Abstract：
:Ectopic follicles are non-encapsulated organized lymphoid structures that form at sites of inflammation and presumably contribute to the activation and differentiation of cells with autoreactive potential within target tissues. As such, directed targeting of ectopic follicles in settings of autoimmunity may provide a means to specifically inhibit the activation of autoreactive cells without impairing protective immune responses ongoing in peripheral lymphoid tissues. NOD·H2h4 mice are a non-diabetic strain of NOD mice which develop a Sjögren's syndrome-like disease which includes the formation of ectopic follicles in the salivary gland and characteristic Sjögren's autoantibodies. The goal of these studies was to better characterize the formation of ectopic follicles in this model and to explore their contribution to autoimmunity. Our studies show that by 8 weeks of age, young NOD·H2h4 mice spontaneously develop an abundance of splenic germinal centers, prior to the emergence of lymphocyte infiltration in the salivary gland tissue. Ectopic follicle formation in the salivary gland begins to appear in these mice between 12 and 16 weeks of age. Interestingly, anti-Ro and anti-La autoantibodies precede the development of ectopic follicles in young NOD·H2h4 mice. In contrast, production of anti-dsDNA antibodies is delayed and largely coincides with the formation of ectopic follicles in these mice. These data suggest that tertiary lymphoid structures may arise from the trafficking of activated T and B cells to sites of inflammation in non-lymphoid tissues. Furthermore, local presentation of autoantigens may then promote the expansion of autoreactive cells with specificities distinct from those generated in the splenic micro-environment.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Karnell JL,Mahmoud TI,Herbst R,Ettinger Rdoi
10.1016/j.molimm.2014.05.006subject
Has Abstractpub_date
2014-12-01 00:00:00pages
277-82issue
2eissn
0161-5890issn
1872-9142pii
S0161-5890(14)00102-3journal_volume
62pub_type
杂志文章abstract：:Mutations in the RAS family of oncogenes are highly prevalent in human cancer and, amongst its manifold effects, oncogenic RAS impairs the expression of components of the antigen presentation pathway. This allows evasion of cytotoxic T lymphocytes (CTL). CTL and natural killer (NK) cells are reciprocally regulated by ...
journal_title：Molecular immunology
pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.molimm.2007.09.022
更新日期：2008-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0161-5890(03)00024-5
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pub_type： 杂志文章
doi：10.1016/j.molimm.2009.11.020
更新日期：2010-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1986-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1998-06-01 00:00:00
