当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > Immune evasion by acquisition of complement inhibitors: the mould Aspergillus binds both factor H and C4b binding protein.

Immune evasion by acquisition of complement inhibitors: the mould Aspergillus binds both factor H and C4b binding protein.

Abstract：

:Pathogenic fungi represent a major threat particularly to immunocompromised hosts, leading to severe, and often lethal, systemic opportunistic infections. Although the impaired immune status of the host is clearly the most important factor leading to disease, virulence factors of the fungus also play a role. Factor H (FH) and its splice product FHL-1 represent the major fluid phase inhibitors of the alternative pathway of complement, whereas C4b-binding protein (C4bp) is the main fluid phase inhibitor of the classical and lectin pathways. Both proteins can bind to the surface of various human pathogens conveying resistance to complement destruction and thus contribute to their pathogenic potential. We have recently shown that Candida albicans evades complement by binding both Factor H and C4bp. Here we show that moulds such as Aspergillus spp. bind Factor H, the splicing variant FHL-1 and also C4bp. Immunofluorescence and flow cytometry studies show that the binding of Factor H and C4bp to Aspergillus spp. appears to be even stronger than to Candida spp. and that different, albeit possibly nearby, binding moieties mediate this surface attachment.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Vogl G,Lesiak I,Jensen DB,Perkhofer S,Eck R,Speth C,Lass-Flörl C,Zipfel PF,Blom AM,Dierich MP,Würzner R

doi

10.1016/j.molimm.2007.08.011

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

1485-93

issue

5

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(07)00714-6

journal_volume

45

pub_type

杂志文章

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • Role of MAIT cells in metabolic diseases.

    abstract：:MAIT cells are innate-like T cells that are enriched in mucosal sites and tissues including adipose tissue and liver. They play an important role in immunity against microbial pathogens. Recently, it has been reported that MAIT cells could also be important in metabolic diseases and can be involved in setting up and m...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.12.014

    authors： Toubal A,Lehuen A

    更新日期：2021-02-01 00:00:00

  • Carbohydrate binding specificity of the basic lectin from winged bean (Psophocarpus tetragonolobus).

    abstract：:The carbohydrate binding specificity of the basic lectin from winged bean (Psophocarpus tetragonolobus) was investigated by quantitative precipitin analysis using blood group A, B, H, Le and I substances and by precipitation inhibition with various mono- and oligosaccharides. The lectin precipitated best with A1 subst...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(89)90101-6

    authors： Matsuda T,Kabat EA,Surolia A

    更新日期：1989-02-01 00:00:00

  • Molecular cloning and characterization of CD9 cDNA from cartilaginous fish, red stingray, Dasyatis akajei.

    abstract：:CD9 is a glycoprotein of the transmembrane 4 superfamily (TM4SF) and is involved in various cellular processes. In this study, we describe the isolation of the full-length cDNA encoding for CD9 molecule (daCD9) of red stingray, Dasyatis akajei. This 1252 bp cDNA was isolated from leukocyte cDNA library and contains 68...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.10.005

    authors： Zhu J,Yan K,Lu L,Peng C,Zhou C,Chen S,Xie X,Dong M,Xu A

    更新日期：2006-04-01 00:00:00

  • Nucleotide deletion of T cell receptor V gamma 2 and J gamma 2 coding sequences at V gamma 2-J gamma 2 junctions in immature B cell lines.

    abstract：:Immature B cell lines transformed with a temperature-sensitive mutant of Abelson murine leukaemia virus undergo preferentially V gamma 2 to J gamma 2 joinings during culture at a non-permissive temperature (39 degrees C). Here we examined nucleotide addition and deletion at the V gamma 2-J gamma 2 junctions in these V...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90123-f

    authors： Tsukada S,Oka Y,Sugiyama H

    更新日期：1992-07-01 00:00:00

  • Immunochemical and related interactions with dextrans reviewed in terms of improved structural information.

    abstract：:Structurally diverse dextrans from Leuconostoc mesenteroides and related bacteria have been used extensively in fundamental immunochemical studies such as induction and characterization of anti-dextran antibodies, as well as in studies of their interaction with pneumococcal antisera, normal bovine serum, concanavalin ...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/0161-5890(86)90131-8

    authors： Jeanes A

    更新日期：1986-09-01 00:00:00

  • Linkage of two pseudogenes from V kappa 1 and V kappa 9 murine immunoglobulin families.

    abstract：:As an initial step towards the molecular analysis of the murine V kappa locus, a cosmid library from BALB/cJ mouse liver DNA was screened with probes representing 10 V kappa families. Of eight cosmids that were isolated from the initial screen, five contained a single restriction fragment that hybridized to the probes...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90015-p

    authors： Lawler AM,Umar A,Gearhart PJ

    更新日期：1992-03-01 00:00:00

  • Functional analysis of naturally occurring amino acid substitutions in human IFN-gammaR1.

