mature B cells and most malignant B cells, but not stem or plasma cells. It is an ideal target for monoclonal antibodies (mAb), such as rituximab and ofatumumab, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the p...

journal_title：Molecular immunology

authors： Glennie MJ,French RR,Cragg MS,Taylor RP

更新日期：2007-09-01 00:00:00

abstract：:Notexin and nigexine are monomeric phospholipases A2(PLA2s) from the venoms of Notechis scutatus scutatus and Naja nigricollis, respectively. Polyclonal antibodies raised in mice against these antigenic proteins displayed non-reciprocal cross-reactivity; anti-notexin antibodies recognized notexin but not nigexine, whe...

journal_title：Molecular immunology

authors： Mollier P,Chwetzoff S,Ménez A

更新日期：1990-01-01 00:00:00

abstract：:We have recently isolated and characterized human and mouse genes of a putative natural killer (NK) cell tumour-recognition protein (NK-TR) that is specifically expressed in NK cells. This gene codes for a 150 kD protein with a cyclophilin-related amino terminus followed by several positively charged domains. We repor...

journal_title：Molecular immunology

authors： Rinfret A,Anderson SK

更新日期：1993-10-01 00:00:00

abstract：:Selection of specific antibodies from large repertoires is of importance in generating antibodies to specific structural determinants and in studying structure-function relationships. Alkaline phosphatase (AP) has several isozymes with various degrees of homology and a range of common synthetic substrates. We have pre...

journal_title：Molecular immunology

authors： Jain V,Saini D,Goswami P,Sinha S

更新日期：2007-01-01 00:00:00

abstract：:A panel of hybridomas producing antibodies specific for human growth hormone (hGH) were prepared by using a recombinant hGH [methionylsomatotropin (r-hGH)] as an immunogen. Thirteen representative monoclonal antibodies which showed different reactivity patterns were used to analyze the antigenicities of four different...

journal_title：Molecular immunology

authors： Sawada J,Wada N,Irie M,Tokunaga-Doi T,Ohtsuka E,Ikehara M,Terao T

更新日期：1986-06-01 00:00:00

abstract：:Tunicamycin inhibited the synthesis of glycosylated mu-chains and kappa-chains in the human lymphoblastoid cell line, Daudi. Nonglycosylated IgM could not be detected on the surface of tunicamycin-treated cells by cell surface iodination techniques even under conditions where membrane IgM was re-expressed in control c...

journal_title：Molecular immunology

authors： Kubo RT,Pelanne ML

更新日期：1983-01-01 00:00:00

abstract：:Fibroblast-like synoviocyte (FLS) is the ultimate effectual cells in the pathogenesis of rheumatoid arthritis (RA). The current study was undertaken to investigate whether a proliferation-inducing ligand (APRIL) mediates the function of FLS in an animal model of RA. Rat adjuvant-induced arthritis (AA) was induced by i...

journal_title：Molecular immunology

authors： Chang Y,Jia X,Sun X,Xu S,Wu Y,Zhang L,Wei W

更新日期：2015-03-01 00:00:00

abstract：:Natural killer (NK) cells express receptors that are specific for MHC class I molecules. These receptors play a crucial role in regulating the lytic and cytokine expression capabilities of NK cells. In humans, three distinct families of genes have been defined that encode for receptors of HLA class I molecules. The fi...

journal_title：Molecular immunology

authors： Borrego F,Kabat J,Kim DK,Lieto L,Maasho K,Peña J,Solana R,Coligan JE

更新日期：2002-02-01 00:00:00

abstract：:Dendritic cells (DCs) serve to maintain peripheral tolerance under steady state conditions. Upon triggering by activation signals they initiate strong immune responses. The activation of DCs is accompanied by a rapid upregulation of proinflammatory cytokines, which were shown in other cell types to be regulated by mec...

journal_title：Molecular immunology

authors： Bros M,Wiechmann N,Besche V,Art J,Pautz A,Grabbe S,Kleinert H,Reske-Kunz AB

更新日期：2010-02-01 00:00:00

abstract：:V(D)J recombination is a mechanism peculiar to the somatic rearrangement of antigen receptor genes. It requires both expression of the RAG-1 and RAG-2 recombinases and accessibility of the substrate to its recombinase and post-cleavage/DNA repair stage. TCR revision is a genetic correction mechanism that changes T cel...

journal_title：Molecular immunology

authors： Lantelme E,Orlando L,Porcedda P,Turinetto V,De Marchi M,Amoroso A,Mantovani S,Giachino C

更新日期：2008-01-01 00:00:00