Abstract:
:Human CD63 has been reported to play a role either as an inhibitor or as a co-stimulator of T- cell responses, although the mechanism of this is unclear. In this study, an anti-human CD63 monoclonal antibody (mAb) COS3A was used to monitor the role of CD63 in T-cell activation. MAb COS3A could inhibit CD3-mediated T-cell proliferation and CD25 expression in peripheral blood mononuclear cells (PBMCs), used as a study model, but the suppressive effect was not observed when purified T-cells were used instead of PBMCs. The inhibitory phenomenon was associated with downregulation of IL-2 and IFN-γ by T-cells, but upregulation of IL-10 by monocytes. Neutralizing IL-10 with anti-IL-10 mAb improved the T-cell response, indicating the role of IL-10 in T-cell suppression. In this study, monocytes were demonstrated to play a role in impeding T-cell activation by the anti-CD63 mAb COS3A. This is the first evidence that anti-CD63 mAb induces IL-10 secretion by monocytes, which later play a role in T-cell hypo-responsiveness.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Wansook S,Mahasongkram K,Chruekamlow N,Pata S,Kasinrerk W,Khunkaewla Pdoi
10.1016/j.molimm.2019.09.005subject
Has Abstractpub_date
2019-10-01 00:00:00pages
591-599eissn
0161-5890issn
1872-9142pii
S0161-5890(19)30300-1journal_volume
114pub_type
杂志文章abstract::The number of V alpha and V beta sequences of T cell receptors now available allows a meaningful analysis of their variability profiles. Variability plots were derived using a modified form of Wu and Kabat's algorithm: variability is not computed as a proportion of the number of different residues occurring at a posit...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(91)90178-m
更新日期:1991-09-01 00:00:00
abstract::The B1 molecule (CD20) is a phosphoprotein expressed only by B-lymphocytes. In this study, analysis of B1 immunoprecipitated from surface iodinated B-cell lines and B-lymphocytes has shown that there are several expressed forms of B1. A predominant species of Mr 33,000 represents 75-80% of the iodinated cell surface B...
journal_title:Molecular immunology
pub_type: 杂志文章
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journal_title:Molecular immunology
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journal_title:Molecular immunology
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pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2012.03.023
更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.molimm.2011.09.008
更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0161-5890(02)00259-6
更新日期:2003-01-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(86)90147-1
更新日期:1986-11-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2011.06.216
更新日期:2011-09-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(95)00019-b
更新日期:1995-05-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(90)90140-u
更新日期:1990-03-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(84)90069-5
更新日期:1984-06-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2019.07.003
更新日期:2019-10-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2017.08.025
更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(99)00140-6
更新日期:1999-12-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章,评审
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更新日期:2002-10-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2020.12.019
更新日期:2021-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(87)90079-4
更新日期:1987-10-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(01)00095-5
更新日期:2002-01-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2017.08.006
更新日期:2017-10-01 00:00:00
abstract::A monoclonal antibody (vpg15) has been described which can block infection with feline immunodeficiency virus (FIV) and which recognizes the feline homologue of CD9. In order to study the role of feline CD9 in infection with FIV we have molecularly cloned a cDNA encoding feline CD9 by R.A.C.E (rapid amplification of c...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(95)00008-3
更新日期:1995-04-01 00:00:00
abstract::Pulmonary surfactant proteins, SP-A and SP-D, are carbohydrate pattern recognition molecules of innate immunity, which significantly enhance phagocytosis and killing of Aspergillus fumigatus, a pathogenic fungus, by neutrophils and macrophages. The present study examined the susceptibility of immunosuppressed SP-A gen...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2010.02.027
更新日期:2010-06-01 00:00:00