    abstract：:IFN-gamma plays an essential role in the IL-12/IL-23/IFN-gamma pathway that is required for the defense against intracellular pathogens. In the IFN-gammaR1 several amino acid substitutions have been reported that abrogate IFN-gamma signaling. These substitutions can lead to a null phenotype and enhanced susceptibility...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.11.016

    authors： van de Wetering D,de Paus RA,van Dissel JT,van de Vosse E

    更新日期：2010-02-01 00:00:00

  • Optimal combination of beneficial mutations for improved ADCC effector function of aglycosylated antibodies.

    abstract：:The Fc region of IgG antibodies is crucial for binding to Fc receptors expressed on the surfaces of various immune leukocytes and eliciting therapeutic effector functions such as clearance of antibody-opsonized tumor cells. Despite abrogated Fc gamma receptor (FcγR) binding and therapeutic effector function in the abs...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.07.007

    authors： Yoon HW,Jo M,Ko S,Kwon HS,Lim CS,Ko BJ,Lee JC,Jung ST

    更新日期：2019-10-01 00:00:00

  • Specificity of ganglioside binding to rat macrophages.

    abstract：:The binding specificity of rat alveolar macrophages (AM phi) for sheep erythrocytes (E) coated with gangliosides GM1, GM2, GM3, GD1a, GD1b or GT1b was analyzed in a rosette assay by studying the inhibitory effect of gangliosides, various carbohydrates, IgG, C3b-like C3, and fibronectin in this assay. The uptake of gan...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90163-x

    authors： Förster O,Boltz-Nitulescu G,Holzinger C,Wiltschke C,Riedl M,Ortel B,Fellinger A,Bernheimer H

    更新日期：1986-11-01 00:00:00

  • ASF1a enhances antiviral immune response by associating with CBP to mediate acetylation of H3K56 at the Ifnb promoter.

    abstract：:ASF1a (anti-silencing function 1a), an evolutionarily conserved protein and a histone chaperone, is required for a variety of chromatin-mediated cellular processes. However, the function of ASF1a in innate immune response remains unclear. Here, we find that ASF1a is induced in Vesicular Stomatitis Virus (VSV)-infected...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2016.08.008

    authors： Liu Z,Yang L,Sun Y,Xie X,Huang J

    更新日期：2016-10-01 00:00:00

  • Discerning the kinetics of autoimmune manifestations in a model of Sjögren's syndrome.

    abstract：:Ectopic follicles are non-encapsulated organized lymphoid structures that form at sites of inflammation and presumably contribute to the activation and differentiation of cells with autoreactive potential within target tissues. As such, directed targeting of ectopic follicles in settings of autoimmunity may provide a ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2014.05.006

    authors： Karnell JL,Mahmoud TI,Herbst R,Ettinger R

    更新日期：2014-12-01 00:00:00

  • Prolactin peptide (pPRL) induces anti-prolactin antibodies, ROS and cortisol but suppresses specific immune responses in rainbow trout.

    abstract：:Prolactin has several immune functions in fish however, the effects on innate and specific components of rainbow trout immunity are currently unknown. Therefore in this study, prolactin peptide (pPRL) injection in rainbow trout generated anti-PRL antibodies that were confirmed through Western blot assays of fish brain...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.08.020

    authors： Villalba M,Gómez G,Torres L,Maldonado N,Espiñeira C,Payne G,Vargas-Chacoff L,Figueroa J,Yáñez A,Olavarría VH

    更新日期：2020-11-01 00:00:00

  • Association between combined properdin and mannose-binding lectin deficiency and infection with Neisseria meningitidis.

    abstract：BACKGROUND:Individuals genetically deficient of properdin are more susceptible to meningococcal disease. Likewise low concentration or decreased biological activity of mannose-binding lectin (MBL) is associated with higher incidence of bacterial infections during childhood. In this study we report our findings in a Dan...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.02.017

    authors： Bathum L,Hansen H,Teisner B,Koch C,Garred P,Rasmussen K,Wang P

    更新日期：2006-02-01 00:00:00

  • Junctional diversity prevents negative selection of an antigen-specific T cell repertoire.

    abstract：:Endogenous mouse mammary tumor proviruses (MMTV; Mtv loci) deletes Vbeta6 expressing T cells in the thymus of Mtv-7(+) DBA/2 (H2(d)) mice through negative selection. We found that in Mtv-7(-) BALB/c (H2(d)) mice, Vbeta6 is a dominant V gene used in T cell responses to an 18 amino acid long peptide antigen: EYKEYAEYAEY...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.11.006

    authors： Kilgannon P,Novak Z,Fotedar A,Singh B

    更新日期：2010-02-01 00:00:00

  • Amino acid sequence of a light chain variable region of a human rheumatoid factor of the Wa idiotypic group, in part predicted by its reactivity with antipeptide antibodies.

