Abstract:
:The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword that is essential for protection but may also become harmful and contribute to eye pathology. Here, we review the evidence for the involvement of complement system dysregulation in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica, highlighting the relationship between morphogical changes and complement system protein expression and regulation in these diseases. The potential benefits of complement inhibition in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica are abundant, as are those of further research to improve our understanding of complement-mediated injury in these diseases.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Mohlin C,Sandholm K,Ekdahl KN,Nilsson Bdoi
10.1016/j.molimm.2017.05.028subject
Has Abstractpub_date
2017-09-01 00:00:00pages
84-99eissn
0161-5890issn
1872-9142pii
S0161-5890(17)30162-1journal_volume
89pub_type
杂志文章,评审abstract::We have sequenced the TCRs from Ld-specific alloreactive T cell hybridomas, whose reactivities we have found to be quite representative of those of a primary dm2 anti-BALB/cJ mixed lymphocyte reaction. We find V beta 6, V beta 7, V beta 8 and V beta 10 gene segments. V alpha usage is diverse, although closely related ...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(96)00034-x
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abstract::Dendritic cells (DCs) are suspected to be involved in the development of atherogenesis, but their role is still unclear. The aim of this study was to characterize circulating DCs and monocyte-derived DCs (Mo-DCs) of obese and diabetic patients (T2D), and to study their interaction with human coronary smooth muscle cel...
journal_title:Molecular immunology
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更新日期:2011-10-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:1991-04-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(96)00068-5
更新日期:1996-09-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:1989-04-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2012.09.001
更新日期:2013-04-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(95)00030-i
更新日期:1995-06-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(82)90216-4
更新日期:1982-03-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(95)00107-7
更新日期:1996-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2016.09.004
更新日期:2016-10-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(91)90178-m
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journal_title:Molecular immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:1983-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(93)90002-s
更新日期:1993-06-01 00:00:00