    abstract：:Antipeptide antisera were raised to the second and third complementarity-determining regions of the light chain derived from a human monoclonal IgM (Sie) which had antigammaglobulin activity and belonged to the Wa cross-reactive idiotypic group of human rheumatoid factors, two of whose members (Sie, Wo1) had been prev...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90049-0

    authors： Newkirk M,Chen PP,Carson D,Posnett D,Capra JD

    更新日期：1986-03-01 00:00:00

  • NCCRP-1: a novel receptor protein sequenced from teleost nonspecific cytotoxic cells.

    abstract：:The recognition structure responsible for binding to conventional antigen on target cells has not previously been described for nonspecific cytotoxic cells (NCC) or for mammalian natural killer (NK) cells. Although several biochemical pathways may be available for initiation of the lytic cycle in NCC, evidence present...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(97)00086-2

    authors： Jaso-Friedmann L,Leary JH 3rd,Evans DL

    更新日期：1997-08-01 00:00:00

  • Epitope complementarity and idiotypic interactions: a study of idiotypic-like interactions between anti-cytidine and anti-guanosine A/J mouse monoclonal antibodies--I. Characterization of these interactions.

    abstract：:Idiotypic-like interactions between mAbs directed against cytidine (Cyd) or guanosine (Guo) nucleosides were characterized. These mAbs, Cyd-1 (IgG2b, kappa), Guo-1 (IgG1, kappa) and Guo-2 (IgG1, kappa) were derived from splenocytes of A/J mice immunized with Cyd-KLH or Guo-KLH and recognized the nucleoside base moieti...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(94)90139-2

    authors： Cottet MH,Denoyelle C,Bordenave G

    更新日期：1994-01-01 00:00:00

  • Novel monoclonal antibodies to cyclosporine A: characterization and epitope mapping with cyclosporine analogs and cyclophilin.

    abstract：:Monoclonal antibodies to cyclosporine A (Cs), a potent immunosuppressant, were generated in BALB/c mice using a novel antigen prepared by linking Cs to a protein carrier via a photoactive cross-linking reagent, 4-benzoylbenzoic acid (BBa). Twenty-two monoclonal anti-Cs antibodies were generated, using Cs-BBa-bovine se...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90162-q

    authors： Cacalano NA,Aggarwal R,Quesniaux VF,Cleveland WL,Erlanger BF

    更新日期：1992-01-01 00:00:00

  • The anti-oxidative, anti-inflammatory, and protective effect of S100A8 in endotoxemic mice.

    abstract：:Polymorphonuclear neutrophils (PMNs) produce and release copious amounts of reactive oxygen species (ROS) which target potential bacterial invaders but also contribute to the inflammation-associated organ injuries seen in sepsis. Calprotectin is an immune regulatory protein complex made of S100A8 and S100A9 that inhib...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2012.10.002

    authors： Sun Y,Lu Y,Engeland CG,Gordon SC,Sroussi HY

    更新日期：2013-04-01 00:00:00

  • Hydrophilic-amphiphilic transition of the terminal SC5b-8 complement complex through tryptic modification: biochemical and ultrastructural studies.

    abstract：:the SC5b-8 complex of human complement is a hydrophilic molecule of mol. wt 800,000-850,000 that is seen in the electron microscope as an elongated, straight or curved structure of 50-55 nm total length and 8-9 nm width. Tryptic attack on the fluid-phase complex exposes lipid-binding surfaces on the molecule. The tryp...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90327-3

    authors： Bhakdi S,Tranum-Jensen J

    更新日期：1982-09-01 00:00:00

  • Exogenous interleukin-2 does not reverse the immunoinhibitory effects of 1,25-dihydroxyvitamin D3 on human peripheral blood lymphocyte immunoglobulin production.

    abstract：:1,25-Dihydroxyvitamin D3 (1,25-D3) is known to have potent inhibitory effects on human peripheral blood mononuclear cell (PBMC) functions. Previous experiments suggest that addition of interleukin-2 (IL-2) to cell cultures can reverse the antiproliferative action of 1,25-D3. Previous studies have also shown that the C...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(90)90064-7

    authors： Jordan SC,Lemire JM,Sakai RS,Toyoda M,Adams JS

    更新日期：1990-01-01 00:00:00

  • Antigenic determinants reacting with rheumatoid factor: epitopes with different primary sequences share similar conformation.

    abstract：:Polyclonal or monoclonal human IgM rheumatoid factors (RF) react with eight antigenic sites on the CH3 IgG domain, four sites on CH2 and two on human beta 2-microglobulin. All 14 of these RF-reactive epitopes are linear 7-11 amino acid peptides with different primary sequence. We questioned whether RF reactivity with ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(97)00024-2

    authors： Williams RC Jr,Malone CC,Kolaskar AS,Kulkarni-Kale U

    更新日期：1997-05-01 00:00:00

  • Comprehensive gene expression profiling following DNA vaccination of rainbow trout against infectious hematopoietic necrosis virus.

    abstract：:The DNA vaccine based on the glycoprotein gene of Infectious hematopoietic necrosis virus induces a non-specific anti-viral immune response and long-term specific immunity against IHNV. This study characterized gene expression responses associated with the early anti-viral response. Homozygous rainbow trout were injec...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.12.005

    authors： Purcell MK,Nichols KM,Winton JR,Kurath G,Thorgaard GH,Wheeler P,Hansen JD,Herwig RP,Park LK

    更新日期：2006-05-01 00:00:00

  • Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells.

    abstract：:The anti-inflammatory cytokine IL-10 is a key modulator of immune responses. A better understanding of the regulation of this cytokine offers the possibility of tipping the balance of the immune response toward either tolerance, or enhanced immune responses. Histone deacetylases (HDACs) have been widely described as n...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2014.02.019

    authors： Cheng F,Lienlaf M,Perez-Villarroel P,Wang HW,Lee C,Woan K,Woods D,Knox T,Bergman J,Pinilla-Ibarz J,Kozikowski A,Seto E,Sotomayor EM,Villagra A

    更新日期：2014-07-01 00:00:00

  • Epitope analysis of the allergen ovalbumin (Gal d II) with monoclonal antibodies and patients' IgE.

    abstract：:Ovalbumin (OVA) is a major allergen (Gal d II) of hen egg white and is often the cause of hypersensitivity reactions to food. Further knowledge of the antigenic and allergenic epitopes of allergens will provide better treatment of this disease. To analyse these epitopes we produced a panel of monoclonal antibodies (mA...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90055-3

    authors： Kahlert H,Petersen A,Becker WM,Schlaak M

    更新日期：1992-10-01 00:00:00

  • High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G.

    abstract：:A common feature of human IgG1 antibodies used for cancer treatment is that their anti-tumour efficacy requires high serum trough levels and continued therapy for several months. Treatment cycles, thereby, consume several grams of IgG1 translating into significant drug needs and costs. The basis for the low in vivo ef...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.07.010

    authors： Preithner S,Elm S,Lippold S,Locher M,Wolf A,da Silva AJ,Baeuerle PA,Prang NS

    更新日期：2006-03-01 00:00:00

  • Gene structures and promoter characteristics of interferon regulatory factor 1 (IRF-1), IRF-2 and IRF-7 from snakehead Channa argus.

    abstract：:Three interferon regulatory factor (IRF) genes, CaIRF-1, CaIRF-2 and CaIRF-7, and their promoters of snakehead (Channa argus) were cloned and characterized. The CaIRF-1 gene consists of ten exons, spans 4.3 kb and encodes a putative peptide of 299 aa. The CaIRF-2 gene consists of nine exons, spans 8 kb and encodes a p...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.11.011

    authors： Jia W,Guo Q

    更新日期：2008-04-01 00:00:00

  • Low ligand binding activities of two distinct types of Fc gamma receptor on guinea-pig peripheral blood polymorphonuclear leukocytes are differentially improved by proteolysis or platelet activating factor.

    abstract：:The expression and ligand binding activity of Fc receptors for IgG (Fc gamma R) on guinea-pig peripheral blood polymorphonuclear leukocytes (blood PMN) have been compared with those on casein-elicited peritoneal PMN (exudate PMN). Both the PMN were found to express two distinct types of Fc gamma R, one specific for Ig...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90194-3

    authors： Fukuchi Y,Sato M,Yamashita T,Koyama J

    更新日期：1992-05-01 00:00:00

  • Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.

    abstract：:Somatic hypermutation (SHM) in immunoglobulin gene (Ig) variable (V) regions is critical for the maturation of the antibody response. It is dependent on the expression of activation-induced cytidine deaminase (AID) and translesion DNA polymerases in germinal center B cells as well as Ig V transcription, as regulated b...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.10.018

    authors： Komori A,Xu Z,Wu X,Zan H,Casali P

    更新日期：2006-04-01 00:00:00

  • Serologic variations in kappa light chains of various Mus species correlate with differences in gene structure.

    abstract：:Kappa light chains were investigated in sera of several groups of wild derived mouse strains by radioimmunological analysis using xenogeneic anti-mouse kappa light chain antibodies. Although the majority of strains tested expressed serologically indistinguishable kappa chains, several significant exceptions were obser...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90068-4

    authors： Mami F,Gris C,Guenet JL,Bonhomme F,Cazenave PA

    更新日期：1986-08-01 00:00